{"title":"人类虱子中新的低敲抗性突变:人工产物还是新出现的抗性?","authors":"Om P Singh, Rajnikant Dixit, David Weetman","doi":"10.1016/j.pt.2025.05.011","DOIUrl":null,"url":null,"abstract":"<p><p>An exceptionally high number of novel mutations within domain II of the voltage-gated sodium channel have been reported in human lice from Iran and Saudi Arabia. We critically evaluate these reports, highlighting that many of them may be methodological artifacts, and urge rigorous confirmation before assigning biological significance.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":"521-524"},"PeriodicalIF":6.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel knockdown resistance mutations in human lice: artifacts or emerging resistance?\",\"authors\":\"Om P Singh, Rajnikant Dixit, David Weetman\",\"doi\":\"10.1016/j.pt.2025.05.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An exceptionally high number of novel mutations within domain II of the voltage-gated sodium channel have been reported in human lice from Iran and Saudi Arabia. We critically evaluate these reports, highlighting that many of them may be methodological artifacts, and urge rigorous confirmation before assigning biological significance.</p>\",\"PeriodicalId\":23327,\"journal\":{\"name\":\"Trends in parasitology\",\"volume\":\" \",\"pages\":\"521-524\"},\"PeriodicalIF\":6.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in parasitology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.pt.2025.05.011\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pt.2025.05.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Novel knockdown resistance mutations in human lice: artifacts or emerging resistance?
An exceptionally high number of novel mutations within domain II of the voltage-gated sodium channel have been reported in human lice from Iran and Saudi Arabia. We critically evaluate these reports, highlighting that many of them may be methodological artifacts, and urge rigorous confirmation before assigning biological significance.
期刊介绍:
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.