发布求助
文献互助 智能选刊 最新文献

Trends in parasitology最新文献

筛选
英文 中文
Placental malaria and circumsporozoite protein-specific immunity. 胎盘疟疾和环孢子虫蛋白特异性免疫。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-21 DOI: 10.1016/j.pt.2024.11.003
Lars Hviid, Nicaise Tuikue Ndam, Stephen J Rogerson
{"title":"Placental malaria and circumsporozoite protein-specific immunity.","authors":"Lars Hviid, Nicaise Tuikue Ndam, Stephen J Rogerson","doi":"10.1016/j.pt.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.pt.2024.11.003","url":null,"abstract":"<p><p>Circumsporozoite protein-specific active and passive immunization can protect significantly against Plasmodium falciparum malaria and are being considered as tools to prevent placental malaria. Despite recent encouraging findings, a closer view of the underlying biology indicates significant challenges to preventing placental malaria.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Plasmodium circumsporozoite protein. 疟原虫周孢子虫蛋白。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-20 DOI: 10.1016/j.pt.2024.10.017
Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, Photini Sinnis
{"title":"The Plasmodium circumsporozoite protein.","authors":"Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, Photini Sinnis","doi":"10.1016/j.pt.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.017","url":null,"abstract":"<p><p>The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood. Here we review the current state of knowledge of CSP structure and function, as sporozoites develop in the mosquito and establish infection in the mammalian host, and outline outstanding questions that need to be addressed.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmania (Leishmania) amazonensis. 亚马逊利什曼病（利什曼病）。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-20 DOI: 10.1016/j.pt.2024.10.023
Marcus S A Garcia, Virlânio A Oliveira Filho, Mariana B C Brioschi, Karen Minori, Danilo Ciccone Miguel
{"title":"Leishmania (Leishmania) amazonensis.","authors":"Marcus S A Garcia, Virlânio A Oliveira Filho, Mariana B C Brioschi, Karen Minori, Danilo Ciccone Miguel","doi":"10.1016/j.pt.2024.10.023","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.023","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating metabolomics into the diagnosis and investigation of anthelmintic resistance. 将代谢组学纳入抗蠕虫药耐药性的诊断和调查。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-20 DOI: 10.1016/j.pt.2024.10.020
Amanda O Shaver, Erik C Andersen
{"title":"Integrating metabolomics into the diagnosis and investigation of anthelmintic resistance.","authors":"Amanda O Shaver, Erik C Andersen","doi":"10.1016/j.pt.2024.10.020","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.020","url":null,"abstract":"<p><p>Anthelmintic resistance (AR) in parasitic nematodes poses a global health problem in livestock and domestic animals and is an emerging problem in humans. Consequently, we must understand the mechanisms of AR, including target-site resistance (TSR), in which mutations affect drug binding, and non-target site resistance (NTSR), which involves alterations in drug metabolism and detoxification processes. Because much of the focus has been on TSR, NTSR has received less attention. Here, we describe how metabolomics approaches using Caenorhabditis elegans offer the ability to disentangle nematode drug metabolism, identify metabolic changes associated with resistance, uncover novel biomarkers, and enhance diagnostic methods.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiomic interrogation of an endomembrane disrupting antimalarial. 内膜干扰抗疟药物的多组学研究。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-20 DOI: 10.1016/j.pt.2024.11.002
Sophie L Collier, Stuart A Ralph
{"title":"Multiomic interrogation of an endomembrane disrupting antimalarial.","authors":"Sophie L Collier, Stuart A Ralph","doi":"10.1016/j.pt.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.pt.2024.11.002","url":null,"abstract":"<p><p>Challenges in adapting natural products as antimalarials include their cryptic mechanism of action (and by extension resistance), as well as their complex and expensive synthesis without an abundant natural source. Recently, Chahine et al. presented plausible means to address these challenges in the case of the kalihinol family of isocyanoterpenes.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teratogenic parasites: disease mechanisms and emerging study models. 致畸寄生虫：疾病机制和新出现的研究模型。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-20 DOI: 10.1016/j.pt.2024.10.016
Rafaela Jose da Silva, Leah F Cabo, Jon P Boyle
{"title":"Teratogenic parasites: disease mechanisms and emerging study models.","authors":"Rafaela Jose da Silva, Leah F Cabo, Jon P Boyle","doi":"10.1016/j.pt.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.016","url":null,"abstract":"<p><p>Congenital infections are a leading preventable cause of pregnancy complications impacting both mother and fetus. Although advancements have been made in understanding various congenital infections, the mechanisms of parasitic infections during pregnancy remain poorly understood. This review covers the global incidence of three parasites capable of congenital transmission - Trypanosoma cruzi, Plasmodium spp., and Toxoplasma gondii - and the state of research into their transplacental transmission strategies. We highlight technological advancements in placental modeling that offer opportunities to reveal how parasites cause gestational pathology. Additionally, we discuss the likelihood that selective adaptation contributed to the evolution of mechanisms that facilitate placental infection. These insights provide a foundation for understanding the progression and pathology of congenital parasitic diseases and identifying future research directions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The apicoplast biogenesis and metabolism: current progress and questions. apicoplast 的生物发生和新陈代谢：当前的进展和问题。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-19 DOI: 10.1016/j.pt.2024.10.019
Xiaowei Chen, Xun Suo, Guan Zhu, Bang Shen
{"title":"The apicoplast biogenesis and metabolism: current progress and questions.","authors":"Xiaowei Chen, Xun Suo, Guan Zhu, Bang Shen","doi":"10.1016/j.pt.2024.10.019","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.019","url":null,"abstract":"<p><p>Many apicomplexan parasites have a chloroplast-derived apicoplast containing several metabolic pathways. Recent studies have greatly expanded our understanding of apicoplast biogenesis and metabolism while also raising new questions. Here, we review recent progress on the biological roles of individual metabolic pathways, focusing on two medically important parasites, Plasmodium spp. and Toxoplasma gondii. We highlight the similarities and differences in how similar apicoplast metabolic pathways are utilized to adapt to different parasitic lifestyles. The execution of apicoplast metabolic functions requires extensive interactions with other subcellular compartments, but the underlying mechanisms remain largely unknown. Apicoplast metabolic functions have historically been considered attractive drug targets, and a comprehensive understanding of their metabolic capacities and interactions with other organelles is essential to fully realize their potential.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bric-à-brac, an 'umbilical cord' and trypanosome kinetoplast segregation. 砖块、"脐带 "和锥虫的内质体分离。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-18 DOI: 10.1016/j.pt.2024.10.021
Megan L Povelones, Michael L Ginger
{"title":"Bric-à-brac, an 'umbilical cord' and trypanosome kinetoplast segregation.","authors":"Megan L Povelones, Michael L Ginger","doi":"10.1016/j.pt.2024.10.021","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.021","url":null,"abstract":"<p><p>Cadena et al. recently discovered a conserved trypanosomatid 'nabelschnur' protein TbNAB70 from a search through the protein localization resource TrypTag, providing new insight into kinetoplast origin and evolution.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective targeting of phosphodiesterases to develop potent antiparasitic drugs. 选择性靶向磷酸二酯酶，开发强效抗寄生虫药物。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-15 DOI: 10.1016/j.pt.2024.11.001
Shahbaz M Khan, Md Mukthar Mia, William H Witola
{"title":"Selective targeting of phosphodiesterases to develop potent antiparasitic drugs.","authors":"Shahbaz M Khan, Md Mukthar Mia, William H Witola","doi":"10.1016/j.pt.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.pt.2024.11.001","url":null,"abstract":"<p><p>Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tragedy of the commons: the resource struggle during Plasmodium infection. 公地悲剧：疟原虫感染期间的资源争夺。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-14 DOI: 10.1016/j.pt.2024.10.014
Taylen J Nappi, Noah S Butler
{"title":"Tragedy of the commons: the resource struggle during Plasmodium infection.","authors":"Taylen J Nappi, Noah S Butler","doi":"10.1016/j.pt.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.014","url":null,"abstract":"<p><p>Plasmodium spp. have an ancient history with humans, having been described in ancient texts dating back 3500 years ago, which has led to an evolutionary arms race between Plasmodium and humans with Plasmodium successfully subverting durable, sterilizing host immunity. Mechanisms of immune evasion include polymorphism and antigenic variation, as well as dysregulated immune responses, each facilitating transmission and Plasmodium parasite persistence. Notably, metabolite signaling cues in the host and parasite have more recently been appreciated as key drivers for disease progression. Here, we highlight the metabolic interplay between the host and Plasmodium parasites during malaria. We discuss how immunometabolism studies may be leveraged to elucidate this complex relationship and offer opportunities to augment either vaccine- or infection-induced protective immunity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信