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Trends in parasitology最新文献

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Predicting Plasmodium drug resistance through in vitro evolution.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1016/j.pt.2025.01.008
Liwang Cui
{"title":"Predicting Plasmodium drug resistance through in vitro evolution.","authors":"Liwang Cui","doi":"10.1016/j.pt.2025.01.008","DOIUrl":"10.1016/j.pt.2025.01.008","url":null,"abstract":"<p><p>Knowledge about the resistibility and targets of compounds critically informs antimalarial drug development. Luth et al. systematically analyzed the resistome of Plasmodium falciparum through in vitro evolution and whole-genome analysis of 724 clones resistant to 118 compounds, revealing novel drug targets, multidrug resistance loci, and key determinants of resistance.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"170-171"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ctenocephalides felis (cat flea).
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI: 10.1016/j.pt.2024.12.016
André Pereira, Adrian Cruz, Teresa Novo, Carla Maia
{"title":"Ctenocephalides felis (cat flea).","authors":"André Pereira, Adrian Cruz, Teresa Novo, Carla Maia","doi":"10.1016/j.pt.2024.12.016","DOIUrl":"10.1016/j.pt.2024.12.016","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"249-250"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helminths target macrophage epigenetics and metabolism to evade immunity.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.1016/j.pt.2025.01.012
Bart Everts
{"title":"Helminths target macrophage epigenetics and metabolism to evade immunity.","authors":"Bart Everts","doi":"10.1016/j.pt.2025.01.012","DOIUrl":"10.1016/j.pt.2025.01.012","url":null,"abstract":"<p><p>Parasitic helminths are well known master regulators of host immune responses. Yet, the underlying molecular principles remain largely enigmatic. Recent work from Bohnacker et al. reveals that glutamate dehydrogenase (GDH), a metabolic enzyme secreted by Heligmosomoides polygyrus, can suppress type 2 immunity by multimodal regulation of macrophage metabolism and epigenetics.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"172-174"},"PeriodicalIF":7.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cichlidogyrus casuarinus.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-25 DOI: 10.1016/j.pt.2025.01.013
Maarten P M Vanhove, Antoine Pariselle, Nikol Kmentová
{"title":"Cichlidogyrus casuarinus.","authors":"Maarten P M Vanhove, Antoine Pariselle, Nikol Kmentová","doi":"10.1016/j.pt.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.pt.2025.01.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-glycoproteins in anthelmintic safety, efficacy, and resistance: (Trends in Parasitology 40, 896-913; 2024).
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-25 DOI: 10.1016/j.pt.2025.02.003
Anne Lespine, Clara Blancfuney, Roger Prichard, Melanie Alberich
{"title":"P-glycoproteins in anthelmintic safety, efficacy, and resistance: (Trends in Parasitology 40, 896-913; 2024).","authors":"Anne Lespine, Clara Blancfuney, Roger Prichard, Melanie Alberich","doi":"10.1016/j.pt.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.pt.2025.02.003","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Having your cake and eating it too - a new target for sporozoite-neutralising mAbs.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-21 DOI: 10.1016/j.pt.2025.02.002
Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn
{"title":"Having your cake and eating it too - a new target for sporozoite-neutralising mAbs.","authors":"Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn","doi":"10.1016/j.pt.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.pt.2025.02.002","url":null,"abstract":"<p><p>Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culex pipiens complex (common house mosquito).
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-21 DOI: 10.1016/j.pt.2025.01.011
Haoues Alout, Maxime Prat, Pierrick Labbé
{"title":"Culex pipiens complex (common house mosquito).","authors":"Haoues Alout, Maxime Prat, Pierrick Labbé","doi":"10.1016/j.pt.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.pt.2025.01.011","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematodinium perezi.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-20 DOI: 10.1016/j.pt.2025.02.001
Hamish J Small, Caiwen Li
{"title":"Hematodinium perezi.","authors":"Hamish J Small, Caiwen Li","doi":"10.1016/j.pt.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.pt.2025.02.001","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crassiphiala bulboglossa.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI: 10.1016/j.pt.2024.11.013
Vasyl V Tkach, Tyler J Achatz
{"title":"Crassiphiala bulboglossa.","authors":"Vasyl V Tkach, Tyler J Achatz","doi":"10.1016/j.pt.2024.11.013","DOIUrl":"10.1016/j.pt.2024.11.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"162-163"},"PeriodicalIF":7.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-scale, functional screen of Plasmodium sexual replication. 基因组尺度，疟原虫有性复制的功能筛选。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI: 10.1016/j.pt.2024.12.014
Surendra K Prajapati, Kim C Williamson
{"title":"Genome-scale, functional screen of Plasmodium sexual replication.","authors":"Surendra K Prajapati, Kim C Williamson","doi":"10.1016/j.pt.2024.12.014","DOIUrl":"10.1016/j.pt.2024.12.014","url":null,"abstract":"<p><p>Malaria mortality remains above 500 000 people annually, demonstrating the need for new and innovative control approaches. Using a genome-scale, functional screen of Plasmodium sexual replication, Sayers et al. identified over 300 genes essential for malaria transmission through the mosquito, providing many new candidates for drug and vaccine development.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"80-82"},"PeriodicalIF":7.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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