Tuberculosis and Respiratory Diseases最新文献

{"title":"Clarifying Geriatric Nutrition Risk Index Classification in Critically Ill Patients with Severe Coronavirus Disease 2019.","authors":"Sheng-Yi Lin, Hsiang-Lan Yu, Hsin-Hsia Lu, Hui-Yu Wu, Shu-Yun Wu, Kuo-Hsien Tseng, Chih-Chung Shiao","doi":"10.4046/trd.2025.0075","DOIUrl":"10.4046/trd.2025.0075","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"744-746"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaco-economic Inequalities in Access to Antifibrotic Treatment for Interstitial Lung Disease in the Asia-Pacific Region.","authors":"Felix Chua, Larry Ellee Nyanti, Shirin Hui Tan, Syazatul Syakirin Sirol Aflah, Sze Shyang Kho, Gin Tsen Chai, Amornpun Wangkarnjana, Su-Ying Low, Sita Andarini, Lutz Beckert, Celeste May Campomanes, Florence Kp Chan, Sally De Boer, Supparerk Disayabutr, Dina Diaz, Fanny Fachrucha, Nicole Goh, Tomohiro Handa, Adelle Jee, Kamon Kawkitinarong, Hsin-Kuo Ko, Valencia Lim, John Mackintosh, Noorul Afidza Muhammad, Moo Suk Park, Eric Tenda, Ying-Ming Tsai, Catherine Joy Tubig, Le Thuong Vu, Trang Vu, Margaret Wilsher, Wing-Ho Yip, Yoshizaku Inoue, Jin Woo Song","doi":"10.4046/trd.2025.0056","DOIUrl":"10.4046/trd.2025.0056","url":null,"abstract":"<p><p>Antifibrotic drugs, available for the best part of the last decade in many parts of the world, have improved outcomes in patients with idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. However, it is unclear whether patients suffering from these devastating conditions have timely and adequate access to antifibrotic therapy in the Asia-Pacific region (APAC). In this mixed-methods narrative review of 12 APAC countries, integration of questionnaire-based insights of 31 regional clinical experts in interstitial lung disease (ILD) with publicly available pharmaco-economic information has been used to understand how country-specific challenges impact on antifibrotic accessibility. Overall, a broad range of approaches are utilized to provide antifibrotic treatment including centrally or state-determined drug budgets, pharmaceutical industry- subsidized initiatives, charitable support and self-paying (out-of-pocket) options. Impediments to antifibrotic access commonly arise from prohibitive drug pricing in relation to income, absence of universal coverage for pharmaceutical costs, lack of formal pharmaco-economic analysis or restrictions on the use of generic preparations. Unequal access to antifibrotic drugs is a vital unmet therapeutic need in the APAC region, one that is likely to be exacerbated by a rising fibrotic ILD burden.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"673-686"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Impact of Clostridium difficile Infection during Treatment of Rifampicin-Susceptible Pulmonary Tuberculosis.","authors":"Sang Woo Ha, Soohee Hwang","doi":"10.4046/trd.2024.0185","DOIUrl":"10.4046/trd.2024.0185","url":null,"abstract":"<p><strong>Background: </strong>Anti-tuberculosis (TB) treatment, although infrequently associated with Clostridium difficile infection (CDI), necessitates updated research on the incidence and clinical features of CDI among TB patients, especially as the demographic of older TB patients in South Korea is growing.</p><p><strong>Methods: </strong>A total of 168 patients with rifampin-susceptible pulmonary TB were enrolled in this study. Initial clinical features of the CDI-suspected group, risk factors for CDI, the primary outcome of all-cause mortality, and secondary outcomes, including delayed conversion of acid-fast bacillus (AFB) smear and culture, were analyzed.</p><p><strong>Results: </strong>The incidence rate of CDI among TB patients was 15.0 cases per 10,000 patient- days. Among initial features associated with TB-related CDI, patients exhibiting diarrhea of Bristol stool scale type 7 for more than 2 days were more likely to receive a CDI diagnosis. Old age and hypoalbuminemia were significant risk factors for CDI occurrence. In the primary outcome analysis, CDI was associated with a 4.63-fold increase in all-cause mortality according to the unadjusted analysis. However, this association dissipated in the adjusted analysis. Older age, underlying respiratory disease, and pneumonia at baseline were strong predictors of all-cause mortality. No significant factors were detected in the analysis of delayed AFB smear and culture conversion.</p><p><strong>Conclusion: </strong>Despite the lack of an independent association between CDI and all-cause mortality among TB patients, monitoring older adults with undernutrition and persistent diarrhea for CDI is crucial.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"718-729"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade of Healthcare Quality Assessment for Chronic Obstructive Pulmonary Disease in South Korea: Trends and Implications (2014-2023).","authors":"Hyeon-Kyoung Koo, Chin Kook Rhee, Kyung Hoon Min, Ji-Yong Moon, Yong Il Hwang, Yong Bum Park, Deog Kyeom Kim","doi":"10.4046/trd.2025.0030","DOIUrl":"10.4046/trd.2025.0030","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder associated with substantial morbidity and healthcare costs. Effective outpatient management can prevent exacerbations and reduce hospitalization rates. Since 2014, the South Korean government has conducted annual COPD quality assessment to improve disease management and ensure high-quality healthcare services. The results of the 9th COPD quality assessment, conducted between January and December 2023, were recently published. Healthcare institutions providing outpatient services for COPD (International Classification of Diseases 10th Revision [ICD-10] codes J43, J44 except J43.0) were evaluated based on pulmonary function test (PFT) rates, rate of continuous outpatient visits, and inhaled bronchodilator prescription rates. The monitoring indices included COPD-related hospitalization, emergency room (ER) visits, and duration of inhaled bronchodilator prescriptions. A total of 6,339 institutions and 158,906 patients were assessed in 2023. The PFT rate increased from 58.7% in 2014 to 80.3% in 2023, with the highest rates observed in tertiary hospitals (92.0%) and the lowest in clinics (53.6%). The inhaled bronchodilator prescription rate reached 91.5%, demonstrating a continuous improvement in pharmacological therapy. However, the rate of continuous outpatient visits declined to 80.2%, and COPD-related hospitalization (10.8%) and ER visits (6.4%) increased, indicating persistent gaps in outpatient management. The COPD quality assessment program has significantly improved diagnostic and pharmacological management; however, it highlights ongoing challenges in rate of continuous outpatient visits. Addressing regional disparities, strengthening primary care, and increasing public awareness are essential for the optimization of COPD management. Future efforts should focus on enhancing the implementation of PFTs and ensuring adequate reimbursement for inhaler education.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"615-621"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Vaccination on Acute Exacerbation of Chronic Obstructive Pulmonary Disease.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4046/trd.2025.0035","DOIUrl":"10.4046/trd.2025.0035","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"740-741"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Enhanced Chemotherapy Response in Never Smokers with Small Cell Lung Cancer than Smokers.","authors":"Samreen Kalhoro, Shadab Fatima, Sandhiya Prem Kumar","doi":"10.4046/trd.2025.0097","DOIUrl":"10.4046/trd.2025.0097","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"747-748"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Achieve Asthma Remission, or to Achieve Asthma Control, That Is the Question in Asthma Treatment.","authors":"Yeon-Mok Oh","doi":"10.4046/trd.2025.0107","DOIUrl":"10.4046/trd.2025.0107","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"754-756"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying Geriatric Nutrition Risk Index Classification in Severe COVID-19: Response to Shiao et al.","authors":"Hye Ju Yeo, Woo Hyun Cho","doi":"10.4046/trd.2025.0093","DOIUrl":"10.4046/trd.2025.0093","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"749-750"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wildfire Exposure and Respiratory Health: A Comprehensive Review of Emerging Evidence.","authors":"Kang-Mo Gu, Taeseung Lee, Jun-Pyo Myong","doi":"10.4046/trd.2025.0064","DOIUrl":"10.4046/trd.2025.0064","url":null,"abstract":"<p><p>In January 2025, a catastrophic wildfire in Los Angeles, California, resulted in extensive economic losses and created a substantial risk to public respiratory health. With the progression of climate change, the increasing frequency and severity of wildfires have become a critical global issue due to their substantial impact on respiratory health. Wildfire smoke comprises elevated levels of ambient air pollutants, such as particulate matter (PM2.5, PM10), carbon monoxide (CO), nitrogen oxides (NOx), ozone (O3), and a range of toxic substances. Notably, wildfire-related PM is especially detrimental because it can penetrate deeply into the lower respiratory tract and alveoli, provoking stronger oxidative and inflammatory responses, and leading to both the development and worsening of respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD). Research indicates that short-term exposure to wildfire smoke is linked to acute exacerbations of asthma, COPD, and pneumonia, contributing to higher mortality rates and increased demands on healthcare utilization. Long-term exposure may increase the risk of developing COPD, accelerate disease progression, and is potentially linked to a heightened risk of lung cancer and mortality. Collectively, these data underscore the substantial threat posed by wildfire smoke, escalating morbidity, mortality, and socioeconomic burdens. This review systematically summarizes recent advances in our understanding of respiratory health impacts linked with wildfire smoke exposure. By aggregating current evidence, the review seeks to guide healthcare practitioners and public health officials, thereby promoting evidence-based interventions for clinical management, health communication, and disaster response amid the escalating risk associated with wildfires.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"643-653"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergilloma presenting as endobronchial mass.","authors":"Ali Chour, David Laville, Benjamin Chappuy, Nicolas Marc","doi":"10.4046/trd.2025.0117","DOIUrl":"https://doi.org/10.4046/trd.2025.0117","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}