利用技术揭示胃癌异质性。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-26 DOI:10.1016/j.trecan.2025.04.011

Yuefan Wang, Ramon U Jin, Joanne Xu, Ding Chiao Lin, Zhenyu Sun, Yuanwei Xu, Qing K Li, Hui Zhang

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引用次数: 0

摘要

胃癌起源于复杂的致癌因子相互作用，由于缺乏可靶向的驱动基因突变和显著的肿瘤异质性，治疗选择有限。最近的研究提供了有希望的新方法，通过整合表征，将基因组学与新兴技术相结合，提高我们对胃癌异质性的理解。明确分子变化，靶向特异性分子亚型，将提高胃癌治疗的疗效，改善临床疗效。本文综述了目前胃癌研究中使用的技术，重点介绍了这些创新驱动的关键发现和治疗策略。最后，我们讨论了新兴的技术导向方向和潜在的突破，可以增强对胃癌肿瘤异质性的认识，最终改善临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Harnessing technologies to unravel gastric cancer heterogeneity.

Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.