Unlocking the potential of miRNAs in cystic echinococcosis.

IF 6.6 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2025-07-15 DOI:10.1016/j.pt.2025.06.004

Paola Pepe, Elena Ciccone, Nunzio Antonio Cacciola, Chiara Bazzocchi, Laura Rinaldi

引用次数: 0

Abstract

This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host-parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.

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揭示囊性包虫病中mirna的潜力。

这篇综述探讨了microRNAs （miRNAs）作为诊断和治疗靶点的潜力，以加强对囊性棘球蚴病（CE）的控制计划，这是一种对全球人类和动物健康构成重大威胁的人畜共患寄生虫病。科学证据表明，棘球蚴衍生的mirna存在于受感染宿主的生物体液中，强调了它们在CE诊断中的潜力。此外，来自细粒棘球绦虫的特异性mirna已被证明可以影响宿主-寄生虫的相互作用，使其成为治疗CE的有希望的靶点。总之，进一步研究mirna在CE中的作用可能会在对抗这种被忽视的疾病方面取得重大突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.