Having your cake and eating it too - a new target for sporozoite-neutralising mAbs.

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI:10.1016/j.pt.2025.02.002

Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn

引用次数: 0

Abstract

Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.

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鱼与熊掌兼得——一个新的目标，为孢子体中和单克隆抗体。

目前的疟疾疫苗提供的保护不够理想，而且正在减弱。Dacon等人在疟原虫孢子体上发现了一种翻译后修饰的保护性表位，目前的疫苗中没有这种表位。这一发现加深了我们对疟原虫生物学的理解，并可能为改进疫苗和补充预防性单克隆抗体的开发提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.