The Plasmodium circumsporozoite protein.

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2024-11-20 DOI:10.1016/j.pt.2024.10.017

Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, Photini Sinnis

引用次数: 0

Abstract

The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood. Here we review the current state of knowledge of CSP structure and function, as sporozoites develop in the mosquito and establish infection in the mammalian host, and outline outstanding questions that need to be addressed.

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疟原虫周孢子虫蛋白。

环孢子虫蛋白（CSP）是研究最多的疟原虫蛋白之一。它是唯一获得许可的疟疾疫苗的靶标，对孢子虫的形成和感染性至关重要。然而，人们对 CSP 的作用机制及其与其他蛋白质的相互作用才刚刚开始了解。在此，我们回顾了目前对 CSP 结构和功能的了解，以及孢子虫在蚊子体内发育和在哺乳动物宿主体内建立感染的情况，并概述了需要解决的悬而未决的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.