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Trends in parasitology最新文献

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More than just a phase: the essential role of condensates in Trypanosoma brucei survival. 不仅仅是一个阶段：凝析物在布鲁氏锥虫的生存中起着至关重要的作用。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-01 DOI: 10.1016/j.pt.2026.08.004
Htay M Aye, Mathieu Cayla, Joana R C Faria
{"title":"More than just a phase: the essential role of condensates in Trypanosoma brucei survival.","authors":"Htay M Aye, Mathieu Cayla, Joana R C Faria","doi":"10.1016/j.pt.2026.08.004","DOIUrl":"10.1016/j.pt.2026.08.004","url":null,"abstract":"<p><p>The study of biomolecular condensates and other membraneless organelles has shifted the paradigm of cellular organisation, yet their role in parasitic biology remains an emerging field. While model eukaryotes provide the blueprint for phase separation and spatial compartmentalisation, kinetoplastid parasites offer a unique lens through which to explore the functional limits of these 'regulatory hubs'. In this opinion article, we argue that their unconventional biology renders them valuable models for understanding spatial regulation of gene expression. While Trypanosoma brucei serves as the current benchmark, significant gaps remain regarding condensate diversity across other kinetoplastids. We propose a broader investigation into whether these organisms utilise conserved condensates with divergent molecular compositions or entirely novel assemblies to drive their life cycle, pathogenesis, and immune evasion.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"980-991"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversible summitting behaviour of Dicrocoelium-infected ants. 感染双棘球蚴的蚂蚁的可逆顶点行为。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-08 DOI: 10.1016/j.pt.2026.08.009
Cameron P Goater, James D Wasmuth, Chen-Hua Li
{"title":"Reversible summitting behaviour of Dicrocoelium-infected ants.","authors":"Cameron P Goater, James D Wasmuth, Chen-Hua Li","doi":"10.1016/j.pt.2026.08.009","DOIUrl":"10.1016/j.pt.2026.08.009","url":null,"abstract":"<p><p>Dicrocoelium dendriticum (Trematoda) larvae cause their ant hosts to attach themselves to a plant with their mandibles. Infected ants detach a few hours later, then repeat the attach/detach sequence over subsequent days. Recognition of reversibility in altered host behaviours can enhance our understanding of the general phenomenon of host manipulation.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"939-942"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolite-effector immunity against malaria. 疟疾代谢物效应免疫。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-08-12 DOI: 10.1016/j.pt.2026.07.016
Miguel P Soares, Miguel Mesquita, Ana Figueiredo
{"title":"Metabolite-effector immunity against malaria.","authors":"Miguel P Soares, Miguel Mesquita, Ana Figueiredo","doi":"10.1016/j.pt.2026.07.016","DOIUrl":"10.1016/j.pt.2026.07.016","url":null,"abstract":"<p><p>Jaundice, caused by the accumulation of bilirubin in plasma, is clinically interpreted as a maladaptive consequence of hemolysis or as indicative of hepatic failure. Drawing on genetic, biochemical, and clinical evidence, we propose to reframe jaundice as an adaptive response to malaria, a hemolytic disease caused by Plasmodium spp. infection. Bilirubin, the molecular basis of jaundice, represents an effector arm of metabolic immunity, distinct from nutritional immunity, which restricts pathogen access to essential nutrients, and from immunometabolism, which shapes immune cell function. In this opinion article, we outline bilirubin's multitarget antiplasmodial mechanisms, define its protective threshold, and discuss its evolutionary implications. We propose metabolite-effector immunity as a broadly applicable framework for host-pathogen biology.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"952-960"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
India's hidden malaria parasitome and zoonotic challenges to elimination. 印度隐藏的疟疾寄生虫和人畜共患疾病面临的消除挑战。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-08-27 DOI: 10.1016/j.pt.2026.08.003
Nikhat Khan, Aparup Das
{"title":"India's hidden malaria parasitome and zoonotic challenges to elimination.","authors":"Nikhat Khan, Aparup Das","doi":"10.1016/j.pt.2026.08.003","DOIUrl":"10.1016/j.pt.2026.08.003","url":null,"abstract":"<p><p>India's current malaria elimination success relies on targeting Plasmodium falciparum and Plasmodium vivax. However, sustaining complete elimination requires expanding beyond this species-centric focus. Embracing a broader One Health paradigm is essential for integrating hidden parasite diversity, addressing zoonotic malaria threats, and implementing risk-based surveillance to detect emerging transmission pathways early.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"947-951"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Equitable access to monoclonal antibodies targeting parasites. 公平获得针对寄生虫的单克隆抗体。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-01 DOI: 10.1016/j.pt.2026.08.002
Sahal Thahir, Natalie M Bowman, Peter D Crompton, Robert A Seder, Kassoum Kayentao, Tuan M Tran
{"title":"Equitable access to monoclonal antibodies targeting parasites.","authors":"Sahal Thahir, Natalie M Bowman, Peter D Crompton, Robert A Seder, Kassoum Kayentao, Tuan M Tran","doi":"10.1016/j.pt.2026.08.002","DOIUrl":"10.1016/j.pt.2026.08.002","url":null,"abstract":"<p><p>Monoclonal antibodies (mAbs) have reshaped prevention and treatment of infectious diseases. However, the development of mAbs against parasitic diseases that disproportionately impact populations in resource-limited settings has received lower priority. Recent trials in Africa show that long-acting mAbs can prevent Plasmodium falciparum infection in children and adults. Early studies suggest that mAb pharmacokinetics differ between malaria-endemic and nonendemic populations, with age and prior parasite exposure possibly affecting the minimum amount of mAb required for durable protection. We present evidence that antiparasitic mAb studies should account for fragment crystallizable receptor polymorphisms and host factors commonly found in endemic populations. We discuss economic and manufacturing barriers to accessing mAbs in resource-limited settings, which have implications for the future use of these promising interventions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"970-979"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sailing to a deeper understanding of malaria parasite invasion. 航行到更深入地了解疟疾寄生虫的入侵。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-23 DOI: 10.1016/j.pt.2026.09.001
Andrew B Tobin
{"title":"Sailing to a deeper understanding of malaria parasite invasion.","authors":"Andrew B Tobin","doi":"10.1016/j.pt.2026.09.001","DOIUrl":"10.1016/j.pt.2026.09.001","url":null,"abstract":"<p><p>In a recent article by Haile et al., the atomic-level structure of the protein complex responsible for the invasion of the malaria parasite into red blood cells is described. Here, the key findings and the implications for the development of next-generation antimalarials are reviewed.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"933-935"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Questing for sustainable control of cattle ticks: bottlenecks in developing efficacious vaccines. 探索可持续控制牛蜱：开发有效疫苗的瓶颈。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-08-31 DOI: 10.1016/j.pt.2026.08.005
Isabel K F de Miranda Santos, Johannes Charlier, Vish Nene, Gary Entrican, Latifa Elhachimi, Bruno Goddeeris, Cynthia Baldwin
{"title":"Questing for sustainable control of cattle ticks: bottlenecks in developing efficacious vaccines.","authors":"Isabel K F de Miranda Santos, Johannes Charlier, Vish Nene, Gary Entrican, Latifa Elhachimi, Bruno Goddeeris, Cynthia Baldwin","doi":"10.1016/j.pt.2026.08.005","DOIUrl":"10.1016/j.pt.2026.08.005","url":null,"abstract":"<p><p>Naturally acquired immunity against cattle ticks, observed in certain breeds of cattle, indicates that development of vaccines to prevent infestations is feasible. This opinion article focuses on the knowledge needed to guide their development, formulation, and testing. It discusses the limitations of current experimental vaccines and tests used to evaluate them and points to the research needed to achieve a truly efficacious vaccine. It includes using better strategies to select antigens, not relying solely on indirect readouts of efficacy but rather elucidating the immune mechanisms responsible for reducing tick loads and overcoming the low coverage of the host's major histocompatibility complex class II molecules, as well as avoiding confounding factors in designs for testing vaccines and considering management practices that impact efficacy.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"992-1003"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights on Plasmodium gene expression from direct RNA sequencing. 直接RNA测序对疟原虫基因表达的新见解。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-03 DOI: 10.1016/j.pt.2026.08.006
Janne Grünebast, David Serre
{"title":"New insights on Plasmodium gene expression from direct RNA sequencing.","authors":"Janne Grünebast, David Serre","doi":"10.1016/j.pt.2026.08.006","DOIUrl":"10.1016/j.pt.2026.08.006","url":null,"abstract":"<p><p>Oxford Nanopore Technology (ONT) direct RNA sequencing enables the sequencing of native RNA molecules without cDNA conversion. The long-read approach captures full-length reads spanning entire genes and has transformed the study of gene expression in Plasmodium parasites by enabling analysis of untranslated regions, isoforms, and alternative splicing. In addition, ONT provides unique insights into non-coding RNAs, RNA modifications, and polyadenylated tail dynamics, which are expanding our understanding of post-transcriptional regulation in Plasmodium, including processes beyond translational repression in gametocytes and sporozoites. Here, we discuss the past and future applications of direct RNA sequencing in Plasmodium research and highlight its advantages, limitations, and future prospects.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"961-969"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A framework to integrate parasites into micro- and nanoplastic pollution research. 将寄生虫纳入微纳米塑料污染研究的框架。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-08-08 DOI: 10.1016/j.pt.2026.07.013
Jerusha Bennett, Chen-Hua Li, Bernd Sures, Robert Poulin, Christian Selbach
{"title":"A framework to integrate parasites into micro- and nanoplastic pollution research.","authors":"Jerusha Bennett, Chen-Hua Li, Bernd Sures, Robert Poulin, Christian Selbach","doi":"10.1016/j.pt.2026.07.013","DOIUrl":"10.1016/j.pt.2026.07.013","url":null,"abstract":"<p><p>Plastic pollution is a global issue. Research on its effects on free-living organisms is growing, but the mechanisms by which micro- and nanoplastics interact with host-parasite systems and their ecological and evolutionary implications remain largely unknown. We propose a framework to better integrate parasites into the context of plastic pollution.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"936-938"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What's in a name? Discovering Leishmania. 名字里有什么？发现利什曼虫。
IF 7.6 1区 医学
Trends in parasitology Pub Date : 2026-10-01 Epub Date: 2026-09-03 DOI: 10.1016/j.pt.2026.08.007
Michael P Barrett, Syamal Roy, Heather M Vincent, Vyacheslav Yurchenko
{"title":"What's in a name? Discovering Leishmania.","authors":"Michael P Barrett, Syamal Roy, Heather M Vincent, Vyacheslav Yurchenko","doi":"10.1016/j.pt.2026.08.007","DOIUrl":"10.1016/j.pt.2026.08.007","url":null,"abstract":"<p><p>2 June 2026 marked the centenary of the death of Sir William Boog Leishman, the Scottish physician after whom Leishmania was named. However, he was not the first to describe the parasite. In this article, we recount this discovery and explain the etymological conventions that ensured Leishman's name was preserved in scientific history.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"943-946"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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