Twin Research and Human Genetics最新文献

Exploring the Link Between Parental Sociodemographic Characteristics and Multiple Births: Insights from National Birth Data in Japan, 1995-2020. 探索父母的社会人口特征与多胞胎之间的联系：1995-2020 年日本全国出生数据的启示》。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-03 DOI: 10.1017/thg.2024.36

Tasuku Okui, Naoki Nakashima

{"title":"Exploring the Link Between Parental Sociodemographic Characteristics and Multiple Births: Insights from National Birth Data in Japan, 1995-2020.","authors":"Tasuku Okui, Naoki Nakashima","doi":"10.1017/thg.2024.36","DOIUrl":"https://doi.org/10.1017/thg.2024.36","url":null,"abstract":"This present study investigated the parental characteristics of multiple births using national birth data in Japan. This study included birth data from Vital Statistics: Occupational and Industrial Aspects every five fiscal years from 1995 to 2020. The multiple birth rates were defined as the number of live-birth deliveries with multiple fetuses (e.g., twins, triplets) per total live-birth deliveries. Parental ages, nationalities, occupations and household occupation (occupation of the top earner of the household) were considered as parental characteristics. The multiple birth rates were calculated based on parental characteristics for each year, and a log-binomial regression model was used to assess the association between parental characteristics and multiple births. The multiple birth rate for Japanese mothers consistently exceeded that for non-Japanese mothers over the years, and the rate increased progressively from manual workers to lower non-manual workers and then to upper non-manual workers for both maternal and paternal occupations. The regression results indicated that the risk ratio (RR) for multiple births among non-Japanese mothers was significantly lower than that among Japanese mothers. Moreover, concerning household occupation, the RRs of self-employed individuals, full-time employees at smaller companies, others, and the unemployed were significantly lower than those of full-time employees at larger companies. Furthermore, the RRs of lower non-manual and manual workers were significantly lower than those of upper non-manual workers in maternal and paternal occupations. The results suggested an association between multiple births and parental socioeconomic status in Japan.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Influence on Social Support: A Twin Study. 遗传对社会支持的影响：双胞胎研究

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-02 DOI: 10.1017/thg.2024.32

Bodine M A Gonggrijp, Steve G A van de Weijer, Jenny van Dongen, Catrien C J H Bijleveld, Dorret I Boomsma

引用次数: 0

Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech. 基因遗传对人类语音的影响：巴西双胞胎语音的基频分析

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-02 DOI: 10.1017/thg.2024.33

Lilian C Luchesi, Julio C Cavalcanti, Tania K Lucci, Vinicius F David, Emma Otta, Patricia F Monticelli

{"title":"Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech.","authors":"Lilian C Luchesi, Julio C Cavalcanti, Tania K Lucci, Vinicius F David, Emma Otta, Patricia F Monticelli","doi":"10.1017/thg.2024.33","DOIUrl":"https://doi.org/10.1017/thg.2024.33","url":null,"abstract":"Voice production can be influenced by interindividual variations related to genetic, physiological, behavioral, and several environmental factors. Here we examined the effect of zygosity on speaking fundamental frequency (F0) statistical descriptors. Our aims were: (1) to determine whether the genetic similarity between monozygotic (MZ) and dizygotic (DZ) twins affects F0 characteristics, and (2) to quantify the contribution of genetic factors to these characteristics. The study involved 79 same-sex twin pairs of Brazilian Portuguese speakers, comprising 65 MZ and 14 DZ twins, aged 18 to 66 years (31.7 ± 11.6 years), with 21 male and 58 female pairs. Participants were recorded while uttering a greeting phrase and the Brazilian Portuguese version of the 'Happy Birthday to You' song. Speech segments were analyzed using Praat free software, and F0 measures were automatically extracted in both Hertz and semitone scales. Statistical descriptors, including centrality, dispersion, and extreme values of F0 were examined, and the ACE model (i.e., total genetic effects, A; shared environmental influences, C; and nonshared environmental influences, E) was employed to estimate the additive effect;ts of monozygosity. As anticipated, we observed a zygosity effect on several F0 parameters, with more similarity between MZ twins compared to DZ twins. We discuss the genetic influences on F0 parameters and the absence of a monozygosity effect in two of them. Additionally, we briefly address potential biases associated with the selected measurement scale for statistical modeling. Finally, we explore the influence of genetic factors on F0 patterns, as well as environmental, life history and linguistic factors, particularly concerning F0 variation in speech.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twin Data Support a Sensitive Period for Singing Ability. 双胞胎数据支持歌唱能力的敏感期

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-02 DOI: 10.1017/thg.2024.30

Daniel Yeom, Nick Haslam, Yi Ting Tan, Gary E McPherson, Sarah J Wilson

{"title":"Twin Data Support a Sensitive Period for Singing Ability.","authors":"Daniel Yeom, Nick Haslam, Yi Ting Tan, Gary E McPherson, Sarah J Wilson","doi":"10.1017/thg.2024.30","DOIUrl":"https://doi.org/10.1017/thg.2024.30","url":null,"abstract":"As with many other musical traits, the social environment is a key influence on the development of singing ability. While the familial singing environment is likely to be formative, its role relative to other environmental influences such as training is unclear. We used structural equation modeling to test relationships among demographic characteristics, familial environmental variables (early and current singing with family), vocal training, and singing ability in a large, previously documented sample of Australian twins (N = 1163). Notably, early singing with family, and to a lesser extent vocal training, predicted singing ability, whereas current singing with family did not. Early familial singing also mediated the relationship between sex and singing ability, with men who sang less with family during childhood showing poorer ability. Bivariate twin models between early familial singing and singing ability showed the phenotypic correlation was largely explained by shared environmental influences. This raises the possibility of a sensitive period for singing ability, with sociocultural expectations around singing potentially differentiating the developmental trajectories of this skill for men and women.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breastfeeding Practices in the Twin Town of India - A Cross-Sectional Study. 印度双城镇的母乳喂养实践--一项横断面研究。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-02 DOI: 10.1017/thg.2024.31

Geeta Bhardwaj, Moonjelly V Smitha

{"title":"Breastfeeding Practices in the Twin Town of India - A Cross-Sectional Study.","authors":"Geeta Bhardwaj, Moonjelly V Smitha","doi":"10.1017/thg.2024.31","DOIUrl":"https://doi.org/10.1017/thg.2024.31","url":null,"abstract":"The global rise in twinning rates poses health challenges due to increased risks for infants and mothers. Despite the benefits, breastfeeding rates among multiples are low, with exclusive breastfeeding (EBF) particularly scarce compared to singletons. Our study focuses on the mothers of twins in a unique population in Kodinhi village, Kerala, India, known for its high twinning rates, which aims to contribute to existing knowledge of breastfeeding practices and perspectives in a high twinning environment and offer valuable insights to promote optimal breastfeeding among mothers of twins. A retrospective cross-sectional survey was adopted. Seventy-five mothers with twins under 3 years of age from Kodinhi and neighboring areas were interviewed face to face using structured validated tools. Data collection focused on quantitative data supplemented by narrative descriptions. Most women delivered preterm (57.3%), operative delivery (58.7%), and had a late initiation of breastfeeding (32.9% within 24 hours). Colostrum feed was common (86.7%). The EBF rate was 4%, with 47.9% initiating nonexclusive breastfeeding before 3 months, and most of the twins (46.6%) were breastfed for 1-2 years. Fatigue (69.9%) and low milk supply (38.7%) were chief concerns. While 16.4% of mothers opted for a tandem breastfeeding technique, many preferred consecutive feeding as tandem was challenging. Mothers in Kodinhi demonstrated commendable efforts in breastfeeding twins; despite the low rate of EBF, breastfeeding extended to 1-2 years. Evidence-based interventions and personalized support, primarily focusing on maternal perspectives of milk insufficiency, fatigue and breastfeeding techniques, are crucial for sustaining optimal breastfeeding practices among mothers of twins.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Predisposition of Different Social Status Indicators in Men and Women. 男性和女性不同社会地位指标的遗传倾向。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-09-09 DOI: 10.1017/thg.2024.23

Martin Fieder, Susanne Huber

{"title":"Genetic Predisposition of Different Social Status Indicators in Men and Women.","authors":"Martin Fieder, Susanne Huber","doi":"10.1017/thg.2024.23","DOIUrl":"https://doi.org/10.1017/thg.2024.23","url":null,"abstract":"Although there is evidence that social status has a genetic basis, it is less known whether the genetic predisposition differs between men and women as well as among different status indicators and whether there are any intercorrelations among predispositions of status indicators. We therefore investigated the genetic predisposition for different indicators of social status separately for men and women, using polygenic scores obtained from the Wisconsin Longitudinal Study. We used multivariate polygenic regression of 7 different social status indicators on a total of 24 different polygenic scores. We find that in both men and women, wages and education show more associations with polygenic scores than the other status indicators. Also, the genetic predispositions for education and wages are correlated in both men and women, whereas in men more than in women, the genetic predispositions seem to cluster into wages and education on the one hand, and status indicators of position in the hierarchy, on the other hand, with being in a management position somewhere in between. These findings are consistent with an assumption of two different forms of selection pressure associated with either cognitive skill or dominance, which holds true particularly in men. We conclude that the genetic predisposition to higher social status may have changed even though the importance of the cultural trait of social status may have been very constant. Social status may thus be an example of a social trait of constant importance, but with a changing genetic predisposition.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies. 自然和医学辅助生殖双卵双胎妊娠的母体特征。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-09-06 DOI: 10.1017/thg.2024.26

Nikki Hubers, Christian M Page, Lannie Ligthart, René Pool, Jouke-Jan Hottenga, Jenny van Dongen, Cornelis B Lambalk, Jennifer R Harris, Gonneke Willemsen, Dorret I Boomsma

{"title":"Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies.","authors":"Nikki Hubers, Christian M Page, Lannie Ligthart, René Pool, Jouke-Jan Hottenga, Jenny van Dongen, Cornelis B Lambalk, Jennifer R Harris, Gonneke Willemsen, Dorret I Boomsma","doi":"10.1017/thg.2024.26","DOIUrl":"https://doi.org/10.1017/thg.2024.26","url":null,"abstract":"Previous studies have shown that mothers of naturally conceived dizygotic (DZ) twins tend to be taller, older, and smoke more than mothers of naturally conceived monozygotic (MZ) twin and mothers of singletons. Here, we investigate whether mothers of naturally conceived DZ twins differ from mothers who conceived their DZ twins after medically assisted reproduction (MAR) in eight maternal traits related to fertility based on observational survey data. We include data from 33,648 mothers from the Netherlands Twin Register (NTR) and 1660 mothers of twins from the Norwegian Mother, Father and Child Cohort Study (MoBA). We contrast mothers of naturally conceived DZ twins with mothers of MAR DZ twins. Next, we further segment the MAR group into mothers who underwent hormonal induction of ovulation but not in vitro fertilization (IVF) and those who IVF twins, comparing them both to each other and against the mothers of naturally conceived DZ twins. Mothers of naturally conceived DZ twins smoke more often, differ in body composition, have a higher maternal age and have more offspring before the twins than mothers of MZ twins. Compared to MAR DZ twin mothers, mothers of naturally conceived DZ twins have fewer miscarriages, lower maternal age and increased height, more offspring and are more often smokers. BMI before the twin pregnancy is similar in both natural and MAR DZ twin mothers. Mothers who received hormonal induction of ovulation (OI) have a lower maternal age, fewer miscarriages, and a higher number of offspring before their twin pregnancy than twin mothers who received IVF and/or intracytoplasmic sperm injection (ICSI) treatments. Our study shows that twin mothers are a heterogenous group and the differences between twin mothers should be taken into account in epidemiological and genetic research that includes twins.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study. 类风湿性关节炎与克隆性造血之间的关系：孟德尔随机研究

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2024-06-03 DOI: 10.1017/thg.2024.24

Jie Zhang, Chun Zhou, Shaoxing Guan

{"title":"Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study.","authors":"Jie Zhang, Chun Zhou, Shaoxing Guan","doi":"10.1017/thg.2024.24","DOIUrl":"https://doi.org/10.1017/thg.2024.24","url":null,"abstract":"Immunity activation and inflammation are the main characteristics of rheumatoid arthritis and clonal hematopoiesis. However, it remains unclear whether rheumatoid arthritis increase the risk of clonal hematopoiesis. Here, a Mendelian randomization (MR) analysis was conduct to explore the causal effects of rheumatoid arthritis on clonal hematopoiesis. Summary statistics data of rheumatoid arthritis (13,838 cases and 33,742 controls) and clonal hematopoiesis (10,203 cases and 173,918 controls) derived from a genomewide association study were selected to analyze. We selected inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode to evaluate the causal effect of rheumatoid arthritis on clonal hematopoiesis. The two-sample MR analysis suggested a strong causal relationship between rheumatoid arthritis and clonal hematopoiesis by inverse-variance weighted (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039706) and weighted median (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039518447) methods. No significant pleiotropy or heterogeneity was found in the sensitivity analysis. These results supported a potentially causal relationship between rheumatoid arthritis and clonal hematopoiesis, and the exposure of rheumatoid arthritis increased the risks of clonal hematopoiesis. Our findings highlight the importance of how chronic inflammation and immune activation induced rheumatoid arthritis enhances the risks of clonal hematopoiesis, and that early intervention with rheumatoid arthritis patients might reduce the clonal hematopoiesis risks in rheumatoid arthritis patients. Moreover, our study provides clues for prediction of risk factors and potential mechanisms of clonal hematopoiesis.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twins Standing in for Co-Twins: Explanation and Speculation/Twin Research Reviews: Single v. Multiple Embryo Transfer; Neurimaging of Twins with Periventricular Nodular Heterotopia; Twin Dietary Study; New Hungarian Text on Twins/Human Interest: Valedictorian and Salutatorian Twins; Twin Mother at Age Seventy; Twins Reunited by Tiktok; New Film on Twins with Selective Mutism; Becoming Twin Doctors. 双胞胎代替同卵双胞胎：解释与推测/双胞胎研究综述：单胚胎移植与多胚胎移植；患有室周结节性异位症的双胞胎的神经成像；双胞胎饮食研究；匈牙利关于双胞胎的新文本/人类兴趣：毕业典礼上的双胞胎姐妹；七十岁的双胞胎母亲；双胞胎通过 Tiktok 重聚；关于患有选择性缄默症的双胞胎的新电影；成为双胞胎医生。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2024-05-13 DOI: 10.1017/thg.2024.22

Nancy L Segal

引用次数: 0

Genetic and Environmental Influences on Perceived Stress in South Korean Twins 遗传和环境对韩国双胞胎感知压力的影响

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2024-05-03 DOI: 10.1017/thg.2024.21

Gwanwoo Jo, Yoon-Mi Hur

{"title":"Genetic and Environmental Influences on Perceived Stress in South Korean Twins","authors":"Gwanwoo Jo, Yoon-Mi Hur","doi":"10.1017/thg.2024.21","DOIUrl":"https://doi.org/10.1017/thg.2024.21","url":null,"abstract":"Researchers have proposed that culture significantly influences perceived stress (PS). To date, however, twin studies on PS have been conducted mostly in western, individualistic cultures, which demonstrate that PS due to controllable (personal) life events is more heritable than PS due to uncontrollable (network) life events. This study aimed to investigate genetic and environmental influences on PS in South Korean twins. South Korea practices a dominant collectivist culture. In total, 1372 twin individuals (mean age = 22.4 ± 2.5 years) completed an online survey on PS, which consisted of the scales, Friendship, Academic Stress, Future Career, Family Conflicts, and Family Financial Difficulties (FFD). Friendship, Academic Stress, and Future Career can be considered PS due to personal life events, and Family Conflict and FFD, PS due to network life events. The general sex-limitation model-fitting analysis revealed the absence of qualitative or quantitative sex differences in genetic and environmental influences. Specifically, additive genetic influences were predominant for Friendship (63%), Academic Stress (67%), and Future Career (57%) for both sexes, with the remaining variance attributable to nonshared environmental influences. In contrast, shared environmental influences were largest for Family Conflict (47% for both genders) and FFD (64% for males, 63% for females) with no significant genetic effects. Despite known cultural differences in the means and variances of PS, South Korean twins exhibited significant genetic effects in PS due to personal life events and large shared environmental effects in PS due to network life events, which is similar to western samples.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0