Ultrastructural Pathology最新文献

The impact of deltamethrin on the testicular structure of adult male albino rats and the possible protective role of lutein: a histological, immunohistochemical, and ultrastructural study. 溴氰菊酯对成年雄性白化大鼠睾丸结构的影响及叶黄素可能的保护作用：组织学、免疫组织化学和超微结构研究。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-05-08 DOI: 10.1080/01913123.2026.2669306

Eman E Elwakeel, Nehal Fahmy Shaheen

{"title":"The impact of deltamethrin on the testicular structure of adult male albino rats and the possible protective role of lutein: a histological, immunohistochemical, and ultrastructural study.","authors":"Eman E Elwakeel, Nehal Fahmy Shaheen","doi":"10.1080/01913123.2026.2669306","DOIUrl":"https://doi.org/10.1080/01913123.2026.2669306","url":null,"abstract":"Lutein provides a promising approach to protect the testes against damage induced by deltamethrin. The current study was applied to investigate the protective effect of lutein on the testis of adult male albino rats against testicular toxicity induced by deltamethrin. Sixty adult male albino rats were randomly allocated into six experimental groups. Group I served as control, group II received lutein (40 mg/kg/day orally), group III received deltamethrin (5 mg/kg/day orally), group IV received deltamethrin (5 mg/kg/day orally) concomitant with lutein (40 mg/kg/day orally), all for 4 weeks. Group V received lutein (40 mg/kg/day) throughout 8 weeks, whereas deltamethrin was given at week 5 till the end of week 8. Group VI served as a withdrawal group in which animals received deltamethrin for four weeks, followed by a four-week treatment-free period to assess the reversibility of its toxic effects. Biochemical, histological, and ultrastructural techniques were used to evaluate the testicular changes. Deltamethrin-treated rats showed decreased serum testosterone. Testicular tissue exhibited pronounced histopathological changes. Histopathological examination of testicular tissue showed that apoptosis was observed in the basal germ cells, primary and secondary spermatocytes. The testes exhibited distorted Sertoli cells accompanied by depletion of spermatogenic cells, along with significant reductions in seminiferous tubular diameter and serum testosterone levels relative to control. While the percentage of apoptotic cells was significantly increased. Group V showed improvement in histological structure, the testosterone levels, and other morphometrical parameters. Pretreatment of lutein to deltamethrin-treated rats prevents the histopathological alterations by deltamethrin in testis.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"1-15"},"PeriodicalIF":1.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bruce Mackay, MD, PhD, founding member of Society for Ultrastructural pathology: in memoriam - his legacy lives on. 布鲁斯·麦凯，医学博士，超微结构病理学学会创始成员：纪念-他的遗产将永存。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-06 DOI: 10.1080/01913123.2025.2610867

John Hicks, Josep Lloreta-Trull

引用次数: 0

Gold nanoparticles induced histological, ultrastructural, and functional changes of the adult rat testis. Is it nano-size dependent? 金纳米颗粒诱导成年大鼠睾丸组织、超微结构和功能的改变。是否依赖于纳米尺寸？

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1080/01913123.2025.2580526

Sahar Galal Gouda, Dalia Muhammad Abd-Elhalim, Nema Soliman

{"title":"Gold nanoparticles induced histological, ultrastructural, and functional changes of the adult rat testis. Is it nano-size dependent?","authors":"Sahar Galal Gouda, Dalia Muhammad Abd-Elhalim, Nema Soliman","doi":"10.1080/01913123.2025.2580526","DOIUrl":"10.1080/01913123.2025.2580526","url":null,"abstract":"Gold nanoparticles (AuNPs) have diverse medical applications, but concerns rose about toxicity. The goal of this work was to evaluate the harmful effects of AuNPs (15-nm and 40-nm) on adult rat testes. Twenty-one male rats were assigned into three groups and received the following treatments via gavage: distilled water as a control, 15-nm AuNPs group, and 40-nm AuNPs group. After 28 days, animals were sacrificed. Testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured. Testicular tissue's levels of malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) were measured. Sperm morphology and count were assessed. Testicular histology was assessed using toluidine blue stain, periodic acid-Schiff (PAS), and hematoxylin and eosin (H&E). Transmission electron microscopy was used to evaluate the testicular ultrastructure. The findings showed that both AuNPs groups saw a substantial (p ≤ .05) rise in FSH, a drop in testosterone, an increase in MDA, and a decrease in GSH. The 15-nm AuNPs group saw a substantial decrease in sperm count. Histological findings showed that the 15-nm AuNPs group had more atrophic seminiferous tubules and a substantial (p ≤ .05) reduction in seminiferous epithelial height. Electron microscopy showed germ cells with degraded mitochondria and cytoplasmic vacuoles. Testicular structure and function were both negatively impacted by AuNPs, with the effects being more pronounced for 15 nm AuNPs.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"37-55"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glomerular epithelial cell differentiation and aberration evaluated using PAX8 and WT1 immunostains. PAX8和WT1免疫染色评价肾小球上皮细胞分化和畸变。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1080/01913123.2025.2594992

Ping L Zhang, Alexander Zarouk, Brandon D MeCalf, Olaf Kroneman, Dilip Samarapungavan, Jamal Abukhaled, Garmpala H Reddy, Sami Zarouk, Wei Li, Hassan D Kanaan

{"title":"Glomerular epithelial cell differentiation and aberration evaluated using PAX8 and WT1 immunostains.","authors":"Ping L Zhang, Alexander Zarouk, Brandon D MeCalf, Olaf Kroneman, Dilip Samarapungavan, Jamal Abukhaled, Garmpala H Reddy, Sami Zarouk, Wei Li, Hassan D Kanaan","doi":"10.1080/01913123.2025.2594992","DOIUrl":"10.1080/01913123.2025.2594992","url":null,"abstract":"Paired box 8 (PAX8) and Wilms' tumor 1 (WT1) of cap mesenchyme play important roles in tubular epithelial transition and podocyte maturation of the kidney. Parietal epithelial cells (PEC) progenitors demonstrate activity of these two factors in mature glomeruli. PECs can be activated into spindle cell crescents in crescentic glomerulonephritis (CreGN) or into podocyte hyperplasia in collapsing glomerulopathy (ColGN) based on histologic evidence. The study aimed to use PAX8 and WT1 stains to demonstrate the two transitional processes of mesonephros/metanephros and aberrant in CreGN, and ColGN. Immunohistochemical (IHC) stains for both PAX8 and WT1 were performed in fetal mesonephros/metanephros, adult negative controls, CreGN, and ColGN. Expressive patterns of PAX8 and WT1 in mesonephros/early fetal kidneys, adult kidneys, and aberrant glomerular changes were evaluated. PAX8 showed continuous nuclear expression in the parietal epithelium of mesonephros/metanephros, adult kidneys, & primordial podocytes, and consistent positivity in all renal tubules. WT1 showed strong nuclear and cytoplasmic expression within mature podocytes at all stages, despite some staining of WT1 in parietal epithelium. Cellular crescents and hyperplastic podocytes were strongly positive for PAX8, and only weakly positive in the nuclei of WT1. Our data support that PAX8+ PEC involve in mesenchymal-epithelial transition (MET) in renal tubules, a possible induction of early podocyte development, and aberrant epithelial proliferation of CreGN and ColGN. In addition, WT1 is fully devoted to podocyte maturation and is also partially involved in the aberrant epithelial proliferation of the two glomerular diseases.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"82-91"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145639893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological study of Astaxanthin's neuroprotective potential in alleviating cisplatin-induced cerebellar cortex damage in adult male rats. 虾青素减轻顺铂诱导的成年雄性大鼠小脑皮质损伤的神经保护作用的组织学研究。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2025-10-25 DOI: 10.1080/01913123.2025.2579690

Eman Ali Elkordy, Amal Ahmed El-Sheikh

{"title":"Histological study of Astaxanthin's neuroprotective potential in alleviating cisplatin-induced cerebellar cortex damage in adult male rats.","authors":"Eman Ali Elkordy, Amal Ahmed El-Sheikh","doi":"10.1080/01913123.2025.2579690","DOIUrl":"10.1080/01913123.2025.2579690","url":null,"abstract":"Cisplatin (CIS) is a widely used chemotherapeutic agent with proven efficacy against various malignancies; however, its clinical utility is often constrained by dose-dependent neurotoxicity. This study investigated the histopathological, ultrastructural, and biochemical effects of astaxanthin (AST), a potent antioxidant, on the cerebellar cortex in a rat model of CIS-induced neurotoxicity. Twenty-four adult male Sprague Dawley rats were randomly assigned to four groups: Control, AST, CIS, and AST + CIS. CIS was administered intraperitoneally (10 mg/kg), while AST was given orally (20 mg/kg) for 10 consecutive days. CIS administration induced marked alterations in the cerebellar cortex, including Purkinje cell shrinkage, dendritic loss, and neuronal vacuolation, accompanied by reduced glutathione (GSH) and elevated malondialdehyde (MDA) levels, indicating oxidative stress. Co-treatment of CIS with AST significantly ameliorated these changes, preserving cerebellar architecture, Purkinje cell morphology, and restoring antioxidant balance. These findings suggest that AST exerts neuroprotection against CIS-induced cerebellar toxicity, likely through its antioxidant and anti-apoptotic properties. Further studies are warranted to clarify the underlying molecular pathways and evaluate AST potential as an adjuvant in CIS-based chemotherapy.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"11-27"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of mast cells in simvastatin-induced myopathy and the possible protective role of omega-3 fatty acids in adult male albino rats: light and electron microscopic study. 肥大细胞在辛伐他汀诱导的肌病中的作用以及成年雄性白化大鼠omega-3脂肪酸可能的保护作用：光镜和电镜研究。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2026-04-14 DOI: 10.1080/01913123.2026.2657294

Dalia Ahmed Baha Eldein, Shereen Hamed, Shireen Mazroa, Amal Mohamed Moustafa

{"title":"The role of mast cells in simvastatin-induced myopathy and the possible protective role of omega-3 fatty acids in adult male albino rats: light and electron microscopic study.","authors":"Dalia Ahmed Baha Eldein, Shereen Hamed, Shireen Mazroa, Amal Mohamed Moustafa","doi":"10.1080/01913123.2026.2657294","DOIUrl":"10.1080/01913123.2026.2657294","url":null,"abstract":"Simvastatin is antihyperlipidemic drugs that inhibit hydroxy methylglutaryl CoA reductase to decrease cholesterol synthesis; however, it causes skeletal myopathy. Omega-3 are polyunsaturated fatty acids with anti-inflammatory and anti-oxidant effects. Mast cells have an important role in the response to tissue injury by secreting different mediators and cytokines. The current study was performed to assess the role of mast cells in simvastatin-induced myopathy and the possible protective role of omega-3 fatty acids. Forty adult male albino rats were divided into four main groups received the drugs orally for of 21 days. Group 1: 1 ml distilled water, group 2: 300 mg/kg/day omega-3, group 3: 88 mg/kg/day simvastatin, and group 4: 88 mg/kg/day simvastatin plus 300 mg/kg/day omega-3. Light and electron microscopic studies were done along with morphometric and statistical studies. Group 1 and 2 showed regular histological structure. By light microscope, group 3 revealed muscle fiber disorganization, splitting, loss of striations, and cytoplasmic fragmentation. Some nuclei were centrally displaced. Toluidine blue sections showed a large number of mast cells. By transmission electron microscope, there was loss of the regular banding pattern with irregular mitochondria, nuclei, and sarcolemma. The concurrent administration of simvastatin with omega-3 showed less myopathic changes, decrease in mast cell numbers and more activation of the satellite stem cells to accomplish the process of muscle regeneration. In conclusion, the administration of omega-3 can decrease the myopathic changes of simvastatin. Further studies are recommended to explore the mast cells' role in the progression and repair of statin-induced myopathy.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"176-195"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural differences in the myocardium of cats with dilated cardiomyopathy eating high- versus low-pulse diets. 扩张型心肌病猫食用高脉冲与低脉冲饮食的心肌超微结构差异。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2026-04-29 DOI: 10.1080/01913123.2026.2664172

Mark D Bilger, Brian R Berridge, Gregory M Hendricks, Esther Gisela Martinez-Romero, Richard N Mitchell, Keith R Reddig, John E Rush, Lisa M Freeman

{"title":"Ultrastructural differences in the myocardium of cats with dilated cardiomyopathy eating high- versus low-pulse diets.","authors":"Mark D Bilger, Brian R Berridge, Gregory M Hendricks, Esther Gisela Martinez-Romero, Richard N Mitchell, Keith R Reddig, John E Rush, Lisa M Freeman","doi":"10.1080/01913123.2026.2664172","DOIUrl":"10.1080/01913123.2026.2664172","url":null,"abstract":"In 2018, the FDA issued an alert about a potential link between dilated cardiomyopathy (DCM) in pet dogs and cats and diets high in pulses (peas, lentils, chickpeas, and beans). Given reported myocardial ultrastructural abnormalities in this disease, the objective was to compare myocardial mitochondria, autophagic structures, and other subcellular organelles in cats with DCM eating high- versus low-pulse diets. Left ventricular tissue from cats with DCM eating high- (n = 4) or low-pulse (n = 3) diets was evaluated using transmission electron microscopy. Myofibrils, mitochondria, T-tubules, nuclei, z-lines, autophagic structures, and intercalated discs were evaluated qualitatively. Diet groups were compared for qualitative findings, as well as mitochondrial number, area, and perimeter; sarcomere length; lipid droplet number and area, and mitochondrial stage in the perinuclear, interfibrillar, and subsarcolemmal regions. Cats with DCM eating high-pulse diets had more unknown vacuoles and fewer Stage B mitochondria, with more Stage BC mitochondria compared to cats with DCM eating low-pulse diets. These results suggest that cats with DCM eating high-pulse diets have mitochondria in more advanced stages of degeneration. The higher number of unknown vacuoles could represent more mitochondrial degeneration or increased autophagy. Further ultrastructural investigation is warranted to help identify the cause of this diet-associated disease.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"196-205"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bruce Mackay, MD, PhD, founding member of Society for Ultrastructural pathology: in memoriam - his legacy lives on. 布鲁斯·麦凯，医学博士，超微结构病理学学会创始成员：纪念-他的遗产将永存。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1080/01913123.2025.2610867

John Hicks, Josep Lloreta-Trull

引用次数: 0

Granulocyte-colony stimulating factor protection against tramadol-induced changes in the adrenal cortex of adult male albino rats: histology, immunohistology, endocrine, and ultrastructure aspects. 粒细胞集落刺激因子对曲马多诱导成年雄性白化大鼠肾上腺皮质变化的保护作用：组织学、免疫组织学、内分泌和超微结构方面。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1080/01913123.2025.2584119

Shaymaa Hussein Hasan Ahmed, Hoda Atef Mohamed, Ghalia Mahfouz Attia Attia, Dalia Refat Mohamed El-Bassouny

{"title":"Granulocyte-colony stimulating factor protection against tramadol-induced changes in the adrenal cortex of adult male albino rats: histology, immunohistology, endocrine, and ultrastructure aspects.","authors":"Shaymaa Hussein Hasan Ahmed, Hoda Atef Mohamed, Ghalia Mahfouz Attia Attia, Dalia Refat Mohamed El-Bassouny","doi":"10.1080/01913123.2025.2584119","DOIUrl":"10.1080/01913123.2025.2584119","url":null,"abstract":"Tramadol (TRM) is a centrally acting analgesic drug used for management of moderate to severe pain. Granulocyte colony-stimulating factor (G-CSF) is a cytokine that has the ability to mobilize stem cells from the bone marrow to the peripheral circulation. This study was performed to evaluate the histological and biochemical alterations in the adrenal cortex after intake of tramadol and the possible protective role of G-CSF on it. Fifty adult male albino rats were divided into three groups: Group I as a control group, group II (TRM treated group) received a daily dose of 80 mg/kg body weight orally via gastric tube for 12 weeks and group III (TRM+G-CSF-treated group) received subcutaneous injections of 100 μg/kg body weight of G-CSF for seven consecutive days, then TRM from the 8th day to the end of the experiment in the same dose as group II. At the end of the experiment, blood samples were taken for hormonal essay and tissue samples were processed. Light and electron microscopic studies were done. Morphometric and statistical studies were carried out. The study revealed that TRM induced histological and ultrastructural degenerative changes, decreased serum levels of aldosterone, cortisol, and dehydroepiandrosterone, as well as a strong positive Bax immune reaction. However, G-CSF reversed these alterations and showed a strong positive CD34 immune reaction. In conclusion: G-CSF improved histological, biochemical and immunohistochemical metrics in the rat adrenal cortex after tramadol-induced injury.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"56-81"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is formalin-fixed paraffin embedded tissue good enough for studies of transmission electron microscopy of tumors? a comparative study with wet tissue. 福尔马林固定石蜡包埋组织是否足以用于肿瘤的透射电镜研究？湿组织的比较研究。

IF 1.2 4区医学

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2026-01-04 DOI: 10.1080/01913123.2025.2612475

Katia Gabriela Chan Guzmán, María Del Pilar Ramos-Godínez, Guillermo Ernesto Corredor-Alonso, Hugo Ricardo Domínguez-Malagón

{"title":"Is formalin-fixed paraffin embedded tissue good enough for studies of transmission electron microscopy of tumors? a comparative study with wet tissue.","authors":"Katia Gabriela Chan Guzmán, María Del Pilar Ramos-Godínez, Guillermo Ernesto Corredor-Alonso, Hugo Ricardo Domínguez-Malagón","doi":"10.1080/01913123.2025.2612475","DOIUrl":"10.1080/01913123.2025.2612475","url":null,"abstract":"Transmission electron microscopy (TEM) has historically been pivotal in diagnosing neoplasms with challenging histopathology. However, its use has declined due to cost and the advent of ancillary techniques like immunohistochemistry. This study compares the diagnostic utility of formalin-fixed paraffin-embedded (FFPE) tissue versus wet glutaraldehyde-paraformaldehyde fixed tissue (WT) for TEM in neoplasms. A retrospective analysis of 746 cases (2014-2023) from the National Cancer Institute of Mexico - Instituto Nacional de Cancerología de Mexico (INCan) was performed. Cases were divided into Group A (FFPE, n = 270) and Group B (WT, n = 476). Diagnostic utility was assessed based on ultrastructural preservation and concordance with histopathological reports. Key ultrastructural features, such as microvilli in mesothelioma, cytoplasmic organelles in chondroblastoma, luminal microvilli in secretory breast carcinoma, continuous basal lamina in schwannoma, and abundant rough endoplasmic reticulum in fibroblastic tumors were identifiable in both groups despite artifacts in FFPE. Exact Fisher's test showed no significant difference in diagnostic utility between groups (p = .0548), with 87.03% (235/270) of FFPE cases and 88.66% (422/476) of WT deemed diagnostically useful. Specificity for WT was 100% versus comparable values for FFPE. This study challenges the notion that paraffin embedding severely compromises TEM diagnostic value. FFPE allows precise sampling of archived tissues, expanding TEM's applicability in retrospective studies. Further validation is warranted to confirm these findings.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"107-113"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0