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Fueling the revolution: RIBOTACs manipulating RNA decay. 推动革命：RIBOTACs操纵RNA衰变。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-13 DOI: 10.1016/j.trecan.2025.08.011
Wei Zhou, Jinmei Jin, Hongzhuan Chen, Weidong Zhang, Xin Luan
{"title":"Fueling the revolution: RIBOTACs manipulating RNA decay.","authors":"Wei Zhou, Jinmei Jin, Hongzhuan Chen, Weidong Zhang, Xin Luan","doi":"10.1016/j.trecan.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.011","url":null,"abstract":"<p><p>Ribonuclease-targeting chimeras (RIBOTACs) are innovative RNA-targeting molecules that combine small-molecule RNA binders with endogenous RNase L-recruiting moieties, enabling catalytic degradation of previously considered 'undruggable' transcripts. The unique mechanism of RIBOTACs allows them to circumvent limitations of existing RNA-targeted therapeutics, expanding their therapeutic potential in oncology.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging roles of the urea cycle in tumor microenvironment and therapies. 尿素循环在肿瘤微环境和治疗中的新作用。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-12 DOI: 10.1016/j.trecan.2025.08.007
Jiawen Zhou, Xuan Sun, Peng Jiang
{"title":"The emerging roles of the urea cycle in tumor microenvironment and therapies.","authors":"Jiawen Zhou, Xuan Sun, Peng Jiang","doi":"10.1016/j.trecan.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.007","url":null,"abstract":"<p><p>The urea cycle (UC) is a vital metabolic pathway that is responsible for the disposal of nitrogen and the production of metabolites necessary for biosynthesis. UC dysregulation is common in various cancers and impacts on cellular metabolism and the tumor microenvironment (TME). In this review we explore alterations in the expression of UC genes and metabolites in tumors, focusing on their roles in tumor progression, the TME, and cancer therapies. We discuss the effects of the UC on immune responses involving T cells and immunosuppressive cells, as well as on stromal cells and angiogenesis. We highlight the impact of arginine and polyamine metabolism in the TME. Although therapeutic strategies targeting the UC show promise, including arginine deprivation therapy (ADT), they face challenges such as drug resistance and toxicity. It will be essential to elucidate the specific functions of UC enzymes in tumorigenesis to devise more effective, personalized tumor therapies. Future studies should focus on combination therapies and personalized medicine to improve efficacy and patient prognosis.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming solid-tumor barriers: armored CAR-T cell therapy. 克服实体肿瘤屏障：装甲CAR-T细胞疗法。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-11 DOI: 10.1016/j.trecan.2025.08.009
Nayoung Kwon, Yvonne Y Chen
{"title":"Overcoming solid-tumor barriers: armored CAR-T cell therapy.","authors":"Nayoung Kwon, Yvonne Y Chen","doi":"10.1016/j.trecan.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.009","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR)-T cell therapy has shown significant clinical benefit in hematologic malignancies but remains less effective in solid tumors due to multiple barriers, including limited tumor infiltration, immunosuppressive microenvironments, and heterogeneity or imperfect specificity in tumor-antigen expression. 'Armoring' CAR-T cells to express chemokine receptors, enzymes that degrade extracellular matrix components, proinflammatory cytokines, or factors that modulate immunosuppressive signals could empower CAR-T cells to overcome barriers associated with solid tumors. However, translating promising preclinical results into reliable clinical benefit for patients with solid tumors remains challenging. This review critically examines emerging CAR-T cell armoring approaches and highlights key translational hurdles and the need for innovations in human-relevant disease models, safety designs, and treatment strategies for effective translation.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host and microbiome lipid metabolism in colorectal cancer development and therapy. 宿主和微生物脂质代谢在结直肠癌的发展和治疗中的作用。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-10 DOI: 10.1016/j.trecan.2025.08.005
Gabriel Medina Evora, Madita Brauer, Elisabeth Letellier
{"title":"Host and microbiome lipid metabolism in colorectal cancer development and therapy.","authors":"Gabriel Medina Evora, Madita Brauer, Elisabeth Letellier","doi":"10.1016/j.trecan.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.005","url":null,"abstract":"<p><p>Colorectal cancer (CRC) remains one of the most prevalent cancers, with treatment largely dependent on surgery and chemotherapy, underscoring the need for novel or adjunct therapies. Cancer cells reprogram their lipid metabolism to support proliferation, invasiveness, and chemoresistance, making it a promising therapeutic target. Although several inhibitors of lipogenesis, lipases, lipid uptake, and lipid storage are under investigation in CRC, none have yet shown sufficient efficacy. Importantly, the tumor microenvironment (TME) and the microbiome influence CRC lipid metabolism by supplying compensatory lipids and engaging in crosstalk that affects the efficacy of lipid-targeting therapies. This review describes the role of lipids in CRC and explores how the TME and the gut/tumor microbiome may contribute to current challenges in the development of effective lipid-targeting therapies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
γδT cells and breast cancer: wicked allies. γδT细胞和乳腺癌：邪恶的同盟。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-08 DOI: 10.1016/j.trecan.2025.08.015
Abhiram Charan Tej Mallu, Seth B Coffelt
{"title":"γδT cells and breast cancer: wicked allies.","authors":"Abhiram Charan Tej Mallu, Seth B Coffelt","doi":"10.1016/j.trecan.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.015","url":null,"abstract":"<p><p>Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni et al. uncover a crucial role for IL-17A-producing γδT cells in liver metastasis and therapeutic resistance, offering new insights into the mechanisms underlying these processes.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucose restriction: double edged sword in cancer treatment. 限制血糖：治疗癌症的双刃剑。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-05 DOI: 10.1016/j.trecan.2025.08.012
Shenglong Xia, Dingjiacheng Jia
{"title":"Glucose restriction: double edged sword in cancer treatment.","authors":"Shenglong Xia, Dingjiacheng Jia","doi":"10.1016/j.trecan.2025.08.012","DOIUrl":"https://doi.org/10.1016/j.trecan.2025.08.012","url":null,"abstract":"<p><p>Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural killer (NK) cell-deficient pre-metastatic niche (PMN). This finding provides a new perspective on understanding the dual role of glucose metabolism regulation in cancer treatment.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pericyte phenotype switching in cancer. 癌症中的周细胞表型转换。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-01 Epub Date: 2025-07-07 DOI: 10.1016/j.trecan.2025.06.005
Bo He, Ruth Ganss
{"title":"Pericyte phenotype switching in cancer.","authors":"Bo He, Ruth Ganss","doi":"10.1016/j.trecan.2025.06.005","DOIUrl":"10.1016/j.trecan.2025.06.005","url":null,"abstract":"<p><p>Pericytes play an important physiological role as guardians of vascular integrity. In cancer, however, pericytes undergo profound phenotypic changes which foster tumor progression. Emerging transcriptomics and functional data provide evidence for a shift from quiescent to highly proliferating, matrix-secreting pericytes which destabilize the vasculature and create immune deserts. However, due to their inherent plasticity, proliferative tumor pericytes can be 'coerced' to switch back into a more quiescent and contractile state, a process which underpins durable tumor vessel normalization. Therapeutically, pericyte phenotype switching can be induced by targeting oncogenic, metabolic, or microtubule signaling pathways which induce Rho kinase activity. Thus, harnessing pericyte plasticity provides unique opportunities to synergize targeted anticancer therapies with immunotherapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"877-888"},"PeriodicalIF":17.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving role for eosinophils in cancer: from bench to bedside. 嗜酸性粒细胞在癌症中的进化作用：从实验到临床。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-01 Epub Date: 2025-06-12 DOI: 10.1016/j.trecan.2025.05.005
S Grisaru-Tal, E A Jacobsen, A Munitz
{"title":"Evolving role for eosinophils in cancer: from bench to bedside.","authors":"S Grisaru-Tal, E A Jacobsen, A Munitz","doi":"10.1016/j.trecan.2025.05.005","DOIUrl":"10.1016/j.trecan.2025.05.005","url":null,"abstract":"<p><p>Eosinophils are increasingly recognized as important immune cells in the tumor microenvironment (TME). Recent technological advancements reveal their heterogeneity and complex context-dependent activities including the ability to elicit pro- or anti-tumorigenic effects. For instance, they can mediate cytotoxicity via highly eosinophil-specific granule proteins and reactive oxygen species, and contribute to antitumor immunity by interacting with various cells including T cells. Clinically, eosinophilia is often observed following various treatments including immunotherapy, where they may be beneficial for therapy. This Review explores eosinophil recruitment, immune interactions, therapeutic potential and methods for studying their activity. Understanding the role of eosinophils in the TME may lead to new therapeutic strategies and position them as targets or biomarkers in precision oncology.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"862-876"},"PeriodicalIF":17.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone appetite: bone-derived factors feed distant immune suppression. 骨食欲：骨源性因子喂养远处免疫抑制。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-01 Epub Date: 2025-07-18 DOI: 10.1016/j.trecan.2025.07.002
Debolina Ganguly, Judith Agudo
{"title":"Bone appetite: bone-derived factors feed distant immune suppression.","authors":"Debolina Ganguly, Judith Agudo","doi":"10.1016/j.trecan.2025.07.002","DOIUrl":"10.1016/j.trecan.2025.07.002","url":null,"abstract":"<p><p>The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopontin (OPN) production, which suppressed immunity in distal lesions. This highlights a novel cross-organ communication hindering antitumor immunity.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"831-833"},"PeriodicalIF":17.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting TIM-3 to halt lung precancer progression. 靶向TIM-3阻止肺癌前期进展。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.trecan.2025.07.001
Kostas A Papavassiliou, Alice G Vassiliou, Athanasios G Papavassiliou
{"title":"Targeting TIM-3 to halt lung precancer progression.","authors":"Kostas A Papavassiliou, Alice G Vassiliou, Athanasios G Papavassiliou","doi":"10.1016/j.trecan.2025.07.001","DOIUrl":"10.1016/j.trecan.2025.07.001","url":null,"abstract":"<p><p>Little is known about lung precancer progression. Recently, Zhu et al. explored the early immunologic landscape of lung adenocarcinoma (LUAD) precursors and identified T cell immunoglobulin and mucin domain 3 (TIM-3) as a putative immune checkpoint target for precancer interception. TIM-3 blockade in mice harboring premalignant lesions delayed progression to invasive adenocarcinoma, suggesting potential clinical utility in high-risk individuals detected through screening.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"825-827"},"PeriodicalIF":17.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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