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Making scents of mosquito repellents. 制造驱蚊剂的气味。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1016/j.pt.2025.02.009
Cole J Meier, Minh N Nguyen, Christopher J Potter
{"title":"Making scents of mosquito repellents.","authors":"Cole J Meier, Minh N Nguyen, Christopher J Potter","doi":"10.1016/j.pt.2025.02.009","DOIUrl":"10.1016/j.pt.2025.02.009","url":null,"abstract":"<p><p>Mosquitoes transmit deadly diseases. Chemical repellents deter mosquitoes from approaching or biting a human host and are an effective behavior-based method of personal protection. However, the current standards for selecting repellents often disregard their mode of action. This has likely led many potential repellents to be overlooked. Here, we discuss the sensory systems that underlie host-seeking behavior and how such behaviors are interrupted by repellents. We explore the behavioral assays used to identify repellents and how these have led a handful of contact repellents (DEET, picaridin, IR3535) to dominate the field. Finally, we consider how the development of spatial repellents may further protect against mosquito-borne diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"280-289"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-species immune activation and immunobiotics: a new frontier in vector-borne pathogen control. 跨物种免疫激活和免疫生物：媒介传播病原体控制的新前沿。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1016/j.pt.2025.02.004
Alejandro Cabezas-Cruz, Elianne Piloto-Sardiñas, Pierre Tonnerre, Covadonga Lucas-Torres, Dasiel Obregon
{"title":"Cross-species immune activation and immunobiotics: a new frontier in vector-borne pathogen control.","authors":"Alejandro Cabezas-Cruz, Elianne Piloto-Sardiñas, Pierre Tonnerre, Covadonga Lucas-Torres, Dasiel Obregon","doi":"10.1016/j.pt.2025.02.004","DOIUrl":"10.1016/j.pt.2025.02.004","url":null,"abstract":"<p><p>The persistent global burden of vector-borne diseases (VBDs) needs innovative control strategies, as traditional methods are compromised by acaricides and drug resistance and variable vaccine efficacy. We propose a dual-action strategy using cross-species immune activation: human microbiota triggers the production of natural antibodies that directly target pathogens in the host and modulate vector immunity by interacting with vector microbiota. The human microbiota also modulates cytokine responses, enhancing immune defenses in both host and vector. These mechanisms can be further optimized by identifying immunobiotics - specific gut microbes that stimulate protective immune responses against VBDs. This approach offers a sustainable framework to bridge the gap between host and vector immunity, introducing a novel method to combat VBDs.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"290-300"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virulence attenuation of Theileria annulata-transformed macrophages. 环芽孢杆菌转化巨噬细胞的毒力衰减。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1016/j.pt.2025.02.007
Shahin Tajeri, Gordon Langsley
{"title":"Virulence attenuation of Theileria annulata-transformed macrophages.","authors":"Shahin Tajeri, Gordon Langsley","doi":"10.1016/j.pt.2025.02.007","DOIUrl":"10.1016/j.pt.2025.02.007","url":null,"abstract":"<p><p>Tropical theileriosis is a significant tick-borne disease affecting cattle. For decades an empirical live attenuated vaccine has been the primary method of controlling disease. The vaccine is produced through prolonged culture of Theileria annulata schizont-transformed macrophages, but how loss of virulence occurs remains unclear. Notably attenuated (vaccine) macrophages display dampened dissemination potential compared with their original, virulent counterparts. In addition, parasite schizonts in attenuated macrophages have significantly lost their ability to differentiate into merozoites. This review discusses the changes that occur during long-term passage of T. annulata-transformed bovine macrophages and how they contribute to loss of virulence, defined as heightened dissemination. Finally, we also suggest that a common parasite-dependent pathway is potentially involved in both macrophage dissemination and parasite merogony.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"301-316"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteric neurons and immune cells shape anti-helminth immunity. 肠道神经元和免疫细胞形成抗蠕虫免疫。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1016/j.pt.2025.03.002
Zachary Kerner, Albana L Kodra, Daniel Mucida
{"title":"Enteric neurons and immune cells shape anti-helminth immunity.","authors":"Zachary Kerner, Albana L Kodra, Daniel Mucida","doi":"10.1016/j.pt.2025.03.002","DOIUrl":"10.1016/j.pt.2025.03.002","url":null,"abstract":"<p><p>Wang et al. recently reported that during helminth infection, innate lymphoid cell (ILC)-derived IL-13 is sensed by gut neurons, which in turn secretes CGRP to inhibit ILC2 proliferation and anti-helminth responses. Hence, this study demonstrates a bidirectional crosstalk between enteric neurons and immune cells that regulates type-2 immunity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"267-268"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-glycoproteins in anthelmintic safety, efficacy, and resistance: (Trends in Parasitology 40, 896-913; 2024). p -糖蛋白在驱虫药安全性、有效性和耐药性中的应用[j] .寄生虫学进展，40,896-913；2024)。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1016/j.pt.2025.02.003
Anne Lespine, Clara Blancfuney, Roger Prichard, Melanie Alberich
{"title":"P-glycoproteins in anthelmintic safety, efficacy, and resistance: (Trends in Parasitology 40, 896-913; 2024).","authors":"Anne Lespine, Clara Blancfuney, Roger Prichard, Melanie Alberich","doi":"10.1016/j.pt.2025.02.003","DOIUrl":"10.1016/j.pt.2025.02.003","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"334"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral manifestations of falciparum malaria in adults: more than meets the eye. 成人恶性疟疾的大脑表现：不只是表面现象。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1016/j.pt.2025.02.005
Samuel C Wassmer, Sanjib Mohanty, Praveen K Sahu, Angelika Hoffmann
{"title":"Cerebral manifestations of falciparum malaria in adults: more than meets the eye.","authors":"Samuel C Wassmer, Sanjib Mohanty, Praveen K Sahu, Angelika Hoffmann","doi":"10.1016/j.pt.2025.02.005","DOIUrl":"10.1016/j.pt.2025.02.005","url":null,"abstract":"<p><p>The application of neuroimaging techniques to patients with Plasmodium falciparum infection has uncovered a wide range of brain changes not only in cerebral malaria but also in noncomatose patients. We propose several hypotheses to unify findings across the spectrum of clinical malaria in adults and highlight the urgent need to evaluate potential long-term effects of cerebral alterations on neurocognition in this understudied age group.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"271-279"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culex pipiens complex (common house mosquito). 库蚊复合体（普通家蚊）。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1016/j.pt.2025.01.011
Haoues Alout, Maxime Prat, Pierrick Labbé
{"title":"Culex pipiens complex (common house mosquito).","authors":"Haoues Alout, Maxime Prat, Pierrick Labbé","doi":"10.1016/j.pt.2025.01.011","DOIUrl":"10.1016/j.pt.2025.01.011","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"332-333"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pushing the frontiers of babesiosis research: in vitro culture and gene editing. 推动巴贝斯虫病研究的前沿：体外培养和基因编辑。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1016/j.pt.2025.02.008
Dong-Fang Li, Sen Wang, Carlos E Suarez, Xuenan Xuan, Lan He, Jun-Long Zhao
{"title":"Pushing the frontiers of babesiosis research: in vitro culture and gene editing.","authors":"Dong-Fang Li, Sen Wang, Carlos E Suarez, Xuenan Xuan, Lan He, Jun-Long Zhao","doi":"10.1016/j.pt.2025.02.008","DOIUrl":"10.1016/j.pt.2025.02.008","url":null,"abstract":"<p><p>Babesiosis is a tick-borne parasitic disease that poses a significant risk to both animal and human health. A comprehensive understanding of Babesia biology necessitates the application of advanced laboratory techniques. This review explores recent advancements in gene editing technologies of Babesia, emphasizing the foundational importance of in vitro culture systems. We highlight the historical challenges encountered in establishing effective in vitro culture and discuss the need for optimizing these methods to enhance gene editing efficiency. Here, we describe recent progress in Babesia transfection, different gene manipulation systems, and the applications of gene editing. This review aims to provide essential insights and technical guidance for future studies in Babesia genetics, highlighting the transformative potential of gene manipulation in combating this important parasitic disease.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"317-329"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppressing exudation hides the host from a parasitic plant. 抑制分泌物使寄主不被寄生植物发现。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1016/j.pt.2025.03.006
James H Westwood, Sukhmanpreet Kaur
{"title":"Suppressing exudation hides the host from a parasitic plant.","authors":"James H Westwood, Sukhmanpreet Kaur","doi":"10.1016/j.pt.2025.03.006","DOIUrl":"10.1016/j.pt.2025.03.006","url":null,"abstract":"<p><p>Some parasitic plants rely on strigolactone (SL) chemical signals exuded from host roots to trigger seed germination and initiate parasitism. Shi et al. demonstrate that disabling SL exporters in a sorghum host effectively reduces witchweed parasitism without compromising host plant growth, providing a promising strategy for crop improvement.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"269-270"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding the brakes on the Toxoplasma life cycle. 找到弓形虫生命周期的刹车。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1016/j.pt.2025.02.010
Alice L Herneisen, Sebastian Lourido
{"title":"Finding the brakes on the Toxoplasma life cycle.","authors":"Alice L Herneisen, Sebastian Lourido","doi":"10.1016/j.pt.2025.02.010","DOIUrl":"10.1016/j.pt.2025.02.010","url":null,"abstract":"<p><p>Toxoplasma gondii motility is an all-or-nothing response. Claywell et al. identify negative-feedback loops in cyclic-nucleotide signaling that allow parasites to turn off motility and commit to intracellular replication. Feedback mechanisms and bistability are useful frameworks for describing, modeling, and testing T. gondii motility signaling pathways.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"264-266"},"PeriodicalIF":7.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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