smarca4突变型肺癌中SMARCA2降解的分子见解。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI:10.1016/j.trecan.2025.02.002

Kostas A Papavassiliou, Nektarios Anagnostopoulos, Athanasios G Papavassiliou

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引用次数: 0

摘要

开关/蔗糖不可发酵（SWI/SNF）相关BAF染色质重塑复合体亚基atp酶2 （SMARCA2）降解的分子机制仍然是未知的。最近，Kotagiri等人发现，SMARCA2降解诱导smarca4突变肺癌细胞中的增强子重编程，使关键细胞周期基因的增强子无法进入并抑制其表达。此外，作者发现转录增强相关结构域（TEAD）抑制剂与SMARCA2降解物协同作用，抑制smarca4突变肺癌的生长。

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Molecular insights into SMARCA2 degradation in SMARCA4-mutant lung cancers.

The molecular mechanisms of switch/sucrose nonfermentable (SWI/SNF)-related BAF chromatin remodeling complex subunit ATPase 2 (SMARCA2) degradation remain elusive. Recently, Kotagiri et al. revealed that SMARCA2 degradation induces enhancer reprogramming in SMARCA4-mutant lung cancer cells, rendering enhancers of key cell-cycle genes inaccessible and suppressing their expression. In addition, the authors identified that transcriptional enhanced associate domain (TEAD) inhibitors synergize with SMARCA2 degraders in inhibiting SMARCA4-mutant lung cancer growth.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.