发布求助
文献互助 智能选刊 最新文献

Trends in parasitology最新文献

筛选
英文 中文
Plant-nematode battle: engagement of complex signaling network. 植物与线虫之战：复杂信号网络的参与
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.1016/j.pt.2024.07.010
Jinping Zou, Tina Kyndt, Jingquan Yu, Jie Zhou
{"title":"Plant-nematode battle: engagement of complex signaling network.","authors":"Jinping Zou, Tina Kyndt, Jingquan Yu, Jie Zhou","doi":"10.1016/j.pt.2024.07.010","DOIUrl":"10.1016/j.pt.2024.07.010","url":null,"abstract":"<p><p>Plant-parasitic nematodes (PPNs) are widely distributed and highly adaptable. To evade the invasion and infection of PPNs, plants initiate a series of defense responses. In turn, PPNs secrete effectors into the host tissues to suppress plant defense. In this ongoing battle between PPNs and plants, complex signal transduction processes are typically involved. This article aims to review the plant signaling network involved in host perception by the nematode, nematode perception, and downstream activation of plant defense signaling and how nematodes attempt to interfere with this network. Our goal is to establish a foundation for elucidating the signaling and regulatory mechanisms of plant-nematode interactions, and to provide insights and tools for developing PPN-resistant crops and technologies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"846-857"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pass the boron: benzoxaboroles as antiparasite drugs. 传递硼：作为抗寄生虫药物的苯并氧硼烷。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-05 DOI: 10.1016/j.pt.2024.07.003
Martin Zoltner, David Horn, Mark C Field
{"title":"Pass the boron: benzoxaboroles as antiparasite drugs.","authors":"Martin Zoltner, David Horn, Mark C Field","doi":"10.1016/j.pt.2024.07.003","DOIUrl":"10.1016/j.pt.2024.07.003","url":null,"abstract":"<p><p>The development of new drug modalities has been facilitated recently by the introduction of boron as a component of organic compounds, and specifically within a benzoxaborale scaffold. This has enabled exploration of new chemical space and the development of effective compounds targeting a broad range of morbidities, including infections by protozoa, fungi, worms, and bacteria. Most notable is the recent demonstration of a single oral dose cure using acoziborole against African trypanosomiasis. Common and species-/structure-specific interactions between benzoxaboroles and parasite species have emerged and provide vital insights into the mechanisms of cidality, as well as potential challenges in terms of resistance and/or side effects. Here, we discuss the literature specific to benzoxaborole studies in parasitic protists and consider unanswered questions concerning this important new drug class.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"820-828"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dicyema moschatum. Dicyema moschatum.
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1016/j.pt.2024.06.015
Marie Drábková, Jan Štefka
{"title":"Dicyema moschatum.","authors":"Marie Drábková, Jan Štefka","doi":"10.1016/j.pt.2024.06.015","DOIUrl":"10.1016/j.pt.2024.06.015","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"858-859"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BASEHIT scores home run: elucidates pathogen-host interactions. BASEHIT 打出全垒打：阐明病原体与宿主之间的相互作用。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1016/j.pt.2024.07.004
Kelly A Brayton, Jason M Park
{"title":"BASEHIT scores home run: elucidates pathogen-host interactions.","authors":"Kelly A Brayton, Jason M Park","doi":"10.1016/j.pt.2024.07.004","DOIUrl":"10.1016/j.pt.2024.07.004","url":null,"abstract":"<p><p>In a tour de force, Hart and colleagues recently used a technique known as BASEHIT (bacterial selection to elucidate host-microbe interactions in high throughput) to screen a yeast display library containing 3324 curated human exoproteins with 82 pathogen samples, focusing on vector-borne pathogens, to identify 1303 putative interactions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"777-779"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis. 迈向淋巴丝虫病和盘尾丝虫病新疗法的道路漫长而曲折。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.1016/j.pt.2024.07.005
Frederic Risch, Alexander Kazakov, Sabine Specht, Kenneth Pfarr, Peter U Fischer, Achim Hoerauf, Marc P Hübner
{"title":"The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis.","authors":"Frederic Risch, Alexander Kazakov, Sabine Specht, Kenneth Pfarr, Peter U Fischer, Achim Hoerauf, Marc P Hübner","doi":"10.1016/j.pt.2024.07.005","DOIUrl":"10.1016/j.pt.2024.07.005","url":null,"abstract":"<p><p>Although lymphatic filariasis and onchocerciasis have been targeted for global elimination, these helminth infections are still a major public health problem across the tropics and subtropics. Despite decades of research, treatment options remain limited and drugs that completely clear the infections, and can be used on a large scale, are still unavailable. In the present review we discuss the strengths and weaknesses of currently available treatments and new ones in development. Novel candidates (corallopyronin A, DNDi-6166, emodepside, and oxfendazole) are currently moving through (pre)clinical development, while the development of two candidates (AWZ1066S and ABBV-4083/flubentylosin) was recently halted. The preclinical R&D pipeline for filarial infections continues to be limited, and recent setbacks highlight the importance of continuous drug discovery and testing.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"829-845"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unconditional versus condition-dependent social immunity. 无条件的社会免疫力与依赖条件的社会免疫力。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-15 DOI: 10.1016/j.pt.2024.07.014
Sylvia Cremer, Christopher D Pull
{"title":"Unconditional versus condition-dependent social immunity.","authors":"Sylvia Cremer, Christopher D Pull","doi":"10.1016/j.pt.2024.07.014","DOIUrl":"10.1016/j.pt.2024.07.014","url":null,"abstract":"<p><p>Socially living animals can counteract disease through cooperative defences, leading to social immunity that collectively exceeds the sum of individual defences. In superorganismal colonies of social insects with permanent caste separation between reproductive queen(s) and nonreproducing workers, workers are obligate altruists and thus engage in unconditional social immunity, including highly specialised and self-sacrificial hygiene behaviours. Contrastingly, cooperation is facultative in cooperatively breeding families, where all members are reproductively totipotent but offspring transiently forgo reproduction to help their parents rear more siblings. Here, helpers should either express condition-dependent social immunity or disperse to pursue independent reproduction. We advocate inclusive fitness theory as a framework to predict when and how indirect fitness gains may outweigh direct fitness costs, thus favouring conditional social immunity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"780-787"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunomicrotope of Leishmania control and persistence. 利什曼病控制和持续存在的免疫微观图谱。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.1016/j.pt.2024.07.013
Christian Bogdan, Noor-A-Kasida Islam, David Barinberg, Didier Soulat, Ulrike Schleicher, Baplu Rai
{"title":"The immunomicrotope of Leishmania control and persistence.","authors":"Christian Bogdan, Noor-A-Kasida Islam, David Barinberg, Didier Soulat, Ulrike Schleicher, Baplu Rai","doi":"10.1016/j.pt.2024.07.013","DOIUrl":"10.1016/j.pt.2024.07.013","url":null,"abstract":"<p><p>Leishmania is an intracellular protozoan transmitted by sand fly vectors; it causes cutaneous, mucocutaneous, or visceral disease. Its growth and survival are impeded by type 1 T helper cell responses, which entail interferon (IFN)-γ-mediated macrophage activation. Leishmania partially escapes this host defense by triggering immune cell and cytokine responses that favor parasite replication rather than killing. Novel methods for in situ analyses have revealed that the pathways of immune control and microbial evasion are strongly influenced by the tissue context, the micro milieu factors, and the metabolism at the site of infection, which we collectively term the 'immunomicrotope'. Understanding the components and the impact of the immunomicrotope will enable the development of novel strategies for the treatment of chronic leishmaniasis.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"788-804"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-08-07 DOI: 10.1016/s1471-4922(24)00210-1
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4922(24)00210-1","DOIUrl":"https://doi.org/10.1016/s1471-4922(24)00210-1","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"23 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-08-07 DOI: 10.1016/s1471-4922(24)00186-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4922(24)00186-7","DOIUrl":"https://doi.org/10.1016/s1471-4922(24)00186-7","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"18 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A key regulator of male gametogenesis in Cryptosporidium. 隐孢子虫雄性配子发生的关键调节因子。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI: 10.1016/j.pt.2024.06.007
Noelia Lander, Miguel A Chiurillo
{"title":"A key regulator of male gametogenesis in Cryptosporidium.","authors":"Noelia Lander, Miguel A Chiurillo","doi":"10.1016/j.pt.2024.06.007","DOIUrl":"10.1016/j.pt.2024.06.007","url":null,"abstract":"<p><p>Gamete development is a precisely programmed process in Cryptosporidium parvum, a leading cause of diarrheal disease worldwide. Nava et al. recently described the developmentally regulated expression of CDPK5 during male gametogenesis. Here we discuss their main findings, posing this protein kinase as a promising target for antiparasitic interventions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"662-663"},"PeriodicalIF":7.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信