Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-01-31DOI: 10.1016/j.pt.2025.01.003
Sugandika Bulumulla, Lihua Xiao, Yaoyu Feng, Amanda Ash, Una Ryan, Amanda D Barbosa
{"title":"Update on transmission of zoonotic Giardia in cattle.","authors":"Sugandika Bulumulla, Lihua Xiao, Yaoyu Feng, Amanda Ash, Una Ryan, Amanda D Barbosa","doi":"10.1016/j.pt.2025.01.003","DOIUrl":"10.1016/j.pt.2025.01.003","url":null,"abstract":"<p><p>Giardia is the most common protozoan cause of diarrhoeal illness in humans worldwide. Despite this, our understanding of the zoonotic transmission of Giardia, and in particular the role of cattle as a zoonotic reservoir, is not well understood, due to the limitations of current typing systems and a recent taxonomic revision of the genus. Newly improved multilocus sequencing typing tools are not yet widely used and are not applicable to all species. However, data generated to date suggest that zoonotic transmission of Giardia of bovine origin is limited. Carefully designed epidemiological investigations using improved typing tools are essential to understand the extent of zoonotic transmission from cattle. Improved on-farm biosecurity measures are also needed to control the transmission of zoonotic Giardia in cattle.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"210-221"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-13DOI: 10.1016/j.pt.2025.01.012
Bart Everts
{"title":"Helminths target macrophage epigenetics and metabolism to evade immunity.","authors":"Bart Everts","doi":"10.1016/j.pt.2025.01.012","DOIUrl":"10.1016/j.pt.2025.01.012","url":null,"abstract":"<p><p>Parasitic helminths are well known master regulators of host immune responses. Yet, the underlying molecular principles remain largely enigmatic. Recent work from Bohnacker et al. reveals that glutamate dehydrogenase (GDH), a metabolic enzyme secreted by Heligmosomoides polygyrus, can suppress type 2 immunity by multimodal regulation of macrophage metabolism and epigenetics.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"172-174"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-10DOI: 10.1016/j.pt.2025.01.008
Liwang Cui
{"title":"Predicting Plasmodium drug resistance through in vitro evolution.","authors":"Liwang Cui","doi":"10.1016/j.pt.2025.01.008","DOIUrl":"10.1016/j.pt.2025.01.008","url":null,"abstract":"<p><p>Knowledge about the resistibility and targets of compounds critically informs antimalarial drug development. Luth et al. systematically analyzed the resistome of Plasmodium falciparum through in vitro evolution and whole-genome analysis of 724 clones resistant to 118 compounds, revealing novel drug targets, multidrug resistance loci, and key determinants of resistance.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"170-171"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maarten P M Vanhove, Antoine Pariselle, Nikol Kmentová
{"title":"Cichlidogyrus casuarinus.","authors":"Maarten P M Vanhove, Antoine Pariselle, Nikol Kmentová","doi":"10.1016/j.pt.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.pt.2025.01.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-02-01Epub Date: 2025-01-16DOI: 10.1016/j.pt.2024.12.014
Surendra K Prajapati, Kim C Williamson
{"title":"Genome-scale, functional screen of Plasmodium sexual replication.","authors":"Surendra K Prajapati, Kim C Williamson","doi":"10.1016/j.pt.2024.12.014","DOIUrl":"10.1016/j.pt.2024.12.014","url":null,"abstract":"<p><p>Malaria mortality remains above 500 000 people annually, demonstrating the need for new and innovative control approaches. Using a genome-scale, functional screen of Plasmodium sexual replication, Sayers et al. identified over 300 genes essential for malaria transmission through the mosquito, providing many new candidates for drug and vaccine development.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"80-82"},"PeriodicalIF":7.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-02-01Epub Date: 2025-01-09DOI: 10.1016/j.pt.2024.12.006
Ben Lukubye, David J Civitello
{"title":"Integrating hybridization and introgression into host-parasite epidemiology, ecology, and evolution.","authors":"Ben Lukubye, David J Civitello","doi":"10.1016/j.pt.2024.12.006","DOIUrl":"10.1016/j.pt.2024.12.006","url":null,"abstract":"<p><p>Hybridization and introgression between host species or between parasite species are emerging challenges for human, plant, and animal health, especially as global trends like climate change and urbanization increase overlap of species ranges. This creates opportunities for heterospecific crosses between diverged taxa that could generate novel host and parasite genotypes with unique traits (e.g., transmission rate, virulence, susceptibility, and resistance) compared with their parental taxa. However, there seems to be slow appreciation of this biological phenomenon in empirical and theoretical approaches to host-parasite interactions. This limits our understanding of the effects of hybridization on epidemiology, ecology, and evolution. Here, we address some pressing questions regarding the emergence and relevance of eukaryotic hybrid genotypes for disease dynamics.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"129-137"},"PeriodicalIF":7.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-02-01Epub Date: 2025-01-07DOI: 10.1016/j.pt.2024.12.005
Isabela de Brito Duval, Marcelo Eduardo Cardozo, Jorge Lucas Nascimento Souza, Ramayana Morais de Medeiros Brito, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Luisa Mourão Dias Magalhães
{"title":"Parasite infections: how inflammation alters brain function.","authors":"Isabela de Brito Duval, Marcelo Eduardo Cardozo, Jorge Lucas Nascimento Souza, Ramayana Morais de Medeiros Brito, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Luisa Mourão Dias Magalhães","doi":"10.1016/j.pt.2024.12.005","DOIUrl":"10.1016/j.pt.2024.12.005","url":null,"abstract":"<p><p>Parasitic infections can profoundly impact brain function through inflammation within the central nervous system (CNS). Once viewed as an immune-privileged site, the CNS is now recognized as vulnerable to immune disruptions from both local and systemic infections. Recent studies reveal that certain parasites, such as Toxoplasma gondii and Plasmodium falciparum, can invade the CNS or influence it indirectly by triggering neuroinflammation. These processes may disrupt brain homeostasis, influence neurotransmission, and lead to significant behavioral or cognitive changes. This review discusses the pathways by which parasites disrupt CNS function and highlights systemic inflammation as a critical link between peripheral infections and neuroinflammatory conditions, advancing understanding of parasite-associated neurological complications.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"115-128"},"PeriodicalIF":7.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}