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Trends in parasitology最新文献

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Malaria and cancer: common features and interactions. 疟疾和癌症：共同特征和相互作用。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-09-01 Epub Date: 2026-07-30 DOI: 10.1016/j.pt.2026.07.004
Xin-Zhuan Su, Rachel V Stadler, Awet A Teklemichael, Fangzheng Xu, Jian Wu
{"title":"Malaria and cancer: common features and interactions.","authors":"Xin-Zhuan Su, Rachel V Stadler, Awet A Teklemichael, Fangzheng Xu, Jian Wu","doi":"10.1016/j.pt.2026.07.004","DOIUrl":"10.1016/j.pt.2026.07.004","url":null,"abstract":"<p><p>Malaria and cancer are major global health burdens, causing high mortality. While often considered distinct, the two conditions share common features, including continuous cell replication within the body, systemic inflammation, immune modulation and evasion, metabolic reprogramming, endothelial dysfunction, and drug efflux mechanisms. Interestingly, whereas malaria parasite infection promotes Burkitt lymphoma, recent studies in animal models indicate that malaria may activate immune mechanisms against various tumors, thereby improving survival rates. The malaria protein VAR2CSA specifically binds to chondroitin sulfate A in the placenta and metastatic cancer cells, which can be exploited for cancer detection and treatment. Studying the common and unique features of malaria and cancer may facilitate the development of treatment strategies for both diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"861-875"},"PeriodicalIF":7.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging methods in noninvasive parasite surveillance in wildlife disease ecology. 野生动物疾病生态学中寄生虫无创监测的新方法。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-09-01 Epub Date: 2026-07-31 DOI: 10.1016/j.pt.2026.07.006
Tamara Szentiványi, Zsóka Vásárhelyi, László Z Garamszegi
{"title":"Emerging methods in noninvasive parasite surveillance in wildlife disease ecology.","authors":"Tamara Szentiványi, Zsóka Vásárhelyi, László Z Garamszegi","doi":"10.1016/j.pt.2026.07.006","DOIUrl":"10.1016/j.pt.2026.07.006","url":null,"abstract":"<p><p>Noninvasive approaches are increasingly reshaping parasite and disease surveillance by reducing stress and harm to hosts while expanding opportunities for ecological and epidemiological research. In this opinion article, we discuss these emerging approaches, which rely on molecular, citizen-science, and computational methods, for monitoring parasites, vectors, and hosts. These tools can improve spatial and temporal coverage, support the surveillance of rare or threatened hosts and parasites, and contribute to the understanding of transmission pathways and disease dynamics. However, their reliability depends on careful validation, standardized protocols, and awareness of methodological limitations. While not direct substitutes for invasive methods, these approaches lift a considerable burden from wildlife. Integrating noninvasive approaches thus provides a strong basis for advancing disease ecology, wildlife health monitoring, and biodiversity conservation.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"808-819"},"PeriodicalIF":7.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissection versus PCR: Malaria vector incrimination in the molecular era. 解剖与PCR：分子时代的疟疾病媒定罪。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-09-01 Epub Date: 2026-07-13 DOI: 10.1016/j.pt.2026.06.011
Indra Vythilingam, Nantha K Jeyaprakasam, Seth R Irish, Kimberly Fornace
{"title":"Dissection versus PCR: Malaria vector incrimination in the molecular era.","authors":"Indra Vythilingam, Nantha K Jeyaprakasam, Seth R Irish, Kimberly Fornace","doi":"10.1016/j.pt.2026.06.011","DOIUrl":"10.1016/j.pt.2026.06.011","url":null,"abstract":"<p><p>Nonhuman primate (NHP) malaria threatens Southeast Asia's 2030 elimination goals as human infections rise across the region. Identifying the correct vectors is important for controlling the disease. This forum advocates for integrating dissection with polymerase chain reaction to ensure precise identification of the vectors driving NHP malaria infections in humans.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"804-807"},"PeriodicalIF":7.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensing the enemy within: Vγ9Vδ2 T cells as metabolic sensors of intracellular parasites. 感应内部的敌人：Vγ9Vδ2 T细胞作为细胞内寄生虫的代谢传感器。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-09-01 Epub Date: 2026-08-01 DOI: 10.1016/j.pt.2026.07.007
Felipe Rodriguez, Jeroen P J Saeij
{"title":"Sensing the enemy within: Vγ9Vδ2 T cells as metabolic sensors of intracellular parasites.","authors":"Felipe Rodriguez, Jeroen P J Saeij","doi":"10.1016/j.pt.2026.07.007","DOIUrl":"10.1016/j.pt.2026.07.007","url":null,"abstract":"<p><p>V gamma 9 V delta 2 (Vγ9Vδ2) T cells, the predominant γδ T cell population in human peripheral blood, uniquely recognize nonpeptidic phosphoantigens (pAgs) independent of major histocompatibility complex molecules. This sensing mechanism relies on intracellular pAg accumulation, which triggers heteromeric cooperation between transmembrane butyrophilin 3A1 (BTN3A1) and butyrophilin 2A1 (BTN2A1) receptors to activate the γδ T cell receptor. This review synthesizes current knowledge of Vγ9Vδ2 T cell immunobiology, focusing on responses to Plasmodium falciparum and Toxoplasma gondii. We examine how these cells detect parasite- or host-derived pAgs to drive rapid cytotoxicity and interferon gamma production. Understanding these sensing mechanisms offers novel insights for harnessing γδ T cells in antiparasitic therapies and vaccine design.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"846-860"},"PeriodicalIF":7.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement C1q-binding protein at the host-protozoan interface: knowns and unknowns. 宿主-原生动物界面的补体c1q结合蛋白：已知和未知。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-09-01 Epub Date: 2026-07-21 DOI: 10.1016/j.pt.2026.07.001
Sajad Rashidi, Kurosh Kalantar, Seppo Meri
{"title":"Complement C1q-binding protein at the host-protozoan interface: knowns and unknowns.","authors":"Sajad Rashidi, Kurosh Kalantar, Seppo Meri","doi":"10.1016/j.pt.2026.07.001","DOIUrl":"10.1016/j.pt.2026.07.001","url":null,"abstract":"<p><p>Complement C1q-binding protein (C1QBP) is exploited by protozoan parasites. In this forum, we summarize direct evidence for C1QBP as an adhesion receptor (Plasmodium) and an immune subversion target (Toxoplasma), highlight gaps, and propose research priorities to define C1QBP as a multifunctional signaling hub at the host-parasite interface.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"794-797"},"PeriodicalIF":7.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden diversity in Trichuris control. 真菌控制中隐藏的多样性。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-08-01 Epub Date: 2026-07-04 DOI: 10.1016/j.pt.2026.06.009
Josué de Moraes, Lucas Fukui-Silva, Dora Buonfrate
{"title":"Hidden diversity in Trichuris control.","authors":"Josué de Moraes, Lucas Fukui-Silva, Dora Buonfrate","doi":"10.1016/j.pt.2026.06.009","DOIUrl":"10.1016/j.pt.2026.06.009","url":null,"abstract":"<p><p>Recent advances in combination therapies have improved trichuriasis treatment, yet efficacy remains highly variable. Emerging genomic, clinical, and epidemiological evidence suggests that this variability may reflect hidden biological diversity rather than operational factors alone. Recognizing this complexity is essential to align control strategies with parasite biology and achieve sustainable outcomes.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"689-693"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fragmented rRNAs and lineage-specific RNA-binding proteins define myzozoan mitoribosomes. 碎片化的rnas和谱系特异性的rna结合蛋白定义了myzoan的线粒体。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-08-01 Epub Date: 2026-05-30 DOI: 10.1016/j.pt.2026.05.008
Chaoyue Wang, Sari Kassem, Xun Suo, Dominique Soldati-Favre, Yonggen Jia
{"title":"Fragmented rRNAs and lineage-specific RNA-binding proteins define myzozoan mitoribosomes.","authors":"Chaoyue Wang, Sari Kassem, Xun Suo, Dominique Soldati-Favre, Yonggen Jia","doi":"10.1016/j.pt.2026.05.008","DOIUrl":"10.1016/j.pt.2026.05.008","url":null,"abstract":"<p><p>Myzozoa, a clade of alveolate protists including Apicomplexa, Chromerida, Perkinsozoa, and dinoflagellates, possesses the most reduced mitochondrial genomes among eukaryotes. Apicomplexan parasites, such as Toxoplasma gondii and Plasmodium spp., retain mitochondrial genomes encoding only three proteins and highly fragmented rRNAs. Despite this reduction, recent structural studies show that T. gondii mitoribosome incorporates lineage-specific RNA-binding proteins as integral components to maintain a functional complex composed of over 50 rRNA fragments. The conservation of rRNA fragmentation and protein repertoire observed among Apicomplexa suggests a shared evolution within the phylum. This radical divergence from all other currently investigated cytoplasmic and mitochondrial ribosomes highlights evolutionary plasticity and common ancestry, providing a model for studying mitochondrial evolution and potential antiparasitic drug discovery.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"749-762"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequencing parasite genomes, one worm at a time. 测序寄生虫的基因组，一次一个蠕虫。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-08-01 Epub Date: 2026-07-06 DOI: 10.1016/j.pt.2026.06.006
Lewis Stevens, Stephen R Doyle
{"title":"Sequencing parasite genomes, one worm at a time.","authors":"Lewis Stevens, Stephen R Doyle","doi":"10.1016/j.pt.2026.06.006","DOIUrl":"10.1016/j.pt.2026.06.006","url":null,"abstract":"<p><p>Genomes are central to understanding how parasitic worms-a taxonomically diverse group comprising roundworms (nematodes) and flatworms (platyhelminths)-adapt to and persist in their hosts and environments. The ongoing genomics revolution is delivering high-quality genomes across the tree of life, but parasitic worms risk being left behind due to limited sample accessibility, low DNA yield, and high genetic diversity. Advances in whole-genome amplification and long-read sequencing now allow high-quality genomes to be generated from individual worms. We argue that these approaches will drive a rapid increase in the quality and diversity of parasitic worm reference genomes and enable a transition toward pangenomes that fully capture within-species variation. Together, these advances will provide a more complete understanding of parasitic worm biology.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"694-704"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of generalism under Muller's ratchet. 穆勒棘轮下通才论的演变。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-08-01 Epub Date: 2026-06-27 DOI: 10.1016/j.pt.2026.06.003
Cock van Oosterhout
{"title":"Evolution of generalism under Muller's ratchet.","authors":"Cock van Oosterhout","doi":"10.1016/j.pt.2026.06.003","DOIUrl":"10.1016/j.pt.2026.06.003","url":null,"abstract":"<p><p>Host-range expansion in parasites is usually framed as an adaptive response to heterogeneous environments and trade-offs. In this opinion article, I propose Ratchet-Driven Generalism (RDG): in some parasites, broad host range may instead arise non-adaptively after the loss of sexual recombination. Under Muller's ratchet, deleterious mutations accumulate in asexual or rarely recombining lineages. Over time, genomic erosion can degrade host-specific adaptations, including host-interaction genes. In parallel, reduced competitive filtering among parasite genotypes can weaken selection for host-specific performance. Consequently, genotypes that are merely viable across hosts may persist. RDG predicts genomic signatures of functional decay and reduced efficacy of selection. It also suggests that such generalism may be transient, because continued genomic erosion can increase extinction risk. I outline comparative genomic tests to examine RDG.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"705-715"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aedes japonicus (Asian bush mosquito). 日本伊蚊（亚洲灌木蚊）。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-08-01 Epub Date: 2026-07-09 DOI: 10.1016/j.pt.2026.06.008
Takele A Kassegn, Zhancheng Tian, Temesgen K Getahun, Hong Yin
{"title":"Aedes japonicus (Asian bush mosquito).","authors":"Takele A Kassegn, Zhancheng Tian, Temesgen K Getahun, Hong Yin","doi":"10.1016/j.pt.2026.06.008","DOIUrl":"10.1016/j.pt.2026.06.008","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"781-782"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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