Tuberculosis and Respiratory Diseases最新文献

{"title":"Unbalanced Associations Between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation analyses.","authors":"Jieun Kang, Jiyeon Kang, Sung Jun Chung, Hyung Koo Kang, Sung-Soon Lee, Yun-Jeong Jeong, Ji-Yong Moon, Deog Kyeom Kim, Jin Woo Kim, Seung Hun Jang, Jae-Woo Kwon, Byung-Jae Lee, Hyeon-Kyoung Koo","doi":"10.4046/trd.2025.0031","DOIUrl":"https://doi.org/10.4046/trd.2025.0031","url":null,"abstract":"<p><strong>Background: </strong>The Leicester Cough Questionnaire (LCQ) is a validated tool for assessing cough-related impairments across three domains: physical, psychological, and social. This study explored the interrelationships among the physical, psychological, and social domains of chronic cough using the LCQ.</p><p><strong>Methods: </strong>Adult patients with chronic cough from 16 respiratory centers who completed the LCQ and diagnostic workup were retrospectively analyzed. Spearman's rank correlation analysis was conducted to evaluate the correlations among LCQ items across the physical, psychological, and social domains. Causal mediation analysis decomposed the total effect between domains into direct and indirect effects mediated by the third domain. Findings from the mediation analysis were further validated in an independent cohort.</p><p><strong>Results: </strong>Network analysis of the LCQ items revealed distinct characteristics for each domain. The items in the physical domain demonstrated weaker intra- and inter-domain correlations compared to those in the psychological and social domains. In contrast, strong correlations were observed between the items in the psychological and social domains. Mediation analysis demonstrated that direct effects from one domain to another varied across the three domains. The total estimated effects of the physical domain on the social and psychological domains were predominantly mediated by the psychological (76.1%) and social domains (67.1%), respectively. However, the physical domain had a minimal mediating effect on the psychological and social domains, contributing only 12.8% and 18.0%, respectively.</p><p><strong>Conclusions: </strong>Given the strong correlations and impacts of the psychological and social domains, a comprehensive assessment including psychosocial influences should be considered for managing chronic cough.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Notification and Incidence: Republic of Korea, 2023.","authors":"Jinsoo Min, Yoolwon Jeong, Hyung Woo Kim, Ju Sang Kim","doi":"10.4046/trd.2025.0022","DOIUrl":"https://doi.org/10.4046/trd.2025.0022","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Care Quality Assessment: Evaluating Diagnosis and Treatment Effectiveness in Korea, 2018 - 2022.","authors":"Kang-Mo Gu, Jinsoo Min","doi":"10.4046/trd.2025.0020","DOIUrl":"10.4046/trd.2025.0020","url":null,"abstract":"<p><strong>Background: </strong>The tuberculosis (TB) care quality assessment has been implemented in the Republic of Korea since 2018. This evaluated the results of six rounds of the quality assessment from 2018 to 2023 focusing on the sixth quality assessment in 2023.</p><p><strong>Methods: </strong>This study utilized cross-linked databases from the Health Insurance Review and Assessment Service, the Korea Disease Control and Prevention Agency, and the Ministry of the Interior and Safety. The study population included newly diagnosed TB patients reported between January and June from 2016 to 2023. The sixth quality assessment included five indicators, including treatment success rate. Trends were analyzed using linear regression, and statistical comparisons were performed using Chi-square tests.</p><p><strong>Results: </strong>The sixth quality assessment demonstrated statistically significant improvements across all indicators. Since the fifth assessment, over 95% of patients diagnosed with respiratory TB have undergone TB confirmation tests. Both phenotype and molecular drug susceptibility test coverages showed significant upward trends since the third and fourth assessments, respectively. The treatment success rate, introduced for the first time in the sixth assessment, was reported at 78.3%. Non-tuberculosis-related deaths (10.3%) were the most common outcome aside from treatment success.</p><p><strong>Conclusion: </strong>The TB care quality assessment has contributed to standardizing TB care in Korea and improving management indicators. Further efforts are needed to enhance treatment success through refined evaluation criteria and innovative management strategies.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Severe Acute Respiratory Infection In Korea: 2022-2024 Surveillance Data.","authors":"Young Seok Lee, Hye Sun Lee, Jae Young Moon","doi":"10.4046/trd.2025.0043","DOIUrl":"https://doi.org/10.4046/trd.2025.0043","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Limiting Life-Sustaining Treatment in Critically Ill COVID-19 Patients: A Multicenter Study in Korean ICUs.","authors":"I Re Heo, Tae Hoon Kim, Won Jai Jung, Gil Myeong Seong, Sun Jung Kwon, Jae Young Moon, Song-I Lee, Do Sik Moon, Tae-Ok Kim, Chul Park, Eun Young Choi, Jung-Wan Yoo, Sunghoon Park, Ae Rin Baek, Sung Yoon Lim, Jung Soo Kim, Jongmin Lee, Chi Ryang Chung, Sang-Min Lee, Su Hwan Lee, Moon Seong Baek, Jin Won Huh, Woo Hyun Cho, Ho Cheol Kim","doi":"10.4046/trd.2024.0137","DOIUrl":"https://doi.org/10.4046/trd.2024.0137","url":null,"abstract":"<p><strong>Background: </strong>Understanding life-sustaining treatment (LST) decisions in critically ill COVID-19 patients remains limited. This study aimed to identify factors influencing LST decisions and compare clinical outcomes between patients with and without LST.</p><p><strong>Methods: </strong>This multicenter, retrospective cohort study analyzed data from 1,081 COVID-19 patients admitted to ICUs across Korea from January 1, 2020, to August 31, 2021. Patients were divided into LST and non-LST groups. Demographic, clinical, and outcome data were collected and compared.</p><p><strong>Results: </strong>Of 1,081 patients, 207 (19.2%) received LST. LST patients were older (median age: 76 vs. 67 years, p < 0.001) and had more comorbidities (85.5% vs. 70.4%, p < 0.001), particularly cardiovascular and chronic lung disease. They had higher BUN, lower albumin, and elevated D-dimer levels (all p < 0.05). ICU interventions, including mechanical ventilation (82.6% vs. 50.9%, p < 0.001) and ECMO (18.8% vs. 9.8%, p < 0.001), were more common. ICU and hospital mortality rates were significantly higher in LST patients (82.6% and 94.2%, respectively, p < 0.001). Logistic regression identified age (OR = 1.054 per year, p < 0.001), mechanical ventilation (OR = 2.789, p = 0.002), and ECMO use (OR = 3.580, p = 0.002) as independent predictors of LST.</p><p><strong>Conclusion: </strong>Age, comorbidities, and ICU interventions significantly influence LST decisions, highlighting the need for ethical and evidence-based critical care guidelines.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Asthma Management: Key Insights from the 10th Asthma Quality Assessment Program.","authors":"Youlim Kim, Jong Geol Jang, Tai Joon An, Joon Young Choi, Chin Kook Rhee, Kyung Hoon Min, Yong Il Hwang","doi":"10.4046/trd.2025.0034","DOIUrl":"https://doi.org/10.4046/trd.2025.0034","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Liquid Biopsy for Optimal Management of NSCLC.","authors":"Yuko Oya, Ichidai Tanaka, Ross A Soo","doi":"10.4046/trd.2024.0146","DOIUrl":"https://doi.org/10.4046/trd.2024.0146","url":null,"abstract":"<p><p>Molecular profiling of tumours from patients plays a crucial role in precision oncology. While tumour tissue-based genomic testing remains the gold standard in clinical management of patients with non-small cell lung cancer, advances in genomic technologies, the analysis of various bodily fluids, mainly blood but also saliva, pleural/ pericardial effusions, urine, and cerebrospinal fluid is now feasible and readily available. In this review, we will focus on the clinical application of circulating tumour DNA in patients with non-small cell lung cancer in the setting of early-stage disease, locally advanced disease with attention to the potential of ctDNA in prognostication, risk stratification, minimal residual disease, and in advanced disease, its role in the detection of genomic markers and mechanisms of acquired resistance. The role of ctDNA and liquid biopsies in lung cancer screening will also be discussed.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue Adequacy and Diagnostic Yield Assessment in Malignant Lymph Nodes using EBUS-guided Miniforcep Biopsy vs. EBUS-guided TBNA.","authors":"Pipu Tavornshevin, Poonchavist Chantranuwatana, Vorawut Thanthitaweewat, Virissorn Wongsrichanalai, Thitiwat Sriprasart, Nophol Leelayuwatanakul","doi":"10.4046/trd.2024.0134","DOIUrl":"https://doi.org/10.4046/trd.2024.0134","url":null,"abstract":"<p><strong>Background: </strong>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a predominantly used method for lymph node (LN) metastasis assessment. This study aims to identify tissue adequacy improvement with the addition of EBUS-guided miniforcep biopsy (EBUS-MFB) to EBUS-TBNA in sampling LNs.</p><p><strong>Methods: </strong>We assessed tissue adequacy in patients with mediastinal and hilar lymphadenopathy, comparing the combination of EBUS-MFB and EBUS-TBNA with EBUS-TBNA alone. EBUS-MFB was performed with the guide sheath (GS) dilatation technique. Tissue adequacy was a tumor cell count (TCC) of >100 and neoplastic cell % (NCP) estimate of >25%. Further, we reported the diagnostic yield, tumor cell characteristics, and safety outcomes.</p><p><strong>Results: </strong>Among 69 patients (74 nodes), malignant diseases were diagnosed in 41 nodes using both techniques. Tissue adequacy with EBUS-TBNA (93.8% in 30/32 nodes) was comparable with the combined group (96.9% in 31/32 nodes, P = 0.317). EBUS-TBNA yielded higher TCC (84.4% with >1,000 cells) than EBUS-MFB (53.1%, P = 0.004). The combined approach significantly improved the diagnostic yield in nonmalignant diseases compared with EBUS-TBNA alone (97% vs. 78.8%, P = 0.014). Of the 32 nodes, 20 demonstrated discordant results between EBUS-TBNA and EBUS-MFB, with EBUS-MFB correctly diagnosing six nodes that EBUS-TBNA misdiagnosed. The complication rate was low (2.9%) with only minor bleeding reported.</p><p><strong>Conclusion: </strong>EBUS-TBNA alone and the combination of EBUS-MFB and EBUS-TBNA demonstrated comparable tissue adequacy, with EBUS-TBNA exhibiting better specimen characteristics, potentially sufficient for various molecular analyses. The addition of EBUS-MFB, performed using the GS-dilatation technique, to EBUS-TBNA improved the diagnostic yield and proved to be a safe and efficient approach, particularly in nonmalignant diseases.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors.","authors":"Jong Hwan Jeong, Manbong Heo, Sunghoon Park, Su Hwan Lee, Onyu Park, Taehwa Kim, Hye Ju Yeo, Jin Ho Jang, Woo Hyun Cho, Jung-Wan Yoo","doi":"10.4046/trd.2024.0160","DOIUrl":"10.4046/trd.2024.0160","url":null,"abstract":"<p><strong>Background: </strong>The development of frailty at hospital discharge affects the clinical outcomes in severe coronavirus disease 2019 (COVID-19) survivors who had no frailty before hospitalization. We aimed to describe the prevalence of new frailty using the clinical frailty scale (CFS) and evaluate its associated factors in patients with severe COVID-19 without pre-existing frailty before hospitalization.</p><p><strong>Methods: </strong>We performed a secondary analysis of clinical data from a nationwide retrospective cohort collected from 22 hospitals between January 1, 2020 and August 31, 2021. The patients were at least 19 years old and survived until discharge after admission to the intensive care unit (ICU) because of severe COVID-19. Development of new frailty was defined as a CFS score ≥5 at hospital discharge.</p><p><strong>Results: </strong>Among 669 severe COVID-19 survivors without pre-existing frailty admitted to the ICU, the mean age was 65.2±12.8 years, 62.5% were male, and 50.2% received mechanical ventilation (MV). The mean CFS score at admission was 2.4±0.9, and new frailty developed in 27.8% (186/483). In multivariate analysis, older age, cardiovascular disease, CFS score of 3-4 before hospitalization, increased C-reactive protein level, longer duration of corticosteroid treatment, and use of MV and extracorporeal membrane oxygenation were identified as factors associated with new-onset frailty.</p><p><strong>Conclusion: </strong>Our study suggests that new frailty is not uncommon and is associated with diverse factors in survivors of severe COVID-19 without pre-existing frailty.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"361-368"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quality changes in intensive care units in South Korea since the initiation of ICU quality assessments.","authors":"Su Hwan Lee, Sunghoon Park","doi":"10.4046/trd.2025.0039","DOIUrl":"10.4046/trd.2025.0039","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}