Trends in parasitology最新文献

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Fasciola hepatica. 肝腹水
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-10-01 Epub Date: 2024-08-10 DOI: 10.1016/j.pt.2024.07.011
Isabella V F Martins, Guilherme G Verocai
{"title":"Fasciola hepatica.","authors":"Isabella V F Martins, Guilherme G Verocai","doi":"10.1016/j.pt.2024.07.011","DOIUrl":"10.1016/j.pt.2024.07.011","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"930-931"},"PeriodicalIF":7.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenic nematodes exploit Achilles' heel of plant symbioses. 致病线虫利用植物共生的致命弱点
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1016/j.pt.2024.08.005
Peter Mergaert, Eric Giraud
{"title":"Pathogenic nematodes exploit Achilles' heel of plant symbioses.","authors":"Peter Mergaert, Eric Giraud","doi":"10.1016/j.pt.2024.08.005","DOIUrl":"10.1016/j.pt.2024.08.005","url":null,"abstract":"<p><p>Cyst nematode parasites disrupt beneficial associations of crops with rhizobia and mycorrhiza. Chen et al. discovered the mechanism and demonstrated that the soybean cyst nematode Heterodera glycines secretes a chitinase that destroys key symbiotic signals from the microbial symbionts. The authors further developed a chitinase inhibitor that alleviates symbiosis inhibition.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"873-875"},"PeriodicalIF":7.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gels and cells: the Leishmania biofilm as a space and place for parasite transmission. 凝胶和细胞:利什曼病生物膜作为寄生虫传播的空间和场所。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.pt.2024.08.001
Matthew E Rogers, Luis Miguel de Pablos, Jack D Sunter
{"title":"Gels and cells: the Leishmania biofilm as a space and place for parasite transmission.","authors":"Matthew E Rogers, Luis Miguel de Pablos, Jack D Sunter","doi":"10.1016/j.pt.2024.08.001","DOIUrl":"10.1016/j.pt.2024.08.001","url":null,"abstract":"<p><p>Leishmania make an abundant glycoprotein and proteophosphoglycan-rich gel, called the promastigote secretory gel, in the anterior midgut of their sand fly vector. This gel is a multi-faceted virulence factor which promotes the survival and transmission of the parasites between hosts. Here, we present the case that Leishmania parasites embedded in the promastigote secretory gel should be redefined as a biofilm as it shares striking similarities in biogenesis, form, and function with biofilms of other unicellular organisms. We believe that this reinterpretation will stimulate new hypotheses and avenues of research to improve our understanding of the developmental programme of Leishmania and the interaction these parasites and other kinetoplastids have with their insect hosts.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"876-885"},"PeriodicalIF":7.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-glycoproteins in anthelmintic safety, efficacy, and resistance. P-糖蛋白在抗蠕虫药物安全性、有效性和抗药性中的作用。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1016/j.pt.2024.07.008
Anne Lespine, Clara Blancfuney, Roger Prichard, Mélanie Alberich
{"title":"P-glycoproteins in anthelmintic safety, efficacy, and resistance.","authors":"Anne Lespine, Clara Blancfuney, Roger Prichard, Mélanie Alberich","doi":"10.1016/j.pt.2024.07.008","DOIUrl":"10.1016/j.pt.2024.07.008","url":null,"abstract":"<p><p>P-glycoprotein (PGP) is a pivotal transmembrane transporter governing the cellular flux of diverse substances shielding mammals from toxics. It can thwart the effectiveness of medicines such as ivermectin (IVM) and other macrocyclic lactone (ML) anthelmintics, undermining therapeutic efforts. We analyze the role of PGPs in limiting the toxicity of these drugs in hosts, and their potential contribution to anthelmintic resistance in nematodes. Targeting nematode PGPs to increase drug sensitivity to MLs seems interesting, but is hampered by the lack of selective inhibitors. The nuclear hormone receptor (NHR)-8 should be seriously considered as a target because it upregulates multiple PGPs involved in anthelmintic resistance and it is specific to nematodes. This would advance our understanding of host-pathogen dynamics and foster innovative therapeutic strategies.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"896-913"},"PeriodicalIF":7.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusion of arts and science: ‘Parasitology Got Talent’ 艺术与科学的融合:"寄生虫学达人秀
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-09-16 DOI: 10.1016/j.pt.2024.08.004
Alexander G. Maier, Tahlia Creighton, Lilian Brewer, Isabella Lingam, Anja Pössnecker, Ella Yardley, Julia Phillips, Vivian Steel, Natasha Evans, Hunter Seabrook, Avery Rowe, Christy-Amber Radmann, Marion Halas, Emma Sommerville, Aidan Hickey, Ethan Jenkins
{"title":"Fusion of arts and science: ‘Parasitology Got Talent’","authors":"Alexander G. Maier, Tahlia Creighton, Lilian Brewer, Isabella Lingam, Anja Pössnecker, Ella Yardley, Julia Phillips, Vivian Steel, Natasha Evans, Hunter Seabrook, Avery Rowe, Christy-Amber Radmann, Marion Halas, Emma Sommerville, Aidan Hickey, Ethan Jenkins","doi":"10.1016/j.pt.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.pt.2024.08.004","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"20 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RH5: rationally-designed malaria vaccine antigen improving efficacy RH5:合理设计疟疾疫苗抗原,提高疗效
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-09-13 DOI: 10.1016/j.pt.2024.09.001
Eizo Takashima, Takafumi Tsuboi
{"title":"RH5: rationally-designed malaria vaccine antigen improving efficacy","authors":"Eizo Takashima, Takafumi Tsuboi","doi":"10.1016/j.pt.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.pt.2024.09.001","url":null,"abstract":"<p><em>Plasmodium falciparum</em> reticulocyte-binding protein homolog 5 (RH5) is a unique asexual blood-stage malaria vaccine candidate because of its high conservation and essential biological function of binding to basigin on the erythrocyte surface. Recent studies by <span><span>Barrett <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, <span><span>Wang <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, and <span><span>King <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, have brought RH5-based vaccine development a step forward based on a rational antigen design strategy.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"44 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermanyssus gallinae (Poultry red mite) 家禽红螨(Dermanyssus gallinae)
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-09-09 DOI: 10.1016/j.pt.2024.08.006
David Hartmann, Jan Votýpka, Julius Lukeš, Jan Perner
{"title":"Dermanyssus gallinae (Poultry red mite)","authors":"David Hartmann, Jan Votýpka, Julius Lukeš, Jan Perner","doi":"10.1016/j.pt.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.pt.2024.08.006","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"2018 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-09-04 DOI: 10.1016/s1471-4922(24)00223-x
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4922(24)00223-x","DOIUrl":"https://doi.org/10.1016/s1471-4922(24)00223-x","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"44 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 9.6 1区 医学
Trends in parasitology Pub Date : 2024-09-04 DOI: 10.1016/s1471-4922(24)00226-5
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4922(24)00226-5","DOIUrl":"https://doi.org/10.1016/s1471-4922(24)00226-5","url":null,"abstract":"No Abstract","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":"20 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Toxoplasma gondii virulence: the mechanisms of IRG protein inactivation. 解码弓形虫的毒力:IRG 蛋白失活的机制。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI: 10.1016/j.pt.2024.07.009
Mateo Murillo-Léon, Aura María Bastidas-Quintero, Tobias Steinfeldt
{"title":"Decoding Toxoplasma gondii virulence: the mechanisms of IRG protein inactivation.","authors":"Mateo Murillo-Léon, Aura María Bastidas-Quintero, Tobias Steinfeldt","doi":"10.1016/j.pt.2024.07.009","DOIUrl":"10.1016/j.pt.2024.07.009","url":null,"abstract":"<p><p>Toxoplasmosis is a common parasitic zoonosis that can be life-threatening in immunocompromised patients. About one-third of the human population is infected with Toxoplasma gondii. Primary infection triggers an innate immune response wherein IFN-γ-induced host cell GTPases, namely IRG and GBP proteins, serve as a vital component for host cell resistance. In the past decades, interest in elucidating the function of these GTPase families in controlling various intracellular pathogens has emerged. Numerous T. gondii effectors were identified to inactivate particular IRG proteins. T. gondii is re-optimizing its effectors to combat IRG function and in this way secures transmission. We discuss the IRG-specific effectors employed by the parasite in murine infections, contributing to a better understanding of T. gondii virulence.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"805-819"},"PeriodicalIF":7.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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