Twin Research and Human Genetics最新文献_第3页

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-03-30 DOI: 10.1017/thg.2026.10050

Hans Fredrik Sunde, Philipp Dierker

{"title":"Are Spouses Similar in Divorce? Investigating Spousal Similarity in Couple-Shared Outcomes.","authors":"Hans Fredrik Sunde, Philipp Dierker","doi":"10.1017/thg.2026.10050","DOIUrl":"10.1017/thg.2026.10050","url":null,"abstract":"In behavioral genetics, divorce is typically analyzed as an individual-level outcome, even though marital dissolution can only be experienced by couples. In this article, we discuss how assortative mating complicates the study of couple-shared outcomes because individual-level effects can be confounded by effects of the spouse. We then show how chain-linking affines (i.e., in-laws) provides sufficient information to estimate spousal similarity for couple-shared outcomes, which we incorporate into an extended twin model that we use to test for sex differences and assortative mating for individuals' liability to divorce. We linked the Norwegian twin register to the Norwegian population register and constructed 124,544 extended family units (1196 units with monozygotic twins) comprising 353,210 marriages entered between 1983 and 2008. We found that divorce was significantly correlated among affines, and that female relatives were more highly correlated than male relatives. The extended twin model estimated a strong correlation (r = .60, SE = .10) between female and male familial factors. Couples' liability to divorce was attributed to 18% (SE = 5%) female and 10% (SE = 3%) male familial factors, with an additional 16% (SE = 4%) accounted for by their correlation. Estimates from a classic twin model were considerably higher. These findings show that spousal similarity is an important source of variation in divorce liability and that failing to model it can inflate estimates of individual-level effects. Overall, the analytical framework offers a blueprint for dissecting any couple-shared outcome into sex-specific and assortative components.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"291-299"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Murcia Twin Registry: 20 Years of Study and Progress in Health and Behavioral Traits in Spain. 穆尔西亚双胞胎登记：西班牙健康和行为特征的20年研究和进展。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-03-31 DOI: 10.1017/thg.2026.10048

Juan F Sánchez-Romera, Federico J Blanco-García, Eduvigis Carrillo, Lucía Colodro-Conde, Francisca González-Javier, Juan J Madrid-Valero, José M Martínez-Selva, Olga Monteagudo, José J Morosoli, Juan R Ordoñana

{"title":"The Murcia Twin Registry: 20 Years of Study and Progress in Health and Behavioral Traits in Spain.","authors":"Juan F Sánchez-Romera, Federico J Blanco-García, Eduvigis Carrillo, Lucía Colodro-Conde, Francisca González-Javier, Juan J Madrid-Valero, José M Martínez-Selva, Olga Monteagudo, José J Morosoli, Juan R Ordoñana","doi":"10.1017/thg.2026.10048","DOIUrl":"10.1017/thg.2026.10048","url":null,"abstract":"The Murcia Twin Registry (MTR) has steadily expanded over two decades and has become a key resource for twin research in the Mediterranean region. The registry currently includes data from 3971 individual twins born between 1940 and 1999, as well as an associated biobank containing samples from 1586 participants. Its primary research focus is on health and health-related behaviors within a public health framework, covering areas such as lifestyle, health promotion, quality of life, and environmental factors. Across multiple waves of data collection, the MTR has compiled extensive and wide-ranging phenotypic data. These data can be further expanded and have strong potential for record linkage with other health databases, particularly those of the regional public health care system, including both primary and inpatient care. Efforts are also underway to establish record linkage with additional sources of information, such as the educational system. In the near future, the registry aims to expand its biobank and continue the collection of longitudinal data, as well as increasing the ability to collect additional data that could enrich the information from participants in the register.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"308-313"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twin Research in Ethological and Evolutionary Perspective /: News and Views from the International Society for Human Ethology / Twin Research Summaries: Parthenogenetic 46, XX/46, XY Congenital Chimera; Parental Favoritism of One Twin; Parasitic Twins; Twin Study of Primal World Beliefs / Human Interest: Twins' Matching Lives; Birth of Three Triplet Sets; Chinese Twins Reared Apart; Conjoined Twin Separation. 动物行为学和进化视角下的双胞胎研究/：国际人类动物行为学学会的新闻和观点/双胞胎研究综述：孤雌生殖46、XX/46、XY先天性嵌合体；一对双胞胎的父母偏爱；寄生双胞胎;原始世界信念/人类兴趣的双胞胎研究：双胞胎的配对生活三个三胞胎的诞生；分开抚养的中国双胞胎；连体双胞胎分离。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-08-05 DOI: 10.1017/thg.2026.10091

Nancy Segal

引用次数: 0

The German Twin Registry (GERTRUD): Towards Harmonized, Multisource Twin Research. 德国双胞胎登记（GERTRUD）：朝着协调，多源双胞胎研究。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-05-04 DOI: 10.1017/thg.2026.10057

Moana Beyer, Dmitry Kuznetsov, Simone Kühn

{"title":"The German Twin Registry (GERTRUD): Towards Harmonized, Multisource Twin Research.","authors":"Moana Beyer, Dmitry Kuznetsov, Simone Kühn","doi":"10.1017/thg.2026.10057","DOIUrl":"10.1017/thg.2026.10057","url":null,"abstract":"Twin registries worldwide increasingly function as large-scale research infrastructures, enabling standardized phenotyping across the lifespan, integration of biological and environmental data streams, and international cross-cohort collaborative research and replications. This development is also taking place in Germany. The GERman Twin Registry Under Development (GERTRUD; www.gertrud.info) was established in 2022 as the first nationwide research platform for recruiting twins and higher order multiples of all ages within Germany to support the large-scale genetically informative psychological, sociological, health, and neuroscience twin research at national and international levels. GERTRUD is being developed as a modular infrastructure that supports classical and extended twin family designs, combining annual core survey waves with optional embedded modules for intensive phenotyping (e.g., neuroimaging, smartphone-based assessments), biosampling, and linkage of participants' residential context to external geographic datasets via geospatial information systems (GIS). To operate within Germany's stringent data protection landscape, GERTRUD implements project-specific pseudonymisation, role-based access control, and contract-governed remote analysis access. This article describes GERTRUD's governance and legal-technical framework, its multisource data architecture, and the potential for collaboration across Germany and internationally. Examples of early data implementations further illustrate that the continuously collected multimodal twin data constitute a critical asset, essential for successful harmonization, replication, and collaborative and integrative behavioral genetics research.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"258-268"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years. 基因与环境的相互作用跨越多个研究（IGEMS）联盟十五年。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2025-12-19 DOI: 10.1017/thg.2025.10036

Deborah Finkel, Brian K Finch, Margaret Gatz, Kaare Christensen, Carol E Franz, Ida K Karlsson, William S Kremen, Robert F Krueger, Michelle Lupton, Nicholas Martin, Matt McGue, Miriam A Mosing, Jenae Neiderhiser, Marianne Nygaard, Elizabeth Prom-Worley, Chandra Reynolds, Perminder Sachdev, Elina Sillanpää, Eero Vuoksimaa, Keith E Whitfield, Orla Hayden, Ellen Walters, Nancy L Pedersen

{"title":"The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.","authors":"Deborah Finkel, Brian K Finch, Margaret Gatz, Kaare Christensen, Carol E Franz, Ida K Karlsson, William S Kremen, Robert F Krueger, Michelle Lupton, Nicholas Martin, Matt McGue, Miriam A Mosing, Jenae Neiderhiser, Marianne Nygaard, Elizabeth Prom-Worley, Chandra Reynolds, Perminder Sachdev, Elina Sillanpää, Eero Vuoksimaa, Keith E Whitfield, Orla Hayden, Ellen Walters, Nancy L Pedersen","doi":"10.1017/thg.2025.10036","DOIUrl":"10.1017/thg.2025.10036","url":null,"abstract":"The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene-environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"358-367"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking the Twins Early Development Study (TEDS) With NHS Electronic Health Records. 链接双胞胎早期发展研究（TEDS）与NHS电子健康记录。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-05-21 DOI: 10.1017/thg.2026.10066

Celestine Lockhart, Megan Skelton, Shannon Bristow, Andy Boyd, Johnny Downs, Alex Dregan, Helen L Fisher, Ray Leal, Andrew McMillan, Rachel Ogden, Louise Webster, Robert Plomin, Thalia C Eley

{"title":"Linking the Twins Early Development Study (TEDS) With NHS Electronic Health Records.","authors":"Celestine Lockhart, Megan Skelton, Shannon Bristow, Andy Boyd, Johnny Downs, Alex Dregan, Helen L Fisher, Ray Leal, Andrew McMillan, Rachel Ogden, Louise Webster, Robert Plomin, Thalia C Eley","doi":"10.1017/thg.2026.10066","DOIUrl":"10.1017/thg.2026.10066","url":null,"abstract":"The Twins Early Development Study (TEDS) is a longitudinal population study of over 10,000 twin pairs born in England and Wales between 1994 and 1996. As the twins enter their thirties, a primary focus of TEDS is to better understand the development of common physical and mental health problems and the relationship with the different social milestones of adulthood (e.g., employment, partnerships, and/or parenthood). With over 30 years of prospectively collected questionnaire and genetic data, the study is uniquely placed to answer questions about the health challenges facing young adults today. Incorporating linked medical records with the existing research data will provide a different data perspective on our twin's health status and outcomes and support more equitable research by helping to address both response and attrition bias. This article provides an overview of the protocol to link TEDS participants to electronic health records collected by the UK National Health Service (NHS). It will outline the linkage process, characterize the available linked study sample and NHS datasets, and describe the legal basis for this work.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"334-342"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The National Project on Achievement in Twins: Integrating Across Data Resources in the United States. 双胞胎成就国家项目：整合美国的跨数据资源。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-03-31 DOI: 10.1017/thg.2026.10046

Sara A Hart, Ashlyn Hicks, Madison Poisall, Hongcui Du, Patrick Kennedy, Jeffrey Gruen, Jeanette Taylor, Colleen M Ganley, Callie W Little

{"title":"The National Project on Achievement in Twins: Integrating Across Data Resources in the United States.","authors":"Sara A Hart, Ashlyn Hicks, Madison Poisall, Hongcui Du, Patrick Kennedy, Jeffrey Gruen, Jeanette Taylor, Colleen M Ganley, Callie W Little","doi":"10.1017/thg.2026.10046","DOIUrl":"10.1017/thg.2026.10046","url":null,"abstract":"The National Project on Achievement in Twins (NatPAT) is a twin project based in the United States (US) that began in 2017. Using a cohort sequential design, the overall goal of the initial project was to uncover salient factors, including genetic and environmental influences, which contribute to the co-development of reading and math performance during elementary school. In 2022, the focus of NatPAT pivoted towards a new focus on the COVID-19 pandemic's short- and long-term impacts on children's reading achievement. In addition, a genomics data collection began. New enrollment into the registry continues every year, but currently NatPAT follows 1997 twin pairs and their families as they progress through school. The project supports open science principles, with open materials and code, preregistration, and shared data. Here we present the goals of the project, summarize recent results, methods and materials, with a focus on the integration across many different data sources, and future directions of the project.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"353-357"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Population-Based Hungarian Twin Registry: Current Register Data, Researches and Linkages. 以人口为基础的匈牙利孪生登记：当前登记数据、研究和联系。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-06-23 DOI: 10.1017/thg.2026.10075

David Laszlo Tarnoki, Marton Piroska, Dora Melicher, Julia Metneki, Levente Littvay, Adam Domonkos Domonkos Tarnoki

{"title":"The Population-Based Hungarian Twin Registry: Current Register Data, Researches and Linkages.","authors":"David Laszlo Tarnoki, Marton Piroska, Dora Melicher, Julia Metneki, Levente Littvay, Adam Domonkos Domonkos Tarnoki","doi":"10.1017/thg.2026.10075","DOIUrl":"10.1017/thg.2026.10075","url":null,"abstract":"The Hungarian Twin Registry (HTR) has operated as a population-based registry since 2021, following its establishment at Semmelweis University in Budapest. In recent years, the HTR infrastructure has been substantially expanded, including blood storage facilities, information technology systems, a phone bank and voicemail system, and administrative resources. Adult twins (aged ≥18 years) and relatives (parents, foster parents, or caregivers) of twins under 18 years of age can register via the registry's website or by voicemail following a nationwide identification and notification process. The registration questionnaire consists of eight sections covering sociodemographic and anthropometric characteristics, smoking habits, and medical history, including diseases, surgeries, and therapies. By December 20, 2025, a total of 12,676 twin individuals and their parents or guardians had registered, including 7244 adult twins and 5432 parents or guardians of minors. Based on self-reported data, 44.1% of registered adult twins were monozygotic (MZ) and 55.9% dizygotic (DZ), while among registered children 23.5% were MZ and 76.5% DZ. Of the registered adult twins, 68.4% were female. The HTR offers substantial potential for linkage with national health databases, enabling enrichment of phenotypic and outcome data without additional participant burden. In particular, linkage with the Hungarian National Cancer Registry and other health-related databases is feasible under appropriate ethical approval and data protection procedures and may support long-term follow-up and disease-specific analyses. The article also summarizes current research projects conducted within the HTR, which has become the largest population-based twin registry in Central and Eastern Europe based on the number of registrations.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"378-384"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Qatar Twin Registry (QTR): The First Twin Registry in the Arab World. 卡塔尔双胞胎登记处（QTR）：阿拉伯世界第一个双胞胎登记处。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2026-08-10 DOI: 10.1017/thg.2026.10078

Salma Bouabidi, Shahd Nasr, Lubna Abu Rub, Eleni Fthenou, Veronika Odintsova, Dorret Boomsma, Hamdi Mbarak, Kholoud Al-Shafai, Mashael Al-Shafai

{"title":"The Qatar Twin Registry (QTR): The First Twin Registry in the Arab World.","authors":"Salma Bouabidi, Shahd Nasr, Lubna Abu Rub, Eleni Fthenou, Veronika Odintsova, Dorret Boomsma, Hamdi Mbarak, Kholoud Al-Shafai, Mashael Al-Shafai","doi":"10.1017/thg.2026.10078","DOIUrl":"10.1017/thg.2026.10078","url":null,"abstract":"Populations of Arab ancestry remain underrepresented in global twin studies. These populations are described by distinct genetic characteristics, high consanguinity, and strong familial relatedness. To contribute to diversity in genetics and twin research, the Qatar Twin Registry (QTR) was established as the first national twin registry in the Arab world and the second in the Middle East and North Africa. The QTR is a prospective and retrospective cohort study developed by Qatar University in collaboration with the Qatar Precision Health Institute (QPHI). The registry integrates with Qatar's national biobank and whole-genome sequencing infrastructure to enable large-scale twin-based research. Participants contribute comprehensive health, developmental, psychosocial, and lifestyle information, along with biological samples collected through clinic-based assessments and home visits. QTR marks a milestone in regional genetic and epidemiological research. Leveraging and linking to Qatar's national biobank and genomic infrastructure, it establishes a sustainable framework for investigating heritability, gene-environment interactions, and complex diseases in an underrepresented Arab population, contributing to global precision medicine efforts.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"300-307"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data Resource Profile: The Finnish TwinRegistry Project. 数据资源简介：芬兰TwinRegistry项目。

IF 1.3 4区医学

Twin Research and Human Genetics Pub Date : 2026-08-01 Epub Date: 2025-10-09 DOI: 10.1017/thg.2025.10025

Stephanie Zellers, Sarah Niemi de Paiva, Mikko Olkkonen, Hannu Karhunen, Terhi Maczulskij, Annina Ropponen, Jaakko Kaprio, Antti Latvala

引用次数: 0