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CFTR and colorectal cancer susceptibility: an urgent need for further studies. CFTR 与结直肠癌易感性：迫切需要进一步研究。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI: 10.1016/j.trecan.2024.07.006
S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik
{"title":"CFTR and colorectal cancer susceptibility: an urgent need for further studies.","authors":"S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik","doi":"10.1016/j.trecan.2024.07.006","DOIUrl":"10.1016/j.trecan.2024.07.006","url":null,"abstract":"<p><p>Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"876-879"},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in exosomes utilization for clinical applications in cancer. 外泌体在癌症临床应用中的应用进展。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1016/j.trecan.2024.07.010
Inês A Batista, José C Machado, Sonia A Melo
{"title":"Advances in exosomes utilization for clinical applications in cancer.","authors":"Inês A Batista, José C Machado, Sonia A Melo","doi":"10.1016/j.trecan.2024.07.010","DOIUrl":"10.1016/j.trecan.2024.07.010","url":null,"abstract":"<p><p>Exosomes are regarded as having transformative potential for clinical applications. Exosome-based liquid biopsies offer a noninvasive method for early cancer detection and real-time disease monitoring. Clinical trials are underway to validate the efficacy of exosomal biomarkers for enhancing diagnostic accuracy and predicting treatment responses. Additionally, engineered exosomes are being developed as targeted drug delivery systems that can navigate the bloodstream to deliver therapeutic agents to tumor sites, thus enhancing treatment efficacy while minimizing systemic toxicity. Exosomes also exhibit immunomodulatory properties, which are being harnessed to boost antitumor immune responses. In this review, we detail the latest advances in clinical trials and research studies, underscoring the potential of exosomes to revolutionize cancer care.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"947-968"},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The origin of novel traits in cancer. 癌症新性状的起源
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI: 10.1016/j.trecan.2024.07.005
Steven A Frank, Itai Yanai
{"title":"The origin of novel traits in cancer.","authors":"Steven A Frank, Itai Yanai","doi":"10.1016/j.trecan.2024.07.005","DOIUrl":"10.1016/j.trecan.2024.07.005","url":null,"abstract":"<p><p>The traditional view of cancer emphasizes a genes-first process. Novel cancer traits arise by genetic mutations that spread to drive phenotypic change. However, recent data support a phenotypes-first process in which nonheritable cellular variability creates novel traits that later become heritably stabilized by genetic and epigenetic changes. Single-cell measurements reinforce the idea that phenotypes lead genotypes, showing how cancer evolution follows normal developmental plasticity and creates novel traits by recombining parts of different cellular developmental programs. In parallel, studies in evolutionary biology also support a phenotypes-first process driven by developmental plasticity and developmental recombination. These advances in cancer research and evolutionary biology mutually reinforce a revolution in our understanding of how cells and organisms evolve novel traits in response to environmental challenges.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"880-892"},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bispecific antibodies: advancing precision oncology. 双特异性抗体：推动精准肿瘤学的发展。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-30 DOI: 10.1016/j.trecan.2024.07.002
Mercedes Herrera, Giulia Pretelli, Jayesh Desai, Elena Garralda, Lillian L Siu, Thiago M Steiner, Lewis Au
{"title":"Bispecific antibodies: advancing precision oncology.","authors":"Mercedes Herrera, Giulia Pretelli, Jayesh Desai, Elena Garralda, Lillian L Siu, Thiago M Steiner, Lewis Au","doi":"10.1016/j.trecan.2024.07.002","DOIUrl":"10.1016/j.trecan.2024.07.002","url":null,"abstract":"<p><p>Bispecific antibodies (bsAbs) are engineered molecules designed to target two different epitopes or antigens. The mechanism of action is determined by the bsAb molecular targets and structure (or format), which can be manipulated to create variable and novel functionalities, including linking immune cells with tumor cells, or dual signaling pathway blockade. Several bsAbs have already changed the treatment landscape of hematological malignancies and select solid cancers. However, the mechanisms of resistance to these agents are understudied and the management of toxicities remains challenging. Herein, we review the principles in bsAb engineering, current understanding of mechanisms of action and resistance, data for clinical application, and provide a perspective on ongoing challenges and future developments in this field.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"893-919"},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD4+ T cells in antitumor immunity. 抗肿瘤免疫中的 CD4+ T 细胞。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1016/j.trecan.2024.07.009
Elena Montauti, David Y Oh, Lawrence Fong
{"title":"CD4<sup>+</sup> T cells in antitumor immunity.","authors":"Elena Montauti, David Y Oh, Lawrence Fong","doi":"10.1016/j.trecan.2024.07.009","DOIUrl":"10.1016/j.trecan.2024.07.009","url":null,"abstract":"<p><p>Advances in cancer immunotherapy have transformed cancer care and realized unprecedented responses in many patients. The growing arsenal of novel therapeutics - including immune checkpoint inhibition (ICI), adoptive T cell therapies (ACTs), and cancer vaccines - reflects the success of cancer immunotherapy. The therapeutic benefits of these treatment modalities are generally attributed to the enhanced quantity and quality of antitumor CD8<sup>+</sup> T cell responses. Nevertheless, CD4<sup>+</sup> T cells are now recognized to play key roles in both the priming and effector phases of the antitumor immune response. In addition to providing T cell help through co-stimulation and cytokine production, CD4<sup>+</sup> T cells can also possess cytotoxicity either directly on MHC class II-expressing tumor cells or to other cells within the tumor microenvironment (TME). The presence of specific populations of CD4<sup>+</sup> T cells, and their intrinsic plasticity, within the TME can represent an important determinant of clinical response to immune checkpoint inhibitors, vaccines, and chimeric antigen receptor (CAR) T cell therapies. Understanding how the antitumor functions of specific CD4<sup>+</sup> T cell types are induced while limiting their protumorigenic attributes will enable more successful immunotherapies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"969-985"},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunomodulation by endothelial cells: prospects for cancer therapy 内皮细胞的免疫调节作用：癌症治疗的前景
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-09-16 DOI: 10.1016/j.trecan.2024.08.002
Halima Alnaqbi, Lisa M. Becker, Mira Mousa, Fatima Alshamsi, Sarah K. Azzam, Besa Emini Veseli, Lauren A. Hymel, Khalood Alhosani, Marwa Alhusain, Massimiliano Mazzone, Habiba Alsafar, Peter Carmeliet
{"title":"Immunomodulation by endothelial cells: prospects for cancer therapy","authors":"Halima Alnaqbi, Lisa M. Becker, Mira Mousa, Fatima Alshamsi, Sarah K. Azzam, Besa Emini Veseli, Lauren A. Hymel, Khalood Alhosani, Marwa Alhusain, Massimiliano Mazzone, Habiba Alsafar, Peter Carmeliet","doi":"10.1016/j.trecan.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.trecan.2024.08.002","url":null,"abstract":"<p>Growing evidence highlights the importance of tumor endothelial cells (TECs) in the tumor microenvironment (TME) for promoting tumor growth and evading immune responses. Immunomodulatory endothelial cells (IMECs) represent a distinct plastic phenotype of ECs that exerts the ability to modulate immunity in health and disease. This review discusses our current understanding of IMECs in cancer biology, scrutinizing insights from single-cell reports to compare their characteristics and function dynamics across diverse tumor types, conditions, and species. We investigate possible implications of exploiting IMECs in the context of cancer treatment, particularly examining their influence on the efficacy of existing therapies and the potential to leverage them as targets in optimizing immunotherapeutic strategies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"17 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes 代谢和表观遗传学：肿瘤细胞可塑性和治疗效果的驱动因素
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-09-14 DOI: 10.1016/j.trecan.2024.08.005
Benjamin N. Gantner, Flavio R. Palma, Madhura R. Pandkar, Marcelo J. Sakiyama, Daniel Arango, Gina M. DeNicola, Ana P. Gomes, Marcelo G. Bonini
{"title":"Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes","authors":"Benjamin N. Gantner, Flavio R. Palma, Madhura R. Pandkar, Marcelo J. Sakiyama, Daniel Arango, Gina M. DeNicola, Ana P. Gomes, Marcelo G. Bonini","doi":"10.1016/j.trecan.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.trecan.2024.08.005","url":null,"abstract":"<p>Emerging evidence indicates that metabolism not only is a source of energy and biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment resistance. This is because metabolic changes lead to remodeling of chromatin and reprogramming of gene expression patterns, furthering tumor cell phenotypic transitions. Therefore, the crosstalk between metabolism and epigenetics seems to hold immense potential for the discovery of novel therapeutic targets for various aggressive tumors. Here, we highlight recent discoveries supporting the concept that the cooperation between metabolism and epigenetics enables cancer to overcome mounting treatment-induced pressures. We discuss how specific metabolites contribute to cancer cell resilience and provide perspective on how simultaneously targeting these key forces could produce synergistic therapeutic effects to improve treatment outcomes.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"26 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaling data toward pan-cancer foundation models 扩大数据规模，建立泛癌症基础模型
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-09-11 DOI: 10.1016/j.trecan.2024.08.008
Nadieh Khalili, Francesco Ciompi
{"title":"Scaling data toward pan-cancer foundation models","authors":"Nadieh Khalili, Francesco Ciompi","doi":"10.1016/j.trecan.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.trecan.2024.08.008","url":null,"abstract":"<p>Recent advances in artificial intelligence (AI) have revolutionized computational pathology (CPath), particularly through deep learning (DL) and neural networks (NNs). In a recent study, <span><span>Vorontsov <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> introduced Virchow, a new foundation model (FM) for CPath, which has shown promising results in cancer detection and biomarker prediction.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"6 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142206022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental pollutants and bad bugs work hand in glove 环境污染物和坏虫子狼狈为奸
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-09-10 DOI: 10.1016/j.trecan.2024.08.007
Dingjiacheng Jia, Shujie Chen
{"title":"Environmental pollutants and bad bugs work hand in glove","authors":"Dingjiacheng Jia, Shujie Chen","doi":"10.1016/j.trecan.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.trecan.2024.08.007","url":null,"abstract":"<p>‘Bad bacteria’ could alter the toxicokinetics of environmental pollutants, thereby exacerbating chemically induced tumorigenesis. Recently, <span><span>Roje <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> reported that specific gut microbiota can metabolize nitrosamine compounds to a toxic oxidation product, aggravating bladder cancer development and progression. These findings have important implications for tumor intervention through the gut microbiota.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"15 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142206023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-09-10 DOI: 10.1016/s2405-8033(24)00176-6
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s2405-8033(24)00176-6","DOIUrl":"https://doi.org/10.1016/s2405-8033(24)00176-6","url":null,"abstract":"No Abstract","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"8 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142206019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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