{"title":"Tissue-dependent protection mechanisms of antibodies targeting Plasmodium sporozoites.","authors":"Manuela C Aguirre-Botero, Rogerio Amino","doi":"10.1016/j.pt.2025.08.001","DOIUrl":null,"url":null,"abstract":"<p><p>Malaria remains a major global health burden. Antibodies targeting the circumsporozoite protein (CSP), the main surface protein of Plasmodium sporozoites, have emerged as a promising prophylactic tool. Antibodies that bind to the CSP central repetitive region are the foundation of protection against sporozoite infection elicited by CSP-based vaccines. These antibodies have been shown to provide protection in both animal models and humans, although how they confer protection is not fully understood. This review explores how anti-CSP antibodies can neutralize sporozoites and how they mediate protection through tissue-specific mechanisms. Understanding these multilayered mechanisms is critical for improving vaccines and antibody-based prophylaxis.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"853-867"},"PeriodicalIF":6.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pt.2025.08.001","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Malaria remains a major global health burden. Antibodies targeting the circumsporozoite protein (CSP), the main surface protein of Plasmodium sporozoites, have emerged as a promising prophylactic tool. Antibodies that bind to the CSP central repetitive region are the foundation of protection against sporozoite infection elicited by CSP-based vaccines. These antibodies have been shown to provide protection in both animal models and humans, although how they confer protection is not fully understood. This review explores how anti-CSP antibodies can neutralize sporozoites and how they mediate protection through tissue-specific mechanisms. Understanding these multilayered mechanisms is critical for improving vaccines and antibody-based prophylaxis.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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