黑色素瘤发生和进展的表观遗传机制。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-05 DOI:10.1016/j.trecan.2025.04.007

Hyunjeong Joo, Ximena Diaz Olea, Aojia Zhuang, Bin Zheng, Hyungsoo Kim, Ze'ev A Ronai

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引用次数: 0

摘要

在过去的几十年里，对癌症发展和进展的了解使得绘制肿瘤进化不同阶段特有的遗传和表观遗传变化成为可能。在这里，我们关注的是驱动黑色素瘤发展和进展的表观遗传变化。我们强调表观遗传机制的重要性，包括与影响转移和治疗耐药性的黑色素瘤微环境的串扰。这篇综述总结了最近的进展，并描述了利用这些知识设计新疗法的潜在策略。

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Epigenetic mechanisms in melanoma development and progression.

Knowledge of cancer development and progression gained over the last few decades has enabled mapping of genetic and epigenetic changes unique to different phases of tumor evolution. Here we focus on epigenetic changes that drive melanoma development and progression. We highlight the importance of epigenetic mechanisms which encompass crosstalk with melanoma microenvironment that affect metastasis and therapy resistance. This review summarizes recent advances and describes potential strategies to leverage this knowledge to devise new therapies.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.