Translational Vision Science & Technology最新文献

{"title":"Design, Fabrication, and Surgical Testing of the 3D-Printed Large-Array Port-System for the Implantation of Large Epiretinal Stimulators.","authors":"Frederic Kuba Balcewicz, Sabine Baumgarten, Kim Schaffrath, Jiayun Wang, Sandra Johnen, Peter Walter, Tibor Lohmann","doi":"10.1167/tvst.14.2.8","DOIUrl":"10.1167/tvst.14.2.8","url":null,"abstract":"<p><strong>Purpose: </strong>In the treatment of blindness causing retinal dystrophies, that is, retinitis pigmentosa (RP), retinal implants showed promising results. Recently, larger devices restoring a greater visual field were introduced. With larger size, implantation surgery became more difficult. In this study, a novel implantation device was developed, fabricated, and tested in implantation surgeries. The goal was to demonstrate a reproducible, safe, and, in comparison, superior implantation method.</p><p><strong>Methods: </strong>The novel implantation device 3D-Printed Large-Array Port-System (3D-PLAPS) was designed using computer-aided design software. Anatomic dimensions of rabbit, pig, and human eyes were collected from anatomic and histological data sources. The 3D-PLAPS were 3D-printed. In cadaveric porcine and rabbit eyes, 3D-PLAPS was used to implant large epiretinal stimulators developed by this group. A standardized surgical procedure was established. Intraocular pressure (IOP) was measured.</p><p><strong>Results: </strong>The 3D-PLAPS implantation device was designed with a length of 8.4 mm and adapted to the curvature of normal sighted human eyes with a diameter of 24.0 mm. The elliptical aperture is 7.0 mm in length and 1.0 mm in width at its widest points. Marginal apertures for scleral fixation were added. A closing plug was introduced. Design and dimensions were adapted for rabbit eyes. During surgery, the 3D-PLAPS improved ocular stability, sealed the incision, and withstood an elevated IOP. It was suitable for foldable stimulators with a diameter of up to 14.0 mm.</p><p><strong>Conclusions: </strong>The 3D-PLAPS implantation device showed feasibility in implantation of large epiretinal stimulators and possibly also facilitates repositioning of stimulating arrays in acute experiments without the necessity for additional surgical steps.</p><p><strong>Translational relevance: </strong>The 3D printing and CAD software are used to applied surgery for large epiretinal stimulators.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"8"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model.","authors":"Zhihao Jiang, Wenjia Yan, Haili Fang, Chang Liu, Zhaotian Zhang, Zhiquan Li, Yantao Wei, Yao Ni","doi":"10.1167/tvst.14.2.18","DOIUrl":"10.1167/tvst.14.2.18","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the characteristics of refractive development and choroidal vasculature in the form-deprivation (FD) pigmented rabbit model.</p><p><strong>Methods: </strong>Monocular FD was performed in three-week-old pigmented rabbits (n = 18 for FD, n = 12 for control). Throughout the eight-week rearing period, refractive errors, corneal curvature radius (CCR), ocular biometric parameters, retinal thickness (RT), and choroidal thickness (ChT) were measured every two weeks using cycloplegic retinoscopy, keratometer, A-scan ultrasonography, and optical coherence tomography (OCT). The choroidal vascularity index (CVI) was calculated from OCT images by measuring the total choroidal area (TCA), stromal area (SA), and luminal area (LA). At the end of the form deprivation, the vitreous dopamine level was measured using an enzyme-linked immunosorbent assay kit.</p><p><strong>Results: </strong>Relatively myopic refraction was induced in FD eyes after two, four, six, and eight weeks (interocular differences: -1.48 ± 0.88, -1.92 ± 0.90, -1.95 ± 0.80, and -2.00 ± 0.83 diopter; P < 0.001). Furthermore, FD eyes showed significantly longer axial length (AL) and vitreous chamber depth after eight weeks, with mean differences of 0.32 ± 0.03 and 0.32 ± 0.05 mm, respectively (P < 0.001). There were no significant differences in anterior chamber depth, lens thickness, CCR, and RT among the three groups through the intervention (all P > 0.05). After eight weeks, the average ChT of FD eyes was thinner than contralateral eyes (-19.37 ± 7.01 µm; P < 0.001). Additionally, the TCA, SA, and LA in FD eyes were smaller after four, six, and eight weeks (all P < 0.05, week 8: 0.3697 ± 0.0639 vs. 0.4272 ± 0.0968, 0.1047 ± 0.0221 vs. 0.1233 ± 0.0328, and 0.2650 ± 0.0459 vs. 0.3039 ± 0.0659 mm2, respectively). However, the CVI showed no significant difference among the three groups (P > 0.05). Finally, the concentration of vitreous dopamine was lower in the FD eyes, compared with contralateral and control eyes: 0.18 ± 0.20, 0.40 ± 0.67, and 0.33 ± 0.06 ng/mL, respectively (P < 0.05).</p><p><strong>Conclusions: </strong>Form deprivation led to a relatively myopic shift in pigmented rabbits and a decrease in vitreous dopamine levels. In addition, with the lengthening of AL, the choroid thinned, but CVI remained unchanged.</p><p><strong>Translational relevance: </strong>Our study offered data about the refractive characteristics of pigmented rabbits to investigate myopia mechanisms. The modified method imaged the choroid of the inferior species more clearly, achieving in exploring the changes of choroidal vasculature in vivo.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"18"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults.","authors":"Dan-Lin Li, Min-Xin Liu, Ya-Jie Zheng, Yu Qin, Rong Ma, Gang Liang, Chen-Wei Pan","doi":"10.1167/tvst.14.2.19","DOIUrl":"10.1167/tvst.14.2.19","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between serum biochemical variables and corneal biomechanics in healthy young adults.</p><p><strong>Methods: </strong>A total of 1645 healthy university students were included. Every student underwent an ophthalmologic examination by Corvis ST to measure the corneal biomechanics and a blood examination to evaluate the alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, and uric acid (UA) levels. Canonical correlation analysis (CCA) was conducted to assess their relationship.</p><p><strong>Results: </strong>A significant relationship between serum biochemical variables and corneal biomechanics was found in both men and women. For men, the canonical correlation identified an association between the time of the first applanation (A1t), time of the second applanation (A2t), time of the highest concavity (HC-t), deflection amplitude of the highest concavity (HC-DeflA), and biomechanically corrected intraocular pressure (bIOP) with ALT, AST, urea, and UA (r = 0.235, P = 0.03). For women, a significant relationship between A1t, A2t, and bIOP with ALT and UA was found (r = 0.187, P < 0.01).</p><p><strong>Conclusions: </strong>Elevated levels of ALT and UA were associated with softer corneas with greater elasticity and viscidity. The study provides novel evidence for the relationship between serum biochemical variables and ocular changes.</p><p><strong>Translational relevance: </strong>These findings may help clinicians perform adequate preoperative evaluations when performing corneal surgery on patients with liver or kidney disorders, as well as helping public health practitioners understand serum biochemical variables of corneal changes in healthy people.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"19"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Scientific Considerations for Whole Eye Transplantation: An Ophthalmologist's Perspective.","authors":"Kimberly K Gokoffski, Kia M Washington, Roy S Chuck","doi":"10.1167/tvst.14.2.13","DOIUrl":"10.1167/tvst.14.2.13","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"13"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Method of Early RRMS Diagnosis Using OCT-Assessed Structural Retinal Data and Explainable Artificial Intelligence.","authors":"Miguel Ortiz, Ana Pueyo, Francisco J Dongil, Luciano Boquete, Eva M Sánchez-Morla, Rafael Barea, Juan M Miguel-Jimenez, Almudena López-Dorado, Elisa Vilades, María J Rodrigo, Beatriz Cordon, Elena Garcia-Martin","doi":"10.1167/tvst.14.2.14","DOIUrl":"10.1167/tvst.14.2.14","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to provide the development of a method to classify optical coherence tomography (OCT)-assessed retinal data in the context of automatic diagnosis of early-stage multiple sclerosis (MS) with decision explanation.</p><p><strong>Methods: </strong>The database used contains recordings from 79 patients with recently diagnosed relapsing-remitting multiple sclerosis (RRMS) and no history of optic neuritis and from 69 age-matched healthy control subjects. Analysis was performed on the thicknesses (average right and left eye value and inter-eye difference) of the macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular inner retinal complex layer (mIRL), dividing the macular area into six analysis zones. Recursive feature extraction (RFE) and Shapley additive explanations (SHAP) are combined to rank relevant features and select the subset that maximizes classifier (support vector machine [SVM]) performance.</p><p><strong>Results: </strong>Of the initial 48 features, 20 were identified as maximizing classifier accuracy (n = 0.9257). The SHAP values indicate that average thickness has greater relevance than inter-eye difference, that the mGCL and mRNFL are the most influential structures, and that the peripheral papillomacular bundle and the supero-temporal quadrant are the zones most affected.</p><p><strong>Conclusions: </strong>This approach improves the success rate of automatic diagnosis of early-stage RRMS and enhances clinical decision making transparency.</p><p><strong>Translational relevance: </strong>Retinal structure assessment using OCT data could constitute a noninvasive means of diagnosing early-stage MS. This new high-accuracy and high-explainability method of analysis can be implemented in most hospitals and healthcare centers.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Macular Hole Area to Foveal Avascular Zone Ratio and Its Effects on Visual Acuity Before and After Surgery.","authors":"Junji Kanno, Takuhei Shoji, Hirokazu Ishii, Hisashi Ibuki, Yuji Yoshikawa, Takanori Sasaki, Kei Shinoda","doi":"10.1167/tvst.14.2.22","DOIUrl":"10.1167/tvst.14.2.22","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates factors influencing visual acuity logarithmic minimum angle of resolution (logMAR) in idiopathic macular holes (IMH), with a focus on the foveal avascular zone (FAZ).</p><p><strong>Methods: </strong>En face images from optical coherence tomography and optical coherence tomography angiography of 152 patients with stages 2, 3, and 4 IMH were analyzed. The minimum area (MA), base area, and FAZ of the macular hole were quantified, and the ratio of minimum area to FAZ (MFR) was calculated. In addition, central subfield thickness was extracted. Relationships between preoperative and postoperative visual acuity and these parameters, along with age, sex, axial length, and stage, were assessed using univariate and multivariate analyses.</p><p><strong>Results: </strong>The study included 113 patients with high-quality images (113 eyes; median age, 69 years; interquartile range, 65-73 years). Multivariate analysis of factors significantly associated with pre- and postoperative visual acuity identified MFR as the only consistent independent factor (preoperative: β = 0.280, P < 0.05; postoperative: β = 0.357, P < 0.01).</p><p><strong>Conclusions: </strong>The ratio of macular hole area to the FAZ may be a potentially important morphofunctional parameter influencing visual acuity outcomes in patients with IMH. These findings suggest that MFR could be useful in assessing surgical prognosis, although further research with larger, diverse cohorts is needed.</p><p><strong>Translational relevance: </strong>This study bridges the gap between basic retinal morphology and clinical outcomes by identifying MFR as a predictor of visual acuity in patients with IMH. Incorporating MFR into preoperative evaluations could improve surgical prognostication.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"22"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization.","authors":"Jianqi Chen, Xuhao Chen, Xu Cao, Xiaohua Zhuo, Yuwen Wen, Guitong Ye, Yuan Zhang, Jinan Zhan, Hongmei Tan, Yingting Zhu, Yehong Zhuo","doi":"10.1167/tvst.14.2.2","DOIUrl":"10.1167/tvst.14.2.2","url":null,"abstract":"<p><strong>Purpose: </strong>To elucidate the relationship between diabetic retinopathy (DR) and frailty and investigate genetic correlations and causality.</p><p><strong>Methods: </strong>We analyzed data from the US National Health and Nutrition Examination Survey, which included 1003 individuals with diabetes. DR was evaluated via nonmydriatic retinal imaging, and frailty was measured using a 49-item frailty index. The association between DR and frailty was assessed using survey-weighted logistics regression adjusted for multiple covariates, including age, sex, race, education level, family income-to-poverty ratio, marital status, and Healthy Eating Index. Genetic correlations and causal relationships were investigated through linkage disequilibrium score regression and bidirectional Mendelian randomization.</p><p><strong>Results: </strong>DR was significantly associated with higher odds of frailty after full adjustment (odd ratio [OR] = 4.25; 95% confidence interval [CI], 1.08-16.67; P = 0.040). The association was robust and did not significantly differ across age (P interaction = 0.080), sex (P interaction = 0.216), or race (P interaction = 0.749) groups. DR exhibited a moderate but significant genetic correlation with frailty (rg = 0.27, standard error = 0.04; P = 2.43 × 10-10). Genetically inferred DR was significantly associated with a greater frailty index (β = 0.03; 95% CI, 0.01-0.05; P < 0.001), whereas frailty was not associated with DR risk (OR = 1.20; 95% CI, 0.80-1.81; P = 0.376).</p><p><strong>Conclusions: </strong>Our findings suggest that DR is associated with an increased risk of frailty, indicating that DR not only impairs vision but also accelerates physical decline.</p><p><strong>Translational relevance: </strong>This study highlights the critical need for integrated care approaches that incorporate frailty screening and proactive management in individuals with DR to prevent further health deterioration and improve both quality of life and long-term outcomes.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Grading of Tonography Tracings for the Measurement of Outflow Facility.","authors":"Arthur J Sit, Carol B Toris, Vikas Gulati, Arash Kazemi, Jesse Gilbert, Shan Fan, David M Reed, David O Hodge, Sayoko E Moroi","doi":"10.1167/tvst.14.2.10","DOIUrl":"10.1167/tvst.14.2.10","url":null,"abstract":"<p><strong>Purpose: </strong>Tonography is the standard method for non-invasive measurement of aqueous humor outflow facility. However, assessment of tonography tracing quality is currently subjective, and acceptance of poor-quality data or inappropriately discarding valid data can bias results. The purpose of this study was to develop an objective method for assessing the quality of tonography tracings.</p><p><strong>Methods: </strong>Pneumatonography tracings were obtained from glaucoma and ocular hypertension patients as part of an ongoing multicenter study of aqueous humor dynamics. Intraocular pressure (IOP) was captured digitally at 40 Hz over 2 minutes. Root mean square error (RMSE) of a linear best-fit line was obtained for each tracing. Each tracing was also graded by seven experienced tonographers using a scale of 1 (worst) to 10 (best) for quality (Expert score). A Reference set of 35 tracings was used to determine the relationship between RMSE values and Expert scores using a logarithmic curve. This relationship was used to calculate a predicted score in a second Test set of 20 tracings. A logarithmic curve was used to account for the fixed range of Expert scores and unbounded upper range for RMSE values. The differences between the predicted scores and the Expert scores were evaluated using Bland-Altman analysis.</p><p><strong>Results: </strong>There was a very strong correlation between predicted and Expert scores (R = 0.94). The mean difference between Expert and predicted scores was -1.01 ± 0.84, and the limits of agreement were between -2.65 and +0.63.</p><p><strong>Conclusions: </strong>Objective assessment of pneumatonography tracings can be performed using RMSE of a fitted line and calculation of a predicted quality score that closely matches scores given by expert graders.</p><p><strong>Translational relevance: </strong>Tonography tracing quality can now be objectively assessed.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"10"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Tract Integrity Before and After Gene Therapy in Congenital Achromatopsia.","authors":"Hillel Abramovitch, Atira S Bick, Nitzan Guy, Deena Elul, Ayelet Mckyton, Eyal Banin, Netta Levin","doi":"10.1167/tvst.14.2.9","DOIUrl":"10.1167/tvst.14.2.9","url":null,"abstract":"<p><strong>Purpose: </strong>CNGA3 achromatopsia is a rare hereditary syndrome caused by dysfunction of cone photoreceptors. Visual information is therefore obtained only by rod photoreceptors, resulting in low acuity, photoaversion, and color blindness. Trials using gene therapy have been initiated recently, in which clinical improvement was subtle.</p><p><strong>Methods: </strong>To explain this suboptimal outcome, we used diffusion tensor imaging to assess visual pathway integrity in 3 CNGA3 achromatopsia patients before and after gene therapy, and compared them with 16 normally sighted adults.</p><p><strong>Results: </strong>No significant differences from normal subjects in optic tract and radiation were detected. Fiber integrity reduction was observed in the occipitocallosal fibers. These differences showed some normalization after treatment, but intersubject variability was evident. Specifically, the observed changes were related to radial diffusivities, reflecting fiber myelination or glial cell alterations.</p><p><strong>Conclusions: </strong>Despite the fundamental role of cone photoreceptors in human sight, primary visual pathways in patients are comparable with those of healthy individuals and thereby fiber integrity is probably not an obstacle for recovery. Preliminary results suggest that the splenial fibers are less cohesive in naïve patients and regain some integrity after treatment. These findings add to previous reports on this rare population and suggest that novel information is processed within the visual cortex after treatment.</p><p><strong>Translational relevance: </strong>Patients with complete color blindness were treated using a novel gene augmentation therapy. Unfortunately, the patients did not experience a sudden eureka moment of being able to perceive the full spectrum of colors. In this study, we rule out fiber disintegration as the cause of their limited recovery.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"9"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hormone Levels and Retinopathy in Patients With Type 2 Diabetes: A Cross-Sectional Study.","authors":"Yu Meng, Xueli Yang, Yuxin Fan, Ming Liu, Fengqi Zhou, Qihua Wang, Yuezhu Lu, Yun Zhu, Hua Yan","doi":"10.1167/tvst.14.2.17","DOIUrl":"10.1167/tvst.14.2.17","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the relationship between hormone levels and diabetic retinopathy (DR).</p><p><strong>Methods: </strong>This cross-sectional study recruited 2432 patients with type 2 diabetes from Tianjin Medical University General Hospital between 2016 and 2019. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between hormone levels and DR.</p><p><strong>Results: </strong>DR was diagnosed in 953 patients (39.19%), with no significant gender difference in prevalence. Among men, DR prevalence increased with testosterone level increasing (Q4 vs. Q1: odds ratio [OR] = 1.64; 95% confidence interval [CI], 1.11-2.41) but decreased with prolactin levels increasing (Q4 vs. Q1: OR = 0.65; 95% CI, 0.44-0.96). Among women, high follicle-stimulating hormone (FSH) (Q4 vs. Q1: OR = 2.22; 95% CI, 1.40-3.52) and luteinizing hormone (LH) levels (Q4 vs. Q1: OR = 1.77; 95% CI, 1.20-2.63) were linked with increased DR prevalence. No associations were found in premenopausal women, but postmenopausal women with high prolactin level had increased DR prevalence (Q2 vs. Q1: OR = 1.56; 95% CI, 1.01-2.19). Dose-response relationships were suggested for FSH (P = 0.087) and testosterone (P = 0.088) with DR prevalence, though caution is advised due to the risk of type I error arising from multiple comparisons. Other risk factors included low body mass index (OR = 0.98), smoking (OR = 1.32), long diabetes duration (OR = 1.02), and high systolic blood pressure (OR = 1.01).</p><p><strong>Conclusions: </strong>Prolactin (negatively) and testosterone (positively) were correlated with DR risk in men. FSH and testosterone showed suggestive dose-response relationship with DR prevalence in postmenopausal women. Further research is needed for type 1 diabetes.</p><p><strong>Translational relevance: </strong>Sex hormones play a crucial role in DR development, affecting men and women differently.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"17"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}