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Navigating life as an early career researcher. 作为早期职业研究人员的生活导航。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-28 DOI: 10.1016/j.trecan.2025.03.006
Shruti Bhatt, Yash Chhabra, Merav Cohen, Anniina Färkkilä, Shom Goel, Guideng Li, Sandra Romero-Córdoba
{"title":"Navigating life as an early career researcher.","authors":"Shruti Bhatt, Yash Chhabra, Merav Cohen, Anniina Färkkilä, Shom Goel, Guideng Li, Sandra Romero-Córdoba","doi":"10.1016/j.trecan.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.006","url":null,"abstract":"","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical landscape of CAR-engineered unconventional T cells. CAR 工程非常规 T 细胞的临床前景。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-27 DOI: 10.1016/j.trecan.2025.03.001
Yan-Ruide Li, Yichen Zhu, Yuning Chen, Lili Yang
{"title":"The clinical landscape of CAR-engineered unconventional T cells.","authors":"Yan-Ruide Li, Yichen Zhu, Yuning Chen, Lili Yang","doi":"10.1016/j.trecan.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.001","url":null,"abstract":"<p><p>Unconventional T cells, such as invariant natural killer T (iNKT), γδ T, and mucosal-associated invariant T (MAIT) cells, play a pivotal role in bridging innate and adaptive immunity. Their capacity for rapid tumor targeting and effective modulation of the tumor microenvironment (TME) makes them promising candidates for cancer immunotherapy. Advances in chimeric antigen receptor (CAR) engineering have further highlighted their therapeutic potential, particularly for treating challenging cancers. Notably, these cells exhibit favorable safety profiles, enhancing their viability as off-the-shelf therapeutic options. We provide a comprehensive analysis of the clinical applications of CAR-engineered unconventional T cells, focusing on genetic modifications, manufacturing processes, preconditioning regimens, and dosing strategies. We discuss successful examples from recent clinical trials and explore future directions for utilizing these cells in cancer therapy and beyond.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid cell path to malignancy: insights into liver cancer.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-25 DOI: 10.1016/j.trecan.2025.02.006
Christel F A Ramirez, Leila Akkari
{"title":"Myeloid cell path to malignancy: insights into liver cancer.","authors":"Christel F A Ramirez, Leila Akkari","doi":"10.1016/j.trecan.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.006","url":null,"abstract":"<p><p>Clinically approved treatments for advanced liver cancer often lack potency because of the heterogeneous characteristics of hepatocellular carcinoma (HCC). This complexity is largely driven by context-dependent inflammatory responses brought on by diverse etiologies, such as metabolic dysfunction-associated steatohepatitis (MASH), the genetic makeup of cancer cells, and the versatile adaptability of immune cells, such as myeloid cells. In this review, we discuss the evolutionary dynamics of the immune landscape, particularly that of liver-resident Kupffer cells (KCs), TREM2<sup>+</sup>, and SPP1<sup>+</sup> macrophages with an active role during liver disease progression, which eventually fuels hepatocarcinogenesis. We highlight exploitable immunomodulatory avenues amenable to mitigate both the inherent pathological characteristics of liver cancers and the associated external factors that favor malignancy, paving a roadmap toward improving the management and therapeutic outcome for patients with HCC.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and clinical insights into early-onset endometrial cancer.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-25 DOI: 10.1016/j.trecan.2025.03.002
Zimeng Wu, Zhe Hu, Qinlan Li, Geyan Liu, Ana Oaknin, Juan Francisco Grau Bejar, Gordon B Mills, Ding Ma, Chaoyang Sun, Gang Chen
{"title":"Molecular and clinical insights into early-onset endometrial cancer.","authors":"Zimeng Wu, Zhe Hu, Qinlan Li, Geyan Liu, Ana Oaknin, Juan Francisco Grau Bejar, Gordon B Mills, Ding Ma, Chaoyang Sun, Gang Chen","doi":"10.1016/j.trecan.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.002","url":null,"abstract":"<p><p>The global incidence of endometrial cancer is on the rise, marked by a notable surge in early-onset endometrial cancer (EOEC; age at diagnosis <50 years). By contrast to late-onset cases, EOEC displays distinct clinical, pathological, and molecular characteristics. The enhanced understanding of the disease's pathophysiology, enabling a more precise differentiation between low-risk and high-risk patients, could facilitate the establishment of risk-stratified treatments that preserve ovarian function and fertility in low-risk EOEC cases. In this review, we delve into the distinctive epidemiological, molecular, and clinical characteristics of EOEC, as well as early noninvasive screening and fertility preservation treatments.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tackling the next decade of cancer research.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-24 DOI: 10.1016/j.trecan.2025.03.004
Raza Ali, Brittany Jenkins, Wouter Karthaus, Jana Lipkova, Sandra Misale, Jens Puschhof, Melody Smith, Santosha Vardhana, Xin Zhou
{"title":"Tackling the next decade of cancer research.","authors":"Raza Ali, Brittany Jenkins, Wouter Karthaus, Jana Lipkova, Sandra Misale, Jens Puschhof, Melody Smith, Santosha Vardhana, Xin Zhou","doi":"10.1016/j.trecan.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.004","url":null,"abstract":"","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future of cancer research: invest now.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-24 DOI: 10.1016/j.trecan.2025.03.007
Danielle T Loughlin
{"title":"The future of cancer research: invest now.","authors":"Danielle T Loughlin","doi":"10.1016/j.trecan.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.007","url":null,"abstract":"","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting novel immune checkpoints in the B7-H family: advancing cancer immunotherapy from bench to bedside.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-19 DOI: 10.1016/j.trecan.2025.02.007
Yiming Luo, Ye Yuan, Dan Liu, Haoxin Peng, Lin Shen, Yang Chen
{"title":"Targeting novel immune checkpoints in the B7-H family: advancing cancer immunotherapy from bench to bedside.","authors":"Yiming Luo, Ye Yuan, Dan Liu, Haoxin Peng, Lin Shen, Yang Chen","doi":"10.1016/j.trecan.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.007","url":null,"abstract":"<p><p>The B7-H family of immune checkpoint molecules is a crucial component of the immune regulatory network for tumors, offering new opportunities to modulate the tumor microenvironment (TME). The B7-H family - which includes B7-H2 (inducible T cell costimulatory ligand, ICOSL), B7-H3, B7-H4, B7-H5 (V-domain immunoglobulin suppressor of T cell activation, VISTA), B7-H6, and B7-H7 (HHLA2) - is known for its diverse roles in regulating innate and adaptive immunity. These molecules can exhibit co-stimulatory or co-inhibitory effects on T cells, influencing processes such as T cell activation, differentiation, and effector functions, and they are involved in the recruitment and polarization of various immune cells. This review explores the structural characteristics, receptor-ligand interactions, and signaling pathways associated with each B7-H family member. We also discuss the family's impact on tumor immunity and potential therapeutic strategies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-33 and ILC2 in pancreatic cancer: good, bad or a bit of both? 胰腺癌中的 IL-33 和 ILC2：是好是坏，还是两者兼而有之？
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-17 DOI: 10.1016/j.trecan.2025.03.003
Charlotte Simpson, Thomas Yip, Timotheus Y F Halim
{"title":"IL-33 and ILC2 in pancreatic cancer: good, bad or a bit of both?","authors":"Charlotte Simpson, Thomas Yip, Timotheus Y F Halim","doi":"10.1016/j.trecan.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.03.003","url":null,"abstract":"<p><p>Tertiary lymphoid structures (TLS) are associated with anticancer immunity, but the mechanisms underpinning their formation remain poorly understood. Amisaki et al. have recently shown that IL-33 mediates ILC2 gut-tumoral migration and promotes TLS formation in pancreatic ductal adenocarcinoma (PDAC) by inducing group 2 innate lymphoid cell (ILC2) Ltb expression. This study highlights new potential therapeutic avenues to enhance immunotherapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging space innovations for cancer breakthroughs on Earth.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-12 DOI: 10.1016/j.trecan.2025.02.003
Hossein Akbarialiabad, Parnian Jamshidi, Zahra Aminzade, Narges Azizi, Seyed Reza Taha, Najmeh Sadeghian, Lydia Johnson Kolaparambil Varghese, Mohsen Farjoud Kouhanjani, Nafise Niknam, Dora Babocs, Fatima El-Assaad, Thais Russomano, Dedee F Murrell, Shahram Paydar, Christopher G Bunick, Rowena Christiansen, M Mark Melin
{"title":"Leveraging space innovations for cancer breakthroughs on Earth.","authors":"Hossein Akbarialiabad, Parnian Jamshidi, Zahra Aminzade, Narges Azizi, Seyed Reza Taha, Najmeh Sadeghian, Lydia Johnson Kolaparambil Varghese, Mohsen Farjoud Kouhanjani, Nafise Niknam, Dora Babocs, Fatima El-Assaad, Thais Russomano, Dedee F Murrell, Shahram Paydar, Christopher G Bunick, Rowena Christiansen, M Mark Melin","doi":"10.1016/j.trecan.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.003","url":null,"abstract":"<p><p>Space science is reshaping oncology by providing novel insights into cancer biology, diagnostics, and therapeutics. The unique space environment - characterized by microgravity and cosmic radiation - induces profound alterations in cancer cell behavior, immune responses, and tumor microenvironment (TME) interactions. These conditions offer a platform for studying cancer progression, enhancing drug discovery, and refining treatment strategies. This opinion article explores microgravity-induced changes in tumor biology, space-driven advancements in imaging and radiation research, and extraterrestrial contributions to cancer therapeutics. By leveraging these innovations, space research holds transformative potential for improving cancer diagnostics and treatment on Earth.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protease regulation of tumor-immune cell symbiosis.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-07 DOI: 10.1016/j.trecan.2025.02.004
Lizhi Pang, Yuyun Huang, Jean Huang-Gao, Peiwen Chen
{"title":"Protease regulation of tumor-immune cell symbiosis.","authors":"Lizhi Pang, Yuyun Huang, Jean Huang-Gao, Peiwen Chen","doi":"10.1016/j.trecan.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.004","url":null,"abstract":"<p><p>Proteases play a crucial role in cancer progression and are traditionally known for their protumorigenic role by degrading the extracellular matrix (ECM). Emerging evidence indicates that proteases, such as caspases, cathepsins, and ubiquitin-specific proteases (USPs), regulate diverse immunomodulatory substrates or signals in the tumor microenvironment (TME), generating symbiotic interactions between cancer cells and immune cells. These interactions are critical for tumor progression and immunotherapy resistance across cancer types. In this review, we highlight recent insights into protease-mediated tumor-immune cell crosstalk, emphasizing how this symbiosis affects tumor progression and immunosuppression. Moreover, we discuss therapeutic strategies that exploit protease-mediated tumor-immune cell interactions to inhibit tumor progression and sensitize immunologically 'cold' tumors to immunotherapies, especially immune checkpoint inhibitor (ICI) therapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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