Ultrastructural Pathology最新文献_第3页

Myricetin ameliorates the effects of hydrogen peroxide-induced oxidative stress in human mesenchymal stem cells: an ultrastructural and immunocytochemical study. 杨梅素改善过氧化氢诱导的人间充质干细胞氧化应激的影响：一项超微结构和免疫细胞化学研究。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-17 DOI: 10.1080/01913123.2025.2494618

Mehmet Berker, Sibel Köktürk, Sibel Doğan, Emel Usta

{"title":"Myricetin ameliorates the effects of hydrogen peroxide-induced oxidative stress in human mesenchymal stem cells: an ultrastructural and immunocytochemical study.","authors":"Mehmet Berker, Sibel Köktürk, Sibel Doğan, Emel Usta","doi":"10.1080/01913123.2025.2494618","DOIUrl":"https://doi.org/10.1080/01913123.2025.2494618","url":null,"abstract":"The development of new strategies to raise the survival and viability of transplanted mesenchymal stem cells (MSCs) is very important for the therapeutic potential of stem cells. The natural flavonoid myricetin has anticancer, antioxidant, anti-inflammatory and antiapoptotic effects. The effects of myricetin on human umbilical cord-derived MSCs (HUC-MSCs) induced oxidative stress with hydrogen peroxide (H2O2) were evaluated by transmission electron microscopy (TEM) and immunocytochemistry (ICC) staining. Myricetin showed an increase in the number of live cells, a decrease in caspase-3 and tumor necrosis factor-α (TNF-α) ICC staining intensity, an increase in the translocase of the mitochondrial inner membrane 17 (TIM17) ICC staining intensity, and a decrease in degeneration of cell ultrastructure in TEM against oxidative stress damage in HUC-MSCs. The results suggest that myricetin prevents oxidative stress-induced apoptosis and inflammation in the HUC-MSCs. Myricetin can be combined with HUC-MSCs in cell culture and considered as a supportive alternative treatment option.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"257-264"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of olanzapine on testes of adult albino rats and the possible role of granulocyte colony stimulating factor versus umbelliferone light and electron microscopic study. 奥氮平对成年白化病大鼠睾丸的影响及粒细胞集落刺激因子对伞蛋白的作用。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-24 DOI: 10.1080/01913123.2025.2495159

Maha A Khattab, Samah M Ahmed, Haidy G Salama, Noura H Mekawy

{"title":"Effect of olanzapine on testes of adult albino rats and the possible role of granulocyte colony stimulating factor versus umbelliferone light and electron microscopic study.","authors":"Maha A Khattab, Samah M Ahmed, Haidy G Salama, Noura H Mekawy","doi":"10.1080/01913123.2025.2495159","DOIUrl":"https://doi.org/10.1080/01913123.2025.2495159","url":null,"abstract":"Olanzapine (OLZ) is one of atypical antipsychotic drugs (second generation) used for treating schizophrenia, manic, and mixed episodes of bipolar disorder. Continuous evaluation of its effects is necessary, and there is a need to explore alternative natural products as G-CSF and UMB to manage potential side effects. This research designed to mitigate the atypical antipsychotic drugs' adverse effects through biochemical analyses, light and electron microscopic studies. Fifty-six rats were divided into five groups: Control, OLZ, G-CSF, UMB, and Recovery groups. End body and testicular weights, serum testosterone, testicular MDA levels, and seminal analysis were recorded. Testicular specimens were processed to evaluate histological structure, PCNA, and CD34 immune expression. Morphometric and statistical analyses were also performed. OLZ group exhibited a distorted testicular structure, a significant increase in end body and a decline in testicular weight, a significant decline in the serum level of testosterone level, testicular MDA, and seminal analysis parameters. Furthermore, disturbed histoarchitecture, reduction in PCNA, and elevation in CD34 immunoreaction were observed. These alterations were partially attenuated by G-CSF therapy, whereas UMB significantly improved all parameters. In conclusion, UMB, and to a lesser degree G-CSF, appeared to be superior therapeutic options by attenuating oxidative stress and restoring intact histological structure and biochemical parameters.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"265-287"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphometric study of proximal tubular cell mitochondria using TEM images in renal diseases. 肾脏疾病近端小管细胞线粒体的透射电镜形态学研究。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-24 DOI: 10.1080/01913123.2025.2494621

Dibyajyoti Boruah, Varun Bajaj, Barun Kumar Chakrabarty, Sarika Pardeshi, A W Kashif, S Venkatesan

{"title":"Morphometric study of proximal tubular cell mitochondria using TEM images in renal diseases.","authors":"Dibyajyoti Boruah, Varun Bajaj, Barun Kumar Chakrabarty, Sarika Pardeshi, A W Kashif, S Venkatesan","doi":"10.1080/01913123.2025.2494621","DOIUrl":"https://doi.org/10.1080/01913123.2025.2494621","url":null,"abstract":"The kidney is rich in mitochondria, and any alterations or damage to tubular cell mitochondria play an important role in renal metabolic activities and the pathogenesis of various kidney diseases. Quantitative analysis of mitochondrial concentration, size, and shape is essential for understanding mitochondrial biology in renal disorders. This study assessed mitochondrial morphometric parameters of the proximal convoluted tubular cell adjacent to the glomerulus in different renal disorders and investigated how they correlated with serum creatinine. A total of 65 kidney biopsy cases received by the transmission electron microscope (TEM) laboratory for diagnosis were included in the study. TEM images of glutaraldehyde-osmium tetroxide fixed epoxy-resin embedded 70 nm thick sections were used for the evaluation of (i) minor axis(MinX) (ii) major axis(MajX) (iii) Area, (iv)Perimeter, (v) Aspect ratio and (vi) Roundness of mitochondria in renal tubular cells using QuPath software. Mitochondrial density (MDensity), % of mitochondrial space (MSpace), and mitochondrial surface density (MSDensity) in the cytoplasm of tubular space were estimated for each sample. Serum creatinine showed good negative correlations with MSpace and MSDensity, and elongation of mitochondria was more in renal disorder in comparison to normal histology, which indicated the variation of mitochondrial concentration and shape in proximal tubular cells could be important features in the renal function disorder.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"315-325"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical and ultrastructural identification of telocytes in the infantile hemangioma. 通过免疫组化和超微结构鉴定婴儿血管瘤中的毛细血管细胞。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-10-13 DOI: 10.1080/01913123.2024.2415608

Han-Wen Ding, Qian Wang, Min Wang, Yong Chen, Si-Ming Yuan

{"title":"Immunohistochemical and ultrastructural identification of telocytes in the infantile hemangioma.","authors":"Han-Wen Ding, Qian Wang, Min Wang, Yong Chen, Si-Ming Yuan","doi":"10.1080/01913123.2024.2415608","DOIUrl":"10.1080/01913123.2024.2415608","url":null,"abstract":"Telocytes (TCs) are a distinctive cell entity of the stromal microenvironment of multiple tumors; to date, their existence in infantile hemangioma (IH) remains almost unexplored. This study was therefore undertaken to characterize the immunophenotype, location, morphology, and ultrastructure of telocytes in the IH by means of immunohistochemistry, immunofluorescence confocal microscopy, and transmission electron microscopy. Telocytes were initially identified by CD34, PDGFR-α, Vimentin, and AQP-1 immunostaining. Analyzing the spatial relationship among telocytes, stem cells, endothelial cells, pericytes in the IH with AQP-1/CD31, AQP-1/Glut-1, AQP-1/α-SMA, AQP-1/CD146 and AQP-1/CD133 double immunofluorescence. TCs were immunonegative for CD31, Glut-1, CD146, α-SMA, CD133, and C-kit in the IH. The ultrastructural examination confirmed the presence of TCs, namely stromal cells with characteristic cytoplasmic processes (i.e. telopodes) forming labyrinthine networks around microvessels and releasing extracellular vesicles. Our study provides evidence that telocytes are present and PDGFR-α and AQP-1 are specific antigenic markers in the IH.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"563-574"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possible effects of chronic administration of amiodarone hydrochloride on the seminiferous tubules of adult male albino rats: histological and biochemical study. 长期服用盐酸胺碘酮对成年雄性白化大鼠曲细精管的可能影响：组织学和生化研究。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI: 10.1080/01913123.2024.2407330

Amany M Abo-Ouf, Amany F Mohamed, Heba Abdelnaser Aboelsoud, Ayman Geddawy, Heba F Ibrahim

{"title":"The possible effects of chronic administration of amiodarone hydrochloride on the seminiferous tubules of adult male albino rats: histological and biochemical study.","authors":"Amany M Abo-Ouf, Amany F Mohamed, Heba Abdelnaser Aboelsoud, Ayman Geddawy, Heba F Ibrahim","doi":"10.1080/01913123.2024.2407330","DOIUrl":"10.1080/01913123.2024.2407330","url":null,"abstract":"Amiodarone hydrochloride is an antiarrhythmic agent that is widely prescribed. However, it has serious side effects that approximately affect the whole body organs. In our study, we aimed to assess the possible effects of chronic administration of two different doses of amiodarone hydrochloride on the oxidative and inflammatory parameters as well as the histological morphology and ultrastructure of the seminiferous tubules of adult male albino rats. Forty rats were divided into four groups; Control group 1: each rat did not receive any drugs at all. Control group 2: each rat received 3 ml of 0.16% methylcellulose, orally and daily for 4 weeks. Low dose amiodarone group: each rat received 3 ml of 0.16% methylcellulose contained 3.6 mg amiodarone, orally and daily for 4 weeks. High dose amiodarone group: each rat received 3 ml of 0.16% methylcellulose contained 7.2 mg amiodarone, orally and daily for 4 weeks. Blood samples were collected for measuring serum levels of malondialdehyde, superoxide dismutase, interleukin-6 and tumor necrosis factor-alpha. Testes specimens were examined to assess the morphological changes and the level of expression of caspase-3 apoptotic marker. The results indicated that; amiodarone hydrochloride could induce a dose-dependent toxicity, causing oxidative stress, inflammation, cellular degeneration, deposition of collagen and enhanced apoptosis in the seminiferous tubules.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"476-495"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streptozotocin-induced morphological changes in rat lungs. 链脲佐菌素诱导的大鼠肺形态变化

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-11-15 DOI: 10.1080/01913123.2024.2426567

Felicia M Masetla, Mia-Jeanne Van Rooy, June C Serem, Hester M Oberholzer

{"title":"Streptozotocin-induced morphological changes in rat lungs.","authors":"Felicia M Masetla, Mia-Jeanne Van Rooy, June C Serem, Hester M Oberholzer","doi":"10.1080/01913123.2024.2426567","DOIUrl":"10.1080/01913123.2024.2426567","url":null,"abstract":"Streptozotocin (STZ) is a commonly used compound for the induction of type 2 diabetes (T2D) in animal models, but its effects on non-pancreatic tissues like the lungs are not well understood. This study aimed to examine the histopathological impact of STZ on the lungs using male Sprague-Dawley rats. The rats were divided into two groups: a control group on a normal diet and an STZ-treated group receiving a high-fat diet and 10% sucrose water for 8 weeks, followed by an STZ injection (30 mg/kg body weight). All rats were terminated 9 days after STZ administration, and lung samples were collected for light microscopy, transmission electron microscopy (TEM), and confocal laser scanning microscopy. Light microscopy revealed thickening of alveolar septa, narrowing of alveoli, and inflammatory infiltrates in the STZ group. TEM showed mitochondrial damage in type 2 pneumocytes, including membrane fragmentation, cristae loss, and formation of mitochondrial-derived vesicles. Confocal microscopy revealed significantly higher expression of myeloperoxidase, neutrophil elastase, and citrullinated histone 3 in the STZ group compared to controls. These findings suggest that STZ induces considerable lung damage, emphasizing the need to consider lung toxicity in studies involving STZ.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"550-562"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic efficacy of adipose mesenchymal stem cell-derived microvesicles versus infliximab in a dextran sodium sulfate induced ulcerative colitis rat model. 脂肪间充质干细胞衍生微囊与英夫利西单抗在右旋糖酐硫酸钠诱导的溃疡性结肠炎大鼠模型中的疗效对比。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-11-15 DOI: 10.1080/01913123.2024.2426566

Sahar F Shaban, Eman A Abdel-Fattah, Manar M Ali, Arigue A Dessouky

{"title":"The therapeutic efficacy of adipose mesenchymal stem cell-derived microvesicles versus infliximab in a dextran sodium sulfate induced ulcerative colitis rat model.","authors":"Sahar F Shaban, Eman A Abdel-Fattah, Manar M Ali, Arigue A Dessouky","doi":"10.1080/01913123.2024.2426566","DOIUrl":"10.1080/01913123.2024.2426566","url":null,"abstract":"Ulcerative colitis (UC) is a chronic relapsing intestinal inflammation that is becoming of increasing incidence worldwide and has insufficient treatment. Therefore, finding effective therapies remains a priority. A dextran sodium sulfate colitis model was established to elucidate colonic layers alterations and compare adipose mesenchymal stem cell-derived microvesicles (MSC-MVs) versus infliximab (IFX) efficacy through biochemical, light, and electron microscope studies. Fifty-four rats were allocated to 4 groups: Control (Con), UC, UC+IFX, and UC+MSC-MVs groups. End body weights (BW) and serum malondialdehyde (MDA) levels were recorded. Colitis severity was estimated by disease activity index (DAI). Colonic specimens were processed to evaluate the histological structure, collagen content, surface mucous and goblet cells, CD44, TNF-α, and GFAP immune expression. Morphometric and statistical analyses were performed. The UC group revealed congested, stenosed colons, a significant decline in end BW, and a significant increase in serum MDA and DAI. Furthermore, disturbed histoarchitecture, inflammatory infiltration, depletion of surface mucous and goblet cells, increased collagen, and TNF-α expression and decreased GFAP expression were observed. Alterations were partially attenuated by IFX therapy, whereas MSC-MVs significantly improved all parameters. In conclusion, MSC-MVs were a superior therapeutic option, via attenuating oxidative stress and inflammatory infiltration, in addition to restoring intestinal epithelial integrity and mucosal barrier.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"526-549"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of ozone versus mesenchymal stem cell-derived microvesicles in ameliorating testicular changes after hypothyroidism in adult albino rats: a histological and immunohistochemical study. 臭氧与间充质干细胞衍生的微囊在改善成年白化大鼠甲状腺功能减退后睾丸变化方面的功效：组织学和免疫组织化学研究。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-11-17 DOI: 10.1080/01913123.2024.2423863

Magdy F Gawish, Samia A Abd El-Baset, Salma S Shalabi, Nahla E Ibrahem

{"title":"Efficacy of ozone versus mesenchymal stem cell-derived microvesicles in ameliorating testicular changes after hypothyroidism in adult albino rats: a histological and immunohistochemical study.","authors":"Magdy F Gawish, Samia A Abd El-Baset, Salma S Shalabi, Nahla E Ibrahem","doi":"10.1080/01913123.2024.2423863","DOIUrl":"10.1080/01913123.2024.2423863","url":null,"abstract":"This study was performed to: detect the histological, immunohistochemical, and biochemical alterations that may occur in the testes of adult rats in induced hypothyroidism. And to investigate which one, ozone or MSCs-MVs have better therapeutic effect on testicular changes after hypothyroidism. Eighty-four male adult rats were separated into: control group, hypothyroidism group: rats will be given carbimazole for 30 days, ozone group: rats treated as hypothyroidism group then will be injected with ozone intraperitoneal for 7 days. MSC-MVs group: rats treated as hypothyroidism group then will be injected with a single intravenous dose MSC-MVs. Specimens of testes were handled for light, electron microscope, and immunohistochemical of vimentin and S100. Biochemical analysis for; MDA and TNFα; serum testosterone, TSH, T3, and T4 was done, also, sperm count and morphology assay. Morphometric and statistical analysis were performed. Hypothyroidism group showed disorganized seminiferous tubules. A noticeable gap was between the basement membrane and the germinal epithelium. Wide interstitium had congested vessels and acidophilic homogenous material. Vacuolated germinal epithelium and few germ cells had dark nuclei with noticeable separation of between the basement membrane and the germinal epithelium. Ozone and MSCs-MVs induced improvement in all the previous parameters and restoration of spermatogenesis. In Conclusion MSCs-MVs has better ameliorative effect than ozone on hypothyroidism-exposed testes.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"496-525"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Value of electron microscopy as perceived by nephrologists in Flanders, Belgium. 比利时佛兰德斯地区肾病专家对电子显微镜价值的看法。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.1080/01913123.2024.2423083

Laura Desnerck, Laure-Anne Kerckhaert, Steven Van Laecke, Amélie Dendooven

{"title":"Value of electron microscopy as perceived by nephrologists in Flanders, Belgium.","authors":"Laura Desnerck, Laure-Anne Kerckhaert, Steven Van Laecke, Amélie Dendooven","doi":"10.1080/01913123.2024.2423083","DOIUrl":"10.1080/01913123.2024.2423083","url":null,"abstract":"Electron microscopy (EM) is an important complementary tool in biopsy diagnosis of kidney disease. However, EM is a costly technique and not universally available. In order to understand nephrologists' perspectives on EM, a survey among Flemish nephrologists was conducted. The survey explores nephrologists' knowledge and satisfaction with EM, the barriers in its use, and its role in decision-making.A questionnaire was sent out to Dutch-speaking nephrologists in Belgium (Flanders) via the professional organization NBVN (Nederlandstalige Belgische Vereniging voor Nefrologie).The average satisfaction of EM accessibility in nephrologists, was 4.0 on a scale from 1 (very unsatisfied) to 5 (very satisfied). The main barrier in ordering EM appeared to be the long turnaround time, indicated by 32.5% of nephrologists. The reports were found mostly understandable by 61.0% of the nephrologists. The impact of EM on diagnosis of kidney disease was estimated higher than its impact on the treatment: 24.4% of respondents estimated diagnosis changes in less than 5% of cases, versus 68.3% estimated treatment changes in less than 5% of cases.This study provides key insights into nephrologists' perception on EM services, revealing high overall satisfaction. However, there is potential for improvement, especially regarding turnaround times.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"575-581"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possible protective effect of ginger extract on toxic changes induced by bisphenol A on the thyroid gland of adult male albino rats: light and electron microscopic study. 生姜提取物对双酚 A 诱导的成年雄性白化大鼠甲状腺毒性变化的可能保护作用：光镜和电子显微镜研究。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1080/01913123.2024.2395849

Sara Mohammed Taha Denewer, Safinaz Moustafa Mahmoud Ali, Nawal Awad Hasanin, Dalia Refat El-Bassouny

{"title":"The possible protective effect of ginger extract on toxic changes induced by bisphenol A on the thyroid gland of adult male albino rats: light and electron microscopic study.","authors":"Sara Mohammed Taha Denewer, Safinaz Moustafa Mahmoud Ali, Nawal Awad Hasanin, Dalia Refat El-Bassouny","doi":"10.1080/01913123.2024.2395849","DOIUrl":"10.1080/01913123.2024.2395849","url":null,"abstract":"Bisphenol A (BPA) is a chemical substance used in the plastic industry and considered as an endocrine disruptor. Ginger is a herbal material used in the food industry and has antioxidant activity. The present study was performed to evaluate the histological changes in the thyroid gland of adult male albino rats after intake of BPA and if there is any protective role for ginger extract (GE). Eighty adult male rats were divided equally into four groups. Group I as a control group, group II included rats that received 250 mg/kg/day GE orally for eight weeks, group III included rats that received 200 mg/kg/day BPA orally for the same period and group IV included rats that received BPA in the same dose for the same duration concomitantly with GE. At the end of the experiment, blood samples were taken for hormonal essay and tissue samples were processed. Light and electron microscopic studies were done. Morphometric and statistical studies were carried out. Group III showed degenerative changes in the thyroid gland, decreased serum levels of T3 and T4 and a strong positive inducible nitric oxide synthase (iNOS) immune response. Group IV showed restoration of thyroid gland architecture and function. In conclusion, GE protected the thyroid structure from the damaging effect of BPA oxidative stress through its anti-oxidant effect, thus preserving thyroid activity.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"445-475"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0