Kyrie P Dickson, Jaime A Costales, Malgorzata A Domagalska, Ferre Vander Veken, Martin S Llewellyn
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引用次数: 0
Abstract
Chagas disease affects millions globally and is caused by Trypanosoma cruzi, a parasite with a remarkable ability to adapt and persist in complex environments. Emerging evidence suggests that this adaptability may be driven by its extensive genome instability yet the underlying mechanisms remain poorly understood. Drawing insights from related trypanosomatids, we explore how processes such as aneuploidy, copy number variations and genetic rearrangements can be strategically exploited for immune evasion, host adaptation and drug resistance, and consider whether similar processes shape the adaptive potential of T. cruzi. Unravelling the fundamental biology governing genome instability in this parasite will undoubtedly advance our understanding of its evolution, pathogenesis and resilience - crucial steps towards reducing the burden of Chagas disease.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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