Financial Stressors and Risk of Suicidal Behavior in a Swedish National Cohort.

IF 1 4区 医学 Q4 GENETICS & HEREDITY
Alexis C Edwards, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler
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引用次数: 0

Abstract

Although financial stressors are implicated as risk factors for suicidal behavior, these associations might be confounded by other factors. Furthermore, a move toward high-risk subgroup definition is necessary. The authors used Swedish national registry data to examine the associations between receipt of social welfare, unemployment benefits, or early retirement (N = 627,745-2,260,753) with suicidal behavior in Cox proportional hazards models. They applied co-relative models to improve causal inference, and examined interactions with aggregate genetic risk for suicidality. All three exposures were associated with elevated suicidal behavior risk. Initial hazard ratios for suicide attempt ranged from 1.37-3.86, were similar for suicide death, and declined after controlling for psychopathology and time elapsed after exposure. Age at registration differentially impacted risk of suicidal behavior. Aggregate genetic liability for suicidality was associated with risk, but its effect was not moderated by financial stress. Financial stressors are associated with suicidal behavior risk even after controlling for psychopathology. Associations are attributable in part to familial confounding, though a potentially causal pathway was observed in most cases. Suicidality risk varied as a function of sex and age at exposure; these findings could be used to identify subgroups at high risk who warrant targeted prevention.

瑞典国家队列的财务压力因素和自杀行为风险。
尽管经济压力因素被认为是自杀行为的风险因素,但这些关联可能会被其他因素所混淆。此外,向高风险亚群定义迈进是必要的。作者使用瑞典国家登记数据,在Cox比例风险模型中检验领取社会福利、失业救济或提前退休(N = 627,745-2,260,753)与自杀行为之间的关系。他们应用了相关模型来改进因果推理,并检查了与自杀总遗传风险的相互作用。这三种暴露都与自杀行为风险升高有关。自杀企图的初始风险比在1.37-3.86之间,自杀死亡的风险比相似,在控制了精神病理和暴露后的时间后下降。登记年龄对自杀行为的影响不同。总体遗传倾向与自杀风险相关,但其影响不受经济压力的影响。即使在控制了精神病理因素后,财务压力源仍与自杀行为风险相关。尽管在大多数情况下观察到潜在的因果途径,但这些关联部分可归因于家族混杂。自杀风险随暴露时的性别和年龄而变化;这些发现可用于确定需要有针对性预防的高危亚群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Twin Research and Human Genetics
Twin Research and Human Genetics 医学-妇产科学
CiteScore
1.50
自引率
11.10%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.
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