Ultrastructural Pathology最新文献_第2页

Not so fast, we have to weight the cost. 别急，我们得权衡一下成本。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-12-24 DOI: 10.1080/01913123.2024.2446231

Christopher-Rasheem Mcmillan

引用次数: 0

Live and let die: analyzing ultrastructural features in cell death. 生与死：分析细胞死亡的超微结构特征

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-11-17 DOI: 10.1080/01913123.2024.2428703

Ida Perrotta

{"title":"Live and let die: analyzing ultrastructural features in cell death.","authors":"Ida Perrotta","doi":"10.1080/01913123.2024.2428703","DOIUrl":"10.1080/01913123.2024.2428703","url":null,"abstract":"Cell death is an important process that supports morphogenesis during development and tissue homeostasis during adult life by removing damaged or unwanted cells and its dysregulation is associated with numerous disease states. There are different pathways through which a cell can undergo cell death, each relying on peculiar molecular mechanisms and morpho-ultrastructural features. To date, however, while molecular and genetic approaches have been successfully integrated into the field, cell death studies rarely incorporate ultrastructural data from electron microscopy. This review article reports a gallery of original transmission electron microscopy images to describe the ultrastructural features of cells undergoing different types of cell death programs, including necrosis, apoptosis, autophagy, mitotic catastrophe, ferroptosis, methuosis, and paraptosis. TEM has been an important technology in cell biology for well over 50 years and still continues to offer significant advantages in the area of cell death research. TEM allows detailed characterization of the ultrastructural changes within the cell, such as the alteration of organelles and subcellular structures, the nuclear reorganization, and the loss of membrane integrity that enable a distinction between the different forms of cell death based on morphological criteria. Possible pitfalls are also described.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"1-19"},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorating role of co-administration of granulocyte colony stimulating factor and sodium bicarbonate on the skeletal muscle of a rat model of chronic kidney disease (A histological and immunohistochemical study). 粒细胞集落刺激因子和碳酸氢钠对慢性肾脏疾病大鼠骨骼肌模型的改善作用（组织学和免疫组织化学研究）。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-12-30 DOI: 10.1080/01913123.2024.2446242

Fayza E Ahmed, Ebtahal Z Hassen, Fatma M E Mousa, Karima F Abdelfadeel

{"title":"Ameliorating role of co-administration of granulocyte colony stimulating factor and sodium bicarbonate on the skeletal muscle of a rat model of chronic kidney disease (A histological and immunohistochemical study).","authors":"Fayza E Ahmed, Ebtahal Z Hassen, Fatma M E Mousa, Karima F Abdelfadeel","doi":"10.1080/01913123.2024.2446242","DOIUrl":"https://doi.org/10.1080/01913123.2024.2446242","url":null,"abstract":"Over half million individuals suffer from chronic kidney disease (CKD) worldwide. In addition to raising the possibility of cardiovascular diseases, skeletal myopathy remains a challenging complication that is highly correlated with mortality and a lower quality of life. Granulocyte-colony stimulating factor (G-CSF) is an active cytokine for mobilization of immunological and hematopoietic stem cells that can replace exogenous stem cell infusions. So, it is seen as a less expensive and noninvasive tool for regenerative medicine. Sixty three rats were divided into 4 groups: I control, II CKD induced, IIIa, IIIb treated and IV recovery groups. After induction of CKD in all rats, group II were sacrificed after 4 weeks. Rats of group IIIa received NaHCO3. Group IIIb rats were injected subcutaneously by G-CSF as 100 µg/kg/day for 5 successive days in addition to NaHCO3 as group IIIa. Group IV rats were housed for 4 weeks without treatment. Serum urea, creatinine, tissue MDA& TNF-α were assessed. Renal and gastrocnemius muscle sections were evaluated for histological structure, CD34 and myogenin immune expression, morphometric and statistical analyses. The CKD group revealed a significant increase in MDA and TNF-α. Furthermore, features of renal injury, muscle degenerative changes, increased collagen and decreased CD34 and myogenin expression were observed. Alterations were partially attenuated by NaHCO3, while GCSF remarkably improved most parameters. The current results indicated that co-administration of GCSF and NaHCO3 could ameliorate CKD myopathy via attenuating oxidative stress, immunomodulation, pro-angiogenic ability, myocyte regeneration. In addition to the reduction of mitochondrial stress and maintenance of cellular homeostasis.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 1","pages":"67-92"},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin ameliorates diabetes-induced hepatic ultrastructural damage and the immune biomarker CD86 and inflammation in rats. 二甲双胍改善大鼠糖尿病诱导的肝脏超微结构损伤、免疫生物标志物CD86和炎症。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-12-11 DOI: 10.1080/01913123.2024.2440479

Mohammad Y Alshahrani, Fahad S Al Amri, Mohammed A Alzahrani, Abdulaziz S Alshahrani, Dina H Abdel Kader, Faris Almasabi, Hind Zafrah, Mohammad Dallak, Osama M Osman, Bahjat Al-Ani, Norah M Alzamil

{"title":"Metformin ameliorates diabetes-induced hepatic ultrastructural damage and the immune biomarker CD86 and inflammation in rats.","authors":"Mohammad Y Alshahrani, Fahad S Al Amri, Mohammed A Alzahrani, Abdulaziz S Alshahrani, Dina H Abdel Kader, Faris Almasabi, Hind Zafrah, Mohammad Dallak, Osama M Osman, Bahjat Al-Ani, Norah M Alzamil","doi":"10.1080/01913123.2024.2440479","DOIUrl":"10.1080/01913123.2024.2440479","url":null,"abstract":"Diabetes is a known inducer of hepatic ultrastructural alterations, and the expression of the immune biomarker that involves in T-cell immunity, cluster of differentiation 86 (CD86) is increased in diabetic patients with liver cirrhosis. The antidiabetic drug metformin has not previously been used to protect against type 2 diabetes mellitus (T2DM)-induced alternations in hepatic ultrastructure and the induction of the hepatic CD86/inflammation axis in diabetic animal models induced by streptozotocin and a high fat diet. To test our hypotheses, T2DM was induced in rats (model group) and the protective animals were treated with the antidiabetic drug metformin (200 mg/kg) until being sacrificed at week 12. A profound ultrastructural damage to the hepatocytes and liver tissue injury was induced by T2DM as demonstrated by hepatocytes with dark shrunken irregular nuclei, rarefied cytoplasm with lipid droplets, mitochondria with disrupted cristae, as well as depletion of glycogen granules and damaged of liver architecture, which were effectively (p < .0001) protected with metformin. Metformin also suppressed diabetes-induced hepatic gene expression of CD86 and inflammation as well as glycemia and liver injury markers. Furthermore, a significant correlation between hepatocyte damage and CD86, inflammation, glycemia, and biomarkers of liver injury was observed. These findings demonstrate that diabetes is associated with the induction of the hepatic CD86/inflammation axis and hepatocyte ultrastructural alterations while being protected by metformin.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"58-66"},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat. 基于成年雄性白化大鼠小脑组织学、免疫组织化学和生化变化相互作用的自闭症动物模型的构建。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-12-09 DOI: 10.1080/01913123.2024.2438382

Eman Saeed Mokhtar Tawfeek, Salwa Aly Abou Elez Gawish, Wafaa Saad Hamed, Samar A Asker

{"title":"Construction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat.","authors":"Eman Saeed Mokhtar Tawfeek, Salwa Aly Abou Elez Gawish, Wafaa Saad Hamed, Samar A Asker","doi":"10.1080/01913123.2024.2438382","DOIUrl":"10.1080/01913123.2024.2438382","url":null,"abstract":"Methods: Twelve pregnant female rats were divided into a control group and a valproic acid (VPA) treated group (injected intraperitoneally on embryonic day 12 with 600 mg/kg body weight of VPA). Neurobehavioral tests were conducted on the offspring of both groups. The cerebellum was studied by light and electron microscopy as well as GFAP and caspase-3 immunohistochemical staining.Results: The VPA-treated group showed signs of neuronal degeneration, such as congested blood vessels, vacuolations, irregularly shrunken with dark small heterochromatic nuclei and numerous apoptotic blebs in the Purkinje and granule cells with vacuolated cerebellar glomeruli. The myelinated nerve fibers showed rarefaction and loss of their neurofilaments. GFAP and caspase-3 immune expression were significantly altered in the VPA-treated group.Conclusion: The VPA rat model can serve as an excellent model of autism at the structural level, which may be used as a validated model in preclinical studies to evaluate novel drugs.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"39-57"},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study on the effect of melatonin and orlistat combination versus orlistat alone on high fat diet-induced hepatic changes in the adult male albino rats (a histological and morphometric study). 褪黑素联合奥利司他与单独奥利司他对成年雄性白化大鼠高脂肪饮食诱导的肝脏变化的影响的比较研究（组织学和形态计量学研究）。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-02 Epub Date: 2024-12-16 DOI: 10.1080/01913123.2024.2438380

Sayed M El-Sayed, Gehan A El-Sayed, Mansour M A, Enas Haridy Ahmed, Sherif A Kamar

{"title":"A comparative study on the effect of melatonin and orlistat combination versus orlistat alone on high fat diet-induced hepatic changes in the adult male albino rats (a histological and morphometric study).","authors":"Sayed M El-Sayed, Gehan A El-Sayed, Mansour M A, Enas Haridy Ahmed, Sherif A Kamar","doi":"10.1080/01913123.2024.2438380","DOIUrl":"10.1080/01913123.2024.2438380","url":null,"abstract":"Background: Nonalcoholic fatty liver disease (NAFLD) is the extremely usual reason of chronic liver disease, extending from simple hepatic steatosis (HS), nonalcoholic steatohepatitis (NASH) to advanced hepatic fibrosis and cirrhosis. Though orlistat is a Food and Drug Administration (FDA) approved drug for long-duration management of obesity, few cases of severe hepatic insult were declared. Melatonin is an efficient antioxidant; it also regulates metabolic processes that lead to fat accumulation and obesity.Aim of the work: The current research aimed to compare the impact of orlistat, melatonin, and their combination on the structural changes of the hepatic tissue of adult male albino rats supplied with high fat diet (HFD).Material and methods: Thirty adult male albino rats divided into five groups. Liver specimens were divided into two parts. One-half was processed to obtain paraffin blocks, and the other half was processed to obtain semithin sections. Morphometric study and statistical analysis were done.Results: Hepatic tissue from the HFD group showed steatosis, ballooning, and inflammation and all these parameters were moderately improved - except for inflammation which worsened with therapy. Combined orlistat and melatonin-treated groups showed marked improvement of all parameters as well as marked improvement in the hepatic fibrosis.Orlistat/Melatonin combination therapy is both safe and effective in comparison to orlistat and melatonin monotherapy.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"20-38"},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes in ultrastructural resistance artery remodeling of human hypertension. 外泌体在人高血压动脉重构超微结构抵抗中的作用。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-23 DOI: 10.1080/01913123.2025.2493116

I D Perrotta, Zh Taherzadeh, G A van Montfrans, L M Brewster

{"title":"Exosomes in ultrastructural resistance artery remodeling of human hypertension.","authors":"I D Perrotta, Zh Taherzadeh, G A van Montfrans, L M Brewster","doi":"10.1080/01913123.2025.2493116","DOIUrl":"https://doi.org/10.1080/01913123.2025.2493116","url":null,"abstract":"We previously reported that human hypertension is associated with ultrastructural remodeling of systemic resistance arteries. Endothelial and smooth muscle cells (SMC) displayed mitochondrial and sarco-endoplasmic reticulum stress, accompanied by SMC migration toward the intima. Exosomes, nano-sized phospholipid bilayer-enclosed vesicles released from cells upon fusion of multivesicular bodies (MVB) with the plasma membrane, are thought to be involved in the endothelial-to-SMC communication regulating these adaptations. However, there is a dearth of ultrastructural studies on microvascular exosomes during hypertension. Therefore, we characterized and quantified exosomes in omental resistance-sized arteries (200-400 μm), obtained during surgery in 19 women (9 hypertensive), mean age 42 y (SE 1). The number of MVBs was around 7-fold higher in hypertensives, mean, 3.8 (SE 0.2)/cell vs 0.5 (0.1) in normotensives, with a shift from a scant dispersion of intracellular MVBs in normotensives, toward a prominent abluminal endothelial location in hypertensives. MVBs also contained significantly more exosomes in hypertensives, mean 7.9 (0.2) vs 5.0 (0.2)/MVB in normotensives.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"306-314"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle disease in severe COVID-19 patients: a microangiopathic myopathy. 重症COVID-19患者的肌肉疾病：微血管病性肌病

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-21 DOI: 10.1080/01913123.2025.2488809

Josep Lloreta-Trull, Judith Marin-Corral, Nuria Juanpere, Sergi Pascual-Guardia, Javier Gimeno, Dolores Naranjo, Laura Segalés, Silvia Hernández, Mercedes Simón, Laia Serrano, Beatriz Casado, Belén Lloveras, Joaquim Gea

{"title":"Muscle disease in severe COVID-19 patients: a microangiopathic myopathy.","authors":"Josep Lloreta-Trull, Judith Marin-Corral, Nuria Juanpere, Sergi Pascual-Guardia, Javier Gimeno, Dolores Naranjo, Laura Segalés, Silvia Hernández, Mercedes Simón, Laia Serrano, Beatriz Casado, Belén Lloveras, Joaquim Gea","doi":"10.1080/01913123.2025.2488809","DOIUrl":"https://doi.org/10.1080/01913123.2025.2488809","url":null,"abstract":"Patients surviving coronavirus disease of 2019 (COVID-19) often complain of skeletal muscle weakness that may be very limiting and long-lasting. There are almost no studies on the skeletal muscle of these patients, and electron microscopic data are scarce. We assessed the ultrastructural changes in the quadriceps of eight patients with COVID-19 and found a combination of features different from those reported in corticosteroid myopathy and acute relaxant-steroid myopathy. The most remarkable and constant changes involved the endothelial cells and consisted of massive amounts of pinocytotic vesicles, degenerative changes, platelet aggregates and, most characteristic of all, an increase in the external lamina thickness that seems to stem from reduplication due to successive bouts of endothelial cell damage and subsequent regeneration. Viral particles were not found in any of the cases. This distinct and quite common set of alterations defines the myopathy associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This association seems to be the result of an inflammatory process that would arise in infected cells but could damage non-infected endomysial blood vessels, thus resulting in persistent changes of the microvasculature that would be related to long-standing myopathic clinical features.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"296-305"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which has a more protective effect against neuronal changes in the cingulate cortex of newborn rats of diabetic mothers: omega 3 or glutathione? 对于糖尿病母亲的新生大鼠，欧米茄3和谷胱甘肽哪一种对其扣带皮层神经元变化的保护作用更强？

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-04-11 DOI: 10.1080/01913123.2025.2490161

Esraa Nafadi, Walaa Farag

{"title":"Which has a more protective effect against neuronal changes in the cingulate cortex of newborn rats of diabetic mothers: omega 3 or glutathione?","authors":"Esraa Nafadi, Walaa Farag","doi":"10.1080/01913123.2025.2490161","DOIUrl":"https://doi.org/10.1080/01913123.2025.2490161","url":null,"abstract":"Different researches suggests that unchecked maternal hyperglycemia during pregnancy may negatively impact the offspring's neurodevelopment. Omega 3 polyunsaturated fatty acids are vital antioxidant micronutrients for neurological health. Glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells. The study aimed to assess the possible ameliorative effect of omega3 versus GSH against the neuronal changes in the cingulate cortex of new born rats of diabetic mothers. Fifty female rats were divided randomly into 5 equal groups: Group I given saline, group II where induction of diabetes by single intraperitoneal injection of 150 mg/kg of alloxan monohydrate, group III given oral omega 3 at a dose of 300 mg/kg, group IV given intraperitoneal injections of GSH at a dose of (200 mg/kg) and group V given both omega 3 and GSH with the same routes and regimens as group III and IV throughout the whole pregnancy. The newborn of each group was collected and anaesthetized then brain specimens were extracted and processed for the light, immunohistochemical and electron microscopic studies. Group II showed marked degenerative changes in the all layers of cingulate cortex by light and electron microscopy. The cingulate cortex of group V showed the most degree of improvement in comparison to group III and IV. There was strong caspase3 immunoreaction in group II while weak reaction appeared with group III, IV and V. We concluded that the combined administration of omega 3 and GSH mitigate the adverse effects of maternal diabetes on the newborn's cingulate cortex.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":"49 3","pages":"243-256"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases. 腹膜间皮瘤病因的最新趋势：10例纤维负荷分析。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-26 DOI: 10.1080/01913123.2025.2483226

Victor L Roggli, Stasha Novakovic, Andrew J Ghio, Huihua Li, Sergio Pina-Oviedo, John M Carney, Thomas A Sporn, Carolyn H Glass, Elizabeth N Pavlisko

{"title":"Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases.","authors":"Victor L Roggli, Stasha Novakovic, Andrew J Ghio, Huihua Li, Sergio Pina-Oviedo, John M Carney, Thomas A Sporn, Carolyn H Glass, Elizabeth N Pavlisko","doi":"10.1080/01913123.2025.2483226","DOIUrl":"10.1080/01913123.2025.2483226","url":null,"abstract":"Mesothelioma in the past has been strongly associated with a history of asbestos exposure. Studies have shown that, on average, a higher dose of asbestos exposure is required for the development of peritoneal mesothelioma, and a smaller percentage of cases are asbestos related. Non-asbestos-related causes have been reported, including prior therapeutic radiation, genetic predisposition, and chronic inflammation (e.g. Crohn disease, endometriosis, ventriculo-peritoneal shunts, and diverticulitis). Cases in children have also been reported. Recent studies have shown a decreasing trend in fiber burdens and percentage of asbestos-related mesotheliomas, with similar observations in epidemiological studies. We performed fiber burden analysis on lung tissue in 10 cases (six men, four women) of peritoneal mesothelioma since 2010. Fiber analysis was performed using the sodium hypochlorite digestion technique, with asbestos body concentrations determined by light microscopy. Fiber concentrations and types were determined by scanning electron microscopy. The median age for the six men was 62 years (range: 53-75 years). Three cases were epithelioid type and three were biphasic. Two of six cases (33%) had an elevated lung fiber burden, with one case exclusively crocidolite and the other predominately amosite. The median age for the four women was 55 years (range: 39-63 years). Two cases were epithelioid type and two were biphasic. None of the four had an elevated lung fiber burden. Our findings are consistent with contemporary epidemiological studies indicating that a minority of peritoneal mesotheliomas occurring in men are asbestos related and very few are asbestos related in women.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"288-295"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0