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Trends in parasitology最新文献

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Midgut and stomodeal valve attachment of Leishmania in sand flies. 利什曼原虫在沙蝇中肠和气孔瓣的附着。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-22 DOI: 10.1016/j.pt.2025.06.017
Petr Volf, Katerina Pruzinova, Ryuji Yanase, Jack D Sunter
{"title":"Midgut and stomodeal valve attachment of Leishmania in sand flies.","authors":"Petr Volf, Katerina Pruzinova, Ryuji Yanase, Jack D Sunter","doi":"10.1016/j.pt.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.017","url":null,"abstract":"<p><p>Leishmania development in sand flies involves critical attachment steps to the midgut epithelium and the stomodeal valve, mediated by parasite- and vector-derived molecules. Initial midgut attachment prevents parasite loss during defecation and determines vector competence. In specific vectors like Phlebotomus papatasi, attachment involves galectins and Leishmania lipophosphoglycan, while in permissive species like Lutzomyia longipalpis, mucin adhesion dominates. Later, promastigotes adhere to the stomodeal valve, forming adhesion plaques, which in combination with the promastigote secretory gel (PSG) blocks the gut and promotes transmission. Recent studies identified three flagellar proteins (KIAP1-3) crucial for plaque formation. Knockouts of KIAPs prevented stomodeal valve colonization and PSG production, likely impacting parasite transmission. Thus, KIAPs are essential for late-stage Leishmania development in sand flies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking parasitoid venoms: beyond immune suppression. 重新思考寄生虫毒液：超越免疫抑制。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-18 DOI: 10.1016/j.pt.2025.07.005
Abraham Y Kpirikai, Nicholas M Bretz, Nathan T Mortimer
{"title":"Rethinking parasitoid venoms: beyond immune suppression.","authors":"Abraham Y Kpirikai, Nicholas M Bretz, Nathan T Mortimer","doi":"10.1016/j.pt.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.pt.2025.07.005","url":null,"abstract":"<p><p>Parasitoid wasp venoms are widely studied for their immunosuppressive properties. Work by Dong et al. expands the venom repertoire to include manipulation of host metabolites with the discovery of the Leptopilina-specific venom lipase (LVL). LVL is an active lipase that converts host lipids to support parasitoid embryogenesis following infection.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging microbial ecology for mosquito-borne disease control. 利用微生物生态学控制蚊媒疾病。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-17 DOI: 10.1016/j.pt.2025.06.010
Holly L Nichols, Kerri L Coon
{"title":"Leveraging microbial ecology for mosquito-borne disease control.","authors":"Holly L Nichols, Kerri L Coon","doi":"10.1016/j.pt.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.010","url":null,"abstract":"<p><p>Mosquitoes transmit pathogens causing 700 000 deaths annually. Microbe-based vector control, which reduces vector populations or blocks pathogen development within vectors, offers an innovative way to lower global morbidity and mortality due to vector-borne disease. This review addresses challenges hindering the widespread adoption of microbe-based vector control in mosquitoes. We consider understudied transmission routes of mosquito-associated microbiota, factors affecting colonization and persistence of candidate microbial control agents in mosquito hosts, and the need for robust tools and methodologies to validate that observations in laboratory populations can be reliably extended to field populations. We highlight how understanding the microbial ecology underlying interactions between mosquitoes and their native microbiota can guide successful vector control efforts in these and other arthropod disease vectors.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outlining the structure of cAMP compartments in Trypanosoma cruzi. 克氏锥虫cAMP区室结构概述。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-16 DOI: 10.1016/j.pt.2025.06.013
Noelia Lander
{"title":"Outlining the structure of cAMP compartments in Trypanosoma cruzi.","authors":"Noelia Lander","doi":"10.1016/j.pt.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.013","url":null,"abstract":"<p><p>Trypanosomatids are protozoan parasites that cause deadly infectious diseases. Despite the unique characteristics of their cAMP signaling pathways, little is known about the mechanisms driving signal specificity in these early divergent eukaryotes. From the activation of adenylate cyclases in response to environmental cues to the downstream regulation of gene expression, the signaling mechanisms triggering developmental transformations in trypanosomes are poorly understood. In this review we integrate previous and new evidence supporting the existence of membrane microdomains that assemble cAMP signaling proteins in different subcellular compartments of Trypanosoma cruzi, the etiologic agent of Chagas disease. We also discuss the main cellular processes regulated by cAMP compartments in this parasite. Advances in this field are crucial to identifying new targets for antiparasitic interventions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermacentor reticulatus (meadow tick; ornate dog tick). 网状皮蜱；华丽的狗蜱)。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-16 DOI: 10.1016/j.pt.2025.06.015
Andrea Springer, Christina Strube
{"title":"Dermacentor reticulatus (meadow tick; ornate dog tick).","authors":"Andrea Springer, Christina Strube","doi":"10.1016/j.pt.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.015","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological targeting of the helminth complex II: are there any rhodoquinone-driven adaptations? 寄生虫复合体的药理靶向II：是否存在红醌驱动的适应性？
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-16 DOI: 10.1016/j.pt.2025.06.016
Franco Vairoletti, Cecilia Saiz, Gustavo Salinas
{"title":"Pharmacological targeting of the helminth complex II: are there any rhodoquinone-driven adaptations?","authors":"Franco Vairoletti, Cecilia Saiz, Gustavo Salinas","doi":"10.1016/j.pt.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.016","url":null,"abstract":"<p><p>Based on a particular biochemical model, the use of rhodoquinone (RQ) under hypoxic conditions has been linked to an alternative complex II in the electron transport chain in helminths. This model was derived from detailed studies on Ascaris suum and generalized for helminths. However, accumulated evidence warrants a critical model re-examination. RQ facilitates complex II to operate in reverse as a fumarate reductase when oxygen is unavailable, but this biochemical adaptation typically does not involve a dedicated alternative complex II. Based on recent genomic, biochemical, and pharmacological data, we argue that the Ascaris scenario cannot be extrapolated to other helminths. Complex II is a promising pharmacological target for helminths; thus, the revision of the model also has practical consequences.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echinococcosis on the Tibetan Plateau, where to go? 青藏高原上的棘球蚴病，去哪儿了？
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-16 DOI: 10.1016/j.pt.2025.07.001
Shilin Miao, Xiuju He, Xin Jin, Ting Zhang, Shu Shen, Yanping Zhao
{"title":"Echinococcosis on the Tibetan Plateau, where to go?","authors":"Shilin Miao, Xiuju He, Xin Jin, Ting Zhang, Shu Shen, Yanping Zhao","doi":"10.1016/j.pt.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.pt.2025.07.001","url":null,"abstract":"<p><p>The post-COVID-19 era has exacerbated challenges in controlling echinococcosis on the Tibetan Plateau, the epicentre of alveolar and cystic echinococcosis, where reduced funding for neglected tropical diseases (NTDs) coincides with growing tourism and trade. This convergence heightens transmission risk, and we provide a novel synthesis of context-specific, integrated control strategies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hijacking plant immunity: nematode effectors target NRC4 pathway. 劫持植物免疫：线虫效应物靶向NRC4通路。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-15 DOI: 10.1016/j.pt.2025.07.002
Zhongshou Wu, Shaojie Han
{"title":"Hijacking plant immunity: nematode effectors target NRC4 pathway.","authors":"Zhongshou Wu, Shaojie Han","doi":"10.1016/j.pt.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.pt.2025.07.002","url":null,"abstract":"<p><p>Plant-parasitic nematodes secrete effectors to suppress host immunity, yet how these effectors disrupt plant defense remains poorly understood. Recently, Qin et al. report that the nematode effector MiV86 stabilizes host E3 ligase NbRNF217, which leads to the degradation of the helper NRC4 receptor and immune suppression.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The apicoplast transportome of the malaria parasite. 疟原虫的顶质体运输体。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-15 DOI: 10.1016/j.pt.2025.06.011
Laura J Akkerman, Taco W A Kooij, Laura E de Vries
{"title":"The apicoplast transportome of the malaria parasite.","authors":"Laura J Akkerman, Taco W A Kooij, Laura E de Vries","doi":"10.1016/j.pt.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.011","url":null,"abstract":"<p><p>The apicoplast, a peculiar organelle of red algal origin surrounded by four membranes, is important for several metabolic processes in the malaria parasite, including isopentenyl pyrophosphate (IPP) and coenzyme A (CoA) biosynthesis. Transporters are required to provide substrates and export products for these metabolic pathways and are therefore excellent novel drug targets. On the basis of known apicoplast pathways, we discuss which functions are expected to be fulfilled by the Plasmodium apicoplast transportome, which comprises 11 confirmed and 17 putative apicoplast transporters identified to date. Facilitated by the development of new tools, we anticipate the discovery of key players of the apicoplast transportome, such as the IPP and CoA exporters, and the exploitation of these proteins as drug targets.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the potential of miRNAs in cystic echinococcosis. 揭示囊性包虫病中mirna的潜力。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-07-15 DOI: 10.1016/j.pt.2025.06.004
Paola Pepe, Elena Ciccone, Nunzio Antonio Cacciola, Chiara Bazzocchi, Laura Rinaldi
{"title":"Unlocking the potential of miRNAs in cystic echinococcosis.","authors":"Paola Pepe, Elena Ciccone, Nunzio Antonio Cacciola, Chiara Bazzocchi, Laura Rinaldi","doi":"10.1016/j.pt.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.pt.2025.06.004","url":null,"abstract":"<p><p>This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host-parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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