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Cellular immune response during Toxoplasma gondii infection: deciphering diverse population immune variations. 刚地弓形虫感染期间的细胞免疫反应：解读不同人群的免疫变异。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-11 DOI: 10.1016/j.pt.2025.08.010
Junjie Li, Weixin Gao, Zixun Yan, Biqing Yan, Jili Zhang
{"title":"Cellular immune response during Toxoplasma gondii infection: deciphering diverse population immune variations.","authors":"Junjie Li, Weixin Gao, Zixun Yan, Biqing Yan, Jili Zhang","doi":"10.1016/j.pt.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.pt.2025.08.010","url":null,"abstract":"<p><p>Toxoplasma gondii is a widespread Apicomplexan parasite that affects approximately one-third of the global population. The development and clinical features of toxoplasmosis are closely related to the immune status of the population. While most immunocompetent individuals are asymptomatic after primary acquired infection, immunocompromised patients may develop a range of severe clinical symptoms and complications. In the case of pregnant women the fetuses are at risk of clinical severity following primary infection during pregnancy. This review aims to elucidate the characteristics of immune interaction patterns in individuals with different immune statuses and provide a theoretical basis for more effective, accurate toxoplasmosis treatment strategies. These findings can achieve targeted and precise prevention and control for different groups, effectively guaranteeing public health security.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyalomma marginatum (the Mediterranean Hyalomma). 边缘透明瘤（地中海透明瘤）。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-07-04 DOI: 10.1016/j.pt.2025.06.007
Agustín Estrada-Peña
{"title":"Hyalomma marginatum (the Mediterranean Hyalomma).","authors":"Agustín Estrada-Peña","doi":"10.1016/j.pt.2025.06.007","DOIUrl":"10.1016/j.pt.2025.06.007","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"822-823"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 'green' toolbox: non-chemotherapeutic approaches for gastrointestinal nematode control in ruminants. “绿色”工具箱：反刍动物胃肠道线虫控制的非化疗方法。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1016/j.pt.2025.07.008
Miguel Peña-Espinoza, Hannah Rose Vineer, Adam D Hayward, Andrew R Williams, Tom N McNeilly, Stig M Thamsborg
{"title":"A 'green' toolbox: non-chemotherapeutic approaches for gastrointestinal nematode control in ruminants.","authors":"Miguel Peña-Espinoza, Hannah Rose Vineer, Adam D Hayward, Andrew R Williams, Tom N McNeilly, Stig M Thamsborg","doi":"10.1016/j.pt.2025.07.008","DOIUrl":"10.1016/j.pt.2025.07.008","url":null,"abstract":"<p><p>Grazing ruminants are commonly infected with gastrointestinal nematodes, and their negative impacts on animal health, welfare and production are intensified by increasing anthelmintic drug resistance. The goal of reducing anthelmintic use while preserving effective parasite control has motivated research on non-chemotherapeutic interventions, including those relevant to 'green'/organic ruminant production systems. However, 'green' control strategies are at varying levels of development, and an updated overview of the fragmented evidence is timely before they can be integrated with current parasite management. Here, we highlight recent scientific progress of selected non-chemotherapeutic tools for gastrointestinal nematode control in ruminants, existing knowledge gaps, and how novel research approaches and new technologies are contributing to their testing, further development and on-farm implementation, while advancing our understanding of host-parasite-environment interactions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"780-795"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safeguarding malaria control gains in Africa through 'species sanitation' and structural resilience. 通过“物种卫生”和结构韧性保护非洲疟疾控制成果。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-01 DOI: 10.1016/j.pt.2025.07.004
Fredros Okumu, Joel O Odero, J Derek Charlwood, Bart G J Knols, April Monroe
{"title":"Safeguarding malaria control gains in Africa through 'species sanitation' and structural resilience.","authors":"Fredros Okumu, Joel O Odero, J Derek Charlwood, Bart G J Knols, April Monroe","doi":"10.1016/j.pt.2025.07.004","DOIUrl":"10.1016/j.pt.2025.07.004","url":null,"abstract":"<p><p>To maintain effective malaria control, endemic countries must reinforce their short-term commodity-based approaches with sustainable, longer-term strategies. In Africa, where only a few highly-efficient Anopheles vectors drive most malaria transmission, we propose a two-tier strategy to safeguard control gains. First, aggressively pursue an expanded interpretation of species sanitation by targeting ecological vulnerabilities of primary vectors to suppress or eliminate them. Second, gradually build structural resilience through improved housing and environmental management. Future innovations, like gene-drive mosquitoes and longer-lasting vaccines, could further amplify impact and enhance resilience in poor communities. This layered strategy must rest on human-centred policies, increased domestic funding, cross-sector partnerships and resilient health systems, anchored in longer-term planning beyond the usual 5-year cycles. Ultimately, countries could preserve control gains, despite limited external financing.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"720-733"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parasite genome organization: come together, right now! 寄生虫基因组组织：团结起来，现在！
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.pt.2025.07.010
Parul Singh, Leon Walther, Maureen D Cabahug, Joana R C Faria, Jessica M Bryant
{"title":"Parasite genome organization: come together, right now!","authors":"Parul Singh, Leon Walther, Maureen D Cabahug, Joana R C Faria, Jessica M Bryant","doi":"10.1016/j.pt.2025.07.010","DOIUrl":"10.1016/j.pt.2025.07.010","url":null,"abstract":"<p><p>Links between genome organization and transcription have been extensively studied in model eukaryotes; however, recent application of state-of-the-art chromosome conformation capture techniques to kinetoplastid and Plasmodium parasites has revealed fascinating and divergent architectural mechanisms underlying gene regulation. Trypanosomes assemble nuclear compartments to fine-tune transcription and splicing of variant surface glycoprotein genes. Plasmodium utilizes specific protein complexes to cluster variant surface antigen genes for their epigenetic regulation and genetic diversity. Recent studies have also observed coalescence of genes transcribed by RNAPII in Trypanosoma brucei and active stage-specific genes in Plasmodium falciparum, which could facilitate bursts of transcription in the dynamic parasite life cycle. Thus, connections between genome architecture and gene regulation are emerging as crucial to parasite survival and pathogenesis.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"753-768"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tick and host microbiotas: immunomodulators in tick-borne diseases? 蜱和宿主微生物：蜱传疾病中的免疫调节剂？
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1016/j.pt.2025.07.009
Nathalie Boulanger
{"title":"Tick and host microbiotas: immunomodulators in tick-borne diseases?","authors":"Nathalie Boulanger","doi":"10.1016/j.pt.2025.07.009","DOIUrl":"10.1016/j.pt.2025.07.009","url":null,"abstract":"<p><p>Vector-borne diseases have a growing impact on human and animal health. Metagenomics has been largely used to characterize the microbiome and has highlighted the key role of the microbiota in modulating the vector competence of insects. Currently, an integrated approach combining vector control, vaccine prevention, and drug treatment is being developed to limit the transmission of insect-borne pathogens. This is more complex for tick-associated diseases, considering the biology of the tick and the possibility of modifications of its microbiota in vector control. Conversely, because the skin is an essential interface in tick-borne diseases, an in-depth study of the precise role of the tick and host microbiota during tick bite and pathogen inoculation opens up new prospects for controlling these diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"796-805"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural strategies in parasitic manipulation. 寄生操作中的神经策略。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1016/j.pt.2025.07.007
Aleksei Miroliubov, Anastasia Lianguzova, Frederic Libersat
{"title":"Neural strategies in parasitic manipulation.","authors":"Aleksei Miroliubov, Anastasia Lianguzova, Frederic Libersat","doi":"10.1016/j.pt.2025.07.007","DOIUrl":"10.1016/j.pt.2025.07.007","url":null,"abstract":"<p><p>By localizing within the host nervous system, parasites gain a strategic foothold that facilitates precise manipulation of host behavior. Despite diverse mechanisms, unrelated metazoan taxa have convergently evolved to target similar neural pathways. Behavioral changes are sometimes dismissed as nonadaptive by-products of infection, particularly in understudied systems, making it difficult to identify true manipulation. However, growing evidence suggests that such by-products may serve as evolutionary precursors to adaptive strategies. In some groups, such as rhizocephalans, neural interaction appears fundamental to the evolution of the entire group. Recent advances are uncovering specific neural targets, molecular effectors, and precise timing of manipulation. As research moves beyond descriptive studies, parasite neuroscience promises new insights into brain function, evolutionary dynamics, and potential applications in bioengineering.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"806-819"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcoptes scabiei (scabies mite).
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-04-22 DOI: 10.1016/j.pt.2025.03.011
Michael J Yabsley, Scott Carver, Jillian Broadhurst, Raquel Francisco
{"title":"Sarcoptes scabiei (scabies mite).","authors":"Michael J Yabsley, Scott Carver, Jillian Broadhurst, Raquel Francisco","doi":"10.1016/j.pt.2025.03.011","DOIUrl":"10.1016/j.pt.2025.03.011","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"820-821"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
After the bite: cellular responses to mosquito blood feeding. 叮咬后：细胞对蚊子吸血的反应。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1016/j.pt.2025.07.018
David R Hall, Ryan C Smith
{"title":"After the bite: cellular responses to mosquito blood feeding.","authors":"David R Hall, Ryan C Smith","doi":"10.1016/j.pt.2025.07.018","DOIUrl":"10.1016/j.pt.2025.07.018","url":null,"abstract":"<p><p>Vial et al. performed single-cell transcriptomics and metabolomics of Aedes aegypti midgut and fat body tissues after blood feeding, characterizing novel cell types and markers, transcriptomic and metabolic responses to feeding, and insect-specific virus infection dynamics. This analysis reveals an intricate cellular ecosystem driving digestion, metabolism, reproduction, and immunity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"709-710"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological targeting of the helminth complex II: are there any rhodoquinone-driven adaptations? 寄生虫复合体的药理靶向II：是否存在红醌驱动的适应性？
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.pt.2025.06.016
Franco Vairoletti, Cecilia Saiz, Gustavo Salinas
{"title":"Pharmacological targeting of the helminth complex II: are there any rhodoquinone-driven adaptations?","authors":"Franco Vairoletti, Cecilia Saiz, Gustavo Salinas","doi":"10.1016/j.pt.2025.06.016","DOIUrl":"10.1016/j.pt.2025.06.016","url":null,"abstract":"<p><p>Based on a particular biochemical model, the use of rhodoquinone (RQ) under hypoxic conditions has been linked to an alternative complex II in the electron transport chain in helminths. This model was derived from detailed studies on Ascaris suum and generalized for helminths. However, accumulated evidence warrants a critical model re-examination. RQ facilitates complex II to operate in reverse as a fumarate reductase when oxygen is unavailable, but this biochemical adaptation typically does not involve a dedicated alternative complex II. Based on recent genomic, biochemical, and pharmacological data, we argue that the Ascaris scenario cannot be extrapolated to other helminths. Complex II is a promising pharmacological target for helminths; thus, the revision of the model also has practical consequences.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"746-752"},"PeriodicalIF":6.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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