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Trends in parasitology最新文献

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Evolution of parasitological knowledge: can the past inform the future? 寄生虫学知识的演变：过去能否启迪未来？
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI: 10.1016/j.pt.2024.10.011
Robert Poulin
{"title":"Evolution of parasitological knowledge: can the past inform the future?","authors":"Robert Poulin","doi":"10.1016/j.pt.2024.10.011","DOIUrl":"10.1016/j.pt.2024.10.011","url":null,"abstract":"<p><p>The growth of scientific knowledge is often likened to the evolution and diversification of life: new disciplines branch off older ones, and subsequently prosper or decline in a manner reminiscent of the expansion or extinction of diverse lineages of organisms. Based on a parallel between evolutionary diversification and knowledge growth, I examine the expansion of subdisciplines within 'ecological and evolutionary parasitology'. Bibliometric data are used to map the rise and fall of subdisciplines over time, capturing historical trends over the past several decades. This historical overview is followed by a critical consideration of its practical applications for decision-making, ranging from rational funding allocation among subdisciplines to whether the collective planning of future research directions is a desirable option.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1089-1096"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientists swarm into Woods Hole for the 10th Kinetoplastid Molecular Cell Biology Meeting. 科学家们涌入伍兹霍尔，参加第 10 届 Kinetoplastid 分子细胞生物学会议。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1016/j.pt.2024.10.009
Caroline Keroack, Raúl Oscar Cosentino, Thaise Lara Teixeira, Lianne Lansink, Stephen D Larcombe, Brittney Davidge, Lucia Serra, Christopher de Graffenried, Luisa M Figueiredo, Omar S Harb, Megan L Povelones
{"title":"Scientists swarm into Woods Hole for the 10th Kinetoplastid Molecular Cell Biology Meeting.","authors":"Caroline Keroack, Raúl Oscar Cosentino, Thaise Lara Teixeira, Lianne Lansink, Stephen D Larcombe, Brittney Davidge, Lucia Serra, Christopher de Graffenried, Luisa M Figueiredo, Omar S Harb, Megan L Povelones","doi":"10.1016/j.pt.2024.10.009","DOIUrl":"10.1016/j.pt.2024.10.009","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1057-1062"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Plasmodium circumsporozoite protein. 疟原虫周孢子虫蛋白。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.pt.2024.10.017
Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, Photini Sinnis
{"title":"The Plasmodium circumsporozoite protein.","authors":"Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, Photini Sinnis","doi":"10.1016/j.pt.2024.10.017","DOIUrl":"10.1016/j.pt.2024.10.017","url":null,"abstract":"<p><p>The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood. Here we review the current state of knowledge of CSP structure and function, as sporozoites develop in the mosquito and establish infection in the mammalian host, and outline outstanding questions that need to be addressed.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1124-1134"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Tinbergian approach to study antiparasite behaviors. 研究抗寄生虫行为的锡伯方法。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1016/j.pt.2024.10.007
Sebastian Stockmaier
{"title":"A Tinbergian approach to study antiparasite behaviors.","authors":"Sebastian Stockmaier","doi":"10.1016/j.pt.2024.10.007","DOIUrl":"10.1016/j.pt.2024.10.007","url":null,"abstract":"<p><p>Antiparasite behaviors are widespread in nature. However, despite significant research advances, a standardized approach to study them is missing. Here, I propose adapting Niko Tinbergen's four levels of analysis framework to study antiparasite behaviors. I highlight its integrative potential to understand fitness benefits, evolutionary history, functional mechanisms, and developmental processes.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1085-1088"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic insights into liver-fluke-induced bile-duct cancer. 肝吸虫诱发胆管癌的机理研究。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.pt.2024.10.012
Michael J Smout, Thewarach Laha, Sujittra Chaiyadet, Paul J Brindley, Alex Loukas
{"title":"Mechanistic insights into liver-fluke-induced bile-duct cancer.","authors":"Michael J Smout, Thewarach Laha, Sujittra Chaiyadet, Paul J Brindley, Alex Loukas","doi":"10.1016/j.pt.2024.10.012","DOIUrl":"10.1016/j.pt.2024.10.012","url":null,"abstract":"<p><p>Liver fluke infection is a major risk for cholangiocarcinoma (CCA). It has been established that the Asian liver flukes, Clonorchis sinensis and Opisthorchis viverrini secrete growth factors, digestive enzymes, and extracellular vesicles (EVs) which contribute to abnormal cell development in the bile ducts where the worms reside. These secretions - combined with aberrant inflammation and repeated cycles of chronic wounding at the site of parasite attachment and grazing on the epithelium - promote biliary hyperplasia and fibrosis and ultimately malignant transformation. Application of post-genomic and gene-editing tools to the study of liver fluke immunobiology and pathogenesis has accelerated the discovery of essential virulence factors to which targeted therapies and diagnostics can be directed.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1183-1196"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leptotrombidium deliense (Asian rodent chigger). Leptotrombidium deliense（亚洲啮齿类恙虫）。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1016/j.pt.2024.10.013
Rohit Beniwal, Govindarajan Renu, Philip S Paulraj
{"title":"Leptotrombidium deliense (Asian rodent chigger).","authors":"Rohit Beniwal, Govindarajan Renu, Philip S Paulraj","doi":"10.1016/j.pt.2024.10.013","DOIUrl":"10.1016/j.pt.2024.10.013","url":null,"abstract":"","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1199-1200"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating metabolomics into the diagnosis and investigation of anthelmintic resistance. 将代谢组学纳入抗蠕虫药耐药性的诊断和调查。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.pt.2024.10.020
Amanda O Shaver, Erik C Andersen
{"title":"Integrating metabolomics into the diagnosis and investigation of anthelmintic resistance.","authors":"Amanda O Shaver, Erik C Andersen","doi":"10.1016/j.pt.2024.10.020","DOIUrl":"10.1016/j.pt.2024.10.020","url":null,"abstract":"<p><p>Anthelmintic resistance (AR) in parasitic nematodes poses a global health problem in livestock and domestic animals and is an emerging problem in humans. Consequently, we must understand the mechanisms of AR, including target-site resistance (TSR), in which mutations affect drug binding, and non-target site resistance (NTSR), which involves alterations in drug metabolism and detoxification processes. Because much of the focus has been on TSR, NTSR has received less attention. Here, we describe how metabolomics approaches using Caenorhabditis elegans offer the ability to disentangle nematode drug metabolism, identify metabolic changes associated with resistance, uncover novel biomarkers, and enhance diagnostic methods.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1097-1106"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paratransgenic quantum vaccinology. 副转基因量子疫苗学。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.pt.2024.10.006
Marinela Contreras, Isidro Sobrino, José de la Fuente
{"title":"Paratransgenic quantum vaccinology.","authors":"Marinela Contreras, Isidro Sobrino, José de la Fuente","doi":"10.1016/j.pt.2024.10.006","DOIUrl":"10.1016/j.pt.2024.10.006","url":null,"abstract":"<p><p>Tick vaccines are an environmentally friendly intervention for the prevention and control of tick-borne diseases affecting humans and animals worldwide. From our perspective, the challenges in tick vaccinology have encouraged the implementation of new interventions. In this opinion article we propose paratransgenic quantum vaccinology as a new approach that integrates platform trends in biotechnology, such as omics datasets combined with big data analytics, machine learning, and paratransgenesis with a systems biology perspective. This innovative approach allows the identification of protective epitopes in tick- and/or pathogen-derived proteins for the design of chimeric vaccine candidate antigens which can be produced by commensal/symbiotic microorganisms eliciting a protective response in the host.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1107-1114"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bats and ectoparasites: exploring a hidden link in zoonotic disease transmission. 蝙蝠和体外寄生虫：探索人畜共患病传播中的隐秘环节。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-07 DOI: 10.1016/j.pt.2024.10.010
Tamara Szentiványi, Kriszta Lilla Szabadi, Tamás Görföl, Péter Estók, Gábor Kemenesi
{"title":"Bats and ectoparasites: exploring a hidden link in zoonotic disease transmission.","authors":"Tamara Szentiványi, Kriszta Lilla Szabadi, Tamás Görföl, Péter Estók, Gábor Kemenesi","doi":"10.1016/j.pt.2024.10.010","DOIUrl":"10.1016/j.pt.2024.10.010","url":null,"abstract":"<p><p>Bats are increasingly in the focus of disease surveillance studies as they harbor pathogens that can cause severe human disease. In other host groups, ectoparasitic arthropods play an important role in transmitting pathogens to humans. Nevertheless, we currently know little about the role of bat-associated ectoparasites in pathogen transmission, not only between bats but also to humans and other species, even though some of these parasites occasionally feed on humans and harbor potentially zoonotic organisms. In this work, we summarize current knowledge on the zoonotic risks linked to bat-associated ectoparasites and provide novel risk assessment guidelines to improve targeted surveillance efforts. Additionally, we suggest research directions to help adjust surveillance strategies and to better understand the eco-epidemiological role of these parasites.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1115-1123"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tragedy of the commons: the resource struggle during Plasmodium infection. 公地悲剧：疟原虫感染期间的资源争夺。
IF 7 1区 医学
Trends in parasitology Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.pt.2024.10.014
Taylen J Nappi, Noah S Butler
{"title":"Tragedy of the commons: the resource struggle during Plasmodium infection.","authors":"Taylen J Nappi, Noah S Butler","doi":"10.1016/j.pt.2024.10.014","DOIUrl":"10.1016/j.pt.2024.10.014","url":null,"abstract":"<p><p>Plasmodium spp. have an ancient history with humans, having been described in ancient texts dating back 3500 years ago, which has led to an evolutionary arms race between Plasmodium and humans with Plasmodium successfully subverting durable, sterilizing host immunity. Mechanisms of immune evasion include polymorphism and antigenic variation, as well as dysregulated immune responses, each facilitating transmission and Plasmodium parasite persistence. Notably, metabolite signaling cues in the host and parasite have more recently been appreciated as key drivers for disease progression. Here, we highlight the metabolic interplay between the host and Plasmodium parasites during malaria. We discuss how immunometabolism studies may be leveraged to elucidate this complex relationship and offer opportunities to augment either vaccine- or infection-induced protective immunity.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"1135-1143"},"PeriodicalIF":7.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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