Twin Research and Human Genetics最新文献_第10页

Twin Births in 42 Sub-Saharan African Countries from 1986 to 2016: Frequency, Trends and Factors of Variation. 1986年至2016年42个撒哈拉以南非洲国家的双胞胎出生：频率、趋势和变异因素。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-04-22 DOI: 10.1017/thg.2025.18

Adama Ouedraogo, Gilles Pison, Sophie le Coeur, Abdramane B Soura

{"title":"Twin Births in 42 Sub-Saharan African Countries from 1986 to 2016: Frequency, Trends and Factors of Variation.","authors":"Adama Ouedraogo, Gilles Pison, Sophie le Coeur, Abdramane B Soura","doi":"10.1017/thg.2025.18","DOIUrl":"https://doi.org/10.1017/thg.2025.18","url":null,"abstract":"Since the 1970s, twin birth rates have increased sharply in developed countries. In Africa, where the rate is the highest globally, its evolution and variation are poorly understood. This article aims to estimate the twinning rate in sub-Saharan African (SSA) countries throughout 1986-2016 and analyze its spatial, temporal, and ethnic variations. It also seeks to identify social and demographic factors associated with a high probability of twin births and outline a forecast of the twinning rate. We used data from 174 Demographic and Health Surveys from 42 countries. We supplemented them with the UN World Population Prospects (WPP). The twinning rate was calculated by reporting the number of twin births per thousand total births. We used logistic regression to analyze the factors associated with twin births. We projected the twinning rate based on WPP. The overall SSA twinning rate is 17.4 per 1000, but it has changed very little over time, and we expect it will grow a little between 2015 and 2050, increasing at most from 17.4 per 1000 to 18.4 per 1000. We also show significant differences in the twinning rate in SSA according to mother ethnicity. Most ethnic groups with high twinning rates belong to the large Bantu ethnic family. SSA remains the 'land of twins', with the twinning rate changing slowly. However, specific health policies must target twin births in SSA to address the public health challenges they present.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-17"},"PeriodicalIF":1.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Financial Stressors and Risk of Suicidal Behavior in a Swedish National Cohort. 瑞典国家队列的财务压力因素和自杀行为风险。

IF 1.2 4区医学

Twin Research and Human Genetics Pub Date : 2025-04-22 DOI: 10.1017/thg.2025.19

Alexis C Edwards, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler

{"title":"Financial Stressors and Risk of Suicidal Behavior in a Swedish National Cohort.","authors":"Alexis C Edwards, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler","doi":"10.1017/thg.2025.19","DOIUrl":"10.1017/thg.2025.19","url":null,"abstract":"Although financial stressors are implicated as risk factors for suicidal behavior, these associations might be confounded by other factors. Furthermore, a move toward high-risk subgroup definition is necessary. The authors used Swedish national registry data to examine the associations between receipt of social welfare, unemployment benefits, or early retirement (N = 627,745-2,260,753) with suicidal behavior in Cox proportional hazards models. They applied co-relative models to improve causal inference, and examined interactions with aggregate genetic risk for suicidality. All three exposures were associated with elevated suicidal behavior risk. Initial hazard ratios for suicide attempt ranged from 1.37-3.86, were similar for suicide death, and declined after controlling for psychopathology and time elapsed after exposure. Age at registration differentially impacted risk of suicidal behavior. Aggregate genetic liability for suicidality was associated with risk, but its effect was not moderated by financial stress. Financial stressors are associated with suicidal behavior risk even after controlling for psychopathology. Associations are attributable in part to familial confounding, though a potentially causal pathway was observed in most cases. Suicidality risk varied as a function of sex and age at exposure; these findings could be used to identify subgroups at high risk who warrant targeted prevention.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capturing Gender Diversity in Twin Research. 捕捉双胞胎研究中的性别多样性。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-04-15 DOI: 10.1017/thg.2025.14

Will Conabere, Anja Ravine, Louise Bourchier, Sue Malta, Jessica Tyler, Shuai Li, John L Hopper, Ken C Pang

引用次数: 0

Abstracts from the 19th International Congress on Twin Studies, 26-28 September 2024. 第19届国际双胞胎研究大会摘要，2024年9月26-28日。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-04-14 DOI: 10.1017/thg.2025.12

引用次数: 0

The Excess Mortality Among Twins in the Dominican Republic and Haiti Through the Components of Age Under Five: A Comparative Study of Trends and Associated Factors. 多明尼加共和国和海地五岁以下双胞胎的超额死亡率：趋势和相关因素的比较研究。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-24 DOI: 10.1017/thg.2025.11

Adama Ouedraogo, David Jean Simon, Ann Kiragu, Nicole Estefany Aponte Cueto, Vénunyé Claude Kondo Tokpovi

{"title":"The Excess Mortality Among Twins in the Dominican Republic and Haiti Through the Components of Age Under Five: A Comparative Study of Trends and Associated Factors.","authors":"Adama Ouedraogo, David Jean Simon, Ann Kiragu, Nicole Estefany Aponte Cueto, Vénunyé Claude Kondo Tokpovi","doi":"10.1017/thg.2025.11","DOIUrl":"https://doi.org/10.1017/thg.2025.11","url":null,"abstract":"Despite the decline in mortality rates among children in developing countries, disparities persist between countries, particularly between twins and singletons. This study employed data from nine Demographic and Health Surveys in the Dominican Republic and Haiti to estimate and compare mortality rates for twins and singletons in categories of the under-5 age group (neonatal, postneonatal, and child mortality) and examine the factors associated with excess mortality among twins. From 1996 to 2013, the under-5 mortality rate (U5MR) for singletons in the Dominican Republic declined from 56‰ (95% CI [47, 64) to 30‰ (22-39) and from 108‰ (53-164) to 53‰ (16-89) among twins. In Haiti, between 1994 and 2016, the U5MR declined from 121‰ (109-133) to 77‰ (68-80) for singletons and from 432‰ (327-538) to 204‰ (149-260) among twins. The adjusted risk of neonatal death for twins is 1.4 (1.0-1.9) times higher than for singletons in the Dominican Republic, compared to a risk of 4.3 (3.5-5.3) times higher in Haiti. In the post-neonatal period, the mortality risk for twins in the Dominican Republic was 1.8 (1.0-3.1) times higher than that for singletons, 2.9 (2.3-3.8) in Haiti. The risk of death for twins was not significantly different from that for singletons in both the Dominican Republic and Haiti at ages 1-4 years. Low birth weight, lack of breastfeeding, absence of, or inadequate, antenatal care, noncesarean section birth, and high birth order were associated with excess mortality among twins in both countries.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-20"},"PeriodicalIF":1.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Experiences of Patients With Vanishing Twin Syndrome: A Mixed-Methods Exploration of Patient Satisfaction and Miscarriage Information. 双胎消失综合征患者的经历：患者满意度和流产信息的混合方法探索。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-21 DOI: 10.1017/thg.2025.10

Nichole M Cubbage, Nicholas Embleton, Carly Levy

{"title":"The Experiences of Patients With Vanishing Twin Syndrome: A Mixed-Methods Exploration of Patient Satisfaction and Miscarriage Information.","authors":"Nichole M Cubbage, Nicholas Embleton, Carly Levy","doi":"10.1017/thg.2025.10","DOIUrl":"https://doi.org/10.1017/thg.2025.10","url":null,"abstract":"Vanishing twin syndrome is a miscarriage of multiples where one or more fetuses 'vanishes' (i.e., partial or full resorption or via calcification) during pregnancy, often before detection via ultrasound. It affects 30-50% of multifetal pregnancies, with most cases resulting in full resorption within the first trimester. Despite its recognition since 1945 and rising occurrence in both natural and assisted pregnancies, standardized clinical guidelines remain inadequate, leading to inconsistent diagnosis, counseling, and communication from healthcare providers. This study examines the experiences of mothers and gestational carriers diagnosed with VTS, focusing on patient-provider communication, risks, and symptom disclosure. A global online survey collected qualitative and quantitative data from 153 participants across 17 countries. Results show that most patients with formal diagnoses experienced negative interactions with healthcare providers, with an average sentiment score of -0.7 (on a scale from -2 to 2). Over 53.4% rated their communication experience as -1, and the average satisfaction score for the amount of information received was 3.5/10. Additionally, 43% of respondents were not informed about chorionicity, a key factor affecting fetal outcomes. Significant discrepancies in care were observed across different countries. The findings highlight major gaps in patient-provider communication and inconsistent clinical practices regarding VTS. Addressing these issues through improved education, clearer protocols, and standardized guidelines could enhance patient experiences and decision-making. Future research should focus on provider training and evidence-based strategies to improve the management of VTS and other types of miscarriage and death of multiples during pregnancy and postpartum.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Diabetes Mellitus and the Longitudinal Fetal Growth Trajectories in Twin Pregnancies. 妊娠糖尿病与双胎妊娠的纵向胎儿生长轨迹

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-14 DOI: 10.1017/thg.2025.6

Xinyu Shu, Mi Yao, Chenglong Li, Na Chen, Yan Zhang, Xin Kang, Juan Juan, Huixia Yang

{"title":"Gestational Diabetes Mellitus and the Longitudinal Fetal Growth Trajectories in Twin Pregnancies.","authors":"Xinyu Shu, Mi Yao, Chenglong Li, Na Chen, Yan Zhang, Xin Kang, Juan Juan, Huixia Yang","doi":"10.1017/thg.2025.6","DOIUrl":"https://doi.org/10.1017/thg.2025.6","url":null,"abstract":"Although it is well established that gestational diabetes mellitus (GDM) is associated with fetal overgrowth in singleton pregnancies, little is known about its role in twins. We aimed to explore the relationship between GDM and the longitudinal fetal growth in twin pregnancies. This was a retrospective matched cohort study of GDM and non-GDM twin pregnancies delivered ≥36 weeks without other complications. All the women performed ≥3 ultrasounds after 22 weeks. Linear mixed models (LMMs) were used to explore the relationships between longitudinal fetal growth trajectories and GDM. Group-based trajectory modeling (GBTM) and generalized estimating equation (GEE) were applied to identify the latent growth patterns and investigate their relationships with GDM. In total, 215 GDM and 645 non-GDM twins were included, the majority of the patients did not require medication therapy (n = 202, GDMA1). LMM revealed that, compared with non-GDM, GDM was associated with an average increase in fetal weight of 4.36 g (95% CI [1.25, 7.48]) per week. GBTM and GEE further revealed that GDM increased the odds of fetal weight trajectory to nearly 40% of the total fetal weight trajectory, classified into the high-speed group (aOR = 1.39, 95% CI [1.03, 1.88]), associating with a 49.44 g (95% CI [11.41, 87.48]) increase in birth weight. Subgroup analysis revealed that all these differences were only significant among the GDMA1 pregnancies (p < .05). GDM (GDMA1) is significantly associated with an increase in fetal weight during gestation in twin pregnancies. However, this acceleration is mild, and its significance requires further exploration.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male Twin Live Births Following Unconditional Cash Transfers in Alaska: A Time-Series Analysis. 阿拉斯加无条件现金转移后的男性双胞胎活产：时间序列分析。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1017/thg.2024.50

Parvati Singh, Nicholas Mark, Sarah Cowan

{"title":"Male Twin Live Births Following Unconditional Cash Transfers in Alaska: A Time-Series Analysis.","authors":"Parvati Singh, Nicholas Mark, Sarah Cowan","doi":"10.1017/thg.2024.50","DOIUrl":"10.1017/thg.2024.50","url":null,"abstract":"Prior studies report a decline in male twin live births during economically stressful periods, presumably owing to higher selection in utero against frail male gestations, yet no study has examined the natural corollary: whether provision of economic support increases rates of male twin births. We examined whether male twin live births increase following income gains from the Alaska Permanent Fund Dividend (PFD)-the longest running unconditional cash transfer program in the US. We obtained the monthly volume of male (and female) twin and singleton live births, from January 1980 to December 2019, from Alaska's Department of Health. Data on PFD timing and payment amounts came from Alaska's Department of Revenue. We used time-series analyses to gauge whether the odds of male twin live births increase within 2-6 months following PFD receipt, controlling for autocorrelation. Results suggest that for every $1000 increase in PFD payments, the odds of male twin live births increase by 0.002 (p < .05) three months following PFD disbursement. This corresponds with 50 additional (individual) male twin live births statistically attributable to the cumulative PFD amount disbursed over our study period. Income gains through the PFD may correspond with reduced male-specific selection in utero in Alaska.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"34-41"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THG volume 28 issue 1 Cover. THG 28卷第1期封面。

IF 1.2 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-01 Epub Date: 2025-04-28 DOI: 10.1017/thg.2025.21

引用次数: 0

Gene-Environment Interplay in the Relationship Between Gaming Addiction and Close Friends' Gaming. 游戏成瘾与好友游戏关系的基因-环境相互作用

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1017/thg.2025.5

Yoon-Mi Hur

{"title":"Gene-Environment Interplay in the Relationship Between Gaming Addiction and Close Friends' Gaming.","authors":"Yoon-Mi Hur","doi":"10.1017/thg.2025.5","DOIUrl":"10.1017/thg.2025.5","url":null,"abstract":"Both peer influences and genetics have been linked to gaming addiction (GA) in adolescents and young adults. This study examined the gene-environment interplay (gene-environment correlation [rGE] and gene-environment interaction [G x E]) between close friends' gaming (CFG) and GA among South Korean twins. A total of 1462 twins aged 15-29 years (mean = 22.63 ± 2.8 years) completed an online survey that included a 20-item GA measure and a single item assessing CFG. Bivariate Cholesky model-fitting analysis was conducted to examine evidence for rGE in the relationship between GA and CFG. Bivariate G x E model-fitting analysis was performed to determine evidence for G x E effects. A significant genetic correlation (rg = .37; 95% CI [0.24, 0.49]) between GA and CFG supported the role of gene-environment correlation, suggesting that individuals with a genetic predisposition for GA may selectively associate with peers who frequently engage in gaming. The model testing G x E effects indicated that environment-environment interaction was present in the relationship between CFG and GA, such that CFG increased nonshared environmental effects on GA. This pattern provided evidence for peer socialization effects, wherein peers influence the development of GA independently of genetic risk.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"21-27"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0