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Trends in parasitology最新文献

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Triatoma infestans (kissing bug). 感染三角瘤（接吻虫）。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-13 DOI: 10.1016/j.pt.2026.03.015
Kaio C C Alevi, Filipe Dantas-Torres
{"title":"Triatoma infestans (kissing bug).","authors":"Kaio C C Alevi, Filipe Dantas-Torres","doi":"10.1016/j.pt.2026.03.015","DOIUrl":"https://doi.org/10.1016/j.pt.2026.03.015","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic insecticide resistance DNA markers in malaria vectors. 疟疾病媒代谢杀虫剂抗性DNA标记。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-10 DOI: 10.1016/j.pt.2026.03.013
Magellan Tchouakui, Carlos S Djoko Tagne, Theofelix A Tekoh, Nelly M T Tatchou-Nebangwa, Mersimine M Kouamo, Charles S Wondji
{"title":"Metabolic insecticide resistance DNA markers in malaria vectors.","authors":"Magellan Tchouakui, Carlos S Djoko Tagne, Theofelix A Tekoh, Nelly M T Tatchou-Nebangwa, Mersimine M Kouamo, Charles S Wondji","doi":"10.1016/j.pt.2026.03.013","DOIUrl":"https://doi.org/10.1016/j.pt.2026.03.013","url":null,"abstract":"<p><p>Metabolic resistance to insecticides in malaria vectors is jeopardizing control strategies. Unlike target-site resistance, metabolic resistance is more complex, making causative variants harder to pinpoint and design field-applicable diagnostics. Recently, multiomics approaches have helped detect several DNA markers in detoxification genes (cytochrome P450s, glutathione S-transferases) in major vectors, including Anopheles gambiae (CYP6P4, CYP6P3, GSTe2) and Anopheles funestus (CYP6P9a/b, CYP6P4a/b, CYP9K1, GSTe2, ASL). These markers now support resistance management by assessing spatiotemporal resistance evolution, its impact on control tools, cross-resistance patterns, fitness costs, and malaria transmission. In this review, we synthesize current knowledge on the discovery of these markers, highlight available DNA-based diagnostic methods for operational genomic surveillance, and outline priorities for extending this framework to new insecticides and other vector species.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimalarial efficacy monitoring after nearly 20 years of artemisinin-based combination therapy in Africa: recalibrating guidance. 非洲近20年以青蒿素为基础的联合治疗后的抗疟疗效监测：重新校准指南。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-02 DOI: 10.1016/j.pt.2026.02.012
Leah F Moriarty, Maria M Betoulle, Peter Troell, Irene Cavros, Kevin Griffith, Mateusz M Plucinski
{"title":"Antimalarial efficacy monitoring after nearly 20 years of artemisinin-based combination therapy in Africa: recalibrating guidance.","authors":"Leah F Moriarty, Maria M Betoulle, Peter Troell, Irene Cavros, Kevin Griffith, Mateusz M Plucinski","doi":"10.1016/j.pt.2026.02.012","DOIUrl":"https://doi.org/10.1016/j.pt.2026.02.012","url":null,"abstract":"<p><p>Timely identification of resistance to antimalarials is necessary to ensure effective malaria case management. The backbone of antimalarial resistance surveillance strategies is the therapeutic efficacy study (TES). Originally designed to be easily deployable, in recent years, TES have become increasingly complex and slow to yield results. Concurrently, advances in molecular surveillance techniques, the emergence and spread of artemisinin partial resistance in Africa, and advances in antimalarial drug stewardship through multiple first-line therapies have changed the context in which TES are implemented. In this opinion article, we outline considerations for recalibrating TES methodology. More efficient TES, coupled with molecular surveillance, could provide timely and actionable data for malaria-endemic countries as they manage treatment policies in the context of drug resistance in Africa.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiostrongylus cantonensis (rat lungworm).
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-02 DOI: 10.1016/j.pt.2026.03.008
Håkon H Jones, Nicole L Gottdenker, Heather D S Walden, Michael J Yabsley
{"title":"Angiostrongylus cantonensis (rat lungworm).","authors":"Håkon H Jones, Nicole L Gottdenker, Heather D S Walden, Michael J Yabsley","doi":"10.1016/j.pt.2026.03.008","DOIUrl":"https://doi.org/10.1016/j.pt.2026.03.008","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlled human helminth infection models: insights into type 2 immunity and therapeutic development. 受控的人类蠕虫感染模型：对2型免疫和治疗发展的见解。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.pt.2026.02.009
H Richard Droghini, Thomas B Nutman, P'ng Loke
{"title":"Controlled human helminth infection models: insights into type 2 immunity and therapeutic development.","authors":"H Richard Droghini, Thomas B Nutman, P'ng Loke","doi":"10.1016/j.pt.2026.02.009","DOIUrl":"10.1016/j.pt.2026.02.009","url":null,"abstract":"<p><p>Controlled human infection models are powerful tools for evaluating pathogenesis, immune responses, vaccines, and therapeutics, including parasitic helminths. Helminths have also been tested as inflammatory disease therapeutics. This review focuses on immune responses during controlled infections with Trichuris species, Necator americanus, and Schistosoma mansoni. Over 700 participants have been experimentally infected across 33 studies to date. These models reveal significant heterogeneity in type 2-associated responses among individuals for all infections. While eosinophilia is most frequently observed, mixed Th1/Th2 responses in CD4+ T cells accompanied by IL-10 production and T regulatory cells are often observed in some individuals. Generally, controlled helminth infection models are safe and answer basic questions on type 2 responses. Improved immunophenotyping will guide future therapeutic applications and vaccine development.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"264-274"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The limits of PCR-based diagnostics in parasitology. 基于pcr的寄生虫学诊断的局限性。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-03-11 DOI: 10.1016/j.pt.2026.02.006
Andrew A Davinack
{"title":"The limits of PCR-based diagnostics in parasitology.","authors":"Andrew A Davinack","doi":"10.1016/j.pt.2026.02.006","DOIUrl":"10.1016/j.pt.2026.02.006","url":null,"abstract":"<p><p>Polymerase chain reaction (PCR) plays a central role in parasite diagnostics but is increasingly interpreted as a general test for parasitic infection. Because parasites lack shared molecular features amenable to universal assays, PCR is inherently primer bounded and hypothesis confirming. This article clarifies the interpretive limits of PCR and argues for aligning diagnostic claims with parasite biology.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"219-221"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diversity of emerging tick-borne viruses globally. 全球新出现的蜱传病毒的多样性。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.pt.2026.03.001
Yicheng Zhao, Jun Zheng, Quan Liu
{"title":"The diversity of emerging tick-borne viruses globally.","authors":"Yicheng Zhao, Jun Zheng, Quan Liu","doi":"10.1016/j.pt.2026.03.001","DOIUrl":"10.1016/j.pt.2026.03.001","url":null,"abstract":"<p><p>Zhang et al. provide the first global synthesis of 230 emerging tick-borne viruses, introducing a genomic model that predicts zoonotic risk. Their approach identifies 25 very-high-risk viruses and clinically validates three novel human pathogens, shifting the paradigm from reactive discovery to proactive risk assessment for global health security.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"207-209"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-suppressor pathways in Schistosoma mansoni support a novel hypothesis on neodermatan flatworm origins. 曼氏血吸虫的肿瘤抑制途径支持了一个关于新皮肤扁平虫起源的新假设。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-03-11 DOI: 10.1016/j.pt.2026.02.003
Paul J Brindley
{"title":"Tumor-suppressor pathways in Schistosoma mansoni support a novel hypothesis on neodermatan flatworm origins.","authors":"Paul J Brindley","doi":"10.1016/j.pt.2026.02.003","DOIUrl":"10.1016/j.pt.2026.02.003","url":null,"abstract":"<p><p>Wendt and Collins identify a cyclin-dependent kinase inhibitor (cki) in Schistosoma mansoni that, along with p53-1 (schistosome homolog of TP-53), suppresses tegument cell proliferation. Knockdown of cki causes hyperproliferation and, together with p53-1 loss, tumorlike growths. Homologs of cki are widespread in parasitic flatworms but absent in free-living relatives, suggesting that the horizontal gene transfer aided the evolution of parasitism.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"212-214"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The survival and escape strategies of microsporidia. 微孢子虫的生存和逃逸策略。
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-03-16 DOI: 10.1016/j.pt.2026.02.008
Fangyan Liu, Xianzhi Meng, Guoqing Pan, Jialing Bao, Jie Chen
{"title":"The survival and escape strategies of microsporidia.","authors":"Fangyan Liu, Xianzhi Meng, Guoqing Pan, Jialing Bao, Jie Chen","doi":"10.1016/j.pt.2026.02.008","DOIUrl":"10.1016/j.pt.2026.02.008","url":null,"abstract":"<p><p>Microsporidia are obligate intracellular parasites that can infect various invertebrate and vertebrate species, including humans. They have evolved resistance strategies to survive in their ecological niche. When dormant, microsporidia exist in the form of spores to withstand harsh environmental stressors and conserve energy. When stimulated by appropriate conditions, microsporidia germinate and inject infective sporoplasm into host cells, hijacking host metabolism to acquire energy and utilizing multiple strategies to regulate and evade host defense, manipulate the host cytoskeleton, and proliferate successfully. In this review, we summarize microsporidia resistance strategies and escape mechanisms that enable them to overcome host- and environment-imposed challenges. Such insights advance our understanding of microsporidia biology and host-pathogen interactions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"249-263"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angomonas deanei.
IF 6.6 1区 医学
Trends in parasitology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.pt.2025.12.008
Natascha A van Geelen-Kuenzel, Vyacheslav Yurchenko, Julius Lukeš, Eva C M Nowack
{"title":"Angomonas deanei.","authors":"Natascha A van Geelen-Kuenzel, Vyacheslav Yurchenko, Julius Lukeš, Eva C M Nowack","doi":"10.1016/j.pt.2025.12.008","DOIUrl":"10.1016/j.pt.2025.12.008","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"309-310"},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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