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Precision oncology: current and future platforms for treatment selection. 精准肿瘤学：当前和未来的治疗选择平台。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI: 10.1016/j.trecan.2024.06.009
Xinran Tang, Michael F Berger, David B Solit
{"title":"Precision oncology: current and future platforms for treatment selection.","authors":"Xinran Tang, Michael F Berger, David B Solit","doi":"10.1016/j.trecan.2024.06.009","DOIUrl":"10.1016/j.trecan.2024.06.009","url":null,"abstract":"<p><p>Genomic profiling of hundreds of cancer-associated genes is now a component of routine cancer care. DNA sequencing can identify mutations, mutational signatures, and structural alterations predictive of therapy response and assess for heritable cancer risk, but it has been less useful for identifying predictive biomarkers of sensitivity to cytotoxic chemotherapies, antibody drug conjugates, and immunotherapies. The clinical adoption of molecular profiling platforms such as RNA sequencing better suited to identifying those patients most likely to respond to immunotherapies and drug combinations will be critical to expanding the benefits of precision oncology. This review discusses the potential advantages of innovative molecular and functional profiling platforms designed to replace or complement targeted DNA sequencing and the major hurdles to their clinical adoption.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"781-791"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARPi, BRCA, and gaps: controversies and future research. PARPi、BRCA 和差距：争议与未来研究。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 DOI: 10.1016/j.trecan.2024.06.008
Diego Dibitetto, Carmen A Widmer, Sven Rottenberg
{"title":"PARPi, BRCA, and gaps: controversies and future research.","authors":"Diego Dibitetto, Carmen A Widmer, Sven Rottenberg","doi":"10.1016/j.trecan.2024.06.008","DOIUrl":"10.1016/j.trecan.2024.06.008","url":null,"abstract":"<p><p>In recent years, various poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) have been approved for the treatment of several cancers to target the vulnerability of homologous recombination (HR) deficiency (e.g., due to BRCA1/2 dysfunction). In this review we analyze the ongoing debates and recent breakthroughs in the use of PARPis for BRCA1/2-deficient cancers, juxtaposing the 'double-strand break (DSB)' and 'single-stranded DNA (ssDNA) gap' models of synthetic lethality induced by PARPis. We spotlight the complexity of this interaction, highlighting emerging research on the role of DNA polymerase theta (POLθ) and ssDNA gaps in shaping therapy responses. We scrutinize the clinical ramifications of these findings, especially concerning PARPi efficacy and resistance mechanisms, underscoring the heterogeneity of BRCA-mutated tumors and the urgent need for advanced research to bridge the gap between laboratory models and patient outcomes.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"857-869"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mind the gap: why we need to consider teenage and young adult cancers across the research pipeline. 注意差距：为什么我们需要在整个研究过程中考虑青少年癌症？
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1016/j.trecan.2024.06.010
Laura Danielson, Phil Prime, Rosanna Larter
{"title":"Mind the gap: why we need to consider teenage and young adult cancers across the research pipeline.","authors":"Laura Danielson, Phil Prime, Rosanna Larter","doi":"10.1016/j.trecan.2024.06.010","DOIUrl":"10.1016/j.trecan.2024.06.010","url":null,"abstract":"<p><p>Historically, teenage and young adult (TYA) cancers have been understudied, with research largely focussing on paediatric or older adult (OA) indications. With increasing TYA cancer incidence rates internationally, now is the time to focus on teenagers and young adults across the research pipeline to improve not only outcomes but also the quality of life for this underserved group.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"774-776"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic hormone-naïve prostate cancer: a distinct biological entity. 转移性激素无效前列腺癌：一种独特的生物学实体。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1016/j.trecan.2024.06.005
Jon Corres-Mendizabal, Francesca Zacchi, Natalia Martín-Martín, Joaquin Mateo, Arkaitz Carracedo
{"title":"Metastatic hormone-naïve prostate cancer: a distinct biological entity.","authors":"Jon Corres-Mendizabal, Francesca Zacchi, Natalia Martín-Martín, Joaquin Mateo, Arkaitz Carracedo","doi":"10.1016/j.trecan.2024.06.005","DOIUrl":"10.1016/j.trecan.2024.06.005","url":null,"abstract":"<p><p>Metastatic hormone-naïve prostate cancer (mHNPC) is often the initial form of presentation for metastatic prostate cancer and encompasses a heterogeneous patient population with high inter-patient heterogeneity in prognosis and response to therapy. A more precise treatment of mHNPC, guided by evidence-based biomarkers, remains an unmet medical need. In addition, the limited number of representative laboratory models of mHNPC hampers the translation of basic research into clinical applications. We provide a comprehensive overview of the clinical and biological features that characterize mHNPC, highlight molecular data that could explain the unique prognostic characteristics of mHNPC, and identify key open questions.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"825-841"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11397905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small molecules targeting microRNAs: new opportunities and challenges in precision cancer therapy. 靶向 microRNA 的小分子：癌症精准治疗的新机遇与挑战。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 Epub Date: 2024-08-05 DOI: 10.1016/j.trecan.2024.06.006
Ancuta Jurj, Beatrice Fontana, Gabriele Varani, George A Calin
{"title":"Small molecules targeting microRNAs: new opportunities and challenges in precision cancer therapy.","authors":"Ancuta Jurj, Beatrice Fontana, Gabriele Varani, George A Calin","doi":"10.1016/j.trecan.2024.06.006","DOIUrl":"10.1016/j.trecan.2024.06.006","url":null,"abstract":"<p><p>Noncoding RNAs, especially miRNAs, play a pivotal role in cancer initiation and metastasis, underscoring their susceptibility to precise modulation via small molecule inhibitors. This review examines the innovative strategy of targeting oncogenic miRNAs with small drug-like molecules, an approach that can reshape the cancer treatment landscape. We review the current understanding of the multifaceted roles of miRNAs in oncogenesis, highlighting emerging therapeutic paradigms that have the potential to expand cancer treatment options. As research on small molecule inhibitors of miRNA is still in its early stages, ongoing investigative efforts and the development of new technologies and chemical matter are essential to fulfill the significant potential of this innovative approach to cancer treatment.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"809-824"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells. 生物物理景观导航：物理线索如何引导骨转移肿瘤细胞的旅程。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-09-01 Epub Date: 2024-08-10 DOI: 10.1016/j.trecan.2024.07.003
Pengrong Ouyang, Bo Cheng, Xijing He, Jiatao Lou, Xiaokang Li, Hui Guo, Feng Xu
{"title":"Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells.","authors":"Pengrong Ouyang, Bo Cheng, Xijing He, Jiatao Lou, Xiaokang Li, Hui Guo, Feng Xu","doi":"10.1016/j.trecan.2024.07.003","DOIUrl":"10.1016/j.trecan.2024.07.003","url":null,"abstract":"<p><p>Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive. The human skeletal system has unique physical properties, that are distinct from other organs, which play a key role in directing the behavior of tumor cells within bone. Understanding the physical journey of tumor cells within bone is crucial. In this review we discuss bone metastasis in the context of how physical cues in the bone vasculature and bone marrow niche regulate the fate of tumor cells. Our objective is to inspire innovative diagnostic and therapeutic approaches for bone metastasis from a mechanobiological perspective.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"792-808"},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-08-13 DOI: 10.1016/s2405-8033(24)00150-x
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s2405-8033(24)00150-x","DOIUrl":"https://doi.org/10.1016/s2405-8033(24)00150-x","url":null,"abstract":"No Abstract","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"11 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription & copyright page 订阅和版权页面
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-08-13 DOI: 10.1016/s2405-8033(24)00153-5
{"title":"Subscription & copyright page","authors":"","doi":"10.1016/s2405-8033(24)00153-5","DOIUrl":"https://doi.org/10.1016/s2405-8033(24)00153-5","url":null,"abstract":"No Abstract","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"147 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142206024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular toxicity in antitumor therapy: biological and therapeutic insights 抗肿瘤治疗中的心血管毒性：生物学和治疗学见解
IF 18.4 1区 医学
Trends in cancer Pub Date : 2024-08-03 DOI: 10.1016/j.trecan.2024.07.004
{"title":"Cardiovascular toxicity in antitumor therapy: biological and therapeutic insights","authors":"","doi":"10.1016/j.trecan.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.trecan.2024.07.004","url":null,"abstract":"<p>The evolution of antitumor therapies has significantly improved cancer prognosis but has concurrently resulted in cardiovascular toxicities. Understanding the biological mechanisms behind these toxicities is crucial for effective management. Immunotherapy-related cardiovascular toxicities are primarily mediated by immune cells and secreted cytokines. Chemotherapy may cause cardiovascular damage through autophagy disruption and mitochondrial dysfunction. Targeted therapies can induce toxicity through endothelin-1 (ET-1) production and cardiac signaling disruption. Radiotherapy may lead to cardiomyopathy and myocardial fibrosis by affecting endothelial cells, triggering inflammatory responses and accelerating atherosclerosis. This review provides insights into these mechanisms and strategies, aiming to enhance the clinical prevention and treatment of cardiovascular toxicities.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":"141 1","pages":""},"PeriodicalIF":18.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141884005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Watch your clock: it matters for immunotherapy. 注意时间：这对免疫疗法很重要。
IF 14.3 1区 医学
Trends in cancer Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1016/j.trecan.2024.06.004
Nicolas Cermakian, Nathalie Labrecque
{"title":"Watch your clock: it matters for immunotherapy.","authors":"Nicolas Cermakian, Nathalie Labrecque","doi":"10.1016/j.trecan.2024.06.004","DOIUrl":"10.1016/j.trecan.2024.06.004","url":null,"abstract":"<p><p>Does time of day matter for cancer immunotherapy? Whereas the concept of optimizing the time of treatment is well documented for chemotherapy, whether it applies to immunotherapy, a revolutionizing treatment exploiting the power of immune cells to control tumors, has recently been addressed in a study published in Cell.</p>","PeriodicalId":23336,"journal":{"name":"Trends in cancer","volume":" ","pages":"671-672"},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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