Twin Research and Human Genetics最新文献

Abstracts from the 19th International Congress on Twin Studies, 11-14 November 2021 - CORRIGENDUM.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-28 DOI: 10.1017/thg.2025.13

引用次数: 0

The Excess Mortality Among Twins in the Dominican Republic and Haiti Through the Components of Age Under Five: A Comparative Study of Trends and Associated Factors.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-24 DOI: 10.1017/thg.2025.11

Adama Ouedraogo, David Jean Simon, Ann Kiragu, Nicole Estefany Aponte Cueto, Vénunyé Claude Kondo Tokpovi

{"title":"The Excess Mortality Among Twins in the Dominican Republic and Haiti Through the Components of Age Under Five: A Comparative Study of Trends and Associated Factors.","authors":"Adama Ouedraogo, David Jean Simon, Ann Kiragu, Nicole Estefany Aponte Cueto, Vénunyé Claude Kondo Tokpovi","doi":"10.1017/thg.2025.11","DOIUrl":"https://doi.org/10.1017/thg.2025.11","url":null,"abstract":"Despite the decline in mortality rates among children in developing countries, disparities persist between countries, particularly between twins and singletons. This study employed data from nine Demographic and Health Surveys in the Dominican Republic and Haiti to estimate and compare mortality rates for twins and singletons in categories of the under-5 age group (neonatal, postneonatal, and child mortality) and examine the factors associated with excess mortality among twins. From 1996 to 2013, the under-5 mortality rate (U5MR) for singletons in the Dominican Republic declined from 56‰ (95% CI [47, 64) to 30‰ (22-39) and from 108‰ (53-164) to 53‰ (16-89) among twins. In Haiti, between 1994 and 2016, the U5MR declined from 121‰ (109-133) to 77‰ (68-80) for singletons and from 432‰ (327-538) to 204‰ (149-260) among twins. The adjusted risk of neonatal death for twins is 1.4 (1.0-1.9) times higher than for singletons in the Dominican Republic, compared to a risk of 4.3 (3.5-5.3) times higher in Haiti. In the post-neonatal period, the mortality risk for twins in the Dominican Republic was 1.8 (1.0-3.1) times higher than that for singletons, 2.9 (2.3-3.8) in Haiti. The risk of death for twins was not significantly different from that for singletons in both the Dominican Republic and Haiti at ages 1-4 years. Low birth weight, lack of breastfeeding, absence of, or inadequate, antenatal care, noncesarean section birth, and high birth order were associated with excess mortality among twins in both countries.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-20"},"PeriodicalIF":1.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Experiences of Patients With Vanishing Twin Syndrome: A Mixed-Methods Exploration of Patient Satisfaction and Miscarriage Information.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-21 DOI: 10.1017/thg.2025.10

Nichole M Cubbage, Nicholas Embleton, Carly Levy

{"title":"The Experiences of Patients With Vanishing Twin Syndrome: A Mixed-Methods Exploration of Patient Satisfaction and Miscarriage Information.","authors":"Nichole M Cubbage, Nicholas Embleton, Carly Levy","doi":"10.1017/thg.2025.10","DOIUrl":"https://doi.org/10.1017/thg.2025.10","url":null,"abstract":"Vanishing twin syndrome is a miscarriage of multiples where one or more fetuses 'vanishes' (i.e., partial or full resorption or via calcification) during pregnancy, often before detection via ultrasound. It affects 30-50% of multifetal pregnancies, with most cases resulting in full resorption within the first trimester. Despite its recognition since 1945 and rising occurrence in both natural and assisted pregnancies, standardized clinical guidelines remain inadequate, leading to inconsistent diagnosis, counseling, and communication from healthcare providers. This study examines the experiences of mothers and gestational carriers diagnosed with VTS, focusing on patient-provider communication, risks, and symptom disclosure. A global online survey collected qualitative and quantitative data from 153 participants across 17 countries. Results show that most patients with formal diagnoses experienced negative interactions with healthcare providers, with an average sentiment score of -0.7 (on a scale from -2 to 2). Over 53.4% rated their communication experience as -1, and the average satisfaction score for the amount of information received was 3.5/10. Additionally, 43% of respondents were not informed about chorionicity, a key factor affecting fetal outcomes. Significant discrepancies in care were observed across different countries. The findings highlight major gaps in patient-provider communication and inconsistent clinical practices regarding VTS. Addressing these issues through improved education, clearer protocols, and standardized guidelines could enhance patient experiences and decision-making. Future research should focus on provider training and evidence-based strategies to improve the management of VTS and other types of miscarriage and death of multiples during pregnancy and postpartum.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Integrity of DSM Categorized Eating Disorders: Exploration of Alternative Methods of Classification and the Implications for Genetic Research.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-03-12 DOI: 10.1017/thg.2025.3

Jessica Livney, Melissa Pehlivan, Nicholas G Martin, Sarah Maguire

引用次数: 0

Causal Effect Between Natural Hair Color and Endometriosis in a European Population: A Two-Sample Mendelian Randomization.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-25 DOI: 10.1017/thg.2025.1

Yuping Zhang, Ying Feng

{"title":"Causal Effect Between Natural Hair Color and Endometriosis in a European Population: A Two-Sample Mendelian Randomization.","authors":"Yuping Zhang, Ying Feng","doi":"10.1017/thg.2025.1","DOIUrl":"https://doi.org/10.1017/thg.2025.1","url":null,"abstract":"Previous observational studies have suggested an association between natural hair color and the risk of endometriosis; however, the causal relationship remains unclear. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the potential causal link between natural hair color and endometriosis using 428 single nucleotide polymorphisms (SNPs) as genetic instruments derived from a genomewide meta-analysis comprising over 4511 cases and 227,260 controls of European ancestry. Our findings indicate that dark brown hair is associated with a decreased risk of developing endometriosis (dark brown IVW OR: 0.844, 95% CI [0.725, 0.984], p < .05). Conversely, dark hair color and lighter hair colors (red, blonde, and light brown) did not demonstrate a significant association with endometriosis risk (dark IVW OR: 0.568, 95% CI [0.280, 1.15], p = .117; red IVW OR: 1.058, 95% CI [0.719, 1.558], p = .77; blonde IVW OR: 1.158, 95% CI [0.886, 1.514], p = .28; light brown IVW OR: 1.306, 95% CI [0.978, 1.743], p = .07). These results provide compelling MR evidence supporting a causal association between natural hair color and endometriosis risk. Our findings underscore the need for larger scale studies and randomized controlled trials to delineate the biological mechanisms driving the association between hair color and endometriosis.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-Environment Interplay in the Relationship Between Gaming Addiction and Close Friends' Gaming.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-24 DOI: 10.1017/thg.2025.5

Yoon-Mi Hur

{"title":"Gene-Environment Interplay in the Relationship Between Gaming Addiction and Close Friends' Gaming.","authors":"Yoon-Mi Hur","doi":"10.1017/thg.2025.5","DOIUrl":"https://doi.org/10.1017/thg.2025.5","url":null,"abstract":"Both peer influences and genetics have been linked to gaming addiction (GA) in adolescents and young adults. This study examined the gene-environment interplay (gene-environment correlation [rGE] and gene-environment interaction [G x E]) between close friends' gaming (CFG) and GA among South Korean twins. A total of 1462 twins aged 15-29 years (mean = 22.63 ± 2.8 years) completed an online survey that included a 20-item GA measure and a single item assessing CFG. Bivariate Cholesky model-fitting analysis was conducted to examine evidence for rGE in the relationship between GA and CFG. Bivariate G x E model-fitting analysis was performed to determine evidence for G x E effects. A significant genetic correlation (rg = .37; 95% CI [0.24, 0.49]) between GA and CFG supported the role of gene-environment correlation, suggesting that individuals with a genetic predisposition for GA may selectively associate with peers who frequently engage in gaming. The model testing G x E effects indicated that environment-environment interaction was present in the relationship between CFG and GA, such that CFG increased nonshared environmental effects on GA. This pattern provided evidence for peer socialization effects, wherein peers influence the development of GA independently of genetic risk.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's in Twins' Names? Mixed Credit Reports/Twin Research Review: Treating Twins with Central Nervous System Infection; Twin Insights into COVID-19; Septal Aneurism in Monozygotic Twins; Twin Births via Assisted Reproduction vs. Natural Conception; Tribute to Dr. Helen E. Fisher/ Human Interest: Twins Rally for Twin Hostages; Tribute to the National Mothers of Twins Clubs Founder; Quadruplet Birth; Identical Twin Politician; Identical Twin Actresses.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-20 DOI: 10.1017/thg.2025.8

Nancy L Segal

{"title":"What's in Twins' Names? Mixed Credit Reports/Twin Research Review: Treating Twins with Central Nervous System Infection; Twin Insights into COVID-19; Septal Aneurism in Monozygotic Twins; Twin Births via Assisted Reproduction vs. Natural Conception; Tribute to Dr. Helen E. Fisher/ Human Interest: Twins Rally for Twin Hostages; Tribute to the National Mothers of Twins Clubs Founder; Quadruplet Birth; Identical Twin Politician; Identical Twin Actresses.","authors":"Nancy L Segal","doi":"10.1017/thg.2025.8","DOIUrl":"https://doi.org/10.1017/thg.2025.8","url":null,"abstract":"Giving twins similar names places them at increased risk for mixed credit reports as they enter young adulthood and beyond. Attorneys specializing in this area of the law are often required to manage lawsuits againt the agencies responsible for such errors. This overview is followed by summaries of twin research and reports of treating twins with central nervous system infection, twins with COVID-19, and twins with septal aneurism, as well as a review of the comparative outcomes of twins born via assisted reproduction versus natural conception and a tribute to the late Dr Helen E. Fisher. Human interest items include a twins' rally for Israeli twins held hostage in Gaza, a tribute to the founding member of the National Mothers of Twins Clubs (now Multiples of America), a quadruplet birth, an identical twin politician, and identical twin actresses.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-4"},"PeriodicalIF":1.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Diabetes Mellitus and the Longitudinal Fetal Growth Trajectories in Twin Pregnancies. 妊娠糖尿病与双胎妊娠的纵向胎儿生长轨迹

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-14 DOI: 10.1017/thg.2025.6

Xinyu Shu, Mi Yao, Chenglong Li, Na Chen, Yan Zhang, Xin Kang, Juan Juan, Huixia Yang

{"title":"Gestational Diabetes Mellitus and the Longitudinal Fetal Growth Trajectories in Twin Pregnancies.","authors":"Xinyu Shu, Mi Yao, Chenglong Li, Na Chen, Yan Zhang, Xin Kang, Juan Juan, Huixia Yang","doi":"10.1017/thg.2025.6","DOIUrl":"https://doi.org/10.1017/thg.2025.6","url":null,"abstract":"Although it is well established that gestational diabetes mellitus (GDM) is associated with fetal overgrowth in singleton pregnancies, little is known about its role in twins. We aimed to explore the relationship between GDM and the longitudinal fetal growth in twin pregnancies. This was a retrospective matched cohort study of GDM and non-GDM twin pregnancies delivered ≥36 weeks without other complications. All the women performed ≥3 ultrasounds after 22 weeks. Linear mixed models (LMMs) were used to explore the relationships between longitudinal fetal growth trajectories and GDM. Group-based trajectory modeling (GBTM) and generalized estimating equation (GEE) were applied to identify the latent growth patterns and investigate their relationships with GDM. In total, 215 GDM and 645 non-GDM twins were included, the majority of the patients did not require medication therapy (n = 202, GDMA1). LMM revealed that, compared with non-GDM, GDM was associated with an average increase in fetal weight of 4.36 g (95% CI [1.25, 7.48]) per week. GBTM and GEE further revealed that GDM increased the odds of fetal weight trajectory to nearly 40% of the total fetal weight trajectory, classified into the high-speed group (aOR = 1.39, 95% CI [1.03, 1.88]), associating with a 49.44 g (95% CI [11.41, 87.48]) increase in birth weight. Subgroup analysis revealed that all these differences were only significant among the GDMA1 pregnancies (p < .05). GDM (GDMA1) is significantly associated with an increase in fetal weight during gestation in twin pregnancies. However, this acceleration is mild, and its significance requires further exploration.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male Twin Live Births Following Unconditional Cash Transfers in Alaska: A Time-Series Analysis.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-02-03 DOI: 10.1017/thg.2024.50

Parvati Singh, Nicholas Mark, Sarah Cowan

{"title":"Male Twin Live Births Following Unconditional Cash Transfers in Alaska: A Time-Series Analysis.","authors":"Parvati Singh, Nicholas Mark, Sarah Cowan","doi":"10.1017/thg.2024.50","DOIUrl":"https://doi.org/10.1017/thg.2024.50","url":null,"abstract":"Prior studies report a decline in male twin live births during economically stressful periods, presumably owing to higher selection in utero against frail male gestations, yet no study has examined the natural corollary: whether provision of economic support increases rates of male twin births. We examined whether male twin live births increase following income gains from the Alaska Permanent Fund Dividend (PFD)-the longest running unconditional cash transfer program in the US. We obtained the monthly volume of male (and female) twin and singleton live births, from January 1980 to December 2019, from Alaska's Department of Health. Data on PFD timing and payment amounts came from Alaska's Department of Revenue. We used time-series analyses to gauge whether the odds of male twin live births increase within 2-6 months following PFD receipt, controlling for autocorrelation. Results suggest that for every $1000 increase in PFD payments, the odds of male twin live births increase by 0.002 (p < .05) three months following PFD disbursement. This corresponds with 50 additional (individual) male twin live births statistically attributable to the cumulative PFD amount disbursed over our study period. Income gains through the PFD may correspond with reduced male-specific selection in utero in Alaska.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report of the 19th International Congress on Twin Studies, 26-28 September 2024, Assisi, Italy.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-01-30 DOI: 10.1017/thg.2025.2

Jeffrey M Craig, Nancy Segal, Adam Domonkos Tarnoki, David Laszlo Tarnoki

引用次数: 0