愈合时间:抑制纤维化可预防胶质母细胞瘤复发。

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-11-01 Epub Date: 2024-10-02 DOI:10.1016/j.trecan.2024.09.008
Dhanashree Mundhe, Neta Erez
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引用次数: 0

摘要

Watson等人的新发现表明,治疗诱导的炎症和纤维化会加剧胶质母细胞瘤的复发。治疗后的纤维化龛使存活的肿瘤细胞免受免疫监视,支持其持续处于休眠状态,并使其反弹生长。及时抑制炎症和瘢痕可减轻复发,鼓励在胶质母细胞瘤治疗中使用新的组合方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time to heal: inhibiting fibrosis prevents glioblastoma recurrence.

New findings by Watson et al. demonstrate that therapy-induced inflammation and fibrosis potentiate glioblastoma recurrence. Post-treatment fibrotic niches shielded surviving tumor cells from immune surveillance, supported their persistence in a dormant state, and enabled rebound growth. Timely inhibition of inflammation and scarring attenuated recurrence, encouraging the use of new combinatorial approaches in glioblastoma therapy.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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