Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea.

IF 2.5 Q2 RESPIRATORY SYSTEM
Tuberculosis and Respiratory Diseases Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI:10.4046/trd.2024.0109
Hye Ju Yeo, Daesup Lee, Mose Chun, Jin Ho Jang, Sunghoon Park, Su Hwan Lee, Onyu Park, Tae Hwa Kim, Woo Hyun Cho
{"title":"Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea.","authors":"Hye Ju Yeo, Daesup Lee, Mose Chun, Jin Ho Jang, Sunghoon Park, Su Hwan Lee, Onyu Park, Tae Hwa Kim, Woo Hyun Cho","doi":"10.4046/trd.2024.0109","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Malnutrition exacerbates the prognosis of numerous diseases; however, its specific impact on severe coronavirus disease 2019 (COVID-19) outcomes remains insufficiently explored.</p><p><strong>Methods: </strong>This multicenter study in Korea evaluated the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were categorized into two groups: GNRI &gt;98 (no-risk) and GNRI ≤98 (risk). Propensity score matching, adjusted for demographic and clinical variables, was conducted.</p><p><strong>Results: </strong>Of the 1,088 patients, 642 (59%) were classified as at risk of malnutrition. Propensity score matching revealed significant disparities in hospital (34.3% vs. 19.4%, p&lt;0.001) and intensive care unit (ICU) mortality (31.5% vs. 18.9%, p&lt;0.001) between the groups. The risk group was associated with a higher hospital mortality rate in the multivariate Cox regression analyses following propensity score adjustment (hazard ratio [HR], 1.64; p=0.001). Among the 670 elderly patients, 450 were at risk of malnutrition. Furthermore, the risk group demonstrated significantly higher hospital (52.1% vs. 29.5%, p&lt;0.001) and ICU mortality rates (47.2% vs. 29.1%, p&lt;0.001). The risk group was significantly associated with increased hospital mortality rates in the multivariate analyses following propensity score adjustment (HR, 1.66; p=0.001).</p><p><strong>Conclusion: </strong>Malnutrition, as indicated by a low GNRI, was associated with increased mortality in patients with severe COVID-19. This effect was also observed in the elderly population. These findings underscore the critical importance of nutritional assessment and effective interventions for patients with severe COVID-19.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":"88 2","pages":"369-379"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010725/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tuberculosis and Respiratory Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4046/trd.2024.0109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Malnutrition exacerbates the prognosis of numerous diseases; however, its specific impact on severe coronavirus disease 2019 (COVID-19) outcomes remains insufficiently explored.

Methods: This multicenter study in Korea evaluated the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were categorized into two groups: GNRI >98 (no-risk) and GNRI ≤98 (risk). Propensity score matching, adjusted for demographic and clinical variables, was conducted.

Results: Of the 1,088 patients, 642 (59%) were classified as at risk of malnutrition. Propensity score matching revealed significant disparities in hospital (34.3% vs. 19.4%, p<0.001) and intensive care unit (ICU) mortality (31.5% vs. 18.9%, p<0.001) between the groups. The risk group was associated with a higher hospital mortality rate in the multivariate Cox regression analyses following propensity score adjustment (hazard ratio [HR], 1.64; p=0.001). Among the 670 elderly patients, 450 were at risk of malnutrition. Furthermore, the risk group demonstrated significantly higher hospital (52.1% vs. 29.5%, p<0.001) and ICU mortality rates (47.2% vs. 29.1%, p<0.001). The risk group was significantly associated with increased hospital mortality rates in the multivariate analyses following propensity score adjustment (HR, 1.66; p=0.001).

Conclusion: Malnutrition, as indicated by a low GNRI, was associated with increased mortality in patients with severe COVID-19. This effect was also observed in the elderly population. These findings underscore the critical importance of nutritional assessment and effective interventions for patients with severe COVID-19.

韩国老年人营养风险指数与2019年严重冠状病毒病预后的关系
背景:营养不良使许多疾病的预后恶化;然而,其对2019年严重冠状病毒病(COVID-19)结局的具体影响仍未得到充分探讨。方法:韩国的这项多中心研究采用基于血清白蛋白水平和体重的老年营养风险指数(GNRI)评估了1088名重症COVID-19成人的营养状况。将患者分为GNRI≤98(无风险)和GNRI≤98(有风险)两组。倾向评分匹配,调整人口统计学和临床变量,进行。结果:在1088例患者中,642例(59%)被划分为营养不良风险。倾向评分匹配显示两组之间在医院(34.3% vs. 19.4%, p<0.001)和重症监护病房(ICU)死亡率(31.5% vs. 18.9%, p<0.001)方面存在显著差异。在倾向评分调整后的多变量Cox回归分析中,危险组与较高的医院死亡率相关(危险比[HR], 1.64;p = 0.001)。在670名老年患者中,有450人有营养不良的风险。此外,高危组的住院死亡率(52.1%比29.5%,p<0.001)和ICU死亡率(47.2%比29.1%,p<0.001)显著高于高危组。在倾向评分调整后的多变量分析中,危险组与医院死亡率增加显著相关(HR, 1.66;p = 0.001)。结论:低GNRI表明,营养不良与重症COVID-19患者死亡率增加有关。这种效应在老年人群中也可以观察到。这些发现强调了对重症COVID-19患者进行营养评估和有效干预的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.30
自引率
0.00%
发文量
42
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信