Var基因、菌株超多样性和疟疾传播动力学。

IF 6.6 1区 医学 Q1 PARASITOLOGY
Trends in parasitology Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI:10.1016/j.pt.2025.04.010
Karen P Day, Mun Hua Tan, Qixin He, Shazia Ruybal-Pesántez, Qi Zhan, Kathryn E Tiedje, Mercedes Pascual
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引用次数: 0

摘要

监测各种病原体的微生物学范式需要了解在最激烈的免疫选择下主要表面抗原的变化,因为对这些抗原的免疫反应驱动了传播动力学。这为群体遗传学/基因组学与数学建模相结合创造了一条途径,以描述传播动态,为公共卫生政策提供信息。在这里,我们考虑如何将种群遗传学和种群动力学结合起来,以应对恶性疟原虫等高度重组的病原体。我们通过最近了解到的var多基因家族的群体遗传学来做到这一点,var多基因家族编码恶性疟原虫血液阶段的主要表面抗原,称为PfEMP1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Var genes, strain hyperdiversity, and malaria transmission dynamics.

The microbiological paradigm for surveillance of diverse pathogens requires knowledge of the variation of the major surface antigen under the most intense immune selection as immune responses to these antigens drive transmission dynamics. This creates a pathway for population genetics/genomics to be combined with mathematical modelling to describe transmission dynamics to inform public health policy. Here we consider how we can bring population genetics and population dynamics together for a highly recombining pathogen like Plasmodium falciparum. We do this through the lens of what has been recently learnt about the population genetics of the var multigene family encoding the major surface antigen of the blood stages of Plasmodium falciparum, known as PfEMP1.

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来源期刊
Trends in parasitology
Trends in parasitology 医学-寄生虫学
CiteScore
14.00
自引率
3.10%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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