来自四个大型遗传信息样本的证据表明表型g既有形成性又有反思性。

IF 1 4区 医学 Q4 GENETICS & HEREDITY
Michael A Woodley Of Menie, Mateo Peñaherrera-Aguirre, John G R Fuerst
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引用次数: 0

摘要

一般智力(g)是一个反映性的构式,代表子测试表现的潜在因果实体,还是一个形成性的构式,更好地被理解为由子测试之间的变化形成并总结的汇总变量?遗传信息数据提供了一个框架,通过比较共同途径和独立途径结构方程模型(SEMs)来测试一个结构是反射性的还是形成性的。先前使用生物识别sem的研究主要支持反射模型,表型介导了遗传和环境对较低水平能力的影响。在当前的研究中,使用验证性因子分析(CFA)分析了四个大型遗传信息数据集(三个来自美国,一个来自英国),以测试三种相互竞争的SEM模型-共同途径,独立途径和合并。在每个样本中,遗传被估计为一个潜在变量,该变量来自于多基因分数,该分数指示教育程度和认知能力。比较结果如下:共同通路模型与反射g一致,包括从遗传g到表型g的直接通路;独立通路模型,与形成g一致,通过亚测试具有从遗传g到表型g的间接通路;合并后的模型同时包含了直接路径和间接路径。在所有四个数据集中,合并模型始终提供最佳拟合(基于拟合优度和简约标准)。表型g介导了基因g对亚测试31%至81%的影响。这些发现表明,g既是一个反思的实体,也是一个形成的实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evidence that Phenotypic g is Both Formative and Reflective From Four Large Genetically-Informative Samples.

Is general intelligence (g) a reflective construct, representing a latent causal entity underlying subtest performance, or a formative construct, better understood as an aggregate variable shaped by and summarizing variation across subtests? Genetically informative data provide a framework for testing whether a construct is reflective or formative by comparing common pathway and independent pathways structural equation models (SEMs). Previous studies using biometric SEMs have predominantly supported the reflective model, with phenotypic g mediating the effects of additive genetic and environmental influences on lower level abilities. In the current study, four large genetically informed datasets (three from the US and one from the UK) were analyzed to test three competing SEM models - common pathway, independent pathways, and merged - using Confirmatory Factor Analysis (CFA). Genetic g was estimated in each sample as a latent variable derived from polygenic scores indexing educational attainment and cognitive abilities. The models were compared as follows: the common pathway model, consistent with a reflective g, included a direct path from genetic g to phenotypic g; the independent pathways model, consistent with a formative g, featured indirect paths from genetic g to phenotypic g via subtests; and the merged model incorporated both direct and indirect paths. Across all four datasets, the merged model consistently provided the best fit (based on goodness-of-fit and parsimony criteria). Phenotypic g mediated between 31% and 81% of the effects of genetic g on subtests. These findings suggest that g functions as both a reflective and formative entity.

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来源期刊
Twin Research and Human Genetics
Twin Research and Human Genetics 医学-妇产科学
CiteScore
1.50
自引率
11.10%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.
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