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Trends in parasitology最新文献

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Neoliberalism and managerialism in academia - a parasitologist's take. 学术界的新自由主义和管理主义--寄生虫学家的观点。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.pt.2024.10.003
Robin B Gasser
{"title":"Neoliberalism and managerialism in academia - a parasitologist's take.","authors":"Robin B Gasser","doi":"10.1016/j.pt.2024.10.003","DOIUrl":"10.1016/j.pt.2024.10.003","url":null,"abstract":"<p><p>This brief article examines how neoliberalism and managerialism have transformed higher education in some countries, affecting academics in parasitology and other disciplines. It highlights the impact of reduced academic freedom, increased performance metrics and administrative burdens, calling for awareness and protection of core academic values amidst these systemic changes.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1066-1068"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabarcoding in gut protozoology. 肠道原生动物学中的元条码。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.pt.2024.10.015
Christen Rune Stensvold
{"title":"Metabarcoding in gut protozoology.","authors":"Christen Rune Stensvold","doi":"10.1016/j.pt.2024.10.015","DOIUrl":"10.1016/j.pt.2024.10.015","url":null,"abstract":"<p><p>Next-generation sequencing (NGS) methods include whole-genome sequencing, metagenomic analysis, and amplicon-based NGS, all of which are gaining territory in parasitology. A modality of particular interest within the field of gut protozoology is exhaustive metabarcoding of ribosomal genes in a complex matrix such as faeces, by which method, amplicon-based NGS enables the detection and differentiation of both eukaryotic and prokaryotic organisms, circumventing Sanger sequencing-based limitations and representing a one-fits-most approach. Apart from being a tool to break the code of intracellular genetic variation and tell mixed species infections apart, metabarcoding can produce data that can serve to augment our understanding of the interplay between the organisms within the gut.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1173-1182"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bric-à-brac, an 'umbilical cord' and trypanosome kinetoplast segregation. 砖块、"脐带 "和锥虫的内质体分离。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1016/j.pt.2024.10.021
Megan L Povelones, Michael L Ginger
{"title":"Bric-à-brac, an 'umbilical cord' and trypanosome kinetoplast segregation.","authors":"Megan L Povelones, Michael L Ginger","doi":"10.1016/j.pt.2024.10.021","DOIUrl":"10.1016/j.pt.2024.10.021","url":null,"abstract":"<p><p>Cadena et al. recently discovered a conserved trypanosomatid 'nabelschnur' protein TbNAB70 from a search through the protein localization resource TrypTag, providing new insight into kinetoplast origin and evolution.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1072-1074"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma. 疟原虫和弓形虫中的 Sec14 蛋白。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.pt.2024.10.018
Florian Lauruol, Dave Richard
{"title":"Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma.","authors":"Florian Lauruol, Dave Richard","doi":"10.1016/j.pt.2024.10.018","DOIUrl":"10.1016/j.pt.2024.10.018","url":null,"abstract":"<p><p>Sec14 domain proteins are broadly conserved in eukaryotes and play essential roles in numerous cellular processes. Limited data on Sec14 proteins of apicomplexan parasites suggest that they could be important for their survival. The development of fungi-specific Sec14 inhibitors raises the tantalizing possibility that their apicomplexan counterparts might also be targeted.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1081-1084"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eimeria falciformis. 镰刀形艾美耳菌
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1016/j.pt.2024.09.008
Özlem Günay-Esiyok, Nishith Gupta
{"title":"Eimeria falciformis.","authors":"Özlem Günay-Esiyok, Nishith Gupta","doi":"10.1016/j.pt.2024.09.008","DOIUrl":"10.1016/j.pt.2024.09.008","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1197-1198"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The apicoplast biogenesis and metabolism: current progress and questions. apicoplast 的生物发生和新陈代谢：当前的进展和问题。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1016/j.pt.2024.10.019
Xiaowei Chen, Xun Suo, Guan Zhu, Bang Shen
{"title":"The apicoplast biogenesis and metabolism: current progress and questions.","authors":"Xiaowei Chen, Xun Suo, Guan Zhu, Bang Shen","doi":"10.1016/j.pt.2024.10.019","DOIUrl":"10.1016/j.pt.2024.10.019","url":null,"abstract":"<p><p>Many apicomplexan parasites have a chloroplast-derived apicoplast containing several metabolic pathways. Recent studies have greatly expanded our understanding of apicoplast biogenesis and metabolism while also raising new questions. Here, we review recent progress on the biological roles of individual metabolic pathways, focusing on two medically important parasites, Plasmodium spp. and Toxoplasma gondii. We highlight the similarities and differences in how similar apicoplast metabolic pathways are utilized to adapt to different parasitic lifestyles. The execution of apicoplast metabolic functions requires extensive interactions with other subcellular compartments, but the underlying mechanisms remain largely unknown. Apicoplast metabolic functions have historically been considered attractive drug targets, and a comprehensive understanding of their metabolic capacities and interactions with other organelles is essential to fully realize their potential.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1144-1158"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teratogenic parasites: disease mechanisms and emerging study models. 致畸寄生虫：疾病机制和新出现的研究模型。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.pt.2024.10.016
Rafaela Jose da Silva, Leah F Cabo, Jon P Boyle
{"title":"Teratogenic parasites: disease mechanisms and emerging study models.","authors":"Rafaela Jose da Silva, Leah F Cabo, Jon P Boyle","doi":"10.1016/j.pt.2024.10.016","DOIUrl":"10.1016/j.pt.2024.10.016","url":null,"abstract":"<p><p>Congenital infections are a leading preventable cause of pregnancy complications impacting both mother and fetus. Although advancements have been made in understanding various congenital infections, the mechanisms of parasitic infections during pregnancy remain poorly understood. This review covers the global incidence of three parasites capable of congenital transmission - Trypanosoma cruzi, Plasmodium spp., and Toxoplasma gondii - and the state of research into their transplacental transmission strategies. We highlight technological advancements in placental modeling that offer opportunities to reveal how parasites cause gestational pathology. Additionally, we discuss the likelihood that selective adaptation contributed to the evolution of mechanisms that facilitate placental infection. These insights provide a foundation for understanding the progression and pathology of congenital parasitic diseases and identifying future research directions.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1159-1172"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young investigators in parasitology meeting: building foundations and supporting early-career researchers. 寄生虫学青年研究人员会议：奠定基础和支持早期职业研究人员。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.pt.2024.10.004
Filipa Rijo-Ferreira, Chi-Min Ho, Alex Rosenberg
{"title":"Young investigators in parasitology meeting: building foundations and supporting early-career researchers.","authors":"Filipa Rijo-Ferreira, Chi-Min Ho, Alex Rosenberg","doi":"10.1016/j.pt.2024.10.004","DOIUrl":"10.1016/j.pt.2024.10.004","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1063-1065"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hypothesis to explain malaria-induced neurocognitive sequelae. 一种解释疟疾引起的神经认知后遗症的假说。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1016/j.pt.2024.10.008
Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro
{"title":"A hypothesis to explain malaria-induced neurocognitive sequelae.","authors":"Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro","doi":"10.1016/j.pt.2024.10.008","DOIUrl":"10.1016/j.pt.2024.10.008","url":null,"abstract":"<p><p>The development of malaria-induced neurocognitive and behavioral sequelae is not entirely understood. We hypothesize that liver dysfunction caused by Plasmodium infection is responsible for malaria-induced neurocognitive and behavioral sequelae. Our metabolic hypothesis not only explains neurocognitive sequelae after cerebral malaria (CM) but also after other severe, non-severe, and asymptomatic malaria infections.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1077-1080"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-based functional genomics for schistosomes and related flatworms. 基于 CRISPR 的血吸虫和相关扁形虫功能基因组学。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI: 10.1016/j.pt.2024.09.010
Wannaporn Ittiprasert, Paul J Brindley
{"title":"CRISPR-based functional genomics for schistosomes and related flatworms.","authors":"Wannaporn Ittiprasert, Paul J Brindley","doi":"10.1016/j.pt.2024.09.010","DOIUrl":"10.1016/j.pt.2024.09.010","url":null,"abstract":"<p><p>CRISPR genome editing is actively used for schistosomes and other flukes. The ability to genetically manipulate these flatworms enables deeper investigation of their (patho)biological nature. CRISPR gene knockout (KO) demonstrated that a liver fluke growth mediator contributes to disease progression. Genome safe harbor sites have been predicted in Schistosoma mansoni and targeted for transgene insertion. CRISPR-based diagnosis has been demonstrated for infection with schistosomes and Opisthorchis viverrini. This review charts the progress, and the state of play, and posits salient questions for the field to address. Derivation of heritably transgenic loss-of-function or gain-of-function lines is the next milestone.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1016-1028"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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