Urology Journal最新文献_第2页

Genetic Etiology Investigation in Treatment-Resistant Nocturnal Enuresis Children: A descriptive study. 难治性夜间遗尿症患儿的遗传病因调查：一项描述性研究。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-12-01 DOI: 10.22037/uj.v21i.8264

Sevim Yener, Metin Eser

{"title":"Genetic Etiology Investigation in Treatment-Resistant Nocturnal Enuresis Children: A descriptive study.","authors":"Sevim Yener, Metin Eser","doi":"10.22037/uj.v21i.8264","DOIUrl":"https://doi.org/10.22037/uj.v21i.8264","url":null,"abstract":"Purpose: Our study aimed to evaluate the genetic etiology of treatment-resistant nocturnal enuresis in children who have undergone at least 6 episodes of behavioral therapy, urotherapy, alarm therapy, and medical treatment.Materials and methods: A total of 21 patients were included in the study. Inclusion criteria for the study comprised children aged 5-18 years diagnosed with treatment-resistant enuresis according to the International Children's Continence Society (ICCS) guidelines. The capture-based Sophia Hereditary Disease Panel by Sophia Genetics was used specifically for nocturnal enuresis, consisting of a panel of 19 genes (AGXT, AQP2, AVPR2, BNC2, CLCNKB, DLG3, ELN, FA2H, FAM20A, FOXP1, HPSE2, KCNJ10, MLXIPL, NPHP3, RNF168, SLC12A3, SLC25A13, SLC5A2, SMARCA2).Results: Patients were analyzed for genetic variations in genes associated with nocturnal enuresis, including AGXT, AQP2, AVPR2, BNC2, CLCNKB, DLG3, ELN, FA2H, FAM20A, FOXP1, HPSE2, KCNJ10, MLXIPL, NPHP3, RNF168, SLC12A3, SLC25A13, SLC5A2, and SMARCA2. No pathogenic changes potentially explaining the etiology of the disease were detected in 20 patients. One patient exhibited a variant in the AQP2 gene at hg19:Chr12:50344908 exon 1, c.295G>A locus, classified as a Variant of Uncertain Significance (VUS) according to the American College of Medical Genetic and Genomics (ACMG) 2015 guidelines. The AQP2 gene is associated with autosomal dominant and autosomal recessive inherited nephrogenic diabetes insipidus (type 2) in the OMIM (Online Mendelian Inheritance in Man) database.Conclusion: Our study resembles studies indicating that nocturnal enuresis cases do not have a monogenic etiology but occur with multifactorial effects and have a weak correlation between genotype and phenotype.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between Systemic Inflammation and the Prostate Cancer: based on the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis. 系统性炎症与前列腺癌之间的关系：基于国家健康与营养调查和孟德尔随机分析。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8268

Rijian Guan, Lijun Wan, Changshui Zhuang

{"title":"The Association between Systemic Inflammation and the Prostate Cancer: based on the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis.","authors":"Rijian Guan, Lijun Wan, Changshui Zhuang","doi":"10.22037/uj.v21i.8268","DOIUrl":"https://doi.org/10.22037/uj.v21i.8268","url":null,"abstract":"Purpose: The purpose of this combination research was to examine the relationship between systemic inflammation and the risk of prostate cancer (PCa) through the National Health and Nutrition Examination Survey (NHANES) cross-sectional study and two-sample Mendelian randomization (MR) analysis.Materials and methods: We incorporated NHANES data spanning the years 2001 to 2010, with exposure as systemic inflammation, evaluated using systemic immune-inflammation index (SII) and outcome as PCa, and performed multivariate logistic regression and restricted cubic spline (RCS) to test the correlation between SII and PCa. Further, two-sample MR was used to identify causal associations between specific immune cells and PCa.Results: A total of 7706 participants (age≥40 years) were included in the analysis in the cross-sectional study, including 350 PCa cases, 7356 controls. Higher SII levels were associated with increased odds of PCa (P<.05). The odds ratio (OR) for PCa was 1.51 (95% CI 1.09-2.08) for the highest versus lowest quartile of SII levels in the fully adjusted model. Also, the RCS analysis showed a threshold effect, with SII levels above 8.90 associated with increased odds of PCa. In addition, MR results suggested a causal relationship between CD62L- monocyte, CD62L- HLA DR+ monocyte, CD14+ CD16+ monocyte, CD62L- Dendritic Cell, Monocytic Myeloid-Derived Suppressor Cell, CD28- CD8dim T cell, CD39+ resting CD4 regulatory T cell and PCa (P<.05).Conclusion: This combination analysis provides evidence for a significant causal relationship between systemic inflammation and PCa risk. These findings highlight systemic inflammation and inflammatory immune responses as potential modifiable risk factors for PCa.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy. 根治性膀胱切除术后肌浸润性膀胱癌患者营养状况控制（CONUT）评分的预后意义

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8266

Cem Yücel, Enes Dumanli, Mahmut Can Karabacak, Esat Kaan Akbay, Mehmet Yoldas, Uygar Micoogullari, Yusuf Ozlem Ilbey, Mehmet Zeynel Keskin

{"title":"Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy.","authors":"Cem Yücel, Enes Dumanli, Mahmut Can Karabacak, Esat Kaan Akbay, Mehmet Yoldas, Uygar Micoogullari, Yusuf Ozlem Ilbey, Mehmet Zeynel Keskin","doi":"10.22037/uj.v21i.8266","DOIUrl":"10.22037/uj.v21i.8266","url":null,"abstract":"Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional status, on the survival and prognosis after radical cystectomy.Materials and methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver operating characteristic (ROC) curve. The group with a CONUT score ≥ 3 was categorized as high CONUT, whereas the group with a CONUT score < 3 was categorized as low CONUT. The groups were compaired according to oncological outcomes and survival risk factors.Results: Cancer-specific survival (CSS) and overall survival (OS) were statistically significantly lower in the High CONUT group compared to the Low CONUT group (p < 0.001, p = 0.024, respectively). Age (HR: 1.02, 95% CI: 1.006-1.04, p = 0.011) and CONUT score (HR: 3.92, 95% CI: 2.66-5.77, p < 0.001) were revealed to be independent prognostic variables in the multivariate analysis for OS.Conclusion: The CONUT score was found to be an independent predictor of survival in patients with muscle-invasive bladder cancer in this study.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"390-396"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Chemotherapy on Gonadal Function and Sexual Function of Male Cancer Survivors: A Review Article. 化疗对男性癌症幸存者性腺功能和性功能的影响：综述文章。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8030

Fatemeh Sodeifian, Naghme Kian, Hediyeh Baghsheikhi, Farzad Allameh

{"title":"Effect of Chemotherapy on Gonadal Function and Sexual Function of Male Cancer Survivors: A Review Article.","authors":"Fatemeh Sodeifian, Naghme Kian, Hediyeh Baghsheikhi, Farzad Allameh","doi":"10.22037/uj.v21i.8030","DOIUrl":"10.22037/uj.v21i.8030","url":null,"abstract":"Purpose: The advancement of anti-cancer treatment has increased survival rates among patients, yet putting them in an increased risk for developing side effects. In addition to early side effects, anti-cancer treatments, in particular chemotherapeutic medications can cause long-term side effects; fertility and sexual dysfunction included. The aim of this study was to review existing data on the effects of different chemotherapeutic agents on fertility and sexual function of male cancer survivors who received chemotherapy at different stages of life.Methods: We searched PubMed/MEDLINE, Scopus, and Google Scholar to detect studies focused on the effect of chemotherapy on the gonadal/testicular function and sexual function of male cancer survivors. We restricted our search to English language publications and manuscript published before the year 2000 were excluded.Results: It has been well understood that chemotherapy impairs gonadal function in a major number of cancer survivors and gonadal dysfunction is not protected if chemotherapeutic agents are administered before puberty in males. Moreover, the effect of chemotherapy on sexual function is controversial.Conclusion: While several articles reported the worst effect of chemotherapy on the sexual function of cancer survivors, some studies reported that chemotherapy does not impair sexual function. Higher levels of chemotherapy dose seem to be associated with more gonadal and sexual dysfunction.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"361-368"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Active Fistulation in Duckett Procedure for Proximal Hypospadias in Children. 儿童尿道下裂 Duckett 手术中主动瘘的疗效

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8064

Linghua Ji, Ze Yang, Tianyi Ji, Yang Yang, Qiyou Yin, Hua Xian, Wenliang Ge

{"title":"The Efficacy of Active Fistulation in Duckett Procedure for Proximal Hypospadias in Children.","authors":"Linghua Ji, Ze Yang, Tianyi Ji, Yang Yang, Qiyou Yin, Hua Xian, Wenliang Ge","doi":"10.22037/uj.v21i.8064","DOIUrl":"10.22037/uj.v21i.8064","url":null,"abstract":"Purpose: To explore the efficacy of active fistulation in the treatment of proximal hypospadias in children by comparing one-stage and two-stage Duckett procedure.Materials and methods: A total of sixty-seven children who were diagnosed with proximal hypospadias and underwent Duckett operation at our hospital between January 2013 and January 2021 were selected for this study. These subjects were divided into two groups: the research group (n = 36), using two-stage Duckett procedure with active fistulation, and the control group (n = 31), using one-stage Duckett procedure. The incidence of postoperative complications and the score of pediatric penile perception Scale were compared between the two groups.Results: The research group exhibits a significantly lower incidence rate of urethral fistula (8.3% Vs 16.1%) and urethral stricture (5.6% Vs 12.9%) in comparison to the control group (P < 0.01). Furthermore, the analysis of Pediatric Penile Perception Scale scores indicates that the research group achieves significantly higher scores in terms of urethral shape, penile skin shape, and overall appearance than the control group (P < 0.05).Conclusion: In the treatment of proximal hypospadias in children, active fistulation within the two-stage Duckett procedure significantly reduces the rate of stage 1 postoperative complications and improves parental satisfaction. Active fistulation may offer a more promising option for the treatment of proximal hypospadias in children.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"397-403"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Knowledge of ChatGPT in Answering Questions Regarding Female Urology. 评估 ChatGPT 在回答有关女性泌尿外科问题时的知识。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8194

Hakan Cakir, Ufuk Caglar, Ahmet Halis, Omer Sarilar, Huseyin Burak Yazili, Faruk Ozgor

{"title":"Assessing the Knowledge of ChatGPT in Answering Questions Regarding Female Urology.","authors":"Hakan Cakir, Ufuk Caglar, Ahmet Halis, Omer Sarilar, Huseyin Burak Yazili, Faruk Ozgor","doi":"10.22037/uj.v21i.8194","DOIUrl":"10.22037/uj.v21i.8194","url":null,"abstract":"Purpose: With the recent increase in the use of artificial intelligence in the medical field, this study aimed to evaluate the accuracy and adequacy of ChatGPT's responses to questions related to female urology.Methods: Intensive internet research was performed to prepare a frequently asked question (FAQs) list. Scientific questions were created in accordance with the European Urology Association (EAU) Non-neurogenic Female Lower Urinary Tract Symptoms Guidelines, EAU Chronic Pelvis Pain Guidelines, and EAU Neuro-Urology Guidelines. All answers by ChatGPT were analysed by two experienced urologists and each answer was scored between 1 and 4 by the physicians. A score of 1 was the highest and showed that the answer was completely true and sufficient. The reproducibility of ChatGPT answers was evaluated by asking each question twice using two different computers.Results: A total of 96 (97.0%) ChatGPT answers about female urology were accurate and sufficient, and categorized as grade 1. Additionally, two (2.0%) answers were scored as grade 2, and one answer (1.0%) was scored as grade 3. None of ChatGPT's responses about female urology were classified as grade 4. In total, 83 questions were prepared according to EAU guidelines recommendations, and ChatGPT gave complete accurate and satisfactory answers for 68 (82.9%) questions. The reproducibility rate was highest for ChatGPT answers for questions related to urinary incontinence, pelvic organ prolapses, and pelvic pain syndromes, and reproducibility rate was 100% for each subgroup. The reproducibility rate for ChatGPT answers was lowest for CPG questions (84.1%).Conclusion: For the first time our study revealed that ChatGPT had an excellent accuracy rate in answering questions related to female urology with 97% success rate. In addition, the outcomes of this study showed that ChatGPT accurately and satisfactorily answered 82.9% of questions about female urology based on EAU guidelines.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"410-414"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostate-Specific Antigen (PSA) Bounces Following Stereotactic Body Radiotherapy for Prostate Cancer: Importance of PSA Test Frequency. 前列腺癌立体定向体外放射治疗后前列腺特异性抗原（PSA）的反弹：PSA检测频率的重要性。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8119

Ki Mun Kang, Hun Sik Choi, Hong Seok Jang, Jin-Ho Song

{"title":"Prostate-Specific Antigen (PSA) Bounces Following Stereotactic Body Radiotherapy for Prostate Cancer: Importance of PSA Test Frequency.","authors":"Ki Mun Kang, Hun Sik Choi, Hong Seok Jang, Jin-Ho Song","doi":"10.22037/uj.v21i.8119","DOIUrl":"10.22037/uj.v21i.8119","url":null,"abstract":"Purpose: Prostate-specific antigen (PSA) bounce is a common phenomenon that can be observed in patients of prostate cancer treated by radiotherapy. However, the clinical, pathological, or dosimetric predictors and clinical significance of PSA bounce in stereotactic body radiotherapy (SBRT) patients is still unknown.Methods: Between August 2006 to December 2015, 74 prostate cancer patients were treated by SBRT with Cyberknife at two medical centers. The prescription dose was 35-37.5 Gy in 5 fractions. Follow-up PSA tests were more frequently performed in one hospital than the other (median 4 vs. 10 times for initial one year). PSA bounce was defined as a rise of 0.2 ng/mL followed by a decline to or below the previous nadir.Results: A total of 74 patients, PSA bounce was observed in 41 patients (55.4%). On univariate analysis, the treated medical center (p = 0.02), PSA follow-up frequency (p = 0.01), patient age (p < 0.01), and total prescription dose (p = 0.03) were significant clinical factors in predicting the incidence of PSA bounce, while in multivariable analysis only the PSA follow-up frequency, and patient age remains significant.Conclusion: PSA bounce was seen in a significant proportion of patients after Cyberknife SBRT. The PSA follow- up test frequency, and patient age were significant factors that were correlated with the incidence of PSA bounces in this study.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"384-389"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological and Pain Factors in Microsurgical Testicular Sperm Extraction (Micro-TESE) for Non-Obstructive Azoospermia: A Comparative Study of Successful and Unsuccessful Cases. 非梗阻性无精子症显微手术取精（Micro-TESE）的心理和疼痛因素：成功与不成功案例的比较研究。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8112

Ali Egemen Avci, Muammer Kendirci, Mehmet Murad Basar

{"title":"Psychological and Pain Factors in Microsurgical Testicular Sperm Extraction (Micro-TESE) for Non-Obstructive Azoospermia: A Comparative Study of Successful and Unsuccessful Cases.","authors":"Ali Egemen Avci, Muammer Kendirci, Mehmet Murad Basar","doi":"10.22037/uj.v21i.8112","DOIUrl":"https://doi.org/10.22037/uj.v21i.8112","url":null,"abstract":"Purpose: This study aimed to assess postoperative pain, depression, and anxiety levels in infertile men who underwent microsurgical testicular sperm extraction (micro-TESE) for non-obstructive azoospermia (NOA) and compare results between patients with successful and unsuccessful sperm retrieval.Material and methods: A total of 105 NOA patients participated, completing preoperative Beck Depression Inventory (BDI) and Situational and Transient Anxiety Inventory (SAI and TAI) questionnaires. Postoperatively, Visual Analog Scale (VAS) scores were recorded. Patients were categorized into primary and repeated micro- TESE groups, and scale scores, operation duration, and collected tubule count were compared. The relationship between micro-TESE outcomes, VAS scores, and additional analgesia needs was also examined.Results: Successful sperm retrieval was achieved in 55.9% of patients. While BDI, SAI, and TAI scores showed no significant intergroup differences, micro-TESE (-) patients exhibited significantly higher mean VAS scores (p < 0.001). VAS scores positively correlated with BDI score, operation duration, and tubule count, while patient age inversely correlated with micro-TESE results.Conclusion: Infertility, azoospermia, and unsuccessful sperm retrieval impact psychogenic status and pain levels in male patients. Additionally, a history of micro-TESE procedures and their outcomes elevate depression levels.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":"21 6","pages":"415-419"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation and Validation of the Persian Version of the Wisconsin Stone Quality of Life Questionnaire. 威斯康辛结石生活质量问卷波斯语版本的翻译和验证。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.7940

Mohammad Soroush Hoseinbeigi, Behnam Shakiba, Ali Faegh, Sevim Soleimani, Robab Maghsoudi

{"title":"Translation and Validation of the Persian Version of the Wisconsin Stone Quality of Life Questionnaire.","authors":"Mohammad Soroush Hoseinbeigi, Behnam Shakiba, Ali Faegh, Sevim Soleimani, Robab Maghsoudi","doi":"10.22037/uj.v21i.7940","DOIUrl":"10.22037/uj.v21i.7940","url":null,"abstract":"Purpose: Patients with kidney stones have a lower quality of life (QOL) than healthy patients; however, treatment guidelines neglect their QOL. Wisconsin stone QOL test (WIS-QOL) is the first specific questionnaire for urolithiasis patients. This study evaluated the reliability and validity of the translated Persian version of the WIS-QOL questionnaire in patients with kidney stones.Material and methods: All patients (> 18 years old) with a history of urolithiasis were included in this cross-sectional. The WIS-QOL questionnaire was translated depending on Hutchinson's guideline. Effects of urolithiasis on the patient's social activity, emotions, disease, and vitality were evaluated. Pearson Correlation and Cronbach's alpha test were used to assess the validity and reliability of the questionnaire. All data were analyzed by SPSS software version 26.0.Results: Among 154 urolithiasis patients, 94 (61%) were males, and 60 (39%) were females. The mean age was 50.4 years (SD: ± 13.6), and the mean QOL score was 84.7 (SD: ± 21.8). For each question, the numerical value of the Pearson Correlation Coefficient has been compared with the numerical value, and the validity of the questionnaire was confirmed. The overall Cronbach's alpha was 0.94 for all four areas of the questionnaire, so the reliability of the questionnaire in Persian was confirmed.Conclusion: The present study showed the reliability and validity of the Persian version of the WIS-QOL questionnaire in symptomatic urolithiasis patients. The present study showed the status and impact of urolithiasis on QOL however, longitudinal and prospective studies should be done to specify changes over time.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"369-373"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of 177Lu-PSMA-617 in Combination with Radical Prostatectomy and Bilateral Orchiectomy in Men with Castrate-Sensitive Metastatic Prostate Cancer: A Pilot Study. 177Lu-PSMA-617联合根治性前列腺切除术和双侧睾丸切除术治疗对阉割敏感的转移性前列腺癌男性患者的有效性和安全性：一项试点研究。

IF 1.5 4区医学

Urology Journal Pub Date : 2024-11-27 DOI: 10.22037/uj.v21i.8101

Saber Amanollahi Soudmand, Samaneh Hoseinzadeh, Maryam Moosavi, Nasser Simforoosh

{"title":"Efficacy and Safety of 177Lu-PSMA-617 in Combination with Radical Prostatectomy and Bilateral Orchiectomy in Men with Castrate-Sensitive Metastatic Prostate Cancer: A Pilot Study.","authors":"Saber Amanollahi Soudmand, Samaneh Hoseinzadeh, Maryam Moosavi, Nasser Simforoosh","doi":"10.22037/uj.v21i.8101","DOIUrl":"10.22037/uj.v21i.8101","url":null,"abstract":"Purpose: To investigate the efficacy and safety of 177Lu-PSMA-617 in combination with radical prostatectomy and bilateral orchiectomy in adult male patients with castrate-sensitive metastatic prostate cancer.Methods: This pilot study included 12 men with metastatic prostate cancer who underwent radical prostatectomy and received 177Lu-PSMA-617 in combination with hormonal therapy. The primary endpoint was the proportion of patients who achieved a PSA response, defined as a ≥ 50% reduction in PSA levels at first follow up from baseline. Secondary endpoints were the proportion of patients who achieved a PSA response, defined as a ≥ 50% reduction in PSA levels at the second follow up from the first one and progression in pain severity that was defined as an increase in score of 30% or greater from baseline without a decrease in analgesic use based on Brief Pain Inventory-short Form (PBI-SF).Results: The PSA levels of 9(75.0%) patients were reduced after the first course of 177Lu-PSMA-617, additional reduction was observed in 7(58.3%) patients after receiving the 2nd course of treatment. Of the 12 patients, 3(25.0%) achieved a PSA response (≥ 50% reduction in PSA levels) at first follow up visit and 3(25.0%) patients had PSA response at second follow up, 6 patients (50.%) had a pain response. The most common adverse events were Mouth dryness and fatigue, which were manageable with supportive care.Conclusion: This pilot study suggests that radical prostatectomy and hormonal therapy in combination with 177Lu-PSMA-617 is a safe and effective treatment option and may have a role in the management of select patients with castrate-sensitive metastatic prostate cancer. Further studies are needed to confirm these findings and determine the optimal use in this setting.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"374-383"},"PeriodicalIF":1.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0