Twin Research and Human Genetics最新文献_第2页

Directional Selection and Evolution of Polygenic Traits in Eastern Eurasia: Insights from Ancient DNA.

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-01-30 DOI: 10.1017/thg.2024.49

Davide Piffer

{"title":"Directional Selection and Evolution of Polygenic Traits in Eastern Eurasia: Insights from Ancient DNA.","authors":"Davide Piffer","doi":"10.1017/thg.2024.49","DOIUrl":"https://doi.org/10.1017/thg.2024.49","url":null,"abstract":"This study explores directional selection on physical and psychosocial phenotypes in Eastern Eurasian populations, utilizing a dataset of 1245 ancient genomes. By analyzing polygenic scores (PGS) for traits including height, educational attainment (EA), IQ, autism, schizophrenia, and others, we observed significant temporal trends spanning the Holocene era. The results suggest positive selection for cognitive-related traits such as IQ, EA and autism spectrum disorder (ASD), alongside negative selection for anxiety and depression. The results for height were mixed and showed nonlinear relationships with Years Before Present (BP). These trends were partially mediated by genetic components linked to distinct ancestral populations. Regression models incorporating admixture, geography, and temporal variables were used to account for biases in population composition over time. Latitude showed a positive effect on ASD PGS, EA and height, while it had a negative effect on skin pigmentation scores. Additionally, latitude exhibited significant nonlinear effects on multiple phenotypes. The observed patterns highlight the influence of climate-mediated selection pressures on trait evolution. Spline regression revealed that several polygenic scores had nonlinear relationships with years BP. The findings provide evidence for complex evolutionary dynamics, with distinct selective pressures shaping phenotypic diversity across different timescales and environments.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-20"},"PeriodicalIF":1.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Predicting Postpartum Hemorrhage in Twin Pregnancies Undergoing Cesarean Section. 人工智能预测剖宫产双胎术后出血。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2025-01-15 DOI: 10.1017/thg.2024.48

Sukran Dogru, Huriye Ezveci, Fatih Akkus, Pelin Bahçeci, Fikriye Karanfil Yaman, Ali Acar

{"title":"Artificial Intelligence in Predicting Postpartum Hemorrhage in Twin Pregnancies Undergoing Cesarean Section.","authors":"Sukran Dogru, Huriye Ezveci, Fatih Akkus, Pelin Bahçeci, Fikriye Karanfil Yaman, Ali Acar","doi":"10.1017/thg.2024.48","DOIUrl":"https://doi.org/10.1017/thg.2024.48","url":null,"abstract":"This study aimed to create a risk prediction model with artificial intelligence (AI) to identify patients at higher risk of postpartum hemorrhage using perinatal characteristics that may be associated with later postpartum hemorrhage (PPH) in twin pregnancies that underwent cesarean section. The study was planned as a retrospective cohort study at University Hospital. All twin cesarean deliveries were categorized into two groups: those with and without PPH. Using the perinatal characteristics of the cases, four different machine learning classifiers were created: Logistic regression (LR), support vector machine (SVM), random forest (RF), and multilayer perceptron (MLP). LR, RF, and SVM models were created a second time by including class weights to manage the underlying imbalances in the data. A total of 615 twin pregnancies were included in the study. There were 150 twin pregnancies with PPH and 465 without PPH. Dichorionity, PAS, and placenta previa were significantly higher in the PPH-positive group (p = .045, p = .004, p = .001 respectively). In our model, LR with class weight was the best model with the highest negative predictive value. The AUC in our LR with class weight model was %75.12 with an accuracy of 70.73%, a PPV of 47.92%, and an NPV of 85.33% in our data. Although the application of machine learning to create predictive models using clinical risk factors and our model's 70% accuracy rate are encouraging, it is not sufficient. Machine learning modeling needs further study and validation before being incorporated into clinical use.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mechanisms Underlying the Intergenerational Transmission of Substance Use and Misuse: An Integrated Research Approach. 物质使用和滥用代际传递的机制：一种综合研究方法。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-12-23 DOI: 10.1017/thg.2024.46

Mannan Luo, Victória Trindade Pons, Nathaniel S Thomas, John Drake, Mei-Hsin Su, Vladimir Vladimirov, Hanna M van Loo, Nathan A Gillespie

{"title":"The Mechanisms Underlying the Intergenerational Transmission of Substance Use and Misuse: An Integrated Research Approach.","authors":"Mannan Luo, Victória Trindade Pons, Nathaniel S Thomas, John Drake, Mei-Hsin Su, Vladimir Vladimirov, Hanna M van Loo, Nathan A Gillespie","doi":"10.1017/thg.2024.46","DOIUrl":"https://doi.org/10.1017/thg.2024.46","url":null,"abstract":"Substance use and substance use disorders run in families. While it has long been recognized that the etiology of substance use behaviors and disorders involves a combination of genetic and environmental factors, two key questions remain largely unanswered: (1) the intergenerational transmission through which these genetic predispositions are passed from parents to children, and (2) the molecular mechanisms linking genetic variants to substance use behaviors and disorders. This article aims to provide a comprehensive conceptual framework and methodological approach for investigating the intergenerational transmission of substance use behaviors and disorders, by integrating genetic nurture analysis, gene expression imputation, and weighted gene co-expression network analysis. We also additionally describe two longitudinal cohorts - the Brisbane Longitudinal Twin Study in Australia and the Lifelines Cohort Study in the Netherlands. By applying the methodological framework to these two unique datasets, our future research will explore the complex interplay between genetic factors, gene expression, and environmental influences on substance use behaviors and disorders across different life stages and populations.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recollections and Reflections on the Reimer Twin Case in Canada: Interview with Dr H. Keith Sigmundson/Tribute and Twin Research Review: Remembering John L. Hopper; Nonhuman Primate Twinning/Human Interest: The Accidental Twins film; Different Looking Identical Twin Newborns. 加拿大雷默双胞胎案例的回忆与思考：专访H. Keith Sigmundson博士/致敬与双胞胎研究回顾：纪念约翰·霍珀；非人类灵长类动物双胞胎/人类利益：意外双胞胎电影；长相不同的同卵双胞胎新生儿。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-12-20 DOI: 10.1017/thg.2024.47

Nancy L Segal

{"title":"Recollections and Reflections on the Reimer Twin Case in Canada: Interview with Dr H. Keith Sigmundson/Tribute and Twin Research Review: Remembering John L. Hopper; Nonhuman Primate Twinning/Human Interest: The Accidental Twins film; Different Looking Identical Twin Newborns.","authors":"Nancy L Segal","doi":"10.1017/thg.2024.47","DOIUrl":"https://doi.org/10.1017/thg.2024.47","url":null,"abstract":"Dr H. Keith Sigmundson co-authored a seminal article (with the late Dr Milton Diamond) that revealed the truth about a highly controversial twin case. Specifically, the genitals of an infant male monozygotic twin were accidentally destroyed during a medical procedure performed to alleviate his difficult urination. The child's parents were advised to physically and psychologically transform their twin son into a girl. Occasional reports about the case indicated that the plan was successful, but some members of the medical community were doubtful. An interview with Dr H. Keith Sigmundson, for the purpose of obtaining his unique perspective on this case, is presented. The interview is followed by a tribute to our late twin research colleague, Dr John L. Hopper, of Melbourne, Australia. A review of research on nonhuman primate twinning, an overview of a 2024 documentary film, The Accidental Twins, and a story of different looking identical twin newborns are also provided.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study. 晚育是早产和分娩的保护因素：来自遗传研究的证据。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-12-16 DOI: 10.1017/thg.2024.44

Jinghui Zou, Cheng Li, Hangyu Wu, Aijiao Xue, Lulu Yan, Yisheng Zhang

{"title":"Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study.","authors":"Jinghui Zou, Cheng Li, Hangyu Wu, Aijiao Xue, Lulu Yan, Yisheng Zhang","doi":"10.1017/thg.2024.44","DOIUrl":"https://doi.org/10.1017/thg.2024.44","url":null,"abstract":"The objective of this study was to investigate the genetic link between the age at first birth (AFB) and the occurrence of preterm labor and delivery, utilizing Mendelian randomization (MR) data alongside genomewide association analysis (GWAS). We obtained AFB-related GWAS summary data from the European Bioinformatics Institute database and preterm labor and delivery data was sourced from the FinnGen Consortium. The study considered AFB as exposure variables, with the incidence of preterm labor and delivery serving as the outcome variable. Several MR analysis methods, such as inverse-variance weighted (IVW), MR Egger, weighted median, simple, and weighted mode were utilized. Besides MR-Egger intercepts, Cochrane's Q test evaluated heterogeneity in the MR data, while MR-PRESSO test checked for horizontal pleiotropy. To assess the association's sensitivity, A leave-one-out approach was utilized to evaluate the sensitivity of the association. The IVW analysis validated that AFB is an independent risk factor for preterm labor and delivery (p < .001). Horizontal pleiotropy was unlikely to bias causality (p > .05). The likelihood of horizontal pleiotropy affecting causality was low (p > .05), and there was no indication of heterogeneity among the genetic variants (p > .05). Ultimately, a leave-one-out analysis confirmed the stability and reliability of this correlation. Our research indicated that AFB is a protective factor for preterm labor and delivery. Further research is required to clarify the possible mechanisms.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygenic Selection and Environmental Influence on Adult Body Height: Genetic and Living Standard Contributions Across Diverse Populations. 多基因选择和环境对成人身高的影响：遗传和生活水平在不同人群中的贡献。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-12-06 DOI: 10.1017/thg.2024.43

Davide Piffer, Emil O W Kirkegaard

{"title":"Polygenic Selection and Environmental Influence on Adult Body Height: Genetic and Living Standard Contributions Across Diverse Populations.","authors":"Davide Piffer, Emil O W Kirkegaard","doi":"10.1017/thg.2024.43","DOIUrl":"https://doi.org/10.1017/thg.2024.43","url":null,"abstract":"We analyzed whole-genome sequencing (WGS) data from 51 populations and combined WGS and array data from 89 populations. Multiple types of polygenic scores (PGS) were employed, derived from multi-ancestry, between-family genome-wide association study (GWAS; MIX-Height), European-ancestry, between-family GWAS (EUR-Height), and European-ancestry siblings GWAS (SIB-Height). Our findings demonstrate that both genetic and environmental factors significantly influence adult body height between populations. Models that included both genetic and environmental predictors best explained population differences in adult body height, with the MIX-Height PGS and environmental factors (Human Development Index [HDI] + per capita caloric intake) achieving an R2 of .83. Our findings shed light on Deaton's 'African paradox', which noted the relatively tall stature of African populations despite poor nutrition and childhood health. Contrary to Deaton's hypotheses, we demonstrate that both genetic differences and environmental factors significantly influence body height in countries with high infant mortality rates. This suggests that the observed tall stature in African populations can be attributed, in part, to a high genetic predisposition for body height. Furthermore, tests of divergent selection based on the QST (i.e., standardized measure of the genetic differentiation of a quantitative trait among populations) and FST (neutral marker loci) measures exceeded neutral expectations, reaching statistical significance (p < .01) with the MIX-Height PGS but not with the SIB-Height PGS. This result indicates potential selective pressures on body height-related genetic variants across populations.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-18"},"PeriodicalIF":1.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factor for Child Maltreatment at 3 Years of Age in Japanese Multiples and Singletons: A Population-Based Study. 日本多胞胎和单胞胎儿童3岁时虐待的危险因素：一项基于人群的研究。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-12-06 DOI: 10.1017/thg.2024.42

Yoshie Yokoyama, Yasue Ogata, Karri Silventoinen

{"title":"Risk Factor for Child Maltreatment at 3 Years of Age in Japanese Multiples and Singletons: A Population-Based Study.","authors":"Yoshie Yokoyama, Yasue Ogata, Karri Silventoinen","doi":"10.1017/thg.2024.42","DOIUrl":"https://doi.org/10.1017/thg.2024.42","url":null,"abstract":"We evaluated the prevalence and risk factors for child maltreatment in multiples aged 3 years and compared them to singletons in Japanese population-based data. Records on child maltreatment and health check-ups at 3 years of age from 17,125 singletons, 488 twins and 18 triplets were collected from a Public Health Center between April 2007 and March 2011. The associations of child maltreatment with potential risk factors were analyzed using the logistic regression model. Out of all children, 76 (4.31 per 1000) children had documented maltreatment including 69 (4.03 per 1000) singletons and seven (14.31 per 1000) twins. All of the cases in twins were physical abuse (100%) and nearly half of the cases (43%) included emotional abuse. Among twins, 86% of the biological mothers were suspected. The alleged perpetrators of twins showed a significantly higher rate of maternal depression compared to those of singletons. After adjusting the results for a number of potential biological and social risk factors, twins or triplets had a higher risk for maltreatment than singletons (OR 3.39, 95% CI [1.17, 9.83]). Healthcare providers should be aware that a multiple birth can place considerable stress on a family leading to child maltreatment and should provide appropriate support and intervention for mothers with multiples.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Twin Births and Survival in Rural Spain: Evidence from 18th to 20th Century. 西班牙农村地区双胞胎出生和存活趋势：18 世纪至 20 世纪的证据。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-11-07 DOI: 10.1017/thg.2024.40

Francisco J Marco-Gracia

{"title":"Trends in Twin Births and Survival in Rural Spain: Evidence from 18th to 20th Century.","authors":"Francisco J Marco-Gracia","doi":"10.1017/thg.2024.40","DOIUrl":"10.1017/thg.2024.40","url":null,"abstract":"This study examines the changes over time of the twinning rate and infant and child mortality across 17 rural villages in the province of Zaragoza (Spain) over a span of 200 years. The aim is to understand how the twinning rate evolved in conjunction with the processes of economic and social modernization, as well as the demographic transition. During the period analyzed, the twinning rate increased by 10%, rising from 1.26 per 1000 births in the second half of the 18th century to 1.38 per 1000 births in the first half of the 20th century. This rate varied due to hereditary issues, biological factors such as the mother's age and parity, and socioeconomic features like family occupation and the mother's education level. In terms of child mortality, twins historically faced a significantly higher mortality rate. However, they benefited greatly from the mortality transition, at least in absolute numbers. While nearly 60% of twins did not survive beyond 5 years of age in earlier periods, the mortality rate for twins decreased to 40% by the first half of the 20th century. The excess mortality was particularly severe for girls, driven by a widespread preference for sons, which led to higher mortality rates for girls in the first 5 years of life, especially in the earliest months. These findings help us understand the improvements in uterine and childhood survival rates for contemporary twins, which can be attributed to the socioeconomic and medical advancements of the 20th century.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chorionicity and Psychomotor Development From Infancy to Childhood: The Japan Environment and Children's Study. 绒毛膜性与婴儿期至儿童期的心理运动发育：日本环境与儿童研究

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-10-28 DOI: 10.1017/thg.2024.39

Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Satoyo Ikehara, Junji Miyazaki, Kanami Tanigawa, Takashi Kimura, Ryo Kawasaki, Hiroyasu Iso

{"title":"Chorionicity and Psychomotor Development From Infancy to Childhood: The Japan Environment and Children's Study.","authors":"Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Satoyo Ikehara, Junji Miyazaki, Kanami Tanigawa, Takashi Kimura, Ryo Kawasaki, Hiroyasu Iso","doi":"10.1017/thg.2024.39","DOIUrl":"https://doi.org/10.1017/thg.2024.39","url":null,"abstract":"Twins lag behind singletons in their early psychomotor development, but little is known about how chorionicity affects this difference. We compared early psychomotor development in singletons, monochorionic (MC) twins and dichorionic (DC) twins. Our longitudinal data from the Japan Environment and Children's Study (JECS; see Appendix) included 98,042 singletons, 577 MC twins and 1051 DC twins representing the general Japanese population. Chorionicity was evaluated by ultrasound images and complemented by postnatal pathological examinations. Five domains of psychomotor development were evaluated at 6 time points from 6 months to 3 years of age using the Ages and Stages Questionnaires (ASQ-3). The data were analyzed using linear regression models. Twins lagged behind singletons in all areas of psychomotor development during infancy. This gap decreased over time but was still noticeable at 3 years of age. More than half of this difference was attributed to twins having lower birth weight and being born earlier in gestation. MC twins showed slightly delayed development compared to DC twins, but this difference was minor compared to the overall gap between twins and singletons. Twins delay singletons in their early psychomotor development, and this delay is not specific to MC twinning.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Predisposition of Different Social Status Indicators in Men and Women. 男性和女性不同社会地位指标的遗传倾向。

IF 1 4区医学

Twin Research and Human Genetics Pub Date : 2024-09-09 DOI: 10.1017/thg.2024.23

Martin Fieder, Susanne Huber

{"title":"Genetic Predisposition of Different Social Status Indicators in Men and Women.","authors":"Martin Fieder, Susanne Huber","doi":"10.1017/thg.2024.23","DOIUrl":"https://doi.org/10.1017/thg.2024.23","url":null,"abstract":"Although there is evidence that social status has a genetic basis, it is less known whether the genetic predisposition differs between men and women as well as among different status indicators and whether there are any intercorrelations among predispositions of status indicators. We therefore investigated the genetic predisposition for different indicators of social status separately for men and women, using polygenic scores obtained from the Wisconsin Longitudinal Study. We used multivariate polygenic regression of 7 different social status indicators on a total of 24 different polygenic scores. We find that in both men and women, wages and education show more associations with polygenic scores than the other status indicators. Also, the genetic predispositions for education and wages are correlated in both men and women, whereas in men more than in women, the genetic predispositions seem to cluster into wages and education on the one hand, and status indicators of position in the hierarchy, on the other hand, with being in a management position somewhere in between. These findings are consistent with an assumption of two different forms of selection pressure associated with either cognitive skill or dominance, which holds true particularly in men. We conclude that the genetic predisposition to higher social status may have changed even though the importance of the cultural trait of social status may have been very constant. Social status may thus be an example of a social trait of constant importance, but with a changing genetic predisposition.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0