Tuberculosis and Respiratory Diseases最新文献_第6页

Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia. 韩国特发性非特异性间质性肺炎诊断和治疗指南。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.4046/trd.2024.0168

Yong Suk Jo, Hyun-Kyung Lee, Sun Hyo Park, Joon Sung Joh, Hye Jin Jang, Jong Sun Park

{"title":"Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia.","authors":"Yong Suk Jo, Hyun-Kyung Lee, Sun Hyo Park, Joon Sung Joh, Hye Jin Jang, Jong Sun Park","doi":"10.4046/trd.2024.0168","DOIUrl":"https://doi.org/10.4046/trd.2024.0168","url":null,"abstract":"Idiopathic nonspecific interstitial pneumonia (iNSIP) is recognized as a distinct entity among various types of idiopathic interstitial pneumonias. It is identified histologically by the nonspecific interstitial pneumonia pattern. A diagnosis of iNSIP is feasible once secondary causes or underlying diseases are ruled out. Usually presenting with respiratory symptoms such as shortness of breath and cough, iNSIP has a subacute or chronic course. It predominantly affects females aged 50 to 60 years who are non-smokers. Key imaging findings on chest high-resolution computed tomography include bilateral reticular opacities in lower lungs, traction bronchiectasis, reduced lung volumes and, ground-glass opacities. Abnormalities are typically diffuse across both lungs with subpleural distributions. Treatment often involves systemic steroids, either alone or in combination with other immunosuppressants, although evidence supporting effectiveness of these treatments is limited. Prognosis is generally more favorable for iNSIP than for idiopathic pulmonary fibrosis, with many studies reporting a 5-year survival rate above 70%. Antifibrotic agents should be considered in a condition, termed progressive pulmonary fibrosis, where pulmonary fibrosis progressively worsens.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":"88 2","pages":"237-246"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Artificial Intelligence in Thoracic Radiology: A Narrative Review. 人工智能在胸部放射学中的应用：人工智能在胸部放射学中的应用：叙述性综述（人工智能在胸部放射学中的应用）。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.4046/trd.2024.0062

Woo Hyeon Lim, Hyungjin Kim

引用次数: 0

Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study. 核转换改善COPD患者肺气肿程度与临床参数的相关性：一项多中心队列研究。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.4046/trd.2024.0166

Tai Joon An, Youlim Kim, Hyun Lee, Hyeon-Kyoung Koo, Naoya Tanabe, Kum Ju Chae, Kwang Ha Yoo

{"title":"Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study.","authors":"Tai Joon An, Youlim Kim, Hyun Lee, Hyeon-Kyoung Koo, Naoya Tanabe, Kum Ju Chae, Kwang Ha Yoo","doi":"10.4046/trd.2024.0166","DOIUrl":"10.4046/trd.2024.0166","url":null,"abstract":"Background: Computed tomography (CT) scans are utilized to assess emphysema, a prominent phenotype of chronic obstructive pulmonary disease (COPD). Variability in CT protocols and equipment across hospitals can impact accuracy. This study aims to implement kernel conversion across different CT settings and evaluate changes in the correlation between the emphysema index pre- and post-kernel conversion, along with clinical measures in COPD patients.Methods: Data were extracted from the Korea COPD Subgroup Study database, which included CT scan images from 484 COPD patients. These images underwent kernel conversion. Emphysema extent was quantified using the percentage of low-attenuation areas (%LAA-950) determined by a deep learning-based program. The correlation between %LAA-950 and clinical parameters, including lung function tests, the modified Medical Research Council (mMRC), 6-minute walking distance (6MWD), COPD assessment test (CAT), and the St. George's Respiratory Questionnaire for COPD (SGRQ-c), was analyzed. Subsequently, these values were compared across various CT settings.Results: A total of 484 participants were included. Kernel conversion significantly reduced the variance in %LAA-950 values (before vs. after: 12.6±11.0 vs. 8.8±11.9). Post-kernel conversion, %LAA-950 demonstrated moderate correlations with forced expiratory volume in 1 second (r=-0.41), residual volume/total lung capacity (r=0.42), mMRC (r=0.25), CAT score (r=0.12), SGRQ-c (r=0.21), and 6MWD (r=0.15), all of which were improved compared to the unconverted dataset (all p<0.01).Conclusion: CT images processed through kernel conversion enhance the correlation between the extent of emphysema and clinical parameters in COPD.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"303-309"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better Chemotherapeutic Response of Small Cell Lung Cancer in Never Smokers than in Smokers. 从不吸烟者比吸烟者对小细胞肺癌的化疗反应更好。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.4046/trd.2024.0056

Ha-Young Park, Hyung-Joo Oh, Hwa Kyung Park, Joon-Young Yoon, Chang-Seok Yoon, Bo Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Chul-Kyu Park, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, In-Jae Oh

{"title":"Better Chemotherapeutic Response of Small Cell Lung Cancer in Never Smokers than in Smokers.","authors":"Ha-Young Park, Hyung-Joo Oh, Hwa Kyung Park, Joon-Young Yoon, Chang-Seok Yoon, Bo Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Chul-Kyu Park, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, In-Jae Oh","doi":"10.4046/trd.2024.0056","DOIUrl":"10.4046/trd.2024.0056","url":null,"abstract":"Background: Small cell lung cancer (SCLC) is called 'smoker's disease' because it is strongly associated with smoking and most cases occur in smokers. However, it can also occur in never smokers. We investigated the clinical features of never smokers with SCLC and compared their treatment outcomes with those of smokers with SCLC.Methods: We retrospectively reviewed the clinical data of patients who had proven SCLC and had received chemotherapy at a single cancer center between July 2002 and April 2021.Results: Of 1,643 patients, 1,416 (86.2%) were enrolled in this study. A total of 162 (11.4%) and 1,254 (88.6%) patients were never smokers and smokers, respectively. There were more female never smokers than smokers (n=130; 80.2% vs. 79, 6.3%, p=0.000), and the incidence of ischemic heart disease was lower among never smokers than among smokers (4/1,416, [2.5%] vs. 83/1,416 [6.6%], p=0.036). Never smokers showed less symptoms at diagnosis than smokers (80.9% vs. 87.2%, p=0.037); however, they showed more toxicity after first-line treatment (61.7% vs. 47.8%, p=0.001). The objective response rate (ORR) was significantly higher in never smokers (74.1% vs. 59.6%, p=0.000). In the multivariate analysis, never smoking and second-line treatment were associated with a better ORR. However, progression-free survival and overall survival were not significantly different between never smokers and smokers.Conclusion: In conclusion, never smokers accounted for 11.4% of patients with SCLC. They had distinguishing clinical characteristics and showed better chemotherapeutic responses than smokers.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"334-341"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea. 慢性阻塞性肺病急性加重患者中各种病原体的临床意义：韩国的一项多中心研究

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2024-12-30 DOI: 10.4046/trd.2024.0089

Hyun Woo Ji, Soojoung Yu, Yun Su Sim, Hyewon Seo, Jeong-Woong Park, Kyung Hoon Min, Deog Kyeom Kim, Hyun Woo Lee, Chin Kook Rhee, Yong Bum Park, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji Ye Jung

{"title":"Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea.","authors":"Hyun Woo Ji, Soojoung Yu, Yun Su Sim, Hyewon Seo, Jeong-Woong Park, Kyung Hoon Min, Deog Kyeom Kim, Hyun Woo Lee, Chin Kook Rhee, Yong Bum Park, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji Ye Jung","doi":"10.4046/trd.2024.0089","DOIUrl":"10.4046/trd.2024.0089","url":null,"abstract":"Background: Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD.Methods: This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens, basic patient characteristics, clinical features, and the factors associated with infections by potentially drug-resistant (PDR) pathogens using various microbiological tests.Results: Bacteria, viruses, and both were detected in 262 (22.1%), 265 (22.5%), and 129 (10.9%) of patients, respectively. The most common pathogens included Pseudomonas aeruginosa (17.8%), Mycoplasma pneumoniae (11.2%), Streptococcus pneumoniae (9.0%), influenza A virus (19.0%), rhinovirus (15.8%), and respiratory syncytial virus (6.4%). Notably, a history of pulmonary tuberculosis (odds ratio [OR], 1.66; p=0.046), bronchiectasis (OR, 1.99; p=0.032), and the use of a triple inhaler regimen within the past 6 months (OR, 2.04; p=0.005) were identified as significant factors associated with infection by PDR pathogens. Moreover, patients infected with PDR pathogens exhibited extended hospital stays (15.9 days vs. 12.4 days, p=0.018) and higher intensive care unit admission rates (15.9% vs. 9.5%, p=0.030).Conclusion: This study demonstrates that a variety of pathogens are involved in episodes of AECOPD. Nevertheless, additional research is required to confirm their role in the onset and progression of AECOPD.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"292-302"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea. 韩国老年人营养风险指数与2019年严重冠状病毒病预后的关系

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.4046/trd.2024.0109

Hye Ju Yeo, Daesup Lee, Mose Chun, Jin Ho Jang, Sunghoon Park, Su Hwan Lee, Onyu Park, Tae Hwa Kim, Woo Hyun Cho

{"title":"Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea.","authors":"Hye Ju Yeo, Daesup Lee, Mose Chun, Jin Ho Jang, Sunghoon Park, Su Hwan Lee, Onyu Park, Tae Hwa Kim, Woo Hyun Cho","doi":"10.4046/trd.2024.0109","DOIUrl":"https://doi.org/10.4046/trd.2024.0109","url":null,"abstract":"Background: Malnutrition exacerbates the prognosis of numerous diseases; however, its specific impact on severe coronavirus disease 2019 (COVID-19) outcomes remains insufficiently explored.Methods: This multicenter study in Korea evaluated the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were categorized into two groups: GNRI >98 (no-risk) and GNRI ≤98 (risk). Propensity score matching, adjusted for demographic and clinical variables, was conducted.Results: Of the 1,088 patients, 642 (59%) were classified as at risk of malnutrition. Propensity score matching revealed significant disparities in hospital (34.3% vs. 19.4%, p<0.001) and intensive care unit (ICU) mortality (31.5% vs. 18.9%, p<0.001) between the groups. The risk group was associated with a higher hospital mortality rate in the multivariate Cox regression analyses following propensity score adjustment (hazard ratio [HR], 1.64; p=0.001). Among the 670 elderly patients, 450 were at risk of malnutrition. Furthermore, the risk group demonstrated significantly higher hospital (52.1% vs. 29.5%, p<0.001) and ICU mortality rates (47.2% vs. 29.1%, p<0.001). The risk group was significantly associated with increased hospital mortality rates in the multivariate analyses following propensity score adjustment (HR, 1.66; p=0.001).Conclusion: Malnutrition, as indicated by a low GNRI, was associated with increased mortality in patients with severe COVID-19. This effect was also observed in the elderly population. These findings underscore the critical importance of nutritional assessment and effective interventions for patients with severe COVID-19.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":"88 2","pages":"369-379"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid. 支气管扩张受累肺叶中性粒细胞弹性酶增高及其痰液和支气管灌洗液水平的相关性

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.4046/trd.2024.0078

Lam Nguyen-Ho, Hoang Kim Tu Trinh, Vu Le-Thuong, Kieu Minh Le, Van Thanh Niem Vo, Diem My Vu, Ngoc Tran-Van, James D Chalmers

{"title":"Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid.","authors":"Lam Nguyen-Ho, Hoang Kim Tu Trinh, Vu Le-Thuong, Kieu Minh Le, Van Thanh Niem Vo, Diem My Vu, Ngoc Tran-Van, James D Chalmers","doi":"10.4046/trd.2024.0078","DOIUrl":"10.4046/trd.2024.0078","url":null,"abstract":"Background: Neutrophil elastase (NE) has been proposed as a potential biomarker for evaluating the severity and prognosis of bronchiectasis. This study aimed to compare bronchial lavage quantification of NE levels and activities with those of sputum.Methods: A cross-sectional study was conducted in which 24 Vietnamese adults with bronchiectasis were enrolled from June 2023 to August 2023. All participants underwent bronchoscopy to collect bronchial lavage fluid (BLF) from two bronchial locations: one in the region with the greatest bronchial dilatation and one in the normal bronchi or in patients with all lobes affected, the least abnormal lobe (abnormal BLF [ABLF] and normal BLF [NBLF], respectively). Spontaneously expectorated sputum was also collected.Results: Out of 24 cases, the prevalence of mild, moderate and severe bronchiectasis was 14/24 (58.4%), 5/24 (20.8%), and 5/24 (20.8%), respectively. NE concentration and activity were significantly higher in sputum and ABLF than in NBLF (p<0.001). Sputum and ABLF were highly correlated (r=0.841, p<0.001) with no significant difference in NE activity between sputum and ABLF. Higher levels of NE activity were seen in more severe bronchiectasis than in mild bronchiectasis in all samples but were only statistically significant for NE activity in sputum (r=0.418, p=0.042).Conclusion: NE activity and concentration are elevated in areas of the lung most affected by bronchiectasis. Sputum is a valid surrogate of pulmonary NE levels, as they correlate strongly with ABLF and confirm in a Vietnamese population the relationship between NE activity and disease severity.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"399-407"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease. 对稳定期COPD药物管理指南的依从性。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.4046/trd.2024.0130

Sang Min Han, Hyo Seon Kim, Seung Yong Park, Heung Bum Lee, Young Bum Park, Chin Kook Rhee, Youlim Kim, Seoung Ju Park

{"title":"Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease.","authors":"Sang Min Han, Hyo Seon Kim, Seung Yong Park, Heung Bum Lee, Young Bum Park, Chin Kook Rhee, Youlim Kim, Seoung Ju Park","doi":"10.4046/trd.2024.0130","DOIUrl":"10.4046/trd.2024.0130","url":null,"abstract":"Background: This study evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Korean guidelines in the prescription patterns of respiratory specialists for stable chronic obstructive pulmonary disease (COPD) management.Methods: Data were collected on medications from 2011 to 2022 using the Korea COPD Subtype Study (KOCOSS) cohort. Patients were divided into two groups: those registered before and after 2019, and we analyzed the percentage of patients meeting the recommended treatment criteria established by each guideline.Results: Among 3,477 patients, 85.6% received pharmacological therapy, and 81.6% utilized inhaled medications. Compared to patients enrolled before 2019, there was an increase in inhaler prescriptions among those registered after 2019 (79.7% vs. 86.7%), with dual bronchodilators being the predominant therapy prescribed. Of the patients receiving treatment, 56.9% adhered to the Korean 2018 guideline. Compliance with the GOLD 2019 and GOLD 2023 guidelines was observed in 31.3% and 28.0% of cases, respectively. When analyzing inhaler prescription patterns according to both subgroups and considering the Korean 2018, GOLD 2019, and GOLD 2023 guidelines concurrently, the adherence rates were as follows: (56.6%, 37.8%, 24.0%) and (57.7%, 14.0%, 38.6%).Conclusion: Adherence rates were higher for the Korean guideline compared to the GOLD recommendations. Furthermore, alignment with both the Korean 2018 and GOLD 2023 guidelines increased among patients enrolled after 2019, compared to those registered earlier. These findings suggest that physicians are modifying their therapeutic strategies to align with both domestic and recent international guidelines.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"310-321"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Chronic Obstructive Pulmonary Disease in Vietnam during the COVID-19 Period: Current Situation and Challenges. 2019冠状病毒病期间越南慢性阻塞性肺病的管理：现状和挑战

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.4046/trd.2024.0140

Thuy Thanh Phan, Giap Van Vu, Chau Quy Ngo

{"title":"Management of Chronic Obstructive Pulmonary Disease in Vietnam during the COVID-19 Period: Current Situation and Challenges.","authors":"Thuy Thanh Phan, Giap Van Vu, Chau Quy Ngo","doi":"10.4046/trd.2024.0140","DOIUrl":"10.4046/trd.2024.0140","url":null,"abstract":"Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs).Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment.Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines.Conclusion: Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"322-333"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update in Association between Lung Cancer and Air Pollution. 肺癌与空气污染之间关系的最新进展。

IF 2.5

Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2024-12-11 DOI: 10.4046/trd.2024.0092

Jiye Yoo, Yongchan Lee, Youngil Park, Jongin Lee, Joon Young Choi, Heekwan Lee, Jeong Uk Lim

{"title":"Update in Association between Lung Cancer and Air Pollution.","authors":"Jiye Yoo, Yongchan Lee, Youngil Park, Jongin Lee, Joon Young Choi, Heekwan Lee, Jeong Uk Lim","doi":"10.4046/trd.2024.0092","DOIUrl":"10.4046/trd.2024.0092","url":null,"abstract":"A significant portion of newly diagnosed lung cancer cases occurs in populations exposed to air pollution. The World Health Organization has identified air pollution as a human carcinogen, prompting many countries to implement monitoring systems for ambient particulate matter (PM). PM is composed of a complex mixture of organic and inorganic particles, both solid and liquid, that are found in the air. Given the carcinogenic properties of PM and the high prevalence of lung cancer among exposed populations, exploring their connection and clinical implications is critical for effectively preventing lung cancer in this group. This review explores the relationship between ambient PM and lung cancer. Epidemiological studies have demonstrated a dose-response relationship between PM exposure and lung cancer risk. PM exposure induces oxidative stress, disrupts the body's redox balance, and causes DNA damage, which is a crucial factor in cancer development. Recent findings on the strong correlation between ambient PM and adenocarcinoma highlight the importance of understanding the specific molecular and pathological mechanisms underlying pollution-related lung cancer. In addition to efforts to control emission sources at the international level, a more individualized approach is essential for preventing PM-related lung cancer.","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"228-236"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0