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Ammonia: a metabolic checkpoint for Treg potency. 氨：Treg效力的代谢检查点。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.trecan.2026.02.002
Ali Valipour Motlagh, Eyad Elkord, Weiwei Dai
{"title":"Ammonia: a metabolic checkpoint for Treg potency.","authors":"Ali Valipour Motlagh, Eyad Elkord, Weiwei Dai","doi":"10.1016/j.trecan.2026.02.002","DOIUrl":"10.1016/j.trecan.2026.02.002","url":null,"abstract":"<p><p>Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"307-309"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disarming cancer resistance: FAK as a therapeutic target. 解除癌症抵抗：FAK作为治疗靶点。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.trecan.2025.12.008
Terrance J Haanen, David D Schlaepfer
{"title":"Disarming cancer resistance: FAK as a therapeutic target.","authors":"Terrance J Haanen, David D Schlaepfer","doi":"10.1016/j.trecan.2025.12.008","DOIUrl":"10.1016/j.trecan.2025.12.008","url":null,"abstract":"<p><p>The FDA recently granted accelerated approval of the small-molecule focal adhesion kinase (FAK) inhibitor (FAKi, defactinib) in combination with a RAF-MEK clamp inhibitor (avutometinib) for KRAS-mutated low-grade serous ovarian cancer developed by Verastem Inc. This milestone moment represents a long journey in FAKi development, from initial findings of limited single-agent activity to orally delivered FAKi effects that can sensitize solid tumors to chemotherapy, radiotherapy, and immunotherapy treatments. In this study, we review a short history of FAK, summarize ongoing combinatorial clinical trials, discuss potential mechanisms of action, and highlight studies showing that FAK activation is a chemo- and mechano-sensitive signaling hub driving tumor adaptive changes. Targeting FAK disarms tumor resistance through multiple mechanisms, which supports new biological insights and future clinical combinations.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"358-369"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13174975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung cancer in never smokers: from early detection to prevention. 从不吸烟者的肺癌：从早期发现到预防。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-02-11 DOI: 10.1016/j.trecan.2025.12.009
Deborah R Caswell, Crispin Hiley, Cian Murphy, Loc Carlo Bao, Charles Swanton
{"title":"Lung cancer in never smokers: from early detection to prevention.","authors":"Deborah R Caswell, Crispin Hiley, Cian Murphy, Loc Carlo Bao, Charles Swanton","doi":"10.1016/j.trecan.2025.12.009","DOIUrl":"10.1016/j.trecan.2025.12.009","url":null,"abstract":"<p><p>Lung cancer in never smokers (LCINS) is a growing global health challenge. Unlike smoking-related lung cancer, LCINS is characterized by distinct epidemiological patterns and unique molecular pathogenesis and, consequently, requires different clinical management approaches. Unfortunately, for patients with lung cancer who have never smoked, symptoms are nonspecific and often dismissed due to these patients not fitting a high-risk profile (e.g., smoker), underscoring the need for improved detection and interception. Emerging risk factors, including germline variants, clonal hematopoiesis, and environmental exposures, offer new avenues for risk stratification and preventive strategies. While low-dose computed tomography screening shows promise in high-risk subgroups, challenges remain in optimizing cost-effectiveness. Novel prevention approaches, from interleukin (IL)-1β inhibition to cancer vaccines, are under investigation. This opinion article discusses why LCINS demands unique clinical and research paradigms to address its biological complexity.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"310-319"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving approaches to broaden public and patient involvement in cancer research. 不断发展的方法，扩大公众和患者参与癌症研究。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.trecan.2026.01.006
Asia Jordan, Claire Hughes, Lea Schäfer, Adele E Connor, Yvonne O'Meara, Chowdhury A Jahangir, Teerna Banerjee, Arman Rahman, Antoinette S Perry
{"title":"Evolving approaches to broaden public and patient involvement in cancer research.","authors":"Asia Jordan, Claire Hughes, Lea Schäfer, Adele E Connor, Yvonne O'Meara, Chowdhury A Jahangir, Teerna Banerjee, Arman Rahman, Antoinette S Perry","doi":"10.1016/j.trecan.2026.01.006","DOIUrl":"10.1016/j.trecan.2026.01.006","url":null,"abstract":"<p><p>Public and Patient Involvement (PPI) integrates patients and the public into research design, conduct, and dissemination to ensure future research represents the needs of society. We propose a toolkit for researchers, based on outcomes from an ovarian cancer PPI project, to incorporate meaningful, representative cancer research into future studies.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"299-303"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting tumor lineage features for precision cancer therapy. 利用肿瘤谱系特征进行精准癌症治疗。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-01-03 DOI: 10.1016/j.trecan.2025.12.004
Lois M Kelly, Nina Fenouille, Kris C Wood, Alexandre Puissant
{"title":"Exploiting tumor lineage features for precision cancer therapy.","authors":"Lois M Kelly, Nina Fenouille, Kris C Wood, Alexandre Puissant","doi":"10.1016/j.trecan.2025.12.004","DOIUrl":"10.1016/j.trecan.2025.12.004","url":null,"abstract":"<p><p>Cancer cells often retain lineage- and tissue of origin-specific programs established prior to malignant transformation. This observation has been elaborated by advances in single-cell and lineage-tracing technologies, which provide high-resolution mapping of these features. Here, we provide an overview of these recent technological developments and examine how the tissue of origin shapes tumor behavior and vulnerabilities. We discuss how the preferential selection of oncogenic drivers by specific tissues leads to distinct genetic alterations across cancers. We then explore the continued dependence of cancer cells on lineage-specific physiological functions and signaling pathways, thereby revealing lineage-dependent therapeutic targets. Finally, we highlight how lineage-specific cell surface marker expression informs precision immunotherapies. Together, these insights are driving a shift toward therapies tailored to the developmental and functional identities of cancer cells.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"328-347"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic cancer prevention comes of age. 机械的癌症预防来自年龄。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-02-24 DOI: 10.1016/j.trecan.2026.01.002
Anbalakan Paramasivam, David Crosby, Joanna Janus, Phil Prime
{"title":"Mechanistic cancer prevention comes of age.","authors":"Anbalakan Paramasivam, David Crosby, Joanna Janus, Phil Prime","doi":"10.1016/j.trecan.2026.01.002","DOIUrl":"10.1016/j.trecan.2026.01.002","url":null,"abstract":"<p><p>Historically underfunded and dominated by epidemiological and behavioural research, cancer prevention is now able to embrace mechanistic insights that enable targeted, biologically grounded interventions. As a new generation of mechanistically based strategies begins to take shape, cancer prevention is poised to enter a new era.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"304-306"},"PeriodicalIF":21.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost but not least: Y chromosome loss as a driver of cancer. 丢失但并非不重要：Y染色体丢失是癌症的驱动因素。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2026-03-01 Epub Date: 2025-12-13 DOI: 10.1016/j.trecan.2025.11.009
Luis Antonio Corchete Sanchez, Esther Rheinbay
{"title":"Lost but not least: Y chromosome loss as a driver of cancer.","authors":"Luis Antonio Corchete Sanchez, Esther Rheinbay","doi":"10.1016/j.trecan.2025.11.009","DOIUrl":"10.1016/j.trecan.2025.11.009","url":null,"abstract":"<p><p>Traditionally neglected and frequently excluded from large-scale genomic studies, the Y chromosome is now emerging as a potential Achilles' heel of cancers in men. Recent evidence has suggested that loss of this chromosome - a phenomenon known as loss of Y chromosome (LOY) - is not a silent event, but rather an active driver that promotes tumor progression through loss of tumor suppressor genes, increasing tumor growth and enabling immune evasion. Importantly, LOY creates loss of heterozygosity of paralogous genes on the X chromosome, a vulnerability that can potentially be therapeutically exploited. The exact mechanisms of LOY in cancer, and the utility of LOY as a biomarker and therapeutic target, are open questions for the emerging field of Y chromosome-focused cancer research.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"262-274"},"PeriodicalIF":17.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipids grease the chain of cancer progression. 脂质促进了癌症的发展。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-03-01 Epub Date: 2026-01-13 DOI: 10.1016/j.trecan.2025.11.012
Joseph Rupert, Pham Hong Anh Cao, Daniel E Frigo, Mikhail G Kolonin
{"title":"Lipids grease the chain of cancer progression.","authors":"Joseph Rupert, Pham Hong Anh Cao, Daniel E Frigo, Mikhail G Kolonin","doi":"10.1016/j.trecan.2025.11.012","DOIUrl":"10.1016/j.trecan.2025.11.012","url":null,"abstract":"<p><p>The role of lipids in cancer progression has become a fervent area of exploration. The crosstalk of tumors with adipose tissue is a complex but well-regulated orchestration of signaling pathways, lipid transporters, and enzymes. They regulate fatty acid synthesis, their deposition into lipid droplets (LDs) as triglycerides, induction of lipolysis, shuttling lipids across cells, and their systemic trafficking, modification, and catabolism. For the latter, lipid oxidation has emerged as a metabolic process of particular clinical importance. Products of lipid processing can become secondary messengers, contribute to reactive oxygen species (ROS) generation, stimulate the production of antioxidants, and, if left unchecked, activate cell death pathways including ferroptosis. This review discusses recent updates in the field that are anticipated to have therapeutic implications.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"235-247"},"PeriodicalIF":21.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melanoma-secreted melanosome-MHC I disrupts T cell antitumor immunity. 黑色素瘤分泌黑色素体mhc I破坏T细胞抗肿瘤免疫。
IF 21.6 1区 医学
Trends in cancer Pub Date : 2026-03-01 Epub Date: 2026-02-26 DOI: 10.1016/j.trecan.2026.01.014
Yang Liu, Xuetao Cao
{"title":"Melanoma-secreted melanosome-MHC I disrupts T cell antitumor immunity.","authors":"Yang Liu, Xuetao Cao","doi":"10.1016/j.trecan.2026.01.014","DOIUrl":"10.1016/j.trecan.2026.01.014","url":null,"abstract":"<p><p>Classically, major histocompatibility complex class I (MHC I) molecules present tumor antigens to prime CD8<sup>+</sup> T cell immunosurveillance and induce antitumor responses. Recently, Chemla et al. revealed a new immune evasion mechanism of melanoma by exporting peptide-loaded MHC I on secreted melanosomes to act as decoys that confuse and impair cytotoxic CD8<sup>+</sup> T cells.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"215-216"},"PeriodicalIF":21.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural hijacking in cancer metabolism: from nutrients to organelles. 癌症代谢中的神经劫持：从营养物到细胞器。
IF 17.5 1区 医学
Trends in cancer Pub Date : 2026-03-01 Epub Date: 2025-11-28 DOI: 10.1016/j.trecan.2025.11.006
Songhui Shin, Su Yeon Myoung, Hye Jin Cho, Seongjun Kim, Namgyu Lee, Sung Jin Park
{"title":"Neural hijacking in cancer metabolism: from nutrients to organelles.","authors":"Songhui Shin, Su Yeon Myoung, Hye Jin Cho, Seongjun Kim, Namgyu Lee, Sung Jin Park","doi":"10.1016/j.trecan.2025.11.006","DOIUrl":"10.1016/j.trecan.2025.11.006","url":null,"abstract":"<p><p>Tumors dynamically interact with the central and peripheral nervous systems, hijacking neural plasticity and reprogramming metabolism in a bidirectional manner to drive cancer progression. Neural inputs reshape the metabolism of cancer cells and their microenvironment - glycolysis, oxidative phosphorylation, and lipid metabolism - while tumors exploit neuronal nutrients and mitochondria to thrive under metabolic stress. This review explores neurocancer metabolic crosstalk through multiple mechanisms by three principal modes of interaction, highlighting how targeting these metabolic interdependencies could disrupt tumor progression. By integrating cancer metabolism and neuroscience, it offers a conceptual framework for understanding neural-tumor metabolic circuits in malignancy and identifies potential therapeutic vulnerabilities.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"221-234"},"PeriodicalIF":17.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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