癸酸诺龙对青春期后白化大鼠前列腺影响的组织学和生化评价。

IF 1.1 4区 医学 Q4 MICROSCOPY
Heba M Abdel-Aziz, Amal S Abdel-Salam, Fayza E Ahmed, Abeer A Abdelrahman, Maha Z Mohammed
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引用次数: 0

摘要

癸酸诺龙是一种合成形式的睾酮激素,被一些健美运动员和青少年滥用以增加肌肉质量。我们调查了它对青春期后前列腺的影响,并评估了一段时间后这些影响的可逆性。将30只白化病大鼠分为3组:对照组,治疗组每周肌肉注射癸酸诺龙,剂量为10 mg/kg,连续4周;恢复组与治疗组相似,给予诺龙,再加4周恢复期。治疗组与对照组相比,IL-1β、IL-18、IL-6、TNF-α、COX2、MDA、BAX、PSA、miRNA-155表达显著升高,SOD、GST、bcl2、睾酮水平显著降低。前列腺腺泡上皮分层明显,PAS阳性反应弱,胶原沉积过多,ARs核免疫表达阴性。超微结构上,胞质中含有空泡和内质网扩张池。在恢复组中,恢复组与对照组之间的差异不显著,除微小变化外,大部分腺泡正常。纳雄龙在细胞和分子基础上引起的前列腺结构和功能损害以及恢复组停止前列腺结构和功能损害改善了这种损害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histological and biochemical evaluation of the effect of nandrolone decanoate on the prostate in postpubertal albino rats.

Nandrolone decanoate, a synthetic form of the testosterone hormone, is misused by some bodybuilders and adolescents to gain muscle mass. We investigated its effect on the prostate during postpubertal age and evaluated the reversibility of these effects after a period of cessation. Thirty albino rats were utilized and categorized into three distinct groups: Control group, a treated group that received nandrolone decanoate weekly by intramuscular injection with 10 mg/kg for 4 weeks while recovery group received nandrolone, similar to the treated group, followed by an additional recovery period of 4 weeks. In the treated group, there were significant elevation in IL-1β, IL-18, IL-6, TNF-α, COX2, MDA, BAX, PSA, and miRNA-155 expression and decreased in SOD, GST, bcl2, and testosterone hormone compared to the control group. Prostatic acini showed marked epithelial stratification, weak PAS positive reactions, excess collagen depositions, and negative ARs nuclear immunoexpression. Ultrastructrally, cytoplasm contained vacuoles and dilated cisterna of RER. In the recovery group, insignificant differences were observed between the recovery and control groups, and most of the acini appeared normal except for minimal changes. Nandrolone-induced structural and functional impairment of the prostate at cellular and molecular basis and cessation of it in the recovery group ameliorated the impairment.

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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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