癌症的血统可塑性和代谢重编程机制。

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI:10.1016/j.trecan.2024.08.001
Lillian M Perez, Smrruthi V Venugopal, Anna St Martin, Stephen J Freedland, Dolores Di Vizio, Michael R Freeman
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引用次数: 0

摘要

癌症发展过程中细胞表型的动态变化归因于一种被称为 "品系可塑性 "的现象。这一过程与治疗耐药性有关,涉及代谢状态的同时转变,这种转变有助于适应恶性肿瘤生长过程中固有的各种压力。某些代谢物还可作为染色质修饰的合成库,从而将代谢状态与表观遗传调控联系起来。目前,我们仍然亟需弄清血统可塑性和代谢重编程的趋同机制,以防止致命疾病的出现。本综述试图概述我们目前对癌症背景下代谢重编程和品系可塑性之间相互作用的理解,强调癌症特征的交叉驱动因素,重点是实体瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms governing lineage plasticity and metabolic reprogramming in cancer.

Dynamic alterations in cellular phenotypes during cancer progression are attributed to a phenomenon known as 'lineage plasticity'. This process is associated with therapeutic resistance and involves concurrent shifts in metabolic states that facilitate adaptation to various stressors inherent in malignant growth. Certain metabolites also serve as synthetic reservoirs for chromatin modification, thus linking metabolic states with epigenetic regulation. There remains a critical need to understand the mechanisms that converge on lineage plasticity and metabolic reprogramming to prevent the emergence of lethal disease. This review attempts to offer an overview of our current understanding of the interplay between metabolic reprogramming and lineage plasticity in the context of cancer, highlighting the intersecting drivers of cancer hallmarks, with an emphasis on solid tumors.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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