Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-05DOI: 10.1016/j.pt.2025.01.005
Akram A Da'Dara, Patrick J Skelly
{"title":"The enigmatic heptalaminate surface membrane of intravascular schistosomes.","authors":"Akram A Da'Dara, Patrick J Skelly","doi":"10.1016/j.pt.2025.01.005","DOIUrl":"10.1016/j.pt.2025.01.005","url":null,"abstract":"<p><p>Intravascular schistosomes have an unusual outer, heptalaminate (seven-layered) covering consisting of not one but two lipid bilayers. Here, we present an updated model of the molecular composition of these bilayers in Schistosoma mansoni that places most identified proteins in the outer, and not the inner, membrane. Here, enzymes would have access to their recently described (non-membrane-permeable) substrates. By contrast, nutrient transporter proteins must be in both membranes to facilitate uptake into the worm's inner tissues. Ectoenzyme activities displayed by living worms suggest the presence on their outer surface of several noncanonically extracellular proteins. The advantages of having a double-bilayered covering may relate to impeding host immunological attack and/or to the worm's ability to acquire selected host molecules onto their exterior.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"177-187"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-11DOI: 10.1016/j.pt.2025.01.010
Desiree L Goetting, James W Lightfoot
{"title":"Gas-propelled navigation: CO<sub>2</sub> prompts parasitic worm behavior.","authors":"Desiree L Goetting, James W Lightfoot","doi":"10.1016/j.pt.2025.01.010","DOIUrl":"10.1016/j.pt.2025.01.010","url":null,"abstract":"<p><p>Skin-penetrating nematodes such as Strongyloides stercoralis depend on a suite of chemosensory cues to find their host. Banerjee et al. uncovered life-stage-specific behavioral preferences for CO<sub>2</sub> in S. stercoralis and revealed its distinct influence on navigation behaviors during the complex life cycle in this species.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"175-176"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-11DOI: 10.1016/j.pt.2025.01.004
Jianwei Shi, Ming Sun
{"title":"Bacillus thuringiensis: a gift for nematode management.","authors":"Jianwei Shi, Ming Sun","doi":"10.1016/j.pt.2025.01.004","DOIUrl":"10.1016/j.pt.2025.01.004","url":null,"abstract":"<p><p>Nematodes attacking plants and animals pose a global threat to agricultural industry and public health. Chemicals as long preferred tools for nematode management are facing challenges such as pest resistance and policy restrictions. Recent findings show that Bacillus thuringiensis (Bt) produces rich components with excellent nematicidal competence and is a precious nonchemical resource for controlling a broad range of nematode parasites. Transgenic plants, microbial products, and nanoparticles efficiently deliver and protect Bt nematicidal activities. The combination of nematicidal elements with distinct modes of action can enhance the efficacy and sustainability of Bt-derived nematicidal products. Here we outline these advances, emphasize the promise of Bt in managing nematodes, and discuss issues concerning the optimization of field deployments of Bt-based nematode management.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"235-246"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-11DOI: 10.1016/j.pt.2025.01.006
Mathias Franz, Sophie A O Armitage, Dino McMahon, Bengisu S Subasi, Charlotte Rafaluk
{"title":"Trade-offs in virulence evolution: a Hierarchy-of-Hypotheses approach.","authors":"Mathias Franz, Sophie A O Armitage, Dino McMahon, Bengisu S Subasi, Charlotte Rafaluk","doi":"10.1016/j.pt.2025.01.006","DOIUrl":"10.1016/j.pt.2025.01.006","url":null,"abstract":"<p><p>Understanding the evolution of virulence, that is, the harm pathogens cause their hosts, has major and wide-spread repercussions. A central concept of virulence evolution is the so-called 'trade-off hypothesis', a seemingly straightforward relationship between virulence and transmission. However, substantial ambiguity in terminology related to this hypothesis threatens progress in the field. To address this, we apply a Hierarchy-of-Hypotheses approach to provide structured, visual representations of ideas linked to this hypothesis. We illustrate that the trade-off hypothesis is a complex set of many different hypotheses and trade-offs, and we clarify ambiguities and biases in commonly used terminology in the literature. Thereby, we hope to facilitate a more precise understanding of what the trade-off hypothesis means, enabling more targeted and precise hypothesis testing.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"188-195"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-19DOI: 10.1016/j.pt.2025.01.009
Pedro Cecilio, Eva Iniguez, Patrick Huffcutt, Servio P Ribeiro, Shaden Kamhawi, Jesus G Valenzuela, Tiago D Serafim
{"title":"The impact of blood on vector-borne diseases with emphasis on mosquitoes and sand flies.","authors":"Pedro Cecilio, Eva Iniguez, Patrick Huffcutt, Servio P Ribeiro, Shaden Kamhawi, Jesus G Valenzuela, Tiago D Serafim","doi":"10.1016/j.pt.2025.01.009","DOIUrl":"10.1016/j.pt.2025.01.009","url":null,"abstract":"<p><p>The impact of blood and its factors on vector-borne diseases is significant and multifaceted yet understudied. While blood is expected to play a central role in transmission, pathogen development, vector behavior, and vector competence, in experimental settings, most studies are developed in the frame of a single, infected blood meal. To effectively combat vector-borne diseases, we need to determine what is the influence of insect blood-feeding behavior on transmission and development of pathogens, toward translation to natural field settings. This review summarizes current findings, highlights key gaps, and outlines future research directions to enhance our understanding of the role of blood in vector-borne disease transmission.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"196-209"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-10DOI: 10.1016/j.pt.2025.01.007
Thomas Müller, Timothy Krüger, Markus Engstler
{"title":"Subcellular dynamics in unicellular parasites.","authors":"Thomas Müller, Timothy Krüger, Markus Engstler","doi":"10.1016/j.pt.2025.01.007","DOIUrl":"10.1016/j.pt.2025.01.007","url":null,"abstract":"<p><p>Bioimaging has made tremendous advances in this century. Innovations in high- and super-resolution microscopy are well established, and live-cell imaging is extensively used to gain an overview of dynamic processes. But the combination of high spatial and temporal resolution necessary to capture intracellular dynamics is rarely achieved. Further, efficient software pipelines - that can handle the recorded data and allow comprehensive analyses - are being developed but lag behind other technical innovations in applicability for broad groups of researchers. Especially in parasites, which offer great potential for studying subcellular dynamics, the possibilities have only begun to be probed. In all cases, the complete description of dynamic molecular movement in 3D space remains a challenging necessity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"222-234"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-01-31DOI: 10.1016/j.pt.2025.01.003
Sugandika Bullumulla, Lihua Xiao, Yaoyu Feng, Amanda Ash, Una Ryan, Amanda D Barbosa
{"title":"Update on transmission of zoonotic Giardia in cattle.","authors":"Sugandika Bullumulla, Lihua Xiao, Yaoyu Feng, Amanda Ash, Una Ryan, Amanda D Barbosa","doi":"10.1016/j.pt.2025.01.003","DOIUrl":"10.1016/j.pt.2025.01.003","url":null,"abstract":"<p><p>Giardia is the most common protozoan cause of diarrhoeal illness in humans worldwide. Despite this, our understanding of the zoonotic transmission of Giardia, and in particular the role of cattle as a zoonotic reservoir, is not well understood, due to the limitations of current typing systems and a recent taxonomic revision of the genus. Newly improved multilocus sequencing typing tools are not yet widely used and are not applicable to all species. However, data generated to date suggest that zoonotic transmission of Giardia of bovine origin is limited. Carefully designed epidemiological investigations using improved typing tools are essential to understand the extent of zoonotic transmission from cattle. Improved on-farm biosecurity measures are also needed to control the transmission of zoonotic Giardia in cattle.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"210-221"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trends in parasitologyPub Date : 2025-03-01Epub Date: 2025-02-10DOI: 10.1016/j.pt.2025.01.008
Liwang Cui
{"title":"Predicting Plasmodium drug resistance through in vitro evolution.","authors":"Liwang Cui","doi":"10.1016/j.pt.2025.01.008","DOIUrl":"10.1016/j.pt.2025.01.008","url":null,"abstract":"<p><p>Knowledge about the resistibility and targets of compounds critically informs antimalarial drug development. Luth et al. systematically analyzed the resistome of Plasmodium falciparum through in vitro evolution and whole-genome analysis of 724 clones resistant to 118 compounds, revealing novel drug targets, multidrug resistance loci, and key determinants of resistance.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"170-171"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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