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What is needed to achieve effective and sustainable control of African animal trypanosomosis? 要实现对非洲动物锥虫病的有效和可持续控制，需要做些什么？
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-23 DOI: 10.1016/j.pt.2024.06.013
Liam J Morrison, Michael P Barrett, Pieter C Steketee, Giuliano Cecchi, Oliver Kijanga, Furaha Mramba, Harriet K Auty
{"title":"What is needed to achieve effective and sustainable control of African animal trypanosomosis?","authors":"Liam J Morrison, Michael P Barrett, Pieter C Steketee, Giuliano Cecchi, Oliver Kijanga, Furaha Mramba, Harriet K Auty","doi":"10.1016/j.pt.2024.06.013","DOIUrl":"10.1016/j.pt.2024.06.013","url":null,"abstract":"<p><p>A welcome resurgence in African animal trypanosomosis (AAT) research has resulted in advances in capabilities, foundational datasets, and understanding. Additionally, there is the prospect of the first new trypanocide in >60 years. However, it is vital to ensure that advances translate to improved and sustainable control in the field. A recent meeting, the Symposium on African Livestock Trypanosomes - Tanzania, convened stakeholders from across the spectrum of AAT research and control to ask how this can be achieved. Current constraints on progress were defined, as were critical gaps and opportunities that need addressing. There is a requirement and opportunity for the AAT research community to communicate, collaborate, and coordinate to maintain momentum and achieve the ultimate goal of sustainable AAT control.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"679-686"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional symbiosis in ticks: singularities of the genus Ixodes. 蜱虫的营养共生：伊科虫属的奇特性。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1016/j.pt.2024.06.006
Olivier Duron
{"title":"Nutritional symbiosis in ticks: singularities of the genus Ixodes.","authors":"Olivier Duron","doi":"10.1016/j.pt.2024.06.006","DOIUrl":"10.1016/j.pt.2024.06.006","url":null,"abstract":"<p><p>Symbiosis with intracellular bacteria is essential for the nutrition of ticks, particularly through the biosynthesis of B vitamins. Yet, ticks of the genus Ixodes, which include major vectors of human pathogens, lack the nutritional symbionts usually found in other tick genera. This paradox raises questions about the mechanisms that Ixodes ticks use to prevent nutritional deficiencies. Nonetheless, Ixodes ticks commonly harbor other symbionts belonging to the order Rickettsiales. Although these obligate intracellular bacteria are primarily known as human pathogens, Rickettsiales symbionts often dominate the Ixodes microbial community without causing diseases. They also significantly influence Ixodes physiology, synthesize key B vitamins, and are crucial for immatures. These findings underscore unique associations between Rickettsiales and Ixodes ticks distinct from other tick genera.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"696-706"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paediatric schistosomiasis: last mile preparations for deploying paediatric praziquantel. 小儿血吸虫病：部署小儿吡喹酮的最后准备工作。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-19 DOI: 10.1016/j.pt.2024.06.011
Francisca Mutapi, Amadou Garba, Mark Woolhouse, Paul Kazyoba
{"title":"Paediatric schistosomiasis: last mile preparations for deploying paediatric praziquantel.","authors":"Francisca Mutapi, Amadou Garba, Mark Woolhouse, Paul Kazyoba","doi":"10.1016/j.pt.2024.06.011","DOIUrl":"10.1016/j.pt.2024.06.011","url":null,"abstract":"<p><p>Schistosomiasis is the second most important parasitic disease of public health importance in Africa, affecting over 50 million children aged <5 years old. Schistosomiasis control has focused on treating school-aged children (>6 years) and adults through mass drug administration (MDA). Following the recent development of a paediatric praziquantel (PZQ) formulation for children aged <5 years, there are now concerted efforts to determine optimal and effective ways to integrate treatment of these children into national schistosomiasis control programmes. In this opinion article we outline the pathway for successful drug access, delivery, and mainstreaming of the new formulation in endemic country health systems. Effective and sustained paediatric schistosomiasis treatment is an important target of the 2030 World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"687-695"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards minimizing second-generation mis-identification of Blastocystis. 尽量减少对 Blastocystis 的第二代错误识别。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI: 10.1016/j.pt.2024.06.001
Christen Rune Stensvold, Lee O'Brien Andersen, Eleni Gentekaki
{"title":"Towards minimizing second-generation mis-identification of Blastocystis.","authors":"Christen Rune Stensvold, Lee O'Brien Andersen, Eleni Gentekaki","doi":"10.1016/j.pt.2024.06.001","DOIUrl":"10.1016/j.pt.2024.06.001","url":null,"abstract":"<p><p>At least 1-2% of DNA sequences annotated as Blastocystis in GenBank represent organisms other than Blastocystis or sequence artefacts. As well as being biologically incorrect, such practice can lead to overestimates of genetic diversity, underestimated host specificity, and incorrect classification of samples tested for Blastocystis using DNA-based methods.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"670-674"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malaria endemicity linked to shorter telomeres in leukocytes. 疟疾流行与白细胞端粒缩短有关。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1016/j.pt.2024.06.017
Gavin Band, Ellen M Leffler
{"title":"Malaria endemicity linked to shorter telomeres in leukocytes.","authors":"Gavin Band, Ellen M Leffler","doi":"10.1016/j.pt.2024.06.017","DOIUrl":"10.1016/j.pt.2024.06.017","url":null,"abstract":"<p><p>Leukocyte telomere length is a highly polygenic trait that has been associated with a complex range of lifestyle factors and disease risk. McQuillan et al.'s results comparing telomere length to malaria incidence rates suggest that infections may be another important factor, possibly through permanent shortening of telomeres in hematopoietic progenitor cells.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"660-661"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weep and sweep and the broom: tuft cell acetylcholine limits the worm. 哭泣、扫地和扫帚：丛细胞乙酰胆碱限制了蠕虫。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1016/j.pt.2024.06.014
Alexander Perniss, Lora G Bankova
{"title":"Weep and sweep and the broom: tuft cell acetylcholine limits the worm.","authors":"Alexander Perniss, Lora G Bankova","doi":"10.1016/j.pt.2024.06.014","DOIUrl":"10.1016/j.pt.2024.06.014","url":null,"abstract":"<p><p>Two studies defined how tuft cell acetylcholine promotes parasite expulsion. Billip et al. demonstrated that acetylcholine increases water secretion, to promote the 'weep' response. Ndjim et al. found that tuft cell acetylcholine has a direct effect on worm fecundity. Both processes are only effective in the remodeled epithelium when the rare tuft cells have become abundant.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"664-666"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BioMalPar XX: looking back on, and forward from, 20 years of malaria research. BioMalPar XX：回顾和展望 20 年来的疟疾研究。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1016/j.pt.2024.06.012
Nedal-Djamil Darif, Markus Ganter, Jerzy Michal Dziekan, Nicole Kilian, Nicolas Brancucci, Caroline Ng, Laura E de Vries, David Guttery, Nisha Philip, Justin A Boddey, Nahla Galal Metwally, Fredros Okumu, Taco W A Kooij, Sabrina Absalon, Jessica M Bryant
{"title":"BioMalPar XX: looking back on, and forward from, 20 years of malaria research.","authors":"Nedal-Djamil Darif, Markus Ganter, Jerzy Michal Dziekan, Nicole Kilian, Nicolas Brancucci, Caroline Ng, Laura E de Vries, David Guttery, Nisha Philip, Justin A Boddey, Nahla Galal Metwally, Fredros Okumu, Taco W A Kooij, Sabrina Absalon, Jessica M Bryant","doi":"10.1016/j.pt.2024.06.012","DOIUrl":"10.1016/j.pt.2024.06.012","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"651-656"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Plasmodium falciparum perinuclear var gene expression site. 解密恶性疟原虫核周变异基因表达位点。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-06-22 DOI: 10.1016/j.pt.2024.06.002
Gretchen Diffendall, Artur Scherf
{"title":"Deciphering the Plasmodium falciparum perinuclear var gene expression site.","authors":"Gretchen Diffendall, Artur Scherf","doi":"10.1016/j.pt.2024.06.002","DOIUrl":"10.1016/j.pt.2024.06.002","url":null,"abstract":"<p><p>The protozoan parasite Plasmodium falciparum, responsible for the deadliest form of human malaria, employs antigenic variation via monoallelic expression as a key survival strategy. The selective activation of one out of the 60-member var gene family is key to understanding the parasite's ability to cause severe disease and evade the host immune response. var gene activation is initiated by its relocation to a specialized expression site. While the perinuclear expression site (PES) plays a crucial role in enabling the expression of a single allele, the characteristics of this PES remain largely obscure. Recent breakthroughs in genome editing tools and the discovery of regulatory noncoding RNAs have shed light on this intriguing biological feature, offering significant insights into the mechanisms of pathogen virulence.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"707-716"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spirocerca lupi. 刺杀狼群
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-05-10 DOI: 10.1016/j.pt.2024.04.014
Paula Alfaro-Segura, Gad Baneth, Alicia Rojas
{"title":"Spirocerca lupi.","authors":"Paula Alfaro-Segura, Gad Baneth, Alicia Rojas","doi":"10.1016/j.pt.2024.04.014","DOIUrl":"10.1016/j.pt.2024.04.014","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"763-764"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A breath of fresh air: impact of insect-borne protozoan parasites on the respiratory system. 呼吸新鲜空气：虫媒原生动物寄生虫对呼吸系统的影响。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1016/j.pt.2024.06.010
Sergio Araujo, Dorien Mabille, Alvaro Baeza Garcia, Guy Caljon
{"title":"A breath of fresh air: impact of insect-borne protozoan parasites on the respiratory system.","authors":"Sergio Araujo, Dorien Mabille, Alvaro Baeza Garcia, Guy Caljon","doi":"10.1016/j.pt.2024.06.010","DOIUrl":"10.1016/j.pt.2024.06.010","url":null,"abstract":"<p><p>The protozoan parasites Plasmodium, Leishmania, and Trypanosoma are transmitted by hematophagous insects and cause severe diseases in humans. These infections pose a global threat, particularly in low-resource settings, and are increasingly extending beyond the current endemic regions. Tropism of parasites is crucial for their development, and recent studies have revealed colonization of noncanonical tissues, aiding their survival and immune evasion. Despite receiving limited attention, cumulative evidence discloses the respiratory system as a significant interface for host-pathogen interactions, influencing the course of (co)infection and disease onset. Due to its pathophysiological and clinical implications, we emphasize that further research is needed to better understand the involvement of the respiratory system and its potential to improve prevention, diagnosis, treatment, and interruption of the chain of transmission.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"717-730"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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