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Acetylation: a new target for protein degradation in cancer.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-06 DOI: 10.1016/j.trecan.2025.01.013
Callie E W Crawford, George M Burslem
{"title":"Acetylation: a new target for protein degradation in cancer.","authors":"Callie E W Crawford, George M Burslem","doi":"10.1016/j.trecan.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.01.013","url":null,"abstract":"<p><p>Acetylation is an increasing area of focus for cancer research as it is closely related to a variety of cellular processes through modulation of histone and non-histone proteins. However, broadly targeting acetylation threatens to yield nonselective toxic effects owing to the vital role of acetylation in cellular function. There is thus a pressing need to elucidate and characterize the specific cancer-relevant roles of acetylation for future therapeutic design. Acetylation-mediated protein homeostasis is an example of selective acetylation that affects a myriad of proteins as well as their correlated functions. We review recent examples of acetylation-mediated protein homeostasis that have emerged as key contributors to tumorigenesis, tumor proliferation, metastasis, and/or drug resistance, and we discuss their implications for future exploration of this intriguing phenomenon.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compromised epigenetic robustness in cancer: fueling evolution, exposing weakness.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-06 DOI: 10.1016/j.trecan.2025.02.001
Thomas Stuart Wilson, Paola Scaffidi
{"title":"Compromised epigenetic robustness in cancer: fueling evolution, exposing weakness.","authors":"Thomas Stuart Wilson, Paola Scaffidi","doi":"10.1016/j.trecan.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.001","url":null,"abstract":"<p><p>The complex network of proteins that regulate chromatin and DNA methylation landscapes is often disrupted in cancer. Clonal and subclonal mutations targeting a wide range of molecular functions are frequently observed across cancer types, and emerging evidence suggests that loss of robust epigenetic control promotes both cancer initiation and evolution, independently of context-specific effects. Here, we review how diverse genetic alterations that destabilize the epigenetic regulatory network (ERN) may converge into common phenotypes. We also discuss the implications of altered network topology and systemic epigenetic disorder for the evolution, vulnerability, and therapeutic resistance of cancers.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing FLASH irradiation to improve immunotherapy of medulloblastoma.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-06 DOI: 10.1016/j.trecan.2025.02.005
María Cecilia Lira, Claire Vanpouille-Box, Mara De Martino
{"title":"Harnessing FLASH irradiation to improve immunotherapy of medulloblastoma.","authors":"María Cecilia Lira, Claire Vanpouille-Box, Mara De Martino","doi":"10.1016/j.trecan.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.02.005","url":null,"abstract":"<p><p>Ultra-high dose delivery of radiation (>40 Gy/s), namely FLASH radiation therapy (FLASH-RT), is a novel treatment strategy that maximizes cell kill while sparing normal tissue. Recent data reported by Ni et al. demonstrate that one of the mechanisms through which FLASH-RT promotes inflammation involves the metabolic reprogramming of macrophages to support immune stimulation, thus enhancing immunotherapy in medulloblastoma (MB).</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of metastatic organotropism. 转移性器官性的调节。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI: 10.1016/j.trecan.2024.11.012
Karen J Dunbar, Gizem Efe, Katherine Cunningham, Emily Esquea, Raul Navaridas, Anil K Rustgi
{"title":"Regulation of metastatic organotropism.","authors":"Karen J Dunbar, Gizem Efe, Katherine Cunningham, Emily Esquea, Raul Navaridas, Anil K Rustgi","doi":"10.1016/j.trecan.2024.11.012","DOIUrl":"10.1016/j.trecan.2024.11.012","url":null,"abstract":"<p><p>Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying organotropism are multifactorial and include the generation of a pre-metastatic niche (PMN), metastatic homing, colonization, dormancy, and metastatic outgrowth. Historically, studies of metastatic organotropism have been limited by a lack of models allowing direct comparison of cells exhibiting different patterns of tropism. However, new innovative models and large-scale sequencing efforts have propelled organotropism research. Herein, we summarize the recent discoveries in metastatic organotropism regulation, focusing on lung, liver, brain, and bone tropism. We discuss how emerging technologies are continuing to improve our ability to model and, hopefully, predict and treat organotropism.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"216-231"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of first versus next-line targeted therapies for metastatic non-small cell lung cancer.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1016/j.trecan.2025.01.005
Sarah Waliany, Jessica J Lin, Justin F Gainor
{"title":"Evolution of first versus next-line targeted therapies for metastatic non-small cell lung cancer.","authors":"Sarah Waliany, Jessica J Lin, Justin F Gainor","doi":"10.1016/j.trecan.2025.01.005","DOIUrl":"10.1016/j.trecan.2025.01.005","url":null,"abstract":"<p><p>The expanding armamentarium of targeted therapies has revolutionized treatment for metastatic oncogene-addicted lung cancers. For multiple subsets, such as those harboring EGFR mutations and fusions in ALK or ROS1, successive generation of increasingly potent, selective, and brain-penetrating targeted therapies have shifted the treatment paradigm towards preferential first-line use of next-generation drugs. This evolution in clinical practice provides a lens through which to review the lessons learned from drug development in oncogene-addicted lung cancers, guided by translational insights into tumor biology and mechanisms of therapeutic resistance. For oncogenic drivers that are less sensitive to single-agent targeted therapies, rationally designed combination strategies will be needed to enable first-line use of targeted agents.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"245-257"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence-based biomarkers for treatment decisions in oncology. 肿瘤治疗决策中基于人工智能的生物标志物。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1016/j.trecan.2024.12.001
Marta Ligero, Omar S M El Nahhas, Mihaela Aldea, Jakob Nikolas Kather
{"title":"Artificial intelligence-based biomarkers for treatment decisions in oncology.","authors":"Marta Ligero, Omar S M El Nahhas, Mihaela Aldea, Jakob Nikolas Kather","doi":"10.1016/j.trecan.2024.12.001","DOIUrl":"10.1016/j.trecan.2024.12.001","url":null,"abstract":"<p><p>The development of new therapeutic strategies such as immune checkpoint inhibitors (ICIs) and targeted therapies has increased the complexity of the treatment landscape for solid tumors. At the current rate of annual FDA approvals, the potential treatment options could increase by tenfold over the next 5 years. The cost of personalized medicine technologies limits its accessibility, thus increasing socioeconomic disparities in the treated population. In this review we describe artificial intelligence (AI)-based solutions - including deep learning (DL) methods for routine medical imaging and large language models (LLMs) for electronic health records (EHRs) - to support cancer treatment decisions with cost-effective biomarkers. We address the current limitations of these technologies and propose the next steps towards their adoption in routine clinical practice.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"232-244"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intratumoral immune cell manipulations as a strategy to enhance cancer vaccine efficiency. 肿瘤内免疫细胞操作作为一种提高癌症疫苗效率的策略。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1016/j.trecan.2024.11.007
James Adeosun, Mohammad Omar Faruk Shaikh, Timothy Brauns, Yuki Agarwala, Mark C Poznansky, Yohannes Gemechu
{"title":"Intratumoral immune cell manipulations as a strategy to enhance cancer vaccine efficiency.","authors":"James Adeosun, Mohammad Omar Faruk Shaikh, Timothy Brauns, Yuki Agarwala, Mark C Poznansky, Yohannes Gemechu","doi":"10.1016/j.trecan.2024.11.007","DOIUrl":"10.1016/j.trecan.2024.11.007","url":null,"abstract":"<p><p>Shortcomings in cancer vaccine development are attributable to weak and transient anti-tumor cellular responses in the tumor microenvironment. This restriction of efficacy may be due to an intratumoral immunosuppressive milieu, consisting of regulatory T cells, M2 macrophages, and myeloid derived suppressor cells. Here, we analyze recent advances and propose future directions in the modulation of cellular state propensities combined with cancer vaccines.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"192-195"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer evolution: from Darwin to the Extended Evolutionary Synthesis.
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1016/j.trecan.2025.01.001
Thomas Savy, Lucy Flanders, Thaneswari Karpanasamy, Min Sun, Marco Gerlinger
{"title":"Cancer evolution: from Darwin to the Extended Evolutionary Synthesis.","authors":"Thomas Savy, Lucy Flanders, Thaneswari Karpanasamy, Min Sun, Marco Gerlinger","doi":"10.1016/j.trecan.2025.01.001","DOIUrl":"10.1016/j.trecan.2025.01.001","url":null,"abstract":"<p><p>The fundamental evolutionary nature of cancer has been recognized for decades. Increasingly powerful genetic and single cell sequencing technologies, as well as preclinical models, continue to unravel the evolution of premalignant cells, and progression to metastatic stages and to drug-resistant end-stage disease. Here, we summarize recent advances and distil evolutionary principles and their relevance for the clinic. We reveal how cancer cell and microenvironmental plasticity are intertwined with Darwinian evolution and demonstrate the need for a conceptual framework that integrates these processes. This warrants the adoption of the recently developed Extended Evolutionary Synthesis (EES).</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"204-215"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence improves mammography-based breast cancer risk prediction. 人工智能改进了基于乳房 X 射线照相术的乳腺癌风险预测。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1016/j.trecan.2024.10.007
Wendy V Ingman, Kara L Britt, Jennifer Stone, Tuong L Nguyen, John L Hopper, Erik W Thompson
{"title":"Artificial intelligence improves mammography-based breast cancer risk prediction.","authors":"Wendy V Ingman, Kara L Britt, Jennifer Stone, Tuong L Nguyen, John L Hopper, Erik W Thompson","doi":"10.1016/j.trecan.2024.10.007","DOIUrl":"10.1016/j.trecan.2024.10.007","url":null,"abstract":"<p><p>Artificial intelligence (AI) is enabling us to delve deeply into the information inherent in a mammogram and identify novel features associated with high risk of a future breast cancer diagnosis. Here, we discuss how AI is improving mammographic density-associated risk prediction and shaping the future of screening and risk-reducing strategies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"188-191"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hormetic response model for glutamine stress in cancer. 谷氨酰胺应激在癌症中的致敏反应模型。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2025-03-01 Epub Date: 2024-12-16 DOI: 10.1016/j.trecan.2024.11.008
Shea F Grenier, Cosimo Commisso
{"title":"A hormetic response model for glutamine stress in cancer.","authors":"Shea F Grenier, Cosimo Commisso","doi":"10.1016/j.trecan.2024.11.008","DOIUrl":"10.1016/j.trecan.2024.11.008","url":null,"abstract":"<p><p>Glutamine metabolism supports the development and progression of many cancers and is considered a therapeutic target. Attempts to inhibit glutamine metabolism have resulted in limited success and have not translated into clinical benefit. The outcomes of these clinical studies, along with preclinical investigations, suggest that cellular stress responses to glutamine deprivation or targeting may be modeled as a biphasic hormetic response. By recognizing the multifaceted aspects of glutamine metabolism inhibition within a more comprehensive biological framework, the adoption of this model may guide future fundamental and translational studies. To achieve clinical efficacy, we posit that as a field we will need to anticipate the hormetic effects of glutamine stress and consider how best to co-target cancer cell adaptive mechanisms.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"196-203"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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