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Trends in parasitology最新文献

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Trypanosoma equiperdum.
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-01-27 DOI: 10.1016/j.pt.2025.01.002
Perrine Hervé, Frédéric Bringaud, Loïc Rivière
{"title":"Trypanosoma equiperdum.","authors":"Perrine Hervé, Frédéric Bringaud, Loïc Rivière","doi":"10.1016/j.pt.2025.01.002","DOIUrl":"10.1016/j.pt.2025.01.002","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"504-505"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complementary therapeutic use of exercise in malaria's neurocognitive sequelae. 运动对疟疾神经认知后遗症的辅助治疗。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI: 10.1016/j.pt.2025.04.012
Luciana Pereira de-Sousa, Pamela Rosa-Gonçalves, Beatriz Nogueira Siqueira-E-Silva, Ingrid de Oliveira de-Lavigne, Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro
{"title":"Complementary therapeutic use of exercise in malaria's neurocognitive sequelae.","authors":"Luciana Pereira de-Sousa, Pamela Rosa-Gonçalves, Beatriz Nogueira Siqueira-E-Silva, Ingrid de Oliveira de-Lavigne, Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro","doi":"10.1016/j.pt.2025.04.012","DOIUrl":"10.1016/j.pt.2025.04.012","url":null,"abstract":"<p><p>Malaria can compromise neurocognitive and behavioral integrity. Immunomodulation has been proposed as a mechanism by which exercise benefits brain function, including preventing neurocognitive decline in neurodegenerative diseases. We propose that immunomodulation through moderate-intensity aerobic exercise may be a potential approach to mitigate malaria-related neurocognitive and behavioral alterations.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"428-430"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malaria parasite phenotypic heterogeneity and the power of single-cell technologies. 疟原虫表型异质性和单细胞技术的力量。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1016/j.pt.2025.04.006
Emmanuel Gyamfi, Jake Baum
{"title":"Malaria parasite phenotypic heterogeneity and the power of single-cell technologies.","authors":"Emmanuel Gyamfi, Jake Baum","doi":"10.1016/j.pt.2025.04.006","DOIUrl":"10.1016/j.pt.2025.04.006","url":null,"abstract":"<p><p>The two-host life cycle of the malaria parasite, combined with its ability to regulate gene expression and protein translation within a single clonal genotype, results in a remarkable potential for phenotypic heterogeneity. This heterogeneity presents underappreciated challenges to antimalarial interventions such as vaccines, drugs, and diagnostic tools, with parasites able to evolve resistance rapidly. Here we summarise current knowledge of the different mechanisms driving parasite phenotypic heterogeneity both at the gene and protein level. Centred on the most virulent human malaria parasite, Plasmodium falciparum, we explore the consequences of this diversity for antimalarial interventions and how single-cell technologies present an opportunity to study inter- and intra-clonal heterogeneity to better design future-proofed intervention strategies against this ancient disease.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"460-470"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging mosquito surveillance data to assess ecosystem health. 利用蚊子监测数据评估生态系统健康。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-01 DOI: 10.1016/j.pt.2025.04.011
Nicole A Scavo, Chalmers Vasquez, John-Paul Mutebi, Marco Ajelli, André B B Wilke
{"title":"Leveraging mosquito surveillance data to assess ecosystem health.","authors":"Nicole A Scavo, Chalmers Vasquez, John-Paul Mutebi, Marco Ajelli, André B B Wilke","doi":"10.1016/j.pt.2025.04.011","DOIUrl":"10.1016/j.pt.2025.04.011","url":null,"abstract":"<p><p>Assessing ecosystem health is essential for preserving biodiversity. Mosquito abundance and community composition can serve as indicators of environmental conditions, providing insights into ecosystem health. Mosquitoes are routinely collected through surveillance programs and can be used to develop a metric for assessing both ecosystem health and public health risks.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"424-427"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiparasitics discovery: from genotype to phenotype to compounds. 抗寄生虫的发现：从基因型到表型再到化合物。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI: 10.1016/j.pt.2025.04.007
Richard J Marhöfer, Sandra Noack, Paul M Selzer
{"title":"Antiparasitics discovery: from genotype to phenotype to compounds.","authors":"Richard J Marhöfer, Sandra Noack, Paul M Selzer","doi":"10.1016/j.pt.2025.04.007","DOIUrl":"10.1016/j.pt.2025.04.007","url":null,"abstract":"<p><p>For decades, the discovery of antiparasitics was dominated by whole-organism screening of intact parasite organisms or surrogate parasite models, such as Caenorhabitis elegans, using in vivo animal models or in vitro parasite assays, the latter also known as phenotypic screening. Molecular target-based screening played only a minor role, if at all. While publications using phenotypic screening are abundant in the literature, publications of successful, marketed, antiparasitic drugs discovered using the molecular target-based approach are scarce. This approach, therefore, is often perceived as less relevant for antiparasitic drug discovery than the two other approaches. However, antiparasitics belonging, for example, to the isoxazolines, bispyrazoles, depsipeptides or praziquantel (PZQ) derivatives, imposingly demonstrate the value of this approach, when wisely used in a cooperative manner with phenotypic screening.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"431-440"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation through instability? Genome (dis)organisation in Trypanosoma cruzi. 通过不稳定来创新？克氏锥虫基因组（dis）组织。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1016/j.pt.2025.04.008
Kyrie P Dickson, Jaime A Costales, Malgorzata A Domagalska, Ferre Vander Veken, Martin S Llewellyn
{"title":"Innovation through instability? Genome (dis)organisation in Trypanosoma cruzi.","authors":"Kyrie P Dickson, Jaime A Costales, Malgorzata A Domagalska, Ferre Vander Veken, Martin S Llewellyn","doi":"10.1016/j.pt.2025.04.008","DOIUrl":"10.1016/j.pt.2025.04.008","url":null,"abstract":"<p><p>Chagas disease affects millions globally and is caused by Trypanosoma cruzi, a parasite with a remarkable ability to adapt and persist in complex environments. Emerging evidence suggests that this adaptability may be driven by its extensive genome instability yet the underlying mechanisms remain poorly understood. Drawing insights from related trypanosomatids, we explore how processes such as aneuploidy, copy number variations and genetic rearrangements can be strategically exploited for immune evasion, host adaptation and drug resistance, and consider whether similar processes shape the adaptive potential of T. cruzi. Unravelling the fundamental biology governing genome instability in this parasite will undoubtedly advance our understanding of its evolution, pathogenesis and resilience - crucial steps towards reducing the burden of Chagas disease.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"449-459"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gnathia africana. 非洲Gnathia。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.pt.2025.03.013
Kerry A Hadfield, Anja Erasmus, Nico J Smit
{"title":"Gnathia africana.","authors":"Kerry A Hadfield, Anja Erasmus, Nico J Smit","doi":"10.1016/j.pt.2025.03.013","DOIUrl":"10.1016/j.pt.2025.03.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"506-507"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feline vector-borne diseases: from local risks to global concerns. 猫媒介传播疾病：从地方风险到全球关注。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1016/j.pt.2025.04.009
Domenico Otranto, Mariaelisa Carbonara, Gad Baneth, Filipe Dantas-Torres, Michael R Lappin, Vanessa R Barrs
{"title":"Feline vector-borne diseases: from local risks to global concerns.","authors":"Domenico Otranto, Mariaelisa Carbonara, Gad Baneth, Filipe Dantas-Torres, Michael R Lappin, Vanessa R Barrs","doi":"10.1016/j.pt.2025.04.009","DOIUrl":"10.1016/j.pt.2025.04.009","url":null,"abstract":"<p><p>Although vector-borne pathogens infect cats worldwide, historical research efforts on this topic have been hampered by the belief that cats are less susceptible than dogs to these infections. Additionally, limited data are available on the epidemiology, clinical presentation and zoonotic importance of feline vector-borne diseases (FVBDs). This review discusses and updates the current geographical distribution of FVBDs, along with their clinical features, diagnosis, treatments, and prevention measures, highlighting the key differences between these diseases in cats and dogs and identifying the research needed to address existing knowledge gaps.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"486-503"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmania genomic adaptation: more than just a 36-body problem. 利什曼原虫基因组适应：不仅仅是一个36人的问题。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-01 DOI: 10.1016/j.pt.2025.04.002
Gerald F Späth, Laura Piel, Pascale Pescher
{"title":"Leishmania genomic adaptation: more than just a 36-body problem.","authors":"Gerald F Späth, Laura Piel, Pascale Pescher","doi":"10.1016/j.pt.2025.04.002","DOIUrl":"10.1016/j.pt.2025.04.002","url":null,"abstract":"<p><p>Genome instability has been identified as a major driver of adaptation in fast-growing, eukaryotic cells, including fungi, protists, or cancer. How these cells cope with the toxic effects caused by such copy number variations remains to be elucidated. In recent years, the protist parasites Leishmania spp. have emerged as interesting model pathogens to assess this open question and to study the role of its intrinsic genome instability in fitness gain in culture, experimental infection, and in the field. Here we summarize recent results on Leishmania genomic adaptation and propose thought-provoking evolutionary concepts new to the Leishmania field that need to be considered when mapping genotype-to-phenotype relationships in molecular and epidemiological studies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"441-448"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rice diterpenoids rewire microbiome to fight plant-parasitic nematodes. 水稻二萜重组微生物群以对抗植物寄生线虫。
IF 7 1区 医学
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1016/j.pt.2025.05.001
Muzammil Hussain, Holger Heuer
{"title":"Rice diterpenoids rewire microbiome to fight plant-parasitic nematodes.","authors":"Muzammil Hussain, Holger Heuer","doi":"10.1016/j.pt.2025.05.001","DOIUrl":"10.1016/j.pt.2025.05.001","url":null,"abstract":"<p><p>Microorganisms associated with plant roots can protect the host from plant-parasitic nematodes. Kudjordjie et al. recently demonstrated that rice diterpenoid phytoalexins are involved in the assembly of beneficial root microbiota for nematode suppression. The discovery of phytochemical-mediated modulation of plant-microbe interactions offers an innovative approach to sustainable nematode management.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"421-423"},"PeriodicalIF":7.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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