Translational Vision Science & Technology最新文献

{"title":"Application of 3D MRI and SS-OCT/OCTA in Assessment of Posterior Scleral Contraction for Myopic Traction Maculopathy.","authors":"Danyang Yu, Di Wu, Haoru Li, Hua Rong, Qing He, Xia Zhang, He Xu, Mengdi Chai, Yifan Zhou, Ruihua Wei","doi":"10.1167/tvst.14.3.5","DOIUrl":"10.1167/tvst.14.3.5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical efficacy and safety of posterior scleral contraction (PSC) in the treatment of myopic traction maculopathy (MTM) by three-dimensional magnetic resonance imaging (3D MRI), swept-source optical coherence tomography (SS-OCT) and swept-source optical coherence tomography angiography (SS-OCTA).</p><p><strong>Methods: </strong>In this prospective study, 30 eyes of 25 patients with MTM were treated with PSC. The ocular parameters of the patients were measured before surgery and at 1 month, 6 months, and 1 year after 3D MRI and SS-OCT/OCTA.</p><p><strong>Results: </strong>The differences in preoperative and postoperative parameters, including axial length (AL), spherical equivalent (SE), best-corrected visual acuity (BCVA), retinoschisis area, total posterior staphyloma height (PSH), and vitreous volume were statistically significant (P < 0.001). The choroidal thickness (CT) in each sector, choroidal perfusion area (CPA) in subfoveal and temporal sectors, and choroidal vascularity index (CVI) in inferior and temporal sectors increased significantly after PSC surgery (P < 0.05). Additionally, 3D MRI showed that the surgical strips remained strong and stable during the follow-up period, without complications such as strip displacement, fracture, and loosening.</p><p><strong>Conclusions: </strong>The application of 3D MRI and SS-OCT/OCTA in assessment of the treatment of MTM with PSC was comprehensive with multiple ocular parameters and could further guide the clinical diagnosis and treatment of MTM.</p><p><strong>Translational relevance: </strong>We combined SS-OCT/OCTA and 3D MRI to provide the basis of a theory for guiding the clinical diagnosis and treatment of MTM.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"5"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance, Low-Cost Optical Coherence Tomography System Using a Jetson Orin Nano for Real-Time Control and Image Processing.","authors":"Wan Wang, David A Miller, Hillel B Price, Xiangyue Yang, William J Brown, Adam Wax","doi":"10.1167/tvst.14.3.24","DOIUrl":"10.1167/tvst.14.3.24","url":null,"abstract":"<p><strong>Purpose: </strong>Optical coherence tomography (OCT) has become an indispensable tool for the detection and analysis of diseased retinal tissue. Recent advances in reducing the size and cost of OCT systems have aimed at expanding their use for new applications and settings, such as serving as a screening tool at the point of care or in low-resource areas. Here, we report on the development of a compact, low-cost OCT system that offers significantly improved performance while also further reducing cost and system size.</p><p><strong>Methods: </strong>A high-performance OCT system was realized by leveraging graphics processing unit (GPU)-accelerated parallel processing in a system on module, the NVIDIA Jetson Orin Nano, integrated into a low-cost OCT system. Instrument performance for retinal imaging was benchmarked against current low-cost OCT systems.</p><p><strong>Results: </strong>A fivefold increase in processing speed was obtained for the Jetson-powered low-cost OCT without loss of image quality. The compact and low-cost nature of the system was preserved while its volume was reduced by 67% and computing cost was reduced by 22%.</p><p><strong>Conclusions: </strong>The advance in imaging performance can significantly expand the accessibility and clinical utility of low-cost OCT systems.</p><p><strong>Translational relevance: </strong>Implementation of the system on module computer improved the computational performance without compromising the cost or size of low-cost OCT systems, which will accelerate the application of low-cost OCT to clinical use.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"24"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in: Accelerometer-Measured Daily Behaviors That Mediate the Association Between Refractive Status and Depressive Disorders.","authors":"","doi":"10.1167/tvst.14.3.7","DOIUrl":"10.1167/tvst.14.3.7","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"7"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps.","authors":"Jiachi Hong, Afshan A Nanji, Richard D Stutzman, Winston D Chamberlain, Xubo Song, David Huang, Yan Li","doi":"10.1167/tvst.14.3.17","DOIUrl":"10.1167/tvst.14.3.17","url":null,"abstract":"<p><strong>Purpose: </strong>To train and validate a convolutional neural network (CNN) to detect the history of laser-assisted in situ keratomileusis (LASIK) surgeries using corneal optical coherence tomography (OCT) maps.</p><p><strong>Methods: </strong>Five corneal OCT maps (pachymetry, epithelial thickness, posterior mean curvature, anterior axial power, and anterior stroma reflectance) were utilized as the input of a lightweight CNN model. OCT scans of healthy volunteers and patients who had undergone myopic or hyperopic LASIK were included. Repeated fivefold cross-validation was used to train and evaluate the proposed CNN. In addition, a separate group of post-LASIK participants, who were not included in the cross-validation, was used for out-of-sample testing to assess the CNN model performance.</p><p><strong>Results: </strong>In the cross-validation, the proposed CNN model achieved an overall balanced accuracy of 90.2% ± 3.6% with 93.5% ± 5.2% sensitivity and 97.8% ± 1.7% area under the receiver operating characteristic curve (AUC) in detecting myopic LASIK and 90.2% ± 5.8% sensitivity and 98.2% ± 1.9% AUC in identifying the hyperopic LASIK. In the out-of-sample test, all eyes were classified correctively.</p><p><strong>Conclusions: </strong>The lightweight CNN model with corneal OCT maps provides a useful tool for detecting LASIK history.</p><p><strong>Translational relevance: </strong>Artificial intelligence-assisted OCT may offer better management for patients with LASIK history who need cataract surgeries.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"17"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease.","authors":"Sergio Li Calzi, Ayaka Fujihashi, Dibyendu Chakraborty, Yvonne Adu-Rutledge, Ram Prasad, Edgar L V Ready, Sarbodeep Paul, Srikanth Kakumanu, Xiaoping Qi, Michael E Boulton, Alan J Franklin, Bob H Katz, Maria B Grant","doi":"10.1167/tvst.14.3.21","DOIUrl":"10.1167/tvst.14.3.21","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the safety and bioactivity of carboxyamidotriazole (CAI) using two approaches, a polymeric CAI-PLGA nanoemulsion in the mouse model of choroidal neovascularization (CNV) and CAI-loaded bioresorbable intravitreal implant in a rabbit model of vascular leakage.</p><p><strong>Methods: </strong>Mice underwent laser rupture of Bruch's membrane to induce CNV followed by a single (2 µL volume) intravitreal injection of either vehicle (n = 11); CAI nanoparticles (0.5 µg, 1 µg, 2 µg, 400 nM, 800 nM, and 1.6 µM, respectively); aflibercept 10 µg; or CAI nanoparticles (1 µg) + aflibercept 10 µg. New Zealand white rabbits underwent either sham intravitreal injection, aflibercept 500 µg injection, or CAI-PLGA intravitreal implant. Vascular leakage was induced with injections of VEGF on days 23 and 53. On days 30 and 60, all groups underwent vitreous fluorophotometry and fundus imaging. On day 60, the rabbits were euthanized, and their eyes were enucleated.</p><p><strong>Results: </strong>Intravitreal injection of the CAI-Nano at the dose of 1 µg significantly decreased choroidal neovascular volume, to 25% of saline on day 7 and 30% on day 14, which was comparable to aflibercept. Vitreous fluorophotometry revealed significantly lower levels of fluorescein in the aflibercept and CAI implant groups compared to the sham group on day 30. On day 60, the CAI implant group showed significantly reduced neovascularization as compared with the aflibercept groups. No toxicity was observed in any group.</p><p><strong>Conclusions: </strong>CAI in nanoparticle formulation or as a sustained release bioresorbable implant showed potent efficacy and caused no retinal toxicity in murine and rabbit models.</p><p><strong>Translational significance: </strong>CAI demonstrates strong potential as a sustained release anti-angiogenic therapy with effective long-term durability.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"21"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases.","authors":"Antonio Yaghy, David G Birch, Yunchan Hwang, Edmund Luo, JungAh Jung, Darin Curtiss, Nadia K Waheed","doi":"10.1167/tvst.14.3.25","DOIUrl":"10.1167/tvst.14.3.25","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to propose an alternative statistical approach that addresses the issue of multiplicity in microperimetry data analysis, offering a more balanced and sensitive measure of the efficacy of gene therapy in inherited retinal diseases (IRDs).</p><p><strong>Methods: </strong>We analyzed microperimetry data from a phase II trial of AGTC-501 in patients with X-linked retinitis pigmentosa (XLRP). The Macular Integrity Assessment (MAIA; CenterVue, Padova, Italy) device was used to evaluate test-retest repeatability. A binomial model was used to calculate the probability of ≥7 decibel (dB) improvements due to chance alone across a 68-locus grid. We proposed an alternative approach to detect changes using a threshold of ≥7 loci with ≥7 dB mean improvement.</p><p><strong>Results: </strong>Test-retest repeatability analysis showed a probability of < 5% for observing pointwise improvements ≥7 dB between 2 baseline visits. Applying the binomial distribution model, we found that the probability of observing improvements ≥7 dB in at least 7 unspecified loci purely by chance was 5.3%.</p><p><strong>Conclusions: </strong>The proposed approach provides a balanced way to address multiplicity while maintaining reasonable statistical significance. Using ≥7 unspecified loci as the criterion for assessing sensitivity changes, offers a comprehensive assessment that can detect genuine treatment effects without being overly conservative.</p><p><strong>Translational relevance: </strong>This alternative statistical method has the potential to improve the evaluation of retinal sensitivity changes in gene therapy trials for IRDs, providing a more accurate measure of therapeutic efficacy and enhancing clinical decision making.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"25"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits.","authors":"Hongwei Qin, Xin Yang, Rui He, Yaowen Song, Junchao Wei, Xiaona Liu, Chenyan Wang, Ce Wu, Jie Hou, Zhipeng Gao, Lingfeng Chen, Xiaona Li, Weiyi Chen","doi":"10.1167/tvst.14.3.3","DOIUrl":"10.1167/tvst.14.3.3","url":null,"abstract":"<p><strong>Purpose: </strong>The long-term safety of small-incision lenticule extraction (SMILE) surgery for correcting high myopia with a residual stromal bed thickness (RST) less than 50% of the central corneal thickness (CCT) was investigated from a biomechanical perspective.</p><p><strong>Methods: </strong>Twelve rabbits were enrolled in this study, in which the right eye underwent SMILE surgery (the corneal cap thickness was one third of the preoperative CCT, approximately 120 µm), and the left eye served as the control. The rabbits were evenly divided into two groups, with the RST of 50% and 30% of the preoperative CCT in each group, respectively. Corneal morphology parameters in vivo and biomechanical properties in vitro were determined at 11 months after SMILE surgery. Moreover, the distribution of displacement and Von Mises stress across the cornea were evaluated using finite element analysis.</p><p><strong>Results: </strong>At 11 months after SMILE surgery, there was no obvious forward shift in the posterior corneal elevation and no significant increase in the mean keratometry from the posterior corneal surface. The elastic modulus of the RST 30% group increased significantly compared to the control, although no significant differences were found in the creep rate, elongation rate, and equilibrium modulus among all groups. Compared to the control, the displacement was smaller in the RST 30% group, while the maximum stress was obviously higher.</p><p><strong>Conclusions: </strong>No iatrogenic keratectasia occurred in a rabbit model of high myopic SMILE surgery with an RST of less than 50% of preoperative CCT at 11-month follow-up.</p><p><strong>Translational relevance: </strong>Our findings could provide valuable insights into the safety of performing SMILE with reduced RST values for high myopia correction and guide SMILE procedures.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"3"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke.","authors":"Zhifan Chen, Shuoxin Liao, Guangzhong Chen, Changmao Li, Chunling Liu, Junbin Liu, Guangyu Wu, Zheng Lyu, Mengya Liu, Xiyu Wu, Guixian Ma, Qianli Meng","doi":"10.1167/tvst.14.3.14","DOIUrl":"10.1167/tvst.14.3.14","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).</p><p><strong>Methods: </strong>OCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls). Logistic regression models for IS were constructed. Receiver operating characteristic (ROS) curves were constructed to assess the predictive value of various models for IS.</p><p><strong>Results: </strong>Patients with ipsilateral internal carotid artery stenosis (ICAS) had a greater occurrence of IS. A decrease in the vascular density (VD) of the parafovea, FD-300, and nasal optic disc; a decrease in the thickness of the retinal nerve fiber layer (RNFL) around the nasal optic disc; and an increase in the acircularity index (AI) were observed in patients with IS (P < 0.05). An increase in the AI was identified as a risk factor for IS, whereas the other factors were found to be protective factors. The IS group presented a delayed a-wave implicit time and decreased b-wave amplitudes at the scotopic point. By incorporating traditional risk factors, the degree of ipsilateral ICAS, and OCTA parameters, a high predictive value for IS was achieved (area under the curve [AUC] = 0.933).</p><p><strong>Conclusions: </strong>Patients with IS without visible fundus lesions presented changes in the RNVU, characterized by reductions in retinal VD and RNFL thickness, alongside dysfunction of photoreceptor cells and bipolar cells. The combination of RNVU changes with traditional risk factors can enhance the prediction of IS, which provides valuable guidance for monitoring this disease.</p><p><strong>Translational relevance: </strong>This study demonstrated that the combination of OCTA parameters, the degree of ipsilateral ICAS, and traditional risk factors could can enhance the prediction of IS. These findings provide valuable guidance for monitoring IS by assessing RNVUs.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use.","authors":"Anupam K Garg, Jingyu Wang, Bailee Alonzo, Ji Yi, Amir H Kashani","doi":"10.1167/tvst.14.3.2","DOIUrl":"10.1167/tvst.14.3.2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate outer retinal organization in normal subjects and those using hydroxychloroquine (HCQ) with ultrahigh-resolution visible-light optical coherence tomography (VIS-OCT).</p><p><strong>Methods: </strong>Forty eyes of 22 adult subjects were recruited from a tertiary-care retina practice, including controls (20 eyes, 12 subjects, 40 ± 22 years old) and subjects with a history of HCQ use (20 eyes, 10 subjects, 62 ± 17 years old). Each subject was imaged using a custom-built VIS-OCT device (axial resolution 1.3 µm) and U.S. Food and Drug Administration-approved OCT devices.</p><p><strong>Results: </strong>With the use of VIS-OCT, control subjects demonstrated five and six hyperreflective bands in the foveal and parafoveal regions, respectively, between the outer nuclear layer and Bruch's membrane. These bands demonstrated intensity profiles complementary to the known histopathologic distribution of rods and cones. In comparison to controls, subjects taking HCQ demonstrated reduced intensity of all bands, particularly bands two to four. In all cases of suspected or known toxicity, VIS-OCT demonstrated attenuation of band 3i, and in no cases was there attenuation of other bands that was more severe than band 3i, suggesting that changes in the reflectivity of band 3i may be the earliest identifiable sign of HCQ toxicity.</p><p><strong>Conclusions: </strong>VIS-OCT of the outer retina revealed a unique outer retinal banding pattern corresponding to photoreceptor density distributions. Notable attenuation of the photoreceptor outer segment reflectivity profile was associated with early HCQ toxicity. This finding may be an early, and possibly reversible, sign of HCQ toxicity, primarily impacting the cones.</p><p><strong>Translational relevance: </strong>VIS-OCT is useful in detecting subclinical outer retinal structural changes found in subjects using hydroxychloroquine.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery.","authors":"Sayuri Yasuda, Yoshiko Takai, Yuma Yasuda, Takanori Yamamoto, Ryo Tomita, Takeshi Iwase, Norie Nonobe, Jun Takeuchi, Taiki Kojima, Koji M Nishiguchi, Hiroki Kaneko","doi":"10.1167/tvst.14.3.12","DOIUrl":"10.1167/tvst.14.3.12","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the effects of extraocular muscle recession performed as part of strabismus surgery on posterior retinal and choroidal blood flow.</p><p><strong>Methods: </strong>A single-center prospective study was conducted on patients who underwent strabismus surgery. Optical coherence tomography, optical coherence tomography angiography, and laser speckle flowgraphy of the macula were performed before surgery and at one week, one month, and four months after surgery. Preoperative and postoperative ratios were calculated, and longitudinal changes in retinal blood flow, choroidal thickness, and choroidal blood flow were analyzed. Furthermore, the changes based on the types of resected muscle were examined.</p><p><strong>Results: </strong>In total, 254 eyes from 127 patients were included. The subfoveal choroidal thickness increased significantly at one week and one month after surgery, with no significant change at four months after surgery. The choroidal blood flow increased significantly at one week after surgery, with no significant changes at one and four months after surgery. The retinal vessel density significantly decreased at one week after surgery, with no significant changes at one and four months after surgery. Analysis of groups that had various muscles excised showed no significant changes in any measurements. Choroidal thickness and blood flow were significantly correlated at one week after surgery.</p><p><strong>Conclusions: </strong>Strabismus surgery decreased retinal blood flow but increased choroidal thickness and blood flow in the early postoperative period. Moreover, no significant changes were observed in the long term compared to the preoperative period.</p><p><strong>Translational relevance: </strong>Strabismus surgery affects the retina and choroid in the early postoperative period but not in the long term.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"12"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}