Translational Vision Science & Technology最新文献

{"title":"Time Series Segmentation in Adaptive Optics Ophthalmoscopy With Application to Flicker-Induced Vasodilation.","authors":"Alireza Vard, Abir Aissa, Florence Rossant, Isabelle Bloch, Daniela Castro-Farias, Hugues Chabriat, Michel Paques","doi":"10.1167/tvst.15.10.8","DOIUrl":"10.1167/tvst.15.10.8","url":null,"abstract":"<p><strong>Purpose: </strong>To develop an automated image processing pipeline to segment retinal arterial walls in a series of adaptive optics ophthalmoscopy (AOO) images, overcoming difficulties related to various quality levels within the series, to accurately evaluate morphometric differences.</p><p><strong>Methods: </strong>We first assess the quality of AOO images by deep learning in order to select the best quality image in the sequence. Then, we segment this image by combining deep learning and dedicated active contour models. Finally, we segment the other images of the sequence using the best image segmentation as a regularization exploiting the temporal continuity to compensate for lower quality.</p><p><strong>Results: </strong>We applied the proposed method to flicker series, a challenging use-case given the image quality heterogeneity. The quality assessment method achieves a Spearman correlation coefficient of 0.86, demonstrating very good agreement with the quality ranking established by the medical expert. The automatic segmentation method results in accurate segmentations with a mean root mean square error of 0.5 pixel and 1.8 pixels for the inner and outer borders of the arterial wall, respectively. This leads to accurate and unbiased estimates of the wall to lumen ratio.</p><p><strong>Conclusions: </strong>Our algorithm can be applied as a reliable and useful computer-aided tool to process large time series databases in AOO, and can help experts in longitudinal monitoring applications.</p><p><strong>Translational relevance: </strong>For the first time, AOO image series can be processed with low supervision to accurately monitor morphometric changes in retinal vascularization.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"8"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Parameters Influencing the Rate of Subretinal Injection: A Microfluidic Analysis.","authors":"Aaron Nagiel, Lamberto Rondoni","doi":"10.1167/tvst.15.10.20","DOIUrl":"10.1167/tvst.15.10.20","url":null,"abstract":"<p><strong>Purpose: </strong>Subretinal injection during vitrectomy has become an important technique owing to the growing number of cell and gene therapy trials for retinal disease. Reducing the injection rate can mitigate trauma or shear forces on the retinal pigment epithelium, yet many surgeons alter the subretinal injection system in ways that could influence this rate.</p><p><strong>Methods: </strong>We created a theoretical model of a standard subretinal injection system by applying the Hagen-Poiseuille equation, assuming steady, incompressible, laminar flow of a water-like Newtonian fluid. The system consisted of the vitrectomy console, plastic tubing, the MedOne Microdose kit, and the MedOne 38G/41G subretinal cannula set.</p><p><strong>Results: </strong>This model generated an open-access web app allowing user modification of parameters including cannula length and diameter, beveling, viscosity, console injection pressure, and intraocular pressure. The internal diameter of the cannula had the most prominent effect on flow, with small increases producing large increases in flow. Increasing console pressure linearly increased tip flow. Trimming the tip by 3 mm modestly increased flow by 18%, whereas beveling the tip or altering intraocular pressure produced negligible changes.</p><p><strong>Conclusions: </strong>With this theoretical model, we were able to identify key parameters that influence the rate of subretinal injection, thus providing important guidance for surgeons.</p><p><strong>Translational relevance: </strong>This open-access web application enables vitreoretinal surgeons and gene- and cell-therapy trialists to assess how modifications to the subretinal injection system alter flow at the cannula tip, supporting standardized and reproducible delivery that minimizes flow-related trauma to the outer retina.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"20"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Biometric Measurements Between Anterior Segment Hyperparallel and Swept-Source Optical Coherence Tomography.","authors":"Andrea Servillo, Natalia Porporato, Bingyao Tan, Benjamin Y Xu, Tin A Tun, Shamira Perera, Rahat Husain, Mani Baskaran, Rehena Sultana, Tin Aung, Leopold Schmetterer","doi":"10.1167/tvst.15.10.22","DOIUrl":"10.1167/tvst.15.10.22","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the inter-device agreement between hyperparallel optical coherence tomography (HP-OCT) and swept-source OCT (SS-OCT) in quantitative anterior segment parameters.</p><p><strong>Methods: </strong>Phakic subjects aged ≥40 years were consecutively recruited at a tertiary eye hospital. Horizontal B-scans (0°-180°) were analyzed. On SS-OCT, parameters were measured automatically; on HP-OCT, they were extracted manually using 3D Slicer. Agreement was evaluated using intraclass correlation coefficients (ICCs), Bland-Altman plots, and orthogonal regression.</p><p><strong>Results: </strong>A total of 118 sectors from 59 subjects were analyzed. ICCs were ≥0.88 for all parameters except iris thickness (IT) at 750 µm (IT750, ICC = 0.66). HP-OCT consistently measured lower values than SS-OCT for angle opening distance (AOD) at 500 µm (AOD500: -0.024 [-0.036 to -0.013]) and 750 µm (AOD750: -0.032 [-0.050 to -0.015]), trabecular-iris space area (TISA) at 500 µm (TISA500: -0.008 [-0.013 to -0.003]) and 750 µm (TISA750: -0.012 [-0.020 to -0.004]), iris curvature (IC: -0.015 [-0.021 to -0.009]), IT750 (-0.031 [-0.041 to -0.022]), and anterior chamber depth (-0.118 [-0.138 to -0.098]). For the following parameters, differences between devices increased with larger measurements, with HP-OCT yielding proportionally lower values (proportional bias): AOD500, AOD750, TISA500, TISA750, IC, and lens vault.</p><p><strong>Conclusions: </strong>For anterior segment biometry, HP-OCT and SS-OCT showed high ICCs but limited interchangeability because of systematic and proportional bias.</p><p><strong>Translational relevance: </strong>Understanding how HP-OCT measurements compare with those from SS-OCT is essential for clinical integration, because inter-device agreement and interchangeability guide how HP-OCT can be applied and interpreted in practice.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"22"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults.","authors":"Alex Choi, Alice Haystead, Rachel D'Cunha, John Hsu, Michael Zhu, Kim G Johnson, Michael W Lutz, Heather Whitson, Dilraj S Grewal, Sharon Fekrat","doi":"10.1167/tvst.15.10.6","DOIUrl":"10.1167/tvst.15.10.6","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal imaging offers a noninvasive window into microvascular and neurodegenerative changes, yet its relationship to circulating plasma biomarkers of Alzheimer's disease (AD) remains incompletely understood. We evaluated associations between plasma AD biomarkers and retinal imaging metrics in cognitively normal adults and whether these differ by apolipoprotein E (APOE) ε4 status.</p><p><strong>Methods: </strong>This cross-sectional analysis included cognitively normal participants prospectively enrolled from the Duke/UNC Alzheimer's Disease Research Center. Eighty-three eyes from 44 participants (20 APOE ε4 carriers, 24 noncarriers) underwent optical coherence tomography (OCT) and OCT angiography (OCTA) within 1 year of plasma sampling. Plasma AD biomarkers were assessed for associations with structural OCT and microvascular OCTA metrics. Linear mixed-effects models adjusted for age, sex, treated hypertension, and years of education were used, with interaction terms for APOE ε4 status followed by stratified analyses.</p><p><strong>Results: </strong>Nominally significant APOE ε4-dependent interactions were observed between Aβ42/40 and neurofilament light chain (NfL) with ganglion cell-inner plexiform layer (GCIPL) thickness (uncorrected P = 0.026 and P = 0.028). For OCTA, multiple nominally significant APOE ε4-dependent interactions were identified between plasma biomarkers (NfL, pTau217/Aβ42, and pTau217) and perfusion and vessel density across macular regions (uncorrected P = 0.009-0.048). Stratified analyses suggested stronger or more positive relationships in noncarriers, with attenuated or inverse relationships in carriers. None of the associations remained significant after false discovery rate (FDR) correction.</p><p><strong>Conclusions: </strong>In this exploratory analysis, the APOE ε4 genotype may modify associations between plasma AD biomarkers and retinal structural and microvascular metrics in cognitively normal adults.</p><p><strong>Translational relevance: </strong>These exploratory findings support further investigation of whether APOE ε4 genotype-status should be considered in future studies integrating retinal imaging and plasma biomarkers in preclinical Alzheimer's disease.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"6"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in: The Impact of Inflammatory Hyperreflective Spots and Hard Exudates on Retinal Function in Diabetic Retinal Disease.","authors":"","doi":"10.1167/tvst.15.10.12","DOIUrl":"10.1167/tvst.15.10.12","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"12"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting and Localizing Objects With Color-Contrast With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis.","authors":"Nick Barnes, Matthew A Petoe, Maria Kolic, Elizabeth K Baglin, Samuel A Titchener, Nariman Habili, William G Kentler, Carla J Abbott, Penelope J Allen, Janine G Walker","doi":"10.1167/tvst.15.10.21","DOIUrl":"10.1167/tvst.15.10.21","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the detection of color contrast in retinal prosthesis users by evaluating a novel Detecting Objects with Color-Contrast (DOCC) vision processing algorithm.</p><p><strong>Methods: </strong>Three participants monocularly implanted with a suprachoroidal retinal prosthesis (NCT03406416) were asked to locate and identify objects on a tabletop that were color-contrasted with their backgrounds using the DOCC algorithm, a control algorithm (Lanczos2 [L2]) and system off. The task involved two setups; (i) high-contrast white-on-black objects, and (ii) low-grayscale-contrast (color-only contrast) red-on-green objects. Participants were required to verbally localize (nine alternative forced choice), then touch the object, with the distance measured from their finger to the true object location.</p><p><strong>Results: </strong>For low- (color-only) contrast objects, DOCC (58.3% ± 43.0%) performed better than L2 (27.9% ± 42.5%) for verbally localizing objects (P < 0.0001) and both DOCC (P < 0.0001) and L2 (P = 0.0018) performed better than system off (9.1% ± 33.1%). Furthermore, DOCC (9.7 ± 10.6 cm) had a closer final proximity to the object than L2 (28.0 ± 24.7 cm; P < 0.0001) and system off (45.0 ± 23.9 cm; P < 0.0001). For high-contrast objects, DOCC (59.8% ± 47.8%) performed similarly to L2 (60.8% ± 48.3%) and system off (25.4% ± 41.8%) for verbally localizing objects (P = 0.32, three-condition). Likewise, for final object proximity, DOCC (8.0 ± 7.5 cm) also performed similarly to L2 (6.2 ± 8.4 cm, P = 0.43), whereas both DOCC (P = 0.0014) and L2 (P < 0.0001) performed better than system off (25.6 ± 22.3 cm).</p><p><strong>Conclusions: </strong>Vision processing software can improve object detection and localization for objects of one color against a low-contrast background of another color.</p><p><strong>Translational relevance: </strong>A color-contrast algorithm may assist retinal prosthesis users with detecting and localizing objects that are color-contrasted to their background.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"21"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wall-to-Lumen Ratio Estimation in Adaptive Optics Retinal Imaging: Evaluation and Comparison.","authors":"Radim Kolar, Roman Jakubicek, Eva Orsagova, Jan Odstrcilik, Franziska G Rauscher","doi":"10.1167/tvst.15.10.26","DOIUrl":"10.1167/tvst.15.10.26","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal arteriolar changes reflect systemic microvascular alterations associated with cardiovascular risk, including hypertension. The retinal arteriolar wall-to-lumen ratio (WLR), obtained by adaptive optics (AO) imaging, is a promising noninvasive biomarker of early vascular damage. Its clinical utility is limited by inter- and intra-grader variability, lack of standardized protocols, and dependence on image quality, boundary definition, and measurement method. Standardized, objective WLR quantification is therefore needed to minimize observer bias and improve reproducibility.</p><p><strong>Methods: </strong>We compared point-based and region-based manual WLR estimation using 60 high-resolution AO images from 35 healthy subjects. Two experienced graders performed five point-based measurements per image, yielding one median WLR, followed by manual artery wall and lumen segmentation, yielding one WLR value. Inter-grader variability, method agreement, and sampling-location requirements were evaluated using statistical and Bland-Altman analyses.</p><p><strong>Results: </strong>Point-based assessment showed good inter-grader agreement, with a relative mean difference of 4.5% (Wilcoxon test, P < 0.05). Region-based assessment produced significantly lower WLR values than the point-based method (P < 0.01), with relative mean differences of 19.9% and 26.1% for graders A and B, respectively. Inter-grader relative mean difference was 6.2%, comparable to the point-based method. Approximately 10 measurement positions reduced the estimation error to about 5%; fewer positions increased error. Image quality and vessel-border visibility affected WLR variability.</p><p><strong>Conclusions: </strong>WLR estimation is influenced by measurement approach, grader experience, image quality, and sampling density. Although region-based assessment is more comprehensive, it is time-consuming. For clinical point-based assessment, at least 10 clearly visible arterial locations are recommended to minimize estimation error. Standardized protocols are essential for reliable WLR quantification.</p><p><strong>Translational relevance: </strong>For standardized manual WLR assessment in AO retinal images, we recommend measuring only clearly visible vessel segments, using double-sided measurements whenever possible, avoiding bifurcations, crossings, and adjacent vessels, obtaining ≥12 measurements per artery, excluding the upper and lower deciles, and reporting the median of ≥10 remaining measurements as the final WLR.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"26"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling RP1-Associated Retinal Dystrophies: Comprehensive Genetic, Clinical, and Disease Progression Analysis in China.","authors":"Hong-Li Liu, Ting Li, Ping Xu, Sheng-Hai Zhang, Ji-Hong Wu","doi":"10.1167/tvst.15.10.3","DOIUrl":"10.1167/tvst.15.10.3","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the clinical manifestations, genetic landscape, and natural history of RP1-associated retinopathy in a Chinese cohort.</p><p><strong>Methods: </strong>This longitudinal cohort study enrolled and followed 49 patients with genetically confirmed RP1-associated retinopathy. Phenotyping included visual acuity (VA), visual field, full-field stimulus testing (FST), microperimetry, and multimodal imaging. Genetic analysis and variant interpretation followed American College of Medical Genetics and Genomics and Association for Molecular Pathology guidelines.</p><p><strong>Results: </strong>The cohort predominantly presented with retinitis pigmentosa (RP, 91.8%) and bilateral involvement, with overall no significant interocular differences in major functional parameters (all P > 0.05). Median symptom onset age was 20 years (interquartile range, 7.25-33.75). On linear regression analysis, earlier onset age (P = 0.024) and longer disease duration (P = 0.019) correlated with worse VA. Kaplan-Meier analysis estimated that the median age at which patients reached blindness (>1.3 logarithm of the minimum angle of resolution [logMAR]) was 74 years. Quantified decline rates included VA (0.015 logMAR/year) and visual field index (-7.8%/year) in the first decade and FST (0.167 log cd·s/m2/year) and retinal sensitivity (-1.22 dB/year) over two decades. Classic bone-spicule pigmentation was absent in 33.3% of patients. Genetic analysis identified 46 variants; truncating mutations (71.7%) clustered in exon 4, with c.5797C>T as a founder variant (16.3% of alleles). Variants within the upstream one-third of exon 4 were associated with later onset (P = 0.049).</p><p><strong>Conclusions: </strong>RP1-associated retinopathy manifests as bilateral, atypical RP with quantifiable, duration-dependent decline and a genotype-phenotype correlation linking upstream exon 4 variants to later onset.</p><p><strong>Translational relevance: </strong>Quantified progression rates and genotype-phenotype correlations inform clinical trial endpoints and patient counseling.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"3"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Vascular Contributions to Inactive Dysthyroid Optic Neuropathy: Beyond Mechanical Compression.","authors":"Weijie Liu, Mengting Wang, Hongxiao Jiang, Lu Chen, Xiaozhou Hu, Jie Ye, Wei Rao, Jiayi Zhang, Wentao Yan, Wencan Wu, Yunhai Tu","doi":"10.1167/tvst.15.10.29","DOIUrl":"https://doi.org/10.1167/tvst.15.10.29","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate systemic vascular contributions-spanning microvascular, macrovascular, and molecular levels-to inactive dysthyroid optic neuropathy (DON) beyond the traditional model of mechanical compression.</p><p><strong>Methods: </strong>This cross-sectional comparative study enrolled 52 patients with thyroid-associated ophthalmopathy (TAO), categorized into DON (n = 32) and non-DON (n = 20) groups with comparable orbital apex crowding, and 23 healthy controls. Participants underwent optical coherence tomography angiography (OCTA) to assess superficial macular vessel density (mVD). Systemic macrovascular status was evaluated via internal carotid artery calcification (ICAC) on computed tomography and pulse pressure (PP). Molecular assessments included blood lipids and endothelial injury markers, specifically nitric oxide (NO).</p><p><strong>Results: </strong>Patients with inactive DON exhibited significant microvascular rarefaction, with reduced mVD compared to both controls and non-DON patients (P < 0.002). DON was also associated with a higher prevalence of macrovascular pathology, including ICAC (48.3% vs. 21.7%; P = 0.017) and elevated PP (P = 0.001). At the molecular level, DON was linked to dyslipidemia (elevated triglycerides, P = 0.001; reduced high-density lipoprotein, P = 0.014) and endothelial dysfunction (lower NO; P = 0.033). Reduced mVD correlated significantly with both ICAC and PP (P < 0.033), linking systemic and ocular vascular injury.</p><p><strong>Conclusions: </strong>Inactive DON was associated with abnormalities across retinal microvascular, systemic macrovascular, and circulating biomarker domains. These findings support further investigation of a model in which systemic vascular vulnerability may interact with local orbital compression.</p><p><strong>Translational relevance: </strong>Assessment of systemic vascular risk may complement conventional orbital evaluation in patients with DON. Prospective studies are required to determine whether optimization of thyroid and vascular status can improve prevention or treatment.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"29"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Capillary Loss Is More Severe in the Midperiphery Than in the Macula in Eyes With Diabetic Retinopathy Compared to Healthy Eyes.","authors":"Héloïse Torres-Villaros, Alain Gaudric, Cédric Dulière, Ali Erginay, Carlo Lavia, Hugo Le Boité, Aude Couturier","doi":"10.1167/tvst.15.10.19","DOIUrl":"10.1167/tvst.15.10.19","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether the reduction in retinal capillary density (CD) is uniform across the capillary plexuses, from the foveal center to the midperiphery, in eyes with diabetic retinopathy (DR) compared with healthy eyes.</p><p><strong>Methods: </strong>Twenty-one eyes with nonproliferative or early proliferative DR and 10 healthy eyes were examined using swept-source optical coherence tomography angiography (OCTA). Multiple 3 × 3-mm OCTA scans were acquired to form a horizontal band extending from the fovea to 9 mm temporally. CD was measured in each 0.1-mm sample within each capillary plexus and analyzed using a linear mixed-effects model and a segmented regression.</p><p><strong>Results: </strong>CD was lower in DR eyes than in healthy eyes (adjusted difference: -4.1%, P < 0.001) and decreased toward the temporal midperiphery in all plexuses. The reduction in CD in DR eyes was uniform regardless of eccentricity in the superficial and intermediate plexuses but increased toward the periphery in the deep capillary plexus (DCP) (group × plexus × eccentricity interaction, P < 0.001). After segmented regression, CD in the DCP plateaued beyond 6 mm from the foveal center in healthy eyes but continued to decrease up to 9 mm in DR eyes, where midperipheral loss reached 45% versus 25% in healthy eyes (P < 0.001).</p><p><strong>Conclusions: </strong>In DR eyes, the CD loss from the fovea to the midperiphery varied by plexus, with a stronger peripheral reduction in the DCP beyond 6 mm.</p><p><strong>Translational relevance: </strong>The preferential midperipheral DCP dropout highlights a plexus-specific, region-dependent pattern of capillary loss, which could serve as an imaging marker of ischemia progression in diabetic retinopathy.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"19"},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}