Tuberculosis and Respiratory Diseases最新文献

{"title":"Clarifying Geriatric Nutrition Risk Index Classification in Critically Ill Patients with Severe Coronavirus Disease 2019.","authors":"Sheng-Yi Lin, Hsiang-Lan Yu, Hsin-Hsia Lu, Hui-Yu Wu, Shu-Yun Wu, Kuo-Hsien Tseng, Chih-Chung Shiao","doi":"10.4046/trd.2025.0075","DOIUrl":"https://doi.org/10.4046/trd.2025.0075","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying GNRI Classification in Severe COVID-19: Response to Shiao et al.","authors":"Hye Ju Yeo, Woo Hyun Cho","doi":"10.4046/trd.2025.0093","DOIUrl":"https://doi.org/10.4046/trd.2025.0093","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoeconomic inequalities in access to antifibrotic treatment for interstitial lung disease in the Asia-Pacific region.","authors":"Felix Chua, Larry Ellee Nyanti, Shirin Tan, Syazatul Syakirin Sirol Aflah, Sze Shyang Kho, Gin Tsen Chai, Amornpun Wangkarnjana, Su-Ying Low, Sita Andarini, Lutz Beckert, Celeste May Campomanes, Florence Kp Chan, Sally De Boer, Supparerk Disayabutr, Dina Diaz, Fanny Fachrucha, Nicole Goh, Tomohiro Handa, Adelle Jee, Kamon Kawkitinarong, Hsin-Kuo Ko, Valencia Lim, John Mackintosh, Noorul Afidza Muhammad, Moo Suk Park, Eric Tenda, Ying-Ming Tsai, Catherine Joy Tubig, Le Thuong Vu, Trang Vu, Margaret Wilsher, Wing-Ho Yip, Yoshizaku Inoue, Jin Woo Song","doi":"10.4046/trd.2025.0056","DOIUrl":"https://doi.org/10.4046/trd.2025.0056","url":null,"abstract":"<p><p>Antifibrotic drugs, available for the best part of the last decade in many parts of the world, has improved outcomes in patients with idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. However, it is unclear whether patients suffering from these devastating conditions have timely and adequate access to antifibrotic therapy in the Asia Pacific region (APAC). In this mixed-methods narrative review of 12 APAC countries, integration of questionnaire-based insights of 31 regional clinical experts in interstitial lung disease (ILD) with publicly available pharmaco-economic information has been used to understand how country-specific challenges impact on antifibrotic accessibility. Overall, a broad range of approaches are utilised to provide antifibrotic treatment including centrally or state-determined drug budgets, pharmaceutical industry-subsidised initiatives, charitable support and self-paying (out-of-pocket) options. Impediments to antifibrotic access commonly arise from prohibitive drug pricing in relation to income, absence of universal coverage for pharmaceutical costs, lack of formal pharmaco-economic analysis or restrictions on the use of generic preparations. Unequal access to antifibrotic drugs is a vital unmet therapeutic need in the APAC region, one that is likely to be exacerbated by a rising fibrotic interstitial lung disease burden.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.","authors":"Chul Park, Yoomi Yeo, A La Woo, Jung Wan Yoo, Goohyeon Hong, Jong Wook Shin, Sung Woo Park","doi":"10.4046/trd.2025.0044","DOIUrl":"https://doi.org/10.4046/trd.2025.0044","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) comprises a heterogeneous group of disorders characterized by interstitial compartment proliferation, inflammatory infiltration, and potential fibrosis with abnormal collagen deposition. Diagnosis requires a multidisciplinary consensus integrating clinical, radiological, and pathological findings. Idiopathic interstitial pneumonia (IIP) includes idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), desquamative interstitial pneumonia (DIP), acute interstitial pneumonia (AIP), and respiratory bronchiolitis-ILD (RB-ILD), each exhibiting distinct prognostic and therapeutic implications. Some non-IPF ILDs progress despite standard treatment, classified as progressive fibrosing interstitial lung disease (PF-ILD) or progressive pulmonary fibrosis (PPF), diagnosed by worsening symptoms, physiological decline, and radiological progression. Nintedanib is conditionally recommended for refractory PPF cases. Combined pulmonary fibrosis and emphysema (CPFE) is characterized by upper-lobe predominant emphysema and lower-lobe fibrosis, frequently complicated by pulmonary hypertension and lung cancer. Interstitial lung abnormality (ILA), observed in both smokers and the general population, is associated with increased mortality and disease risk, warranting further research. Despite advancements, refinement in classification, diagnostic criteria, and therapeutic strategies remains crucial for improving patient outcomes.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unbalanced Associations Between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation analyses.","authors":"Jieun Kang, Jiyeon Kang, Sung Jun Chung, Hyung Koo Kang, Sung-Soon Lee, Yun-Jeong Jeong, Ji-Yong Moon, Deog Kyeom Kim, Jin Woo Kim, Seung Hun Jang, Jae-Woo Kwon, Byung-Jae Lee, Hyeon-Kyoung Koo","doi":"10.4046/trd.2025.0031","DOIUrl":"https://doi.org/10.4046/trd.2025.0031","url":null,"abstract":"<p><strong>Background: </strong>The Leicester Cough Questionnaire (LCQ) is a validated tool for assessing cough-related impairments across three domains: physical, psychological, and social. This study explored the interrelationships among the physical, psychological, and social domains of chronic cough using the LCQ.</p><p><strong>Methods: </strong>Adult patients with chronic cough from 16 respiratory centers who completed the LCQ and diagnostic workup were retrospectively analyzed. Spearman's rank correlation analysis was conducted to evaluate the correlations among LCQ items across the physical, psychological, and social domains. Causal mediation analysis decomposed the total effect between domains into direct and indirect effects mediated by the third domain. Findings from the mediation analysis were further validated in an independent cohort.</p><p><strong>Results: </strong>Network analysis of the LCQ items revealed distinct characteristics for each domain. The items in the physical domain demonstrated weaker intra- and inter-domain correlations compared to those in the psychological and social domains. In contrast, strong correlations were observed between the items in the psychological and social domains. Mediation analysis demonstrated that direct effects from one domain to another varied across the three domains. The total estimated effects of the physical domain on the social and psychological domains were predominantly mediated by the psychological (76.1%) and social domains (67.1%), respectively. However, the physical domain had a minimal mediating effect on the psychological and social domains, contributing only 12.8% and 18.0%, respectively.</p><p><strong>Conclusions: </strong>Given the strong correlations and impacts of the psychological and social domains, a comprehensive assessment including psychosocial influences should be considered for managing chronic cough.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Notification and Incidence: Republic of Korea, 2023.","authors":"Jinsoo Min, Yoolwon Jeong, Hyung Woo Kim, Ju Sang Kim","doi":"10.4046/trd.2025.0022","DOIUrl":"https://doi.org/10.4046/trd.2025.0022","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Care Quality Assessment: Evaluating Diagnosis and Treatment Effectiveness in Korea, 2018 - 2022.","authors":"Kang-Mo Gu, Jinsoo Min","doi":"10.4046/trd.2025.0020","DOIUrl":"10.4046/trd.2025.0020","url":null,"abstract":"<p><strong>Background: </strong>The tuberculosis (TB) care quality assessment has been implemented in the Republic of Korea since 2018. This evaluated the results of six rounds of the quality assessment from 2018 to 2023 focusing on the sixth quality assessment in 2023.</p><p><strong>Methods: </strong>This study utilized cross-linked databases from the Health Insurance Review and Assessment Service, the Korea Disease Control and Prevention Agency, and the Ministry of the Interior and Safety. The study population included newly diagnosed TB patients reported between January and June from 2016 to 2023. The sixth quality assessment included five indicators, including treatment success rate. Trends were analyzed using linear regression, and statistical comparisons were performed using Chi-square tests.</p><p><strong>Results: </strong>The sixth quality assessment demonstrated statistically significant improvements across all indicators. Since the fifth assessment, over 95% of patients diagnosed with respiratory TB have undergone TB confirmation tests. Both phenotype and molecular drug susceptibility test coverages showed significant upward trends since the third and fourth assessments, respectively. The treatment success rate, introduced for the first time in the sixth assessment, was reported at 78.3%. Non-tuberculosis-related deaths (10.3%) were the most common outcome aside from treatment success.</p><p><strong>Conclusion: </strong>The TB care quality assessment has contributed to standardizing TB care in Korea and improving management indicators. Further efforts are needed to enhance treatment success through refined evaluation criteria and innovative management strategies.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Severe Acute Respiratory Infection In Korea: 2022-2024 Surveillance Data.","authors":"Young Seok Lee, Hye Sun Lee, Jae Young Moon","doi":"10.4046/trd.2025.0043","DOIUrl":"https://doi.org/10.4046/trd.2025.0043","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Limiting Life-Sustaining Treatment in Critically Ill COVID-19 Patients: A Multicenter Study in Korean ICUs.","authors":"I Re Heo, Tae Hoon Kim, Won Jai Jung, Gil Myeong Seong, Sun Jung Kwon, Jae Young Moon, Song-I Lee, Do Sik Moon, Tae-Ok Kim, Chul Park, Eun Young Choi, Jung-Wan Yoo, Sunghoon Park, Ae Rin Baek, Sung Yoon Lim, Jung Soo Kim, Jongmin Lee, Chi Ryang Chung, Sang-Min Lee, Su Hwan Lee, Moon Seong Baek, Jin Won Huh, Woo Hyun Cho, Ho Cheol Kim","doi":"10.4046/trd.2024.0137","DOIUrl":"https://doi.org/10.4046/trd.2024.0137","url":null,"abstract":"<p><strong>Background: </strong>Understanding life-sustaining treatment (LST) decisions in critically ill COVID-19 patients remains limited. This study aimed to identify factors influencing LST decisions and compare clinical outcomes between patients with and without LST.</p><p><strong>Methods: </strong>This multicenter, retrospective cohort study analyzed data from 1,081 COVID-19 patients admitted to ICUs across Korea from January 1, 2020, to August 31, 2021. Patients were divided into LST and non-LST groups. Demographic, clinical, and outcome data were collected and compared.</p><p><strong>Results: </strong>Of 1,081 patients, 207 (19.2%) received LST. LST patients were older (median age: 76 vs. 67 years, p < 0.001) and had more comorbidities (85.5% vs. 70.4%, p < 0.001), particularly cardiovascular and chronic lung disease. They had higher BUN, lower albumin, and elevated D-dimer levels (all p < 0.05). ICU interventions, including mechanical ventilation (82.6% vs. 50.9%, p < 0.001) and ECMO (18.8% vs. 9.8%, p < 0.001), were more common. ICU and hospital mortality rates were significantly higher in LST patients (82.6% and 94.2%, respectively, p < 0.001). Logistic regression identified age (OR = 1.054 per year, p < 0.001), mechanical ventilation (OR = 2.789, p = 0.002), and ECMO use (OR = 3.580, p = 0.002) as independent predictors of LST.</p><p><strong>Conclusion: </strong>Age, comorbidities, and ICU interventions significantly influence LST decisions, highlighting the need for ethical and evidence-based critical care guidelines.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Asthma Management: Key Insights from the 10th Asthma Quality Assessment Program.","authors":"Youlim Kim, Jong Geol Jang, Tai Joon An, Joon Young Choi, Chin Kook Rhee, Kyung Hoon Min, Yong Il Hwang","doi":"10.4046/trd.2025.0034","DOIUrl":"https://doi.org/10.4046/trd.2025.0034","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}