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γδ T cells in leishmaniasis: intrinsic factors and outcomes. 利什曼病中的γδ T 细胞：内在因素和结果。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1016/j.pt.2025.03.008
Júlio Souza Dos-Santos, Herbert Leonel de Matos Guedes
{"title":"γδ T cells in leishmaniasis: intrinsic factors and outcomes.","authors":"Júlio Souza Dos-Santos, Herbert Leonel de Matos Guedes","doi":"10.1016/j.pt.2025.03.008","DOIUrl":"10.1016/j.pt.2025.03.008","url":null,"abstract":"<p><p>γδ T cells influence immunity in leishmaniasis, responding to Leishmania components, sand flies, and their microbiota. IL-17-producing γδ T cells drive pathogenesis via neutrophil recruitment, while IFN-γ-producing γδ T cells promote resolution by inducing a strong Th1 response. Understanding their activation may improve immune responses and leishmaniasis control.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"348-350"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential and pitfalls of using identity-by-descent for malaria genomic surveillance. 利用血统识别进行疟疾基因组监测的潜力和缺陷。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-21 DOI: 10.1016/j.pt.2025.03.012
Bing Guo, Emma Rowley, Timothy D O'Connor, Shannon Takala-Harrison
{"title":"Potential and pitfalls of using identity-by-descent for malaria genomic surveillance.","authors":"Bing Guo, Emma Rowley, Timothy D O'Connor, Shannon Takala-Harrison","doi":"10.1016/j.pt.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.pt.2025.03.012","url":null,"abstract":"<p><p>The ability to genotype malaria parasites on an epidemiological scale is crucial for genomic surveillance as it aids in understanding malaria transmission dynamics and parasite demography changes in response to antimalarial interventions. Identity-by-descent (IBD)-based methods have demonstrated potential in various aspects of malaria genomic surveillance. However, there is a need for validation of existing approaches and development of new techniques to address challenges posed by the parasites' unique evolutionary dynamics and complex biological characteristics, which differ markedly from organisms like humans. This review examines current IBD use cases, identifies limitations of IBD-based methods, and explores promising future directions to enhance malaria genomic surveillance.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"41 5","pages":"387-400"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aedes aegypti (Yellow fever mosquito). 埃及伊蚊（黄热病蚊子）。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1016/j.pt.2025.03.007
Jacquelyn C LaReau, Andrea Gloria-Soria
{"title":"Aedes aegypti (Yellow fever mosquito).","authors":"Jacquelyn C LaReau, Andrea Gloria-Soria","doi":"10.1016/j.pt.2025.03.007","DOIUrl":"10.1016/j.pt.2025.03.007","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"418-419"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmania genomic adaptation: more than just a 36-body problem. 利什曼原虫基因组适应：不仅仅是一个36人的问题。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 DOI: 10.1016/j.pt.2025.04.002
Gerald F Späth, Laura Piel, Pascale Pescher
{"title":"Leishmania genomic adaptation: more than just a 36-body problem.","authors":"Gerald F Späth, Laura Piel, Pascale Pescher","doi":"10.1016/j.pt.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.pt.2025.04.002","url":null,"abstract":"<p><p>Genome instability has been identified as a major driver of adaptation in fast-growing, eukaryotic cells, including fungi, protists, or cancer. How these cells cope with the toxic effects caused by such copy number variations remains to be elucidated. In recent years, the protist parasites Leishmania spp. have emerged as interesting model pathogens to assess this open question and to study the role of its intrinsic genome instability in fitness gain in culture, experimental infection, and in the field. Here we summarize recent results on Leishmania genomic adaptation and propose thought-provoking evolutionary concepts new to the Leishmania field that need to be considered when mapping genotype-to-phenotype relationships in molecular and epidemiological studies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to 'Diversity and compatibility of human schistosomes and their intermediate snail hosts' [Trends in Parasitology 34, (2018), 493-510]. 人类血吸虫及其中间钉螺宿主的多样性和兼容性 "的撤稿通知[《寄生虫学趋势》34，（2018），493-510]。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1016/j.pt.2025.03.001
Benjamin Sanogo, Dongjuan Yuan, Xin Zeng, Yanhua Zhang, Zhongdao Wu
{"title":"Retraction notice to 'Diversity and compatibility of human schistosomes and their intermediate snail hosts' [Trends in Parasitology 34, (2018), 493-510].","authors":"Benjamin Sanogo, Dongjuan Yuan, Xin Zeng, Yanhua Zhang, Zhongdao Wu","doi":"10.1016/j.pt.2025.03.001","DOIUrl":"10.1016/j.pt.2025.03.001","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"420"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human antibodies against Anopheles salivary proteins: emerging biomarkers of mosquito and malaria exposure. 人抗唾液按蚊蛋白抗体：蚊子和疟疾暴露的新生物标志物。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.1016/j.pt.2025.03.009
Ellen A Kearney, Ashleigh S Heng-Chin, Katherine O'Flaherty, Freya J I Fowkes
{"title":"Human antibodies against Anopheles salivary proteins: emerging biomarkers of mosquito and malaria exposure.","authors":"Ellen A Kearney, Ashleigh S Heng-Chin, Katherine O'Flaherty, Freya J I Fowkes","doi":"10.1016/j.pt.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.pt.2025.03.009","url":null,"abstract":"<p><p>Antibodies developed against Anopheles mosquito salivary proteins injected during biting may serve as proxy biomarkers of Anopheles biting exposure. Anti-salivary biomarkers are being increasingly investigated, with ~60 studies published to date, mostly identifying positive associations with Anopheles human biting rates (HBRs). However, several literature gaps must be addressed to inform the application of anti-salivary biomarkers for serosurveillance of vector exposure and malaria transmission and in vector-control trials. We highlight the need for more studies that collect HBRs and antibody data contemporaneously, investigate novel antigens for non-African Anopheles species, and characterize antibody kinetics to understand how biomarkers can track changes in exposure over time. Together, these directions may improve upon insensitive manual mosquito catch techniques and strengthen malaria surveillance programs.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"41 5","pages":"361-373"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Holding hands to halt malaria: stronger together through heterotypic antibody interactions. 携手遏制疟疾：通过异型抗体相互作用共同增强。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1016/j.pt.2025.04.004
Evelien M Bunnik, Sebastiaan Bol, Gregory C Ippolito
{"title":"Holding hands to halt malaria: stronger together through heterotypic antibody interactions.","authors":"Evelien M Bunnik, Sebastiaan Bol, Gregory C Ippolito","doi":"10.1016/j.pt.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.pt.2025.04.004","url":null,"abstract":"<p><p>Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"41 5","pages":"337-338"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding arthropod vector immunology through bona fide pathogens. 通过真正的病原体解码节肢动物媒介免疫学。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1016/j.pt.2025.03.004
Alejandra Wu-Chuang, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra
{"title":"Decoding arthropod vector immunology through bona fide pathogens.","authors":"Alejandra Wu-Chuang, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra","doi":"10.1016/j.pt.2025.03.004","DOIUrl":"10.1016/j.pt.2025.03.004","url":null,"abstract":"<p><p>The interrelationship between the microbiota, metabolism, and the arthropod immune system has evolved to maintain physiological equilibrium. Arthropods rely on this delicate balance when encountering fitness challenges. The understanding of life history traits in arthropod vectors has been hampered by technological difficulties compounded by limited scientific knowledge compared to established model organisms. Here, we posit that using emerging technologies to study environmental pathogens that cause greater fitness disadvantages to disease vectors (i.e., bona fide pathogens) in contrast to coevolved microbes will enable meaningful insights into arthropod immunophysiology. We propose a conceptual framework whereby understanding immunophysiology through the lens of bona fide pathogens, as opposed to coevolved microbes, should be useful for the management of vector-borne illnesses.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"351-360"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sparicotyle chrysophrii.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-01-14 DOI: 10.1016/j.pt.2024.12.013
Ivona Mladineo
{"title":"Sparicotyle chrysophrii.","authors":"Ivona Mladineo","doi":"10.1016/j.pt.2024.12.013","DOIUrl":"10.1016/j.pt.2024.12.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"416-417"},"PeriodicalIF":7.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptosporidium hominis.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-29 DOI: 10.1016/j.pt.2025.04.001
Wanyi Huang, Yaoyu Feng, Lihua Xiao
{"title":"Cryptosporidium hominis.","authors":"Wanyi Huang, Yaoyu Feng, Lihua Xiao","doi":"10.1016/j.pt.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.pt.2025.04.001","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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