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KMT2C and KMT2D aberrations in breast cancer. 乳腺癌中的 KMT2C 和 KMT2D 畸变。
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-06-01 Epub Date: 2024-03-07 DOI: 10.1016/j.trecan.2024.02.003
Emily Tinsley, Philip Bredin, Sinead Toomey, Bryan T Hennessy, Simon J Furney
{"title":"KMT2C and KMT2D aberrations in breast cancer.","authors":"Emily Tinsley, Philip Bredin, Sinead Toomey, Bryan T Hennessy, Simon J Furney","doi":"10.1016/j.trecan.2024.02.003","DOIUrl":"10.1016/j.trecan.2024.02.003","url":null,"abstract":"<p><p>KMT2C and KMT2D are histone lysine methyltransferases responsible for the monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D are the most frequently mutated histone methyltransferases (HMTs) in breast cancer, occurring at frequencies of 10-20% collectively. Frequent damaging and truncating somatic mutations indicate a tumour-suppressive role of KMT2C/D in breast oncogenesis. Recent studies using cell lines and mouse models to replicate KMT2C/D loss show that these genes contribute to oestrogen receptor (ER)-driven transcription in ER<sup>+</sup> breast cancers through the priming of gene enhancer regions. This review provides an overview of the functions of KMT2C/D and outlines the recent clinical and experimental evidence of the roles of KMT2C and KMT2D in breast cancer development.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"519-530"},"PeriodicalIF":18.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription ©right page 订阅和版权页面
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-14 DOI: 10.1016/s2405-8033(24)00082-7
{"title":"Subscription &copyright page","authors":"","doi":"10.1016/s2405-8033(24)00082-7","DOIUrl":"https://doi.org/10.1016/s2405-8033(24)00082-7","url":null,"abstract":"No Abstract","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"24 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-14 DOI: 10.1016/s2405-8033(24)00079-7
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s2405-8033(24)00079-7","DOIUrl":"https://doi.org/10.1016/s2405-8033(24)00079-7","url":null,"abstract":"No Abstract","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"24 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of ferroptosis in cancer: a matter of context? 癌症中铁蛋白沉积的免疫原性：背景问题？
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-16 DOI: 10.1016/j.trecan.2024.01.013
Elena Catanzaro, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, Dmitri V Krysko
{"title":"Immunogenicity of ferroptosis in cancer: a matter of context?","authors":"Elena Catanzaro, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, Dmitri V Krysko","doi":"10.1016/j.trecan.2024.01.013","DOIUrl":"10.1016/j.trecan.2024.01.013","url":null,"abstract":"<p><p>Ferroptosis is a variant of regulated cell death (RCD) elicited by an imbalance of cellular redox homeostasis that culminates with extensive lipid peroxidation and rapid plasma membrane breakdown. Since other necrotic forms of RCD, such as necroptosis, are highly immunogenic, ferroptosis inducers have attracted considerable attention as potential tools to selectively kill malignant cells while eliciting therapeutically relevant tumor-targeting immune responses. However, rather than being consistently immunogenic, ferroptosis mediates context-dependent effects on anticancer immunity. The inability of ferroptotic cancer cells to elicit adaptive immune responses may arise from contextual deficiencies in intrinsic aspects of the process, such as adjuvanticity and antigenicity, or from microenvironmental defects imposed by ferroptotic cancer cells themselves or elicited by the induction of ferroptosis in immune cells.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"407-416"},"PeriodicalIF":18.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persisting cancer cells are different from bacterial persisters. 顽固的癌细胞与细菌性顽固病菌不同。
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-03-01 DOI: 10.1016/j.trecan.2024.02.002
Morgane Decollogny, Sven Rottenberg
{"title":"Persisting cancer cells are different from bacterial persisters.","authors":"Morgane Decollogny, Sven Rottenberg","doi":"10.1016/j.trecan.2024.02.002","DOIUrl":"10.1016/j.trecan.2024.02.002","url":null,"abstract":"<p><p>The persistence of drug-sensitive tumors poses a significant challenge in cancer treatment. The concept of bacterial persisters, which are a subpopulation of bacteria that survive lethal antibiotic doses, is frequently used to compare to residual disease in cancer. Here, we explore drug tolerance of cancer cells and bacteria. We highlight the fact that bacteria, in contrast to cancer cells, have been selected for survival at the population level and may therefore possess contingency mechanisms that cancer cells lack. The precise mechanisms of drug-tolerant cancer cells and bacterial persisters are still being investigated. Undoubtedly, by understanding common features as well as differences, we, in the cancer field, can learn from microbiology to find strategies to eradicate persisting cancer cells.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"393-406"},"PeriodicalIF":18.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond binary: bridging neutrophil diversity to new therapeutic approaches in NSCLC. 超越二元论：将中性粒细胞多样性与 NSCLC 的新治疗方法联系起来。
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1016/j.trecan.2024.01.010
Lena Horvath, Constanze Puschmann, Alexandra Scheiber, Agnieszka Martowicz, Gregor Sturm, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher, Stefan Salcher
{"title":"Beyond binary: bridging neutrophil diversity to new therapeutic approaches in NSCLC.","authors":"Lena Horvath, Constanze Puschmann, Alexandra Scheiber, Agnieszka Martowicz, Gregor Sturm, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher, Stefan Salcher","doi":"10.1016/j.trecan.2024.01.010","DOIUrl":"10.1016/j.trecan.2024.01.010","url":null,"abstract":"<p><p>Neutrophils represent the most abundant myeloid cell subtype in the non-small-cell lung cancer (NSCLC) tumor microenvironment (TME). By anti- or protumor polarization, they impact multiple aspects of tumor biology and affect sensitivity to conventional therapies and immunotherapies. Single-cell RNA sequencing (scRNA-seq) analyses have unraveled an extensive neutrophil heterogeneity, helping our understanding of their pleiotropic role. In this review we summarize recent data and models on tumor-associated neutrophil (TAN) biology, focusing on the diversity that evolves in response to tumor-intrinsic cues. We categorize available transcriptomic profiles from different cancer entities into a defined set of neutrophil subclusters with distinct phenotypic properties, to step beyond the traditional binary N1/2 classification. Finally, we discuss potential ways to exploit these neutrophil states in the setting of anticancer therapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"457-474"},"PeriodicalIF":18.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Into the era of mycobiome-driven cancer research. 进入霉菌生物群驱动的癌症研究时代。
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-03-16 DOI: 10.1016/j.trecan.2024.02.009
Weici Liu, Zheshun Pi, Ning-Ning Liu, Wenjun Mao
{"title":"Into the era of mycobiome-driven cancer research.","authors":"Weici Liu, Zheshun Pi, Ning-Ning Liu, Wenjun Mao","doi":"10.1016/j.trecan.2024.02.009","DOIUrl":"10.1016/j.trecan.2024.02.009","url":null,"abstract":"<p><p>The cancer mycobiome has recently become a research hotspot. While the intratumor mycobiota is implicated in cancer initiation and progression, the gut mycobiota functions as biomarkers for cancer diagnosis and treatment. In this forum article we highlight the involvement of the mycobiome in correlation-, causation-, and prediction-oriented cancer research and discuss the potential of this burgeoning field.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"389-392"},"PeriodicalIF":18.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy for colorectal cancer: insight from inherited genetics. 结直肠癌免疫疗法：遗传基因的启示。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI: 10.1016/j.trecan.2024.01.008
Nijole Pollock Tjader, Amanda Ewart Toland
{"title":"Immunotherapy for colorectal cancer: insight from inherited genetics.","authors":"Nijole Pollock Tjader, Amanda Ewart Toland","doi":"10.1016/j.trecan.2024.01.008","DOIUrl":"10.1016/j.trecan.2024.01.008","url":null,"abstract":"<p><p>Immunotherapy shows efficacy for multiple cancer types and potential for expanded use. However, current immune checkpoint inhibitors (ICIs) are ineffective against microsatellite-stable colorectal cancer (CRC), which is more commonly diagnosed. Immunotherapy strategies for non-responsive CRC, including new targets and new combination therapies, are being tested to address this need. Importantly, a subset of inherited germline genetic variants associated with CRC risk are predicted to regulate genes with immune functions, including genes related to existing ICIs, as well as new potential targets in the major histocompatibility complex (MHC) region and immunoregulatory cytokines. We review discoveries in the inherited genetics of CRC related to the immune system and draw connections with ongoing developments and emerging immunotherapy targets.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"444-456"},"PeriodicalIF":14.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse effects of ferroptotic therapy: mechanisms and management. 铁剂治疗的不良反应：机制与处理。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-01-20 DOI: 10.1016/j.trecan.2024.01.002
Jiao Liu, Rui Kang, Daolin Tang
{"title":"Adverse effects of ferroptotic therapy: mechanisms and management.","authors":"Jiao Liu, Rui Kang, Daolin Tang","doi":"10.1016/j.trecan.2024.01.002","DOIUrl":"10.1016/j.trecan.2024.01.002","url":null,"abstract":"<p><p>Ferroptosis, a nonapoptotic form of cell death characterized by iron accumulation and uncontrolled lipid peroxidation, holds promise as a therapeutic approach in cancer treatment, alongside established modalities, such as chemotherapy, immunotherapy, and radiotherapy. However, recent research has raised concerns about its side effects, including damage to immune cells, hematopoietic stem cells, liver, and kidneys, the development of cachexia, and the risk of secondary tumor formation. In this review, we provide an overview of these emerging findings, with a specific emphasis on elucidating the underlying mechanisms, and underscore the critical significance of effectively managing side effects associated with targeted ferroptosis-based therapy.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"417-429"},"PeriodicalIF":14.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusion genes in pancreatic tumors. 胰腺肿瘤中的融合基因。
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-19 DOI: 10.1016/j.trecan.2024.01.009
Anastasios Gkountakos, Aatur D Singhi, C Benedikt Westphalen, Aldo Scarpa, Claudio Luchini
{"title":"Fusion genes in pancreatic tumors.","authors":"Anastasios Gkountakos, Aatur D Singhi, C Benedikt Westphalen, Aldo Scarpa, Claudio Luchini","doi":"10.1016/j.trecan.2024.01.009","DOIUrl":"10.1016/j.trecan.2024.01.009","url":null,"abstract":"<p><p>Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events typically detected in KRAS wild-type (WT) pancreatic tumors. Their identification can inform clinical management by enabling precision oncology, as fusions involving BRAF, FGFR2, RET, NTRK, NRG1, and ALK represent actionable targets in KRAS-WT cancers, and serve diagnostic purposes since fusions involving PRKACA/B represent the diagnostic hallmark of intraductal oncocytic papillary neoplasms (IOPNs). Although they are rare, the therapeutic and diagnostic importance of these genomic events should not be underestimated, highlighting the need for quality-ensured molecular diagnostics in the management of cancer. Herein we review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"430-443"},"PeriodicalIF":18.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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