Urology JournalPub Date : 2024-11-27DOI: 10.22037/uj.v21i.8190
Amir Reza Abedi, Jalil Hosseini, Seyyed Ali Hojjati, Amir Alinejad Khorram, Raziyeh Nikmaram, Fatemeh Fakhar
{"title":"Efficacy and Complications of Mitrofanoff Continent Urinary Diversion in Adults with Complex Urethral Strictures: A Single-Center Experience.","authors":"Amir Reza Abedi, Jalil Hosseini, Seyyed Ali Hojjati, Amir Alinejad Khorram, Raziyeh Nikmaram, Fatemeh Fakhar","doi":"10.22037/uj.v21i.8190","DOIUrl":"10.22037/uj.v21i.8190","url":null,"abstract":"<p><strong>Purpose: </strong>The management of complicated and irreparable urethral strictures can be challenging, and continent urinary diversion has emerged as a viable option. This study aims to investigate the complications associated with continent urinary diversion using the Mitrofanoff principle in patients with complex urethral strictures that cannot be corrected through urethroplasty surgery.</p><p><strong>Materials and methods: </strong>A total of 22 patients were included in this study, who underwent continent urinary diversion surgery using the Mitrofanoff technique. The patients were monitored for post-surgical complications over an average follow-up period of 28.36±14.26 months. Surgical failure was defined as the inability to completely and regularly empty urine from the new urinary tract.</p><p><strong>Results: </strong>Half of the patients experienced surgical complications, with only one case resulting in surgery failure. The most common complication observed was stoma stenosis. Two patients reported slight urinary leakage from the stoma site. Notably, all patients except one, regained control over their urine after the procedure. Early therapeutic interventions were classified according to the Clavien-Dindo grading system, showed that none of the patients experienced severe complications (grade 4 or 5).</p><p><strong>Conclusion: </strong>The study examines the outcomes of continent urinary diversion using the Mitrofanoff technique in adults with complex urethral strictures, providing realistic expectations of complications. Overall, the study shows that this approach is a viable option with a high success rate and manageable complication for individuals with complex urethral strictures that cannot be corrected through urethroplasty surgery.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"404-409"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-11-27DOI: 10.22037/uj.v21i.8222
Anahita Ansari Djafari, Babak Javanmard, Ali Koohifard, Fatemeh Hojjati, Amir Alinejad Khorram, Zahra Razzaghi, Seyyed Ali Hojjati
{"title":"Investigating the Prevalence of Autonomic Neuropathy in Diabetic Patients with Urinary Irritation Symptoms Without a Known Cause.","authors":"Anahita Ansari Djafari, Babak Javanmard, Ali Koohifard, Fatemeh Hojjati, Amir Alinejad Khorram, Zahra Razzaghi, Seyyed Ali Hojjati","doi":"10.22037/uj.v21i.8222","DOIUrl":"10.22037/uj.v21i.8222","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluating pseudomotor performance can be a valuable tool for investigating the peripheral autonomic nervous system in diabetic patients. Sudoscan, a simple and non-invasive method for assessing pseudomotor performance, has been developed in recent years. This study aimed to investigate autonomic neuropathy using Sudoscan in diabetic patients with lower urinary tract symptoms (LUTS) of unknown cause.</p><p><strong>Materials and methods: </strong>In this cross-sectional study conducted from April 2022 to April 2023, we included 195 patients with type 2 diabetes who were referred to the urology clinic. We extracted demographic, clinical, and laboratory data from the patient files and evaluated urinary symptoms using the International Prostate Symptom Score (IPSS) questionnaire. Patients underwent Sudoscan testing to evaluate autonomic neuropathy in the physical medicine and rehabilitation clinic. To further assess urinary irritative symptoms, patients underwent urodynamic studies (UDS) and ultrasonography.</p><p><strong>Results: </strong>The Sudoscan test results showed that autonomic neuropathy was present in 77 patients (40%), with 43 (22.1%) having moderate and 44 (22.6%) having severe neuropathy. Patients with autonomic neuropathy were found to be older, had longer diabetes durations, higher average blood glucose levels, and higher creatinine levels. Additionally, we found a significant correlation between autonomic neuropathy and signs of high post-void residue on ultrasound and detrusor contraction disorders on UDS (p-value < 0.05).</p><p><strong>Conclusion: </strong>Our study found a higher prevalence of autonomic neuropathy in diabetic patients with LUTS using Sudoscan (40%). Longer diabetes duration and poor glycemic control were associated with an increased risk of autonomic neuropathy linked with LUTS, such as urge incontinence.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"420-424"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-11-26DOI: 10.22037/uj.v21i.8003
Onursal Varlikli, Mustafa Alper Akay, Semih Metin, Mehmet Akif Cankorur, Yonca Anik
{"title":"Epididimal cyst in children: a single-institutional experience.","authors":"Onursal Varlikli, Mustafa Alper Akay, Semih Metin, Mehmet Akif Cankorur, Yonca Anik","doi":"10.22037/uj.v21i.8003","DOIUrl":"https://doi.org/10.22037/uj.v21i.8003","url":null,"abstract":"<p><strong>Purpose: </strong>Simple epididymal cysts (EC) are rare in childhood and are mostly diagnosed at puberty. Although there is no consensus on the treatment, a conservative approach is generally preferred. To evaluate patients diagnosed with EC at our clinic in terms of presenting symptoms, diagnosis, and treatment methods.</p><p><strong>Materials and methods: </strong>Data of patients treated for epididymal cysts at our institution between March 2012 and March 2023 were retrospectively analyzed in terms of age, symptomatology, diagnostic method, treatment method, and outcomes. In all cases, the diagnosis of EC was based on physical examination with scrotal ultrasonography (US) confirmation.</p><p><strong>Results: </strong>A total of 1829 patients underwent scrotal Doppler US, and EC was detected in 72 patients (10.7%). The median follow-up period of the 43 patients was 21.7 (6-80 months). Of these, 9 were bilateral (12.5%). The mean age of the patients at presentation was 14.8 years. Forty-one patients had scrotal pain, 12 had scrotal swelling, and 19 incidentally had EC. The cysts were between 1.2- 37 mm. Only 3 (4.1%) patients required surgical excision due to persistent pain.</p><p><strong>Conclusion: </strong>EC is a benign lesion, and treatment approaches are usually conservative. Surgical excision is recommended for patients with persistent scrotal pain or an acute scrotum.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-10-26DOI: 10.22037/uj.v21i.8071
Ramazan Inan, Ibrahim Buldu
{"title":"Minimalist Approach for HoLEP with A Low-Power Holmium Source: A Retrospective Study.","authors":"Ramazan Inan, Ibrahim Buldu","doi":"10.22037/uj.v21i.8071","DOIUrl":"https://doi.org/10.22037/uj.v21i.8071","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy and safety of very low-power Holmium Laser Enucleation of the Prostate (HoLEP) on a 30-W holmium laser source.</p><p><strong>Materials and methods: </strong> With the approval of the local ethics committee, we retrospectively analysed 60 patients treated with HoLEP. There were 30 patients in the low-power (LP) group and 30 patients in the very low-power (VLP) group. For the LP group, we used a 60-W holmium laser machine. Throughout the en bloc process, we used laser settings of 2 J and 20 Hz. We used a 30-W low-power holmium source in the VLP group. We used laser settings of 2 J and 10 Hz. All patients were operated on by an experienced surgeon. We evaluated the surgical parameters and practicality of the low-power laser vs. the very low-power laser.</p><p><strong>Results: </strong>All patients underwent successful HoLEP in the very low-power group; it was not necessary to increase the output of the laser in any case. Mean preoperatively estimated prostate volume was 88.1 mL (range, 30-300 mL). Mean enucleation time and enucleation efficiency were 67.9 min (range, 25-150 min) and 0.99 gm/min (range, 0.8-1.8 gm/min), respectively. No patient required blood transfusion postoperatively. No stress urinary incontinence (SUI) was observed in the 3rd month postoperative follow-up.</p><p><strong>Conclusion: </strong>The use of a low-power laser source is encouraging for the learning curve of new surgeons who will begin HoLEP surgery; it can facilitate the adoption of HoLEP in developing countries, where the initial capital investment may be a major obstacle.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Penile and Testicular Incarceration with a Metal Foreign Body - Full Recovery of Erectile Function after 4 Days of Entrapment.","authors":"Dimitrije Jeremić, Žarko Dimitrić, Miroslav Tomić, Ines Kalači, Srđan Govedarica, Đorđe Filipović","doi":"10.22037/uj.v21i.8139","DOIUrl":"https://doi.org/10.22037/uj.v21i.8139","url":null,"abstract":"<p><p>Penile incarceration with a foreign body is a rare urological emergency necessitating prompt intervention. We present a 59-year-old patient who entrapped penis and right testicle with metal thread reducer for sexual arousal four days prior to admission to Emergency room. Ultrasound revealed significantly reduced Color Doppler signal in right testicle and completely absent signal in penile artery. After admission metal reducer was removed using a hacksaw in analgosedation. Magnetic resonance imaging showed penile ishemic changes. Patient had reduction of penile swelling and parts of the skin highly suspected of necrosis recovered fully with preserved sensations. Despite penile ischemia on magnetic resonance imaging patient had full recovery obtaining normal erections. Patient was discharged six days after admission, presenting with normal International Index Erectile Function on follow up exam.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-10-12DOI: 10.22037/uj.v21i.8046
Naveed Mahar, Abdul Saboor Soomro, Sammar Nissa Abbasi, Manzoor Hussain, Syed Anwer Naqvi, Syed Adib Rizvi
{"title":"Endemic Bladder Stone Disease in Children, Pattern And Current Management: Experience From A Centre In Peri-Urban Setting In Pakistan.","authors":"Naveed Mahar, Abdul Saboor Soomro, Sammar Nissa Abbasi, Manzoor Hussain, Syed Anwer Naqvi, Syed Adib Rizvi","doi":"10.22037/uj.v21i.8046","DOIUrl":"10.22037/uj.v21i.8046","url":null,"abstract":"<p><strong>Purpose: </strong>To share our recent experience of the pattern and demography of endemic bladder calculi in children and the outcomes of current management strategies for the removal of bladder calculi in a peri-urban setting.</p><p><strong>Material and methods: </strong>This retrospective longitudinal study was carried out at a dedicated urology centre. All patients with endemic bladder stones from January 2020 to December 2021 managed at our centre were included in this study. After discharge, each patient was followed up for 1 year. Data analysis was carried out with IBM SPSS v23. Mean and standard deviation were calculated for normally distributed continuous variables; for non-normally distributed continuous variables, median and IQR were calculated; frequency and percentage were calculated for categorical variables.</p><p><strong>Results: </strong>This study included 254 patients, with a male-to-female ratio of 10.5:1. The mean age of the patients was 4.80 ± 2.86 years. Ninety-one percent of the patients belonged to rural areas. Open cystolithotomy (OC) was performed in 11 (4.3%) patients, transurethral cystolithotripsy (TUCL) in 165 (65.0%), and percutaneous cystolithotomy (PCCL) in 78 (30.7%). The mean operative time was 48.8 ± 4.34 minutes for TUCL, 36.18 ± 7.4 minutes for open cystolithotomy, and 38.6 ± 5.2 minutes for PCCL. The most common stone composition was ammonium urate + calcium phosphate (33.1%). The complication rate was 4.8% in TUCL, 12.8% in PCCL, and 27.3% in open cystolithotomy. Stone clearance was 98.1% for TUCL and 100% for both PCCL and OC.</p><p><strong>Conclusion: </strong>Paediatric bladder calculus is still endemic in rural areas of Sindh with poor socioeconomic backgrounds. Timely diagnosis and early intervention with preventive measures can lead to better outcomes and fewer complications. Minimally invasive methods of cystolithotomy have a shorter hospital stay, are more cost-effective, and have fewer complications as compared to open cystolithotomy.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"325-330"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-10-12DOI: 10.22037/uj.v21i.8045
Enis Mert Yorulmaz, Osman Köse, Serkan Özcan, Sacit Nuri Görgel, Yiğit Akın
{"title":"The Controlling Nutritional Status (CONUT) Score as a Predictor of Local Recurrence in Patients Underwent Partial Nephrectomy Alongside the R.E.N.A.L. Nephrometry Score.","authors":"Enis Mert Yorulmaz, Osman Köse, Serkan Özcan, Sacit Nuri Görgel, Yiğit Akın","doi":"10.22037/uj.v21i.8045","DOIUrl":"10.22037/uj.v21i.8045","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess the utility of the CONUT (Controlling Nutritional Status) Score and R.E.N.A.L. (Renal Nephrometry Score) Score in predicting tumor recurrence in patients with kidney cancer. Additionally, we investigated which parameters contributed to these scores.</p><p><strong>Materials and methods: </strong>In total, 115 patients who underwent partial nephrectomy between January 2015 and August 2023 at a single tertiary center were enrolled. After the exclusion criteria, data from 88 patients were analyzed. Age, gender, body mass index (BMI), comorbidities (hypertension, diabetes), smoking status, tumor characteristics, CONUT Scores, and R.E.N.A.L. scores were retrospectively recorded. Statistical analyses were performed, and significant p was p < 0.05.</p><p><strong>Results: </strong>The presence of diabetes and hypertension showed a statistically significant association with tumor recurrence (p = 0.033 and p = 0.003, respectively). A high BMI significantly increased the risk of recurrence (p < 0.05). There was a strong positive relationship between the high tumor stage and positive surgical margins with recurrence (p < 0.001). Patients with high R.E.N.A.L. Scores and high CONUT Scores had a higher risk of recurrence (42.1% and 8.7%, respectively), and this difference was statistically significant (p < 0.001).</p><p><strong>Conclusion: </strong>CONUT and R.E.N.A.L. scores may be used to predict tumor recurrence after partial nephrectomy. Additionally, diabetes, hypertension, high BMI, and positive surgical margin rate might affect surgical success rate for recurrences. Clinicians should consider all these parameters and coring systems to gather more successful results after partial nephrectomy.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"313-319"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-10-12DOI: 10.22037/uj.v21i.7970
Zhicheng Tang, Liu Can, Sun Xuan, Lihui Chen, Jiahao Zhang, Binghua Zhang, Xitong Wan, Zhibiao Li, Fucai Tang, Zhaohui He
{"title":"Unveiling the Etiology of Urological Tumors: A Systematic Review of Mendelian Randomization Applications in Renal Cell Carcinoma, Bladder Cancer, and Prostate Cancer.","authors":"Zhicheng Tang, Liu Can, Sun Xuan, Lihui Chen, Jiahao Zhang, Binghua Zhang, Xitong Wan, Zhibiao Li, Fucai Tang, Zhaohui He","doi":"10.22037/uj.v21i.7970","DOIUrl":"10.22037/uj.v21i.7970","url":null,"abstract":"<p><strong>Background: </strong>Our study aims to address two pivotal questions: \"What are the recent advancements in understanding the etiology of urological tumors through Mendelian Randomization?\" and \"How can Mendelian Randomization be more effectively applied in clinical settings to enhance patient health outcomes in the future?\"</p><p><strong>Methods: </strong>In our systematic review conducted in April 2023, we utilized databases like PubMed and Web of Science to explore the influence of Mendelian Randomization in urological oncological diseases. We focused on studies published from January 2018, employing keywords related to urological tumors and Mendelian Randomization, supplemented with MeSH terms and manual reference checks. Our inclusion criteria targeted original research studies, while we excluded reports and non-relevant articles. Data extraction followed a PICO-based approach, and bias risk was independently evaluated, with discrepancies resolved through discussion. This systematic approach adhered to PRISMA guidelines for accuracy and thoroughness in reporting.</p><p><strong>Results: </strong>From the initial 457 publications, we narrowed down to 43 full-text articles after screening and quality assessments. A deeper understanding of Mendelian Randomization can help us explore risk factors with a clear causal relationship to urological tumors. This insight may pave the way for future research in early diagnosis, treatment, and management of associated diseases.</p><p><strong>Conclusion: </strong>Our review underscores the value of MR in urogenital tumor research, highlighting its efficacy in establishing causality and its potential to clarify disease mechanisms. Despite challenges like large sample sizes and variant identification, MR offers new perspectives for understanding and managing these tumors, suggesting a trend towards more inclusive and diverse research approaches.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"283-292"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis.","authors":"Abdolreza Mohammadi, Seyed Hassan Inanloo, AhmadReza Rezaeian, Iman Menbari Oskouie, Alireza Khajavi, Akram Mirzaei, Mahin Ahmadi Pishkuhi, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir","doi":"10.22037/uj.v21i.7943","DOIUrl":"10.22037/uj.v21i.7943","url":null,"abstract":"<p><strong>Objective: </strong>to review the literature regarding the relationship between pre- and post-transplant hypo-Albuminemia with various renal transplant-related infections.</p><p><strong>Materials and methods: </strong>In a systematic review, we included the following keywords in the search: (Albumin*) AND (infection*) AND (\"renal transplant\" OR \"renal transplantation\" OR \"renal transplants\") OR (\"kidney transplant\" OR \"kidney transplantation\" OR \"kidney transplants\") OR \"kidney grafting\") with investigating databases including ProQuest, PubMed, Scopus, and Web of Science to May 2023. All adult patients who had renal transplantation were included. Albumin levels of infected (bacterial, fungal, or viral) patients and the type of infection should be reported in the included studies. The search strategy used in this review was reported by Preferred Reporting Items for Systematic Reviews and Meta-Analyses literature search extension (PRISMA-S). To conduct Meta-analyses, Stata version 17 was used. Also, DerSimonian-Laird random-effects models were used for this study. In our study, heterogeneity was quantified with I2 and τ2 statistics. Inconsistency across studies is quantified by I2 statistics, and the impact of heterogeneity on the meta-analysis is assessed by this quantification.</p><p><strong>Results: </strong>Overall, 18 studies were found to be reporting measures of association including risk ratio, odds ratio, and, hazard ratio. Among them, 10 and 8 studies reported bacterial and viral types of infection. The combined risk ratios were not statistically significant, in either type of infection. The mean (SD) of ages for bacterial and viral infections were found to be 45.3 (6.4) and 50.5 (7.6) years old, respectively.</p><p><strong>Conclusion: </strong>Hypoalbuminemia is not related to post-transplantation infections, and it seems that with adherence to proper pretransplant screening of recipients, vaccination, and post-transplant surveillance and prophylaxis, the impact of infections may be reduced.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"274-282"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urology JournalPub Date : 2024-10-12DOI: 10.22037/uj.v21i.8055
Taha Cetin, Serdar Celik, Sinan Sozen, Haluk Ozen, Bulent Akdogan, Guven Aslan, Sumer Baltaci, Evren Suer, Yıldırım Bayazit, Volkan Izol, Talha Muezzinoglu, Fatih Gokalp, Ilker Tinay
{"title":"Oncological Outcomes of Chromophobe Versus Clear Cell Renal Cell Carcinoma: Results from A Contemporary Turkish Patient Cohort.","authors":"Taha Cetin, Serdar Celik, Sinan Sozen, Haluk Ozen, Bulent Akdogan, Guven Aslan, Sumer Baltaci, Evren Suer, Yıldırım Bayazit, Volkan Izol, Talha Muezzinoglu, Fatih Gokalp, Ilker Tinay","doi":"10.22037/uj.v21i.8055","DOIUrl":"10.22037/uj.v21i.8055","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the oncological outcomes of clear cell RCC (ccRCC), which is common in renal cell carcinomas (RCC), and chromophobic RCC (chRCC), which is less common, and to define the factors affecting survival in the Turkish patient population for both RCC subclassifications.</p><p><strong>Materials and methods: </strong>Patients with a pathologically confirmed RCC diagnosis after radical or partial nephrectomy in the Turkish Urooncology Association (TUOA), Urological Cancers Database-Kidney (UroCaD-K), were retrospectively reviewed. Patients with ccRCC and chRCC were included in the study. Primary outcomes of this study are recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) for each histological subtype.</p><p><strong>Results: </strong>Data from 5300 patients in the TUOA UroCaD-K are reviewed and a total of 2560 patients (2225 in the ccRCC group and 335 in the chRCC group) are included in the final analysis. In the comparison of the groups, tumor size was greater both radiologically and pathologically in chRCC (p=0.019 vs 0.002 respectively). Recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) rates are worse in ccRCC subgroup. In the evaluation of risk factors; pathological stage, local invasion and Fuhrmann grade were found to be significant for recurrence in ccRCC. Age, body mass index and pathological stage were the risk factors affecting overall mortality (OM). Pathological tumor size was an independent risk factor for recurrence in chRCC, while age was analyzed as the only parameter affecting OM.</p><p><strong>Conclusion: </strong>chRCC oncological data and OS, CSS and RFS rates were found to be better than ccRCC in the Turkish patient population.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"320-324"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}