Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases.

IF 1.1 4区 医学 Q4 MICROSCOPY
Victor L Roggli, Stasha Novakovic, Andrew J Ghio, Huihua Li, Sergio Pina-Oviedo, John M Carney, Thomas A Sporn, Carolyn H Glass, Elizabeth N Pavlisko
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Abstract

Mesothelioma in the past has been strongly associated with a history of asbestos exposure. Studies have shown that, on average, a higher dose of asbestos exposure is required for the development of peritoneal mesothelioma, and a smaller percentage of cases are asbestos related. Non-asbestos-related causes have been reported, including prior therapeutic radiation, genetic predisposition, and chronic inflammation (e.g. Crohn disease, endometriosis, ventriculo-peritoneal shunts, and diverticulitis). Cases in children have also been reported. Recent studies have shown a decreasing trend in fiber burdens and percentage of asbestos-related mesotheliomas, with similar observations in epidemiological studies. We performed fiber burden analysis on lung tissue in 10 cases (six men, four women) of peritoneal mesothelioma since 2010. Fiber analysis was performed using the sodium hypochlorite digestion technique, with asbestos body concentrations determined by light microscopy. Fiber concentrations and types were determined by scanning electron microscopy. The median age for the six men was 62 years (range: 53-75 years). Three cases were epithelioid type and three were biphasic. Two of six cases (33%) had an elevated lung fiber burden, with one case exclusively crocidolite and the other predominately amosite. The median age for the four women was 55 years (range: 39-63 years). Two cases were epithelioid type and two were biphasic. None of the four had an elevated lung fiber burden. Our findings are consistent with contemporary epidemiological studies indicating that a minority of peritoneal mesotheliomas occurring in men are asbestos related and very few are asbestos related in women.

腹膜间皮瘤病因的最新趋势:10例纤维负荷分析。
间皮瘤过去一直与石棉接触史密切相关。研究表明,平均而言,腹膜间皮瘤的发生需要较高剂量的石棉暴露,而与石棉有关的病例比例较小。非石棉相关的原因有报道,包括先前的治疗放射、遗传易感和慢性炎症(如克罗恩病、子宫内膜异位症、脑室-腹膜分流和憩室炎)。也报告了儿童病例。最近的研究表明,纤维负担和石棉相关间皮瘤的百分比呈下降趋势,流行病学研究也有类似的观察结果。自2010年以来,我们对10例腹膜间皮瘤(6男4女)的肺组织进行了纤维负荷分析。纤维分析采用次氯酸钠消化技术,用光学显微镜测定石棉体浓度。用扫描电镜测定纤维浓度和种类。6名男性的中位年龄为62岁(范围:53-75岁)。上皮样型3例,双相型3例。6例中有2例(33%)肺纤维负荷升高,1例仅为青石棉肺,另1例主要为阿莫茨肺。四名女性的中位年龄为55岁(范围:39-63岁)。上皮样型2例,双相型2例。四名患者均未出现肺纤维负荷增高。我们的发现与当代流行病学研究一致,表明男性腹膜间皮瘤中有少数与石棉有关,而女性腹膜间皮瘤中很少与石棉有关。
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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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