Inciting commensal human papillomavirus immunity to combat cancer.

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-01 DOI:10.1016/j.trecan.2025.04.006

Natalie E Fulton, Thomas D Horn, Shadmehr Demerhi

引用次数: 0

Abstract

The incidence of squamous cell carcinoma (SCC) is rising, especially in immunosuppressed individuals, highlighting the need for new prevention strategies. Commensal human papillomaviruses (cHPVs) are associated with cutaneous SCC (cSCC) in immunosuppressed patients. Because of the intricate interactions between T cell immunity and cHPVs in virus-colonized tissues, we propose that enhancing T cell immunity against cHPVs through vaccination could suppress SCC.

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激发人类乳头瘤病毒共生免疫以对抗癌症。

鳞状细胞癌（SCC）的发病率正在上升，特别是在免疫抑制的个体中，这突出了对新的预防策略的需求。共生人乳头瘤病毒（chpv）与免疫抑制患者的皮肤SCC （cSCC）相关。由于病毒定植组织中T细胞免疫与chpv之间复杂的相互作用，我们提出通过接种疫苗增强T细胞对chpv的免疫可以抑制SCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.