癌症相关成纤维细胞的可塑性。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-06-04 DOI:10.1016/j.trecan.2025.04.012

Zihan Xia, Olivier De Wever

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引用次数: 0

摘要

癌症相关成纤维细胞（CAFs）的可塑性是指它们能够在肿瘤微环境（TME）的动态变化中采取不同表型或状态的能力。单细胞技术的最新进展已经能够详细表征多种肿瘤类型中CAF亚群的异质性和空间复杂性。值得注意的是，CAF亚型在肿瘤进展和治疗压力期间发生动态转变。本文系统地总结了目前关于CAF可塑性的知识，包括内因和外因，描述了研究空白，并强调CAF表型转换是一种潜在的治疗机会。

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The plasticity of cancer-associated fibroblasts.

The plasticity of cancer-associated fibroblasts (CAFs) refers to their ability to adopt a spectrum of distinct phenotypes or states in response to dynamic changes within the tumor microenvironment (TME). Recent advances in single-cell technologies have enabled detailed characterization of the heterogeneity and spatial complexity of CAF subpopulations across multiple tumor types. Notably, CAF subtypes undergo dynamic transitions during tumor progression and therapy pressure. This review systematically summarizes the current knowledge on CAF plasticity shaped by both intrinsic and extrinsic factors, delineates research gaps, and highlights CAF phenotypic switching as a potential therapeutic opportunity.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.