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Trends in parasitology最新文献

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Human antibodies against Anopheles salivary proteins: emerging biomarkers of mosquito and malaria exposure. 人抗唾液按蚊蛋白抗体：蚊子和疟疾暴露的新生物标志物。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.1016/j.pt.2025.03.009
Ellen A Kearney, Ashleigh S Heng-Chin, Katherine O'Flaherty, Freya J I Fowkes
{"title":"Human antibodies against Anopheles salivary proteins: emerging biomarkers of mosquito and malaria exposure.","authors":"Ellen A Kearney, Ashleigh S Heng-Chin, Katherine O'Flaherty, Freya J I Fowkes","doi":"10.1016/j.pt.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.pt.2025.03.009","url":null,"abstract":"<p><p>Antibodies developed against Anopheles mosquito salivary proteins injected during biting may serve as proxy biomarkers of Anopheles biting exposure. Anti-salivary biomarkers are being increasingly investigated, with ~60 studies published to date, mostly identifying positive associations with Anopheles human biting rates (HBRs). However, several literature gaps must be addressed to inform the application of anti-salivary biomarkers for serosurveillance of vector exposure and malaria transmission and in vector-control trials. We highlight the need for more studies that collect HBRs and antibody data contemporaneously, investigate novel antigens for non-African Anopheles species, and characterize antibody kinetics to understand how biomarkers can track changes in exposure over time. Together, these directions may improve upon insensitive manual mosquito catch techniques and strengthen malaria surveillance programs.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"41 5","pages":"361-373"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Holding hands to halt malaria: stronger together through heterotypic antibody interactions. 携手遏制疟疾：通过异型抗体相互作用共同增强。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1016/j.pt.2025.04.004
Evelien M Bunnik, Sebastiaan Bol, Gregory C Ippolito
{"title":"Holding hands to halt malaria: stronger together through heterotypic antibody interactions.","authors":"Evelien M Bunnik, Sebastiaan Bol, Gregory C Ippolito","doi":"10.1016/j.pt.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.pt.2025.04.004","url":null,"abstract":"<p><p>Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"41 5","pages":"337-338"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding arthropod vector immunology through bona fide pathogens. 通过真正的病原体解码节肢动物媒介免疫学。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1016/j.pt.2025.03.004
Alejandra Wu-Chuang, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra
{"title":"Decoding arthropod vector immunology through bona fide pathogens.","authors":"Alejandra Wu-Chuang, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra","doi":"10.1016/j.pt.2025.03.004","DOIUrl":"10.1016/j.pt.2025.03.004","url":null,"abstract":"<p><p>The interrelationship between the microbiota, metabolism, and the arthropod immune system has evolved to maintain physiological equilibrium. Arthropods rely on this delicate balance when encountering fitness challenges. The understanding of life history traits in arthropod vectors has been hampered by technological difficulties compounded by limited scientific knowledge compared to established model organisms. Here, we posit that using emerging technologies to study environmental pathogens that cause greater fitness disadvantages to disease vectors (i.e., bona fide pathogens) in contrast to coevolved microbes will enable meaningful insights into arthropod immunophysiology. We propose a conceptual framework whereby understanding immunophysiology through the lens of bona fide pathogens, as opposed to coevolved microbes, should be useful for the management of vector-borne illnesses.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"351-360"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sparicotyle chrysophrii.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-01-14 DOI: 10.1016/j.pt.2024.12.013
Ivona Mladineo
{"title":"Sparicotyle chrysophrii.","authors":"Ivona Mladineo","doi":"10.1016/j.pt.2024.12.013","DOIUrl":"10.1016/j.pt.2024.12.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"416-417"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The XI International Symposium on Fish Parasites: fish health, parasite biodiversity, and conservation. 第十一届鱼类寄生虫国际研讨会：鱼类健康、寄生虫生物多样性和养护。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1016/j.pt.2025.02.006
Miguel Rubio-Godoy, Leopoldina Aguirre-Macedo, Martín García-Varela, Mayra I Grano-Maldonado, Sergio Guillén-Hernández, María Amparo Rodríguez-Santiago, Nico J Smit, Víctor M Vidal-Martínez, Gerardo Pérez-Ponce de León
{"title":"The XI International Symposium on Fish Parasites: fish health, parasite biodiversity, and conservation.","authors":"Miguel Rubio-Godoy, Leopoldina Aguirre-Macedo, Martín García-Varela, Mayra I Grano-Maldonado, Sergio Guillén-Hernández, María Amparo Rodríguez-Santiago, Nico J Smit, Víctor M Vidal-Martínez, Gerardo Pérez-Ponce de León","doi":"10.1016/j.pt.2025.02.006","DOIUrl":"10.1016/j.pt.2025.02.006","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"251-260"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Having your cake and eating it too - a new target for sporozoite-neutralising mAbs. 鱼与熊掌兼得——一个新的目标，为孢子体中和单克隆抗体。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1016/j.pt.2025.02.002
Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn
{"title":"Having your cake and eating it too - a new target for sporozoite-neutralising mAbs.","authors":"Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn","doi":"10.1016/j.pt.2025.02.002","DOIUrl":"10.1016/j.pt.2025.02.002","url":null,"abstract":"<p><p>Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"261-263"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoparamoeba perurans. Neoparamoeba perurans。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1016/j.pt.2024.12.012
Martina Lisnerová, Hana Pecková, Ivan Fiala
{"title":"Neoparamoeba perurans.","authors":"Martina Lisnerová, Hana Pecková, Ivan Fiala","doi":"10.1016/j.pt.2024.12.012","DOIUrl":"10.1016/j.pt.2024.12.012","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"330-331"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making scents of mosquito repellents. 制造驱蚊剂的气味。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1016/j.pt.2025.02.009
Cole J Meier, Minh N Nguyen, Christopher J Potter
{"title":"Making scents of mosquito repellents.","authors":"Cole J Meier, Minh N Nguyen, Christopher J Potter","doi":"10.1016/j.pt.2025.02.009","DOIUrl":"10.1016/j.pt.2025.02.009","url":null,"abstract":"<p><p>Mosquitoes transmit deadly diseases. Chemical repellents deter mosquitoes from approaching or biting a human host and are an effective behavior-based method of personal protection. However, the current standards for selecting repellents often disregard their mode of action. This has likely led many potential repellents to be overlooked. Here, we discuss the sensory systems that underlie host-seeking behavior and how such behaviors are interrupted by repellents. We explore the behavioral assays used to identify repellents and how these have led a handful of contact repellents (DEET, picaridin, IR3535) to dominate the field. Finally, we consider how the development of spatial repellents may further protect against mosquito-borne diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"280-289"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-species immune activation and immunobiotics: a new frontier in vector-borne pathogen control. 跨物种免疫激活和免疫生物：媒介传播病原体控制的新前沿。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1016/j.pt.2025.02.004
Alejandro Cabezas-Cruz, Elianne Piloto-Sardiñas, Pierre Tonnerre, Covadonga Lucas-Torres, Dasiel Obregon
{"title":"Cross-species immune activation and immunobiotics: a new frontier in vector-borne pathogen control.","authors":"Alejandro Cabezas-Cruz, Elianne Piloto-Sardiñas, Pierre Tonnerre, Covadonga Lucas-Torres, Dasiel Obregon","doi":"10.1016/j.pt.2025.02.004","DOIUrl":"10.1016/j.pt.2025.02.004","url":null,"abstract":"<p><p>The persistent global burden of vector-borne diseases (VBDs) needs innovative control strategies, as traditional methods are compromised by acaricides and drug resistance and variable vaccine efficacy. We propose a dual-action strategy using cross-species immune activation: human microbiota triggers the production of natural antibodies that directly target pathogens in the host and modulate vector immunity by interacting with vector microbiota. The human microbiota also modulates cytokine responses, enhancing immune defenses in both host and vector. These mechanisms can be further optimized by identifying immunobiotics - specific gut microbes that stimulate protective immune responses against VBDs. This approach offers a sustainable framework to bridge the gap between host and vector immunity, introducing a novel method to combat VBDs.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"290-300"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virulence attenuation of Theileria annulata-transformed macrophages. 环芽孢杆菌转化巨噬细胞的毒力衰减。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1016/j.pt.2025.02.007
Shahin Tajeri, Gordon Langsley
{"title":"Virulence attenuation of Theileria annulata-transformed macrophages.","authors":"Shahin Tajeri, Gordon Langsley","doi":"10.1016/j.pt.2025.02.007","DOIUrl":"10.1016/j.pt.2025.02.007","url":null,"abstract":"<p><p>Tropical theileriosis is a significant tick-borne disease affecting cattle. For decades an empirical live attenuated vaccine has been the primary method of controlling disease. The vaccine is produced through prolonged culture of Theileria annulata schizont-transformed macrophages, but how loss of virulence occurs remains unclear. Notably attenuated (vaccine) macrophages display dampened dissemination potential compared with their original, virulent counterparts. In addition, parasite schizonts in attenuated macrophages have significantly lost their ability to differentiate into merozoites. This review discusses the changes that occur during long-term passage of T. annulata-transformed bovine macrophages and how they contribute to loss of virulence, defined as heightened dissemination. Finally, we also suggest that a common parasite-dependent pathway is potentially involved in both macrophage dissemination and parasite merogony.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"301-316"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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