Trends in cancerPub Date : 2025-08-26DOI: 10.1016/j.trecan.2025.08.004
Susam Lee, Hoyeon Nam, Katelyn Wahl, Heewon Park, DaeYong Lee
{"title":"Leveraging phagocytosis using nanomedicines for cancer immunotherapy.","authors":"Susam Lee, Hoyeon Nam, Katelyn Wahl, Heewon Park, DaeYong Lee","doi":"10.1016/j.trecan.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.004","url":null,"abstract":"<p><p>Phagocytosis upregulation plays a crucial role in bridging to adaptive immunity for cancer immunotherapy. However, current approaches to modulating phagocytosis are beneficial to certain types of cancer only. In this Forum paper, we will highlight how nanoengineering can overcome the current limitation of phagocytosis-mediated cancer immunotherapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-08DOI: 10.1016/j.trecan.2025.07.005
Lukas M Braun, Yunjie Lu, Robert Zeiser
{"title":"Clinical perspective and treatment of immune-related colitis after cancer immunotherapy.","authors":"Lukas M Braun, Yunjie Lu, Robert Zeiser","doi":"10.1016/j.trecan.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.07.005","url":null,"abstract":"<p><p>Targeting negative regulators of immunity with immune-checkpoint inhibitors (ICIs) has led to significant survival benefit in patients with various cancer entities. ICI therapy disrupts mechanisms of immune tolerance, which induces inflammatory toxicities in different target organs, summarized as immune-related adverse events (irAEs) in some patients. ICI-colitis relies on the activation of intestinal tissue-resident memory T cells (T<sub>RM</sub> cells) and is one of the most frequently observed immune-related toxicities; it can be fatal if untreated. The disease is associated with highly cytotoxic intestinal T cells and inflammatory myeloid activation. Current clinical management relies on broad immunosuppression, potentially reducing antitumor immunity. Ideal future therapies for irAEs will uncouple immunosuppressive activities in the inflamed target organ and the tumor microenvironment.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-06-25DOI: 10.1016/j.trecan.2025.06.009
Gaofeng Fan, Yuetong Wang, Ruoning Wang
{"title":"Recharging aged-CAR with NAD<sup>+</sup> to boost immunotherapy.","authors":"Gaofeng Fan, Yuetong Wang, Ruoning Wang","doi":"10.1016/j.trecan.2025.06.009","DOIUrl":"10.1016/j.trecan.2025.06.009","url":null,"abstract":"<p><p>Impaired cellular metabolism contributes to the age-related decline in T cell function, undermining the response to immunotherapy in older patients with cancer. In a recent study, Hope et al. report that a reduction in intracellular NAD<sup>+</sup> levels compromises metabolic fitness and drives immunosenescence. Notably, restoring NAD<sup>+</sup> levels can reverse age-related chimeric antigen receptor (CAR)-T deterioration, suggesting a promising 'metabolic immunotherapy' that widely benefits older patients with cancer.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"711-712"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-05-27DOI: 10.1016/j.trecan.2025.04.011
Yuefan Wang, Ramon U Jin, Joanne Xu, Ding Chiao Lin, Zhenyu Sun, Yuanwei Xu, Qing K Li, Hui Zhang
{"title":"Harnessing technologies to unravel gastric cancer heterogeneity.","authors":"Yuefan Wang, Ramon U Jin, Joanne Xu, Ding Chiao Lin, Zhenyu Sun, Yuanwei Xu, Qing K Li, Hui Zhang","doi":"10.1016/j.trecan.2025.04.011","DOIUrl":"10.1016/j.trecan.2025.04.011","url":null,"abstract":"<p><p>Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"753-769"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-05-05DOI: 10.1016/j.trecan.2025.04.007
Hyunjeong Joo, Ximena Diaz Olea, Aojia Zhuang, Bin Zheng, Hyungsoo Kim, Ze'ev A Ronai
{"title":"Epigenetic mechanisms in melanoma development and progression.","authors":"Hyunjeong Joo, Ximena Diaz Olea, Aojia Zhuang, Bin Zheng, Hyungsoo Kim, Ze'ev A Ronai","doi":"10.1016/j.trecan.2025.04.007","DOIUrl":"10.1016/j.trecan.2025.04.007","url":null,"abstract":"<p><p>Knowledge of cancer development and progression gained over the last few decades has enabled mapping of genetic and epigenetic changes unique to different phases of tumor evolution. Here we focus on epigenetic changes that drive melanoma development and progression. We highlight the importance of epigenetic mechanisms which encompass crosstalk with melanoma microenvironment that affect metastasis and therapy resistance. This review summarizes recent advances and describes potential strategies to leverage this knowledge to devise new therapies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"736-752"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-06-04DOI: 10.1016/j.trecan.2025.04.012
Zihan Xia, Olivier De Wever
{"title":"The plasticity of cancer-associated fibroblasts.","authors":"Zihan Xia, Olivier De Wever","doi":"10.1016/j.trecan.2025.04.012","DOIUrl":"10.1016/j.trecan.2025.04.012","url":null,"abstract":"<p><p>The plasticity of cancer-associated fibroblasts (CAFs) refers to their ability to adopt a spectrum of distinct phenotypes or states in response to dynamic changes within the tumor microenvironment (TME). Recent advances in single-cell technologies have enabled detailed characterization of the heterogeneity and spatial complexity of CAF subpopulations across multiple tumor types. Notably, CAF subtypes undergo dynamic transitions during tumor progression and therapy pressure. This review systematically summarizes the current knowledge on CAF plasticity shaped by both intrinsic and extrinsic factors, delineates research gaps, and highlights CAF phenotypic switching as a potential therapeutic opportunity.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"770-789"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-04-29DOI: 10.1016/j.trecan.2025.04.004
Anna-Marie Finger, Audrey Marie Hendley, Diego Figueroa, Hugo Gonzalez, Valerie Marie Weaver
{"title":"Tissue mechanics in tumor heterogeneity and aggression.","authors":"Anna-Marie Finger, Audrey Marie Hendley, Diego Figueroa, Hugo Gonzalez, Valerie Marie Weaver","doi":"10.1016/j.trecan.2025.04.004","DOIUrl":"10.1016/j.trecan.2025.04.004","url":null,"abstract":"<p><p>Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the heterogeneous population of cancer-associated fibroblasts and myeloid cells that stiffen the extracellular matrix. The heterogeneously stiffened extracellular matrix in turn activates cellular mechanotransduction and creates a hypoxic and metabolically hostile microenvironment. The stiffened extracellular matrix and elevated mechanosignaling also drive tumor aggression by fostering tumor cell growth, survival, and invasion, compromising antitumor immunity, expanding cancer stem cell frequency, and increasing mutational burden, which promote intratumor heterogeneity. Delineating the molecular mechanisms whereby tissue mechanics regulate these phenotypes should help to clarify the basis for tumor heterogeneity and cancer aggression and identify novel therapeutic targets that could improve patient outcome. Here, we discuss the role of the extracellular matrix in driving cancer aggression through its impact on tumor heterogeneity.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"806-824"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-06-05DOI: 10.1016/j.trecan.2025.04.015
Matthew R Kudek, Jacob J Adashek, Razelle Kurzrock
{"title":"Ag(e)nostic precision oncology therapy approvals across the years.","authors":"Matthew R Kudek, Jacob J Adashek, Razelle Kurzrock","doi":"10.1016/j.trecan.2025.04.015","DOIUrl":"10.1016/j.trecan.2025.04.015","url":null,"abstract":"<p><p>Precision oncology leverages targetable molecular aberrations to treat cancer. Initially, use of these therapies required biomarker detection in a specific tumor type. Recently, regulatory agencies have approved highly active biomarker-based, tumor-agnostic therapies, which are crucial for the unmet needs of patients with rare cancer, including children with cancer, because an infrequent biomarker in an already rare cancer represents a prohibitive clinical trial accrual barrier. There are also now several 'ag(e)nostic' precision oncology therapies - agnostic to tumor type and also approved for all ages. In this opinion, we provide historical context for the precision oncology field and contend that, moving forward, ag(e)nostic precision oncology approvals should be the norm for this class of therapeutics rather than an exception to the rule.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"726-735"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-06-07DOI: 10.1016/j.trecan.2025.05.006
Antoine Galmiche, Zuzana Saidak, Cliona C Kirwan
{"title":"Advancing cancer precision surgery with the tumor coagulome.","authors":"Antoine Galmiche, Zuzana Saidak, Cliona C Kirwan","doi":"10.1016/j.trecan.2025.05.006","DOIUrl":"10.1016/j.trecan.2025.05.006","url":null,"abstract":"<p><p>Solid tumors generate a local and systemic procoagulant state, placing cancer patients at risk of hemostatic complications. The interplay between the tumor coagulome, a tumor-intrinsic determinant, and surgery-induced coagulopathy may influence the risk of recurrence following complete surgical resection. Perioperative targeting of the coagulome could advance cancer precision treatment.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"719-721"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in cancerPub Date : 2025-08-01Epub Date: 2025-06-25DOI: 10.1016/j.trecan.2025.06.006
Daolin Tang, Rui Kang
{"title":"Transcriptional regulation of cuproptosis resistance in cancer therapy.","authors":"Daolin Tang, Rui Kang","doi":"10.1016/j.trecan.2025.06.006","DOIUrl":"10.1016/j.trecan.2025.06.006","url":null,"abstract":"<p><p>Cuproptosis is a newly identified form of copper-dependent cell death. Recent studies show that solid tumors evade this process through transcriptional reprogramming, including hypoxia inducible factor 1 subunit alpha (HIF1A) and NFE2 like BZIP transcription factor 2 (NFE2L2) activation and BTB domain and CNC homolog 1 (BACH1) suppression. Targeting these pathways may restore cuproptosis sensitivity, offering a promising strategy to overcome therapy resistance in cancer.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"713-715"},"PeriodicalIF":17.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}