Nan-Ji Lu, Marta Jiménez-García, Ahmed Elsheikh, Ahmed Makarem, Carina Koppen, Jos J Rozema
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To discriminate KC eyes from healthy eyes, receiver operating characteristic curves were generated to calculate the area under the curve (AUC) for both versions of SSI and compared with a Delong test.</p><p><strong>Results: </strong>Both versions of SSI showed statistical differences between the healthy group and the group of patients with KC (all P < 0.001). In the healthy group, significant correlations were found between both versions of SSI and age, K1, K2, and Kmax, between SSI and average relational thickness (ART) Max (R2 = 0.23) and between SSI2 and Belin A (R2 = 0.08). In the KC group, significant correlations were found between both versions of SSI and all tomographic parameters (all P < 0.01, except for SSI2 with age P = 0.346); the R2 values in SSI2 were consistently higher than in SSI. 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Both versions demonstrated the same diagnostic ability for KC.</p><p><strong>Translational relevance: </strong>Both versions of SSI are not interchangeable, SSI2 may be preferred to depict the corneal stiffness.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"23"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951061/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.\",\"authors\":\"Nan-Ji Lu, Marta Jiménez-García, Ahmed Elsheikh, Ahmed Makarem, Carina Koppen, Jos J Rozema\",\"doi\":\"10.1167/tvst.14.3.23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The purpose of this study was to compare the performance of the Stress-Strain Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with keratoconus (KC).</p><p><strong>Methods: </strong>Fifty-two healthy and 104 KC eyes were examined using Scheimpflug-based tomography and air-puff tonometry (Pentacam and Corvis). 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引用次数: 0
摘要
目的：本研究的目的是比较应力-应变指数版本1和版本2 （SSI和SSI2）在健康患者和圆锥角膜患者（KC）中的表现。方法：对52只健康眼和104只KC眼进行了基于scheimpflug的断层扫描和气肿眼压测量（Pentacam和Corvis）检查。评估两种版本SSI与年龄、最薄厚度测量和层析成像参数之间的相关性。为了区分KC眼和健康眼，生成受试者工作特征曲线，计算两种版本SSI的曲线下面积（AUC），并与Delong测试进行比较。结果：两个版本的SSI在健康组和KC患者组之间有统计学差异（均P < 0.001）。在健康组中，SSI与年龄、K1、K2、Kmax、SSI与平均相关厚度（ART） Max （R2 = 0.23）、SSI2与Belin A （R2 = 0.08）均存在显著相关。在KC组中，两种版本的SSI与所有层析参数均存在显著相关性（P < 0.01，除SSI2与年龄P = 0.346）；SSI2的R2值始终高于SSI。正常眼与KC眼比较，SSI和SSI2的AUC分别为0.772和0.740 （P = 0.468）。结论：两个版本的SSI与描述KC严重程度的层析参数相关，但SSI2的相关性更高，且不受年龄的影响。两个版本对kc的诊断能力相同。翻译相关性：两个版本的SSI是不可互换的，SSI2可能更倾向于描述角膜僵硬度。
Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.
Purpose: The purpose of this study was to compare the performance of the Stress-Strain Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with keratoconus (KC).
Methods: Fifty-two healthy and 104 KC eyes were examined using Scheimpflug-based tomography and air-puff tonometry (Pentacam and Corvis). Correlations between both versions of SSI and age, thinnest pachymetry, and tomographic parameters were assessed. To discriminate KC eyes from healthy eyes, receiver operating characteristic curves were generated to calculate the area under the curve (AUC) for both versions of SSI and compared with a Delong test.
Results: Both versions of SSI showed statistical differences between the healthy group and the group of patients with KC (all P < 0.001). In the healthy group, significant correlations were found between both versions of SSI and age, K1, K2, and Kmax, between SSI and average relational thickness (ART) Max (R2 = 0.23) and between SSI2 and Belin A (R2 = 0.08). In the KC group, significant correlations were found between both versions of SSI and all tomographic parameters (all P < 0.01, except for SSI2 with age P = 0.346); the R2 values in SSI2 were consistently higher than in SSI. AUC for SSI and SSI2 when comparing normal and KC eyes was 0.772 and 0.740, respectively (P = 0.468).
Conclusions: Both versions of SSI correlated with tomographic parameters describing KC severity, but correlations were higher for SSI2 and were not affected by age. Both versions demonstrated the same diagnostic ability for KC.
Translational relevance: Both versions of SSI are not interchangeable, SSI2 may be preferred to depict the corneal stiffness.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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