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Trends in parasitology最新文献

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The type 2 immune response in gut homeostasis and parasite transmission in malaria. 肠道稳态中的2型免疫反应和疟疾中的寄生虫传播。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI: 10.1016/j.pt.2024.11.007
Nora Céspedes, Renée M Tsolis, Adrian M Piliponsky, Shirley Luckhart
{"title":"The type 2 immune response in gut homeostasis and parasite transmission in malaria.","authors":"Nora Céspedes, Renée M Tsolis, Adrian M Piliponsky, Shirley Luckhart","doi":"10.1016/j.pt.2024.11.007","DOIUrl":"10.1016/j.pt.2024.11.007","url":null,"abstract":"<p><p>Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"38-51"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMC1g knockdowns reveal malaria blood-stage alveolin functions. IMC1g 基因敲除揭示了疟疾血期肺泡素的功能。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1016/j.pt.2024.11.012
Annie Z Tremp, Sadia Saeed, Johannes T Dessens
{"title":"IMC1g knockdowns reveal malaria blood-stage alveolin functions.","authors":"Annie Z Tremp, Sadia Saeed, Johannes T Dessens","doi":"10.1016/j.pt.2024.11.012","DOIUrl":"10.1016/j.pt.2024.11.012","url":null,"abstract":"<p><p>Plasmodium alveolins are cytoskeletal proteins with important roles in cell shape, tensile strength, and motility of mosquito-stage ookinetes and sporozoites. Two recent studies by Cepeda Diaz et al. and Liu et al. employ inducible knockdown of the essential blood-stage-expressed alveolin IMC1g to identify new roles in merozoite intracellular survival, schizogonic cell division, and male gametogenesis.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"16-18"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPPIRIT: a network connecting Scottish early-career researchers in parasitology. 精神：一个连接苏格兰早期寄生虫学研究人员的网络。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI: 10.1016/j.pt.2024.11.009
Rebecca C S Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C Ridgway
{"title":"SPPIRIT: a network connecting Scottish early-career researchers in parasitology.","authors":"Rebecca C S Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C Ridgway","doi":"10.1016/j.pt.2024.11.009","DOIUrl":"10.1016/j.pt.2024.11.009","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"8-12"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do tissue-dwelling trypanosomes sustain transmission populations? 生活在组织中的锥虫能维持传播种群吗？
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1016/j.pt.2024.12.001
Stephen D Larcombe, Jane C Munday, Richard McCulloch
{"title":"Do tissue-dwelling trypanosomes sustain transmission populations?","authors":"Stephen D Larcombe, Jane C Munday, Richard McCulloch","doi":"10.1016/j.pt.2024.12.001","DOIUrl":"10.1016/j.pt.2024.12.001","url":null,"abstract":"<p><p>Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite's major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"13-15"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Entering the spatial age of parasite genomics. 进入寄生虫基因组学的空间时代。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.pt.2024.11.010
Sarah K Buddenborg, Stephen R Doyle
{"title":"Entering the spatial age of parasite genomics.","authors":"Sarah K Buddenborg, Stephen R Doyle","doi":"10.1016/j.pt.2024.11.010","DOIUrl":"10.1016/j.pt.2024.11.010","url":null,"abstract":"<p><p>Reconciling organism-scale biology at cellular-scale resolution has been a monumental challenge. Recently, Gramberg et al. uncovered the spatial organisation of gene expression in the common liver fluke, Fasciola hepatica. These data provide new insights and opportunities for understanding the fundamental developmental and functional biology of parasites and new targets for control.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"19-21"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From invasion to outbreak: tick introductions and disease. 从入侵到爆发：蜱虫的引入和疾病。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1016/j.pt.2024.11.005
Payton Phillips, Mekala Sundaram
{"title":"From invasion to outbreak: tick introductions and disease.","authors":"Payton Phillips, Mekala Sundaram","doi":"10.1016/j.pt.2024.11.005","DOIUrl":"10.1016/j.pt.2024.11.005","url":null,"abstract":"<p><p>Introductions of tick disease vectors are inevitable in our changing world. While recent attention to tick invasions has increased following prominent invasion events worldwide, our understanding of how tick community ecology drives infection dynamics is lacking. Interactions between invasive and resident ticks can have profound impacts on human diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"24-27"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmania (Leishmania) amazonensis. 亚马逊利什曼病（利什曼病）。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1016/j.pt.2024.10.023
Marcus S A Garcia, Virlânio A Oliveira Filho, Mariana B C Brioschi, Karen Minori, Danilo Ciccone Miguel
{"title":"Leishmania (Leishmania) amazonensis.","authors":"Marcus S A Garcia, Virlânio A Oliveira Filho, Mariana B C Brioschi, Karen Minori, Danilo Ciccone Miguel","doi":"10.1016/j.pt.2024.10.023","DOIUrl":"10.1016/j.pt.2024.10.023","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"66-67"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhipicephalus microplus (Southern cattle tick; Asian blue tick). 微型鼻头蜱(南方牛蜱；亚洲蓝蜱)。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.pt.2024.11.004
Kennan Oyen, Karen C Poh
{"title":"Rhipicephalus microplus (Southern cattle tick; Asian blue tick).","authors":"Kennan Oyen, Karen C Poh","doi":"10.1016/j.pt.2024.11.004","DOIUrl":"10.1016/j.pt.2024.11.004","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"68-69"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular interactions between male and female schistosomes - a role for remote communication? 雌雄血吸虫的分子相互作用——远程通讯的作用？
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/j.pt.2024.11.008
Anthony J Walker, Gabriel Rinaldi, Eman M N Shakir
{"title":"Molecular interactions between male and female schistosomes - a role for remote communication?","authors":"Anthony J Walker, Gabriel Rinaldi, Eman M N Shakir","doi":"10.1016/j.pt.2024.11.008","DOIUrl":"10.1016/j.pt.2024.11.008","url":null,"abstract":"<p><p>Persistent physical interaction between male and female schistosome adult worms has long been shown to be crucial for their development and sexual maturation, particularly for the female. Although not fully understood, worm pairing promotes local molecular communication between sexes, driving gonad and vitellaria differentiation. In this opinion article we (i) summarise evidence concerning molecular interactions underlying the physical pairing, and (ii) propose a new paradigm whereby remote male-female molecular communication may play an overlooked role in parasite sexual maturation. In this context we discuss recent research that supports both physical and remote male-female interactions driving differentiation of the gonads/vitellaria. This remote communication between sexes may be mediated by excretory-secretory products (ESPs). Integrated hypotheses are presented to stimulate research in this important and emerging field.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"28-37"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental malaria and circumsporozoite protein-specific immunity. 胎盘疟疾和环孢子虫蛋白特异性免疫。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1016/j.pt.2024.11.003
Lars Hviid, Nicaise Tuikue Ndam, Stephen J Rogerson
{"title":"Placental malaria and circumsporozoite protein-specific immunity.","authors":"Lars Hviid, Nicaise Tuikue Ndam, Stephen J Rogerson","doi":"10.1016/j.pt.2024.11.003","DOIUrl":"10.1016/j.pt.2024.11.003","url":null,"abstract":"<p><p>Circumsporozoite protein-specific active and passive immunization can protect significantly against Plasmodium falciparum malaria and are being considered as tools to prevent placental malaria. Despite recent encouraging findings, a closer view of the underlying biology indicates significant challenges to preventing placental malaria.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"22-23"},"PeriodicalIF":7.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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