Trends in parasitology最新文献

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Mechanistic insights into liver-fluke-induced bile-duct cancer. 肝吸虫诱发胆管癌的机理研究。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-08 DOI: 10.1016/j.pt.2024.10.012
Michael J Smout, Thewarach Laha, Sujittra Chaiyadet, Paul J Brindley, Alex Loukas
{"title":"Mechanistic insights into liver-fluke-induced bile-duct cancer.","authors":"Michael J Smout, Thewarach Laha, Sujittra Chaiyadet, Paul J Brindley, Alex Loukas","doi":"10.1016/j.pt.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.012","url":null,"abstract":"<p><p>Liver fluke infection is a major risk for cholangiocarcinoma (CCA). It has been established that the Asian liver flukes, Clonorchis sinensis and Opisthorchis viverrini secrete growth factors, digestive enzymes, and extracellular vesicles (EVs) which contribute to abnormal cell development in the bile ducts where the worms reside. These secretions - combined with aberrant inflammation and repeated cycles of chronic wounding at the site of parasite attachment and grazing on the epithelium - promote biliary hyperplasia and fibrosis and ultimately malignant transformation. Application of post-genomic and gene-editing tools to the study of liver fluke immunobiology and pathogenesis has accelerated the discovery of essential virulence factors to which targeted therapies and diagnostics can be directed.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabarcoding in gut protozoology. 肠道原生动物学中的元条码。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-08 DOI: 10.1016/j.pt.2024.10.015
Christen Rune Stensvold
{"title":"Metabarcoding in gut protozoology.","authors":"Christen Rune Stensvold","doi":"10.1016/j.pt.2024.10.015","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.015","url":null,"abstract":"<p><p>Next-generation sequencing (NGS) methods include whole-genome sequencing, metagenomic analysis, and amplicon-based NGS, all of which are gaining territory in parasitology. A modality of particular interest within the field of gut protozoology is exhaustive metabarcoding of ribosomal genes in a complex matrix such as faeces, by which method, amplicon-based NGS enables the detection and differentiation of both eukaryotic and prokaryotic organisms, circumventing Sanger sequencing-based limitations and representing a one-fits-most approach. Apart from being a tool to break the code of intracellular genetic variation and tell mixed species infections apart, metabarcoding can produce data that can serve to augment our understanding of the interplay between the organisms within the gut.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma. 疟原虫和弓形虫中的 Sec14 蛋白。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-08 DOI: 10.1016/j.pt.2024.10.018
Florian Lauruol, Dave Richard
{"title":"Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma.","authors":"Florian Lauruol, Dave Richard","doi":"10.1016/j.pt.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.018","url":null,"abstract":"<p><p>Sec14 domain proteins are broadly conserved in eukaryotes and play essential roles in numerous cellular processes. Limited data on Sec14 proteins of apicomplexan parasites suggest that they could be important for their survival. The development of fungi-specific Sec14 inhibitors raises the tantalizing possibility that their apicomplexan counterparts might also be targeted.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bats and ectoparasites: exploring a hidden link in zoonotic disease transmission. 蝙蝠和体外寄生虫:探索人畜共患病传播中的隐秘环节。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-07 DOI: 10.1016/j.pt.2024.10.010
Tamara Szentiványi, Kriszta Lilla Szabadi, Tamás Görföl, Péter Estók, Gábor Kemenesi
{"title":"Bats and ectoparasites: exploring a hidden link in zoonotic disease transmission.","authors":"Tamara Szentiványi, Kriszta Lilla Szabadi, Tamás Görföl, Péter Estók, Gábor Kemenesi","doi":"10.1016/j.pt.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.010","url":null,"abstract":"<p><p>Bats are increasingly in the focus of disease surveillance studies as they harbor pathogens that can cause severe human disease. In other host groups, ectoparasitic arthropods play an important role in transmitting pathogens to humans. Nevertheless, we currently know little about the role of bat-associated ectoparasites in pathogen transmission, not only between bats but also to humans and other species, even though some of these parasites occasionally feed on humans and harbor potentially zoonotic organisms. In this work, we summarize current knowledge on the zoonotic risks linked to bat-associated ectoparasites and provide novel risk assessment guidelines to improve targeted surveillance efforts. Additionally, we suggest research directions to help adjust surveillance strategies and to better understand the eco-epidemiological role of these parasites.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leptotrombidium deliense (Asian rodent chigger). Leptotrombidium deliense(亚洲啮齿类恙虫)。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-06 DOI: 10.1016/j.pt.2024.10.013
Rohit Beniwal, Govindarajan Renu, Philip S Paulraj
{"title":"Leptotrombidium deliense (Asian rodent chigger).","authors":"Rohit Beniwal, Govindarajan Renu, Philip S Paulraj","doi":"10.1016/j.pt.2024.10.013","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientists swarm into Woods Hole for the 10th Kinetoplastid Molecular Cell Biology Meeting. 科学家们涌入伍兹霍尔,参加第 10 届 Kinetoplastid 分子细胞生物学会议。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-05 DOI: 10.1016/j.pt.2024.10.009
Caroline Keroack, Raúl Oscar Cosentino, Thaise Lara Teixeira, Lianne Lansink, Stephen D Larcombe, Brittney Davidge, Lucia Serra, Christopher de Graffenried, Luisa M Figueiredo, Omar S Harb, Megan L Povelones
{"title":"Scientists swarm into Woods Hole for the 10th Kinetoplastid Molecular Cell Biology Meeting.","authors":"Caroline Keroack, Raúl Oscar Cosentino, Thaise Lara Teixeira, Lianne Lansink, Stephen D Larcombe, Brittney Davidge, Lucia Serra, Christopher de Graffenried, Luisa M Figueiredo, Omar S Harb, Megan L Povelones","doi":"10.1016/j.pt.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.009","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hypothesis to explain malaria-induced neurocognitive sequelae. 一种解释疟疾引起的神经认知后遗症的假说。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-04 DOI: 10.1016/j.pt.2024.10.008
Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro
{"title":"A hypothesis to explain malaria-induced neurocognitive sequelae.","authors":"Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro","doi":"10.1016/j.pt.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.008","url":null,"abstract":"<p><p>The development of malaria-induced neurocognitive and behavioral sequelae is not entirely understood. We hypothesize that liver dysfunction caused by Plasmodium infection is responsible for malaria-induced neurocognitive and behavioral sequelae. Our metabolic hypothesis not only explains neurocognitive sequelae after cerebral malaria (CM) but also after other severe, non-severe, and asymptomatic malaria infections.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-based functional genomics for schistosomes and related flatworms. 基于 CRISPR 的血吸虫和相关扁形虫功能基因组学。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI: 10.1016/j.pt.2024.09.010
Wannaporn Ittiprasert, Paul J Brindley
{"title":"CRISPR-based functional genomics for schistosomes and related flatworms.","authors":"Wannaporn Ittiprasert, Paul J Brindley","doi":"10.1016/j.pt.2024.09.010","DOIUrl":"10.1016/j.pt.2024.09.010","url":null,"abstract":"<p><p>CRISPR genome editing is actively used for schistosomes and other flukes. The ability to genetically manipulate these flatworms enables deeper investigation of their (patho)biological nature. CRISPR gene knockout (KO) demonstrated that a liver fluke growth mediator contributes to disease progression. Genome safe harbor sites have been predicted in Schistosoma mansoni and targeted for transgene insertion. CRISPR-based diagnosis has been demonstrated for infection with schistosomes and Opisthorchis viverrini. This review charts the progress, and the state of play, and posits salient questions for the field to address. Derivation of heritably transgenic loss-of-function or gain-of-function lines is the next milestone.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1016-1028"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of parasitological knowledge: can the past inform the future? 寄生虫学知识的演变:过去能否启迪未来?
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-01 DOI: 10.1016/j.pt.2024.10.011
Robert Poulin
{"title":"Evolution of parasitological knowledge: can the past inform the future?","authors":"Robert Poulin","doi":"10.1016/j.pt.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.pt.2024.10.011","url":null,"abstract":"<p><p>The growth of scientific knowledge is often likened to the evolution and diversification of life: new disciplines branch off older ones, and subsequently prosper or decline in a manner reminiscent of the expansion or extinction of diverse lineages of organisms. Based on a parallel between evolutionary diversification and knowledge growth, I examine the expansion of subdisciplines within 'ecological and evolutionary parasitology'. Bibliometric data are used to map the rise and fall of subdisciplines over time, capturing historical trends over the past several decades. This historical overview is followed by a critical consideration of its practical applications for decision-making, ranging from rational funding allocation among subdisciplines to whether the collective planning of future research directions is a desirable option.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ties that bind us: Leishmania grasps the sandfly. 束缚我们的纽带利什曼病抓住了沙蝇。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1016/j.pt.2024.09.004
Scott M Landfear
{"title":"Ties that bind us: Leishmania grasps the sandfly.","authors":"Scott M Landfear","doi":"10.1016/j.pt.2024.09.004","DOIUrl":"10.1016/j.pt.2024.09.004","url":null,"abstract":"<p><p>The enigmatic haptomonad forms of Leishmania parasites adhere to the sandfly stomodeal valve, damaging this feeding valve and promoting parasite transmission. Yanase et al. recently identified the first parasite proteins involved in adhesion and showed their essentiality in binding to and damaging the valve.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"962-963"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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