Trogocytosis：揭示寄生虫-宿主相互作用的新见解。

IF 6.6 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2025-07-01 Epub Date: 2025-06-03 DOI:10.1016/j.pt.2025.05.008

Jia Shen, Xuesong Li, Geoff Hide, Zhao-Rong Lun, Zhongdao Wu

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引用次数: 0

摘要

Trogocytosis是一种细胞通过啃食和摄取邻近细胞的膜碎片和其他成分的过程，通过调节寄生虫的生存和宿主的免疫反应，在宿主-寄生虫相互作用中起着关键作用。本文综述了寄生虫感染中的虫胞作用，揭示了它的双重作用：寄生虫利用它获取营养和逃避免疫，而宿主利用它清除病原体。我们分析了驱动这一过程的分子机制，它对感染结果的影响，以及在肿瘤/移植中的相似之处。新出现的治疗机会和尚未解决的挑战进行了批判性评估，为未来的研究提供了一个路线图，利用细胞病控制疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Trogocytosis: revealing new insights into parasite-host interactions.

Trogocytosis - a process whereby cells physically nibble and ingest membrane fragments and other components from neighboring cells - plays a critical role in host-parasite interactions by modulating parasite survival and host immune responses. This review explores trogocytosis in parasitic infections, revealing its dual roles: parasites use it for nutrient acquisition and immune evasion, whereas hosts use it for pathogen clearance. We analyze the molecular machinery driving this process, its impact on infection outcomes, and parallels in tumors/transplantation. Emerging therapeutic opportunities and unresolved challenges are critically evaluated, providing a roadmap for future research to harness trogocytosis in disease control.

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.