{"title":"Toxoplasma gondii endodyogeny: how to make perfect daughters.","authors":"Maanasa Bhaskaran, Venkat Mudiyam, Mathieu Gissot","doi":"10.1016/j.pt.2025.07.012","DOIUrl":null,"url":null,"abstract":"<p><p>The pathogenesis of Toxoplasma gondii in humans is largely attributed to its capacity for rapid multiplication via a streamlined division process known as endodyogeny. The assembly of the daughter cell scaffold, occurring through a process termed budding, necessitates strict temporal and spatial regulation. Recent advances have elucidated remarkable details of the early stages of daughter cell formation, underscoring the pivotal role of the apical polar ring during the initial phases. Furthermore, emerging evidence implicates ApiAP2 transcription factors in the regulation of gene expression essential for the synthesis of daughter cell components. This transcriptional control is complemented by post-translational regulatory mechanisms governing both the initiation and maturation of the daughter cell cytoskeleton. Both processes are critical for the successful production of invasive zoites.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"868-879"},"PeriodicalIF":6.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pt.2025.07.012","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The pathogenesis of Toxoplasma gondii in humans is largely attributed to its capacity for rapid multiplication via a streamlined division process known as endodyogeny. The assembly of the daughter cell scaffold, occurring through a process termed budding, necessitates strict temporal and spatial regulation. Recent advances have elucidated remarkable details of the early stages of daughter cell formation, underscoring the pivotal role of the apical polar ring during the initial phases. Furthermore, emerging evidence implicates ApiAP2 transcription factors in the regulation of gene expression essential for the synthesis of daughter cell components. This transcriptional control is complemented by post-translational regulatory mechanisms governing both the initiation and maturation of the daughter cell cytoskeleton. Both processes are critical for the successful production of invasive zoites.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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